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Drug Evaluations

Prasugrel for the treatment of coronary thrombosis: a review of pharmacological properties, indications for use and future development

, MD, , MD PhD & , MD PhD
Pages 119-133 | Published online: 13 Dec 2010

Bibliography

  • Anderson JL, Adams CD, Antman EM, ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2007;116:e148-304
  • Kushner FG, Hand M, Smith SC Jr, 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update) a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2009;54:2205-41
  • Bertrand ME, Rupprecht HJ, Urban P, Gershlick AH. Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the clopidogrel aspirin stent international cooperative study (CLASSICS). Circulation 2000;102:624-9
  • Cadroy Y, Bossavy JP, Thalamas C, Early potent antithrombotic effect with combined aspirin and a loading dose of clopidogrel on experimental arterial thrombogenesis in humans. Circulation 2000;101:2823-8
  • Angiolillo DJ, Ueno M, Goto S. Basic principles of platelet biology and clinical implications. Circ J 2010;74:597-607
  • The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001;345:494-502
  • Mehta SR, Yusuf S, Peters RJG, Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCICURE study. Lancet 2001;358:527-33
  • Steinhubl SR, Berger PB, Mann JT III, Clopidogrel for the reduction of events during observation: early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 2002;288:2411-20
  • Sabatine MS, Cannon CP, Gibson CM, Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with STsegment elevation. N Engl J Med 2005;352:1179-89
  • Sabatine MS, Cannon CP, Gibson CM, Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: the PCI-CLARITY study. JAMA 2005;294:1224-32
  • Chen ZM, Jiang LX, Chen YP, Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 2005;366:1607-21
  • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. J Am Coll Cardiol 2007;49:1505-16
  • Ferreiro JL, Angiolillo DJ. Clopidogrel response variability: current status and future directions. Thromb Haemost 2009;102:7-14
  • Angiolillo DJ, Ferreiro JL. Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions. Rev Esp Cardiol 2010;63:60-76
  • Farid NA, Smith RL, Gillespie TA, The disposition of prasugrel, a novel thienopyridine, in humans. Drug Metab Dispos 2007;35:1096-104
  • Rehmel JL, Eckstein JA, Farid NA, Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450. Drug Metab Dispos 2006;34:600-7
  • Mega JL, Close SL, Wiviott SD, Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation 2009;119:2553-60
  • Farid NA, Kurihara A, Wrighton SA. Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans. J Clin Pharmacol 2010;50:126-42
  • European Medicines Agency. Assessment report for Efient [online]. Available from: http://www.emea.europa.eu/humandocs/PDFs/EPAR/Efient/H-984-en6.pdf [Accessed 15 June 2009]
  • Wiviott SD, Braunwald E, McCabe CH, Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007;357:2001-15
  • Farid NA, Payne CD, Small DS, Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. Clin Pharmacol Ther 2007;81:735-41
  • Small DS, Farid NA, Li YG, Effect of ranitidine on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel. Curr Med Res Opin 2008;24:2251-7
  • Small DS, Farid NA, Payne CD, Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel. J Clin Pharmacol 2008;48:475-84
  • Marin F, Gonzalez-Conejero R, Capranzano P, Pharmacogenetics in cardiovascular antithrombotic therapy. J Am Coll Cardiol 2009;54:1041-57
  • Hulot JS, Collet JP, Silvain J, Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis. J Am Coll Cardiol 2010;56:134-43
  • Brandt JT, Payne CD, Wiviott SD, A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation. Am Heart J 2007;153:66. e9-16
  • Hasegawa M, Sugidachi A, Ogawa T, Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor. Thromb Haemost 2005;94:593-8
  • Algaier I, Jakubowski JA, Asai F, Interaction of the active metabolite of prasugrel, R-138727, with the residues cysteine97 and cysteine175 of the human P2Y12-receptor. J Thromb Haemost 2008;6:1908-14
  • Sugidachi A, Ogawa T, Kurihara A, The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's activemetabolite. J ThrombHaemost 2007;5:1545-51
  • Jernberg T, Payne CD, Winters KJ, Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease. Eur Heart J 2006;27:1166-73
  • Jakubowski JA, Matsushima N, Asai F, A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans. Br J Clin Pharmacol 2007;63:421-30
  • Jakubowski JA, Payne CD, Li YG, A comparison of the antiplatelet effects of prasugrel and high-dose clopidogrel as assessed by VASP-phosphorylation and light transmission aggregometry. Thromb Haemost 2008;99:215-22
  • Wallentin L, Varenhorst C, James S, Prasugrel achieves greater and faster P2Y12 receptor mediated platelet function than clopidogrel due to more efficient generation of its active metabolite in aspirin treated patients with coronary artery disease. Eur Heart J 2008;29:21-30
  • Wiviott SD, Antman EM, Winters KJ, Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial. Circulation 2005;111:3366-73
  • Wiviott SD, Trenk D, Frelinger AL, Prasugrel compared with high loading and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention; the prasugrel in comparison to clopidogrel for inhibition of platelet activation and aggregation-thrombolysis in myocardial infarction 44 trial. Circulation 2007;116:2923-32
  • Angiolillo DJ, Badimon J, Saucedo JF, Comparison of prasugel with clopidogrel on platelet function in coronary artery disease patients with type 2 diabetes mellitus – third optimizing anti-platelet therapy in diabetes mellitUS (OPTIMUS-3). Circulation 2009;120:S1027
  • Montelescot G, Sideris G, Cohen R, Prasugrel compared with high-dose clopidogrel in acute coronary syndrome The randomised, double-blind ACAPULCO* study. Thromb Heamost 2010;103:213-23
  • Angiolillo DJ, Saucedo JF, DeRaad R, Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary syndromes: results of the SWitching Anti Platelet (SWAP) Study. J Am Coll Cardiol 2010;56:1017-23
  • Wiviott SD, Antman EM, Gibson CM, Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: design and rationale for the TRial to assess improvement in therapeutic outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis In Myocardial Infarction 38 (TRITON-TIMI 38). Am Heart J 2006;152:627-35
  • Antman EM, Wiviott SD, Murphy SA, Early and late benefits of prasugrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel-Thrombolysis In Myocardial Infarction) analysis. J Am Coll Cardiol 2008;51:2028-33
  • Murphy SA, Antman EM, Wiviott SD, Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients with acute coronary syndromes from the TRITON-TIMI 38 trial. Eur Heart J 2008;29:2473-9
  • Michelson AD, Frelinger AL III, Braunwald E, Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial. Eur Heart J 2009;30:1753-63
  • Morrow DA, Wiviott SD, White HD. Effect of the novel thienopyridine prasugrel compared with clopidogrel on spontaneous and procedural myocardial infarction in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction 38: an application of the classification system from the universal definition of myocardial infarction. Circulation 2009;119:2758-64
  • Thygesen K, Alpert JS, White HD.; for the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Eur Heart J 2007;28: 2525-2338
  • Wiviott SD, Braunwald E, McCabe CH, Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial. Lancet 2008;371:1353-63
  • Cutlip DE, Windecker S, Mehran R, Clinical end points in coronary stent trials a case for standardized definitions. Circulation 2007;115:2344-51
  • Montalescot G, Wiviott SD, Braunwald E, Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomized controlled trial. Lancet 2009;373:723-31
  • Wiviott SD, Braunwald E, Angiolillo DJ, Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel thrombolysis in myocardial infarction 38. Circulation 2008;118:1626-36
  • Mahoney EM, Wang K, Arnold SV, Cost-effectiveness of prasugrel versus clopidogrel in patients with acute coronary syndromes and planned percutaneous coronary intervention results from the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel–thrombolysis in myocardial infarction TRITON-TIMI 38. Circulation 2010;121:71-9
  • O'Donoghue M, Antman EM, Braunwald E, The efficacy and safety of prasugrel with and without a glycoprotein IIb/IIIa inhibitor in patients with acute coronary syndromes undergoing percutaneous intervention A TRITON–TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis In Myocardial Infarction 38) analysis. J Am Coll Cardiol 2009;54:678-85
  • Effient (prasugrel) [US prescribing information]. Indianapolis: Eli Lilly and Company, 2009. Available from: http://pi.lilly.com/us/effient.pdf [Last accessed 5 November 2010]
  • Wiviott SD, Antman EM, Braunwald E. Prasugrel. Circulation 2010;122:394-403
  • Dangas G, Mehran R, Guagliumi G, Role of clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty: results from the HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trial. J Am Coll Cardiol 2009;54:1438-46

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