375
Views
11
CrossRef citations to date
0
Altmetric
Reviews

Investigational Notch and Hedgehog inhibitors – therapies for cardiovascular disease

, , &
Pages 1649-1664 | Published online: 18 Oct 2011

Bibliography

  • Morrisey EE. Weary of the stress: time to put another notch in cardiomyopathy. Circ Res 2010;106(7):1187-9
  • Majesky MW. Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol 2007;27(12):1248-58
  • Lavine KJ, Ornitz DM. Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature. Circ Res 2009;104(2):159-69
  • Morrow D, Guha S, Sweeney C, Notch and vascular smooth muscle cell phenotype. Circ Res 2008;103(12):1370-82
  • Guo S, Liu M, Gonzalez-Perez RR. Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta 2011;1815(2):197-213
  • Kelleher FC. Hedgehog signaling and therapeutics in pancreatic cancer. Carcinogenesis 2011;32(4):445-51
  • Bisht S, Brossart P, Maitra A, Feldmann G. Agents targeting the Hedgehog pathway for pancreatic cancer treatment. Curr Opin Investig Drugs 2010;11(12):1387-98
  • Ristorcelli E, Lombardo D. Targeting Notch signaling in pancreatic cancer. Expert Opin Ther Targets 2010;14(5):541-52
  • Peukert S, Miller-Moslin K. Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics. ChemMedChem 2010;5(4):500-12
  • Dierks C. GDC-0449–targeting the hedgehog signaling pathway. Recent Results Cancer Res 2010;184:235-8
  • Han J, Hendzel MJ, Allalunis-Turner J. Notch signaling as a therapeutic target for breast cancer treatment? Breast Cancer Res 2011;13(3):210
  • Artavanis-Tsakonas S. The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila. Trends Genet 1988;4(4):95-100
  • Wu J, Zhang S, Sun X. Neuroprotective effect of upregulated sonic Hedgehog in retinal ganglion cells following chronic ocular hypertension. Invest Ophthalmol Vis Sci 2010;51(6):2986-92
  • Iso T, Hamamori Y, Kedes L. Notch signaling in vascular development. Arterioscler Thromb Vasc Biol 2003;23(4):543-53
  • del Alamo D, Rouault H, Schweisguth F. Mechanism and significance of cis-inhibition in Notch signalling. Curr Biol 2011;21(1):R40-7
  • Schwanbeck R, Martini S, Bernoth K, Just U. The Notch signaling pathway: molecular basis of cell context dependency. Eur J Cell Biol 2011;90(6-7):572-81
  • Tien AC, Rajan A, Bellen HJ. A Notch updated. J Cell Biol 2009;184(5):621-9
  • D'Souza B, Miyamoto A, Weinmaster G. The many facets of Notch ligands. Oncogene 2008;27(38):5148-67
  • Fushimi S, Wada N, Nohno T, 17beta-Estradiol inhibits chondrogenesis in the skull development of zebrafish embryos. Aquat Toxicol 2009;95(4):292-8
  • Lacombe P, Oligo C, Domenga V, Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy. Stroke 2005;36(5):1053-8
  • Ingram WJ, McCue KI, Tran TH, Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling. Oncogene 2008;27(10):1489-500
  • Hartmann D, Tournoy J, Saftig P, Implication of APP secretases in notch signaling. J Mol Neurosci 2001;17(2):171-81
  • Sweeney C, Morrow D, Birney YA, Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. FASEB J 2004;18(12):1421-3
  • Morrow D, Sweeney C, Birney YA, Cyclic strain inhibits Notch receptor signaling in vascular smooth muscle cells in vitro. Circ Res 2005;96(5):567-75
  • Kim IM, Wolf MJ, Rockman HA. Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. Circ Res 2010;106(7):1233-43
  • Mumm JS, Schroeter EH, Saxena MT, A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell 2000;5(2):197-206
  • Ramain P, Khechumian K, Seugnet L, Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr Biol 2001;11(22):1729-38
  • Matsuno K, Eastman D, Mitsiades T, Human deltex is a conserved regulator of Notch signalling. Nat Genet 1998;19(1):74-8
  • Amsen D, Blander JM, Lee GR, Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 2004;117(4):515-26
  • Kamakura S, Oishi K, Yoshimatsu T, Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol 2004;6(6):547-54
  • Cahill PA, Morrow D, Sweeney C, Biomechanical regulation of hedgehog signaling in vascular smooth muscle cells in vitro and in vivo. Am J Physiol Cell Physiol 2007;292(1):C488-C96
  • Shimizu T, Kagawa T, Inoue T, Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells. Mol Cell Biol 2008;28(24):7427-41
  • Hansson EM, Lendahl U, Chapman G. Notch signaling in development and disease. Semin Cancer Biol 2004;14(5):320-8
  • Garg V, Muth AN, Ransom JF, Mutations in NOTCH1 cause aortic valve disease. Nature 2005;437(7056):270-4
  • McDaniell R, Warthen DM, Sanchez-Lara PA, NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am J Hum Genet 2006;79(1):169-73
  • Joutel A, Corpechot C, Ducros A, Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 1996;383(6602):707-10
  • Wang Z, Wei J, Zhang X, A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia. Am J Med Genet B Neuropsychiatr 2006;141B(8):902-6
  • Limbourg FP, Takeshita K, Radtke F, Essential role of endothelial Notch1 in angiogenesis. Circulation 2005;111(14):1826-32
  • Gale NW, Dominguez MG, Noguera I, Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci USA 2004;101(45):15949-54
  • Ellisen LW, Bird J, West DC, TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991;66(4):649-61
  • Ito T, Udaka N, Okudela K, Mechanisms of neuroendocrine differentiation in pulmonary neuroendocrine cells and small cell carcinoma. Endocr Pathol 2003;14(2):133-9
  • Alison MR, Lim SM, Nicholson LJ. Cancer stem cells: problems for therapy? J Pathol. 2011;223(2):147-61
  • Harrison H, Farnie G, Brennan KR, Clarke RB. Breast cancer stem cells: something out of notching? Cancer Res 2010;70(22):8973-6
  • Lee JH, Suk J, Park J, Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway. Mol Cancer Res 2009;7(10):1663-71
  • Mazumdar J, Dondeti V, Simon MC. Hypoxia-inducible factors in stem cells and cancer. J Cell Mol Med 2009;13(11-12):4319-28
  • Donnem T, Andersen S, Al-Shibli K, Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival. Cancer 2010;116(24):5676-85
  • Mendelson J, Song S, Li Y, Dysfunctional transforming growth factor-beta signaling with constitutively active notch signaling in Barrett's esophageal Adenocarcinoma. Cancer. 2011;117(16):3691-702
  • Rodilla V, Villanueva A, Obrador-Hevia A, Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci USA 2009;106(15):6315-20
  • Gridley T. Notch signaling in the vasculature. Curr Top Dev Biol 2010;92:277-309
  • Lawson ND, Vogel AM, Weinstein BM. sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 2002;3(1):127-36
  • Swift MR, Weinstein BM. Arterial-venous specification during development. Circ Res 2009;104(5):576-88
  • Morrow D, Cullen JP, Liu W, Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol 2009;29(7):1112-18
  • Guha S, Cullen JP, Morrow D, Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival. Basic Res Cardiol 2011;106(5):773-85
  • Li Y, Takeshita K, Liu PY, Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation 2009;119(20):2686-92
  • Caolo V, Schulten HM, Zhuang ZW, Soluble Jagged-1 inhibits neointima formation by attenuating Notch-Herp2 signaling. Arterioscler Thromb Vasc Biol 2011;31(5):1059-65
  • Joutel A. Pathogenesis of CADASIL: transgenic and knock-out mice to probe function and dysfunction of the mutated gene, Notch3, in the cerebrovasculature. Bioessays 2011;33(1):73-80
  • Boulos N, Helle F, Dussaule JC, Notch3 is essential for regulation of the renal vascular tone. Hypertension 2011;57(6):1176-82
  • Arboleda-Velasquez JF, Manent J, Lee JH, Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci USA 2011;108(21):E128-35
  • Osherovich L. Notch nicked again. SciBX 4(6); doi:10.1038/scibx.2011.151
  • Yan M, Callahan CA, Beyer JC, Chronic DLL4 blockade induces vascular neoplasms. Nature 2010;463(7282):E6-7
  • Wu Y, Cain-Hom C, Choy L, Therapeutic antibody targeting of individual Notch receptors. Nature 2010;464(7291):1052-7
  • Nakayama K, Nagase H, Koh CS, Ohkawara T. Gamma-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease. Cell Mol Neurobiol 2011;31(6):887-900
  • Li YM, Xu M, Lai MT, Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 2000;405(6787):689-94
  • Beel AJ, Sanders CR. Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci 2008;65(9):1311-34
  • Luistro L, He W, Smith M, Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res 2009;69(19):7672-80
  • Paganin M, Ferrando A. Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia. Blood Rev 2011;25(2):83-90
  • Tammam J, Ware C, Efferson C, Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia. Br J Pharmacol 2009;158(5):1183-95
  • Cerchietti LC, Ghetu AF, Zhu X, A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell 2010;17(4):400-11
  • Kalen M, Heikura T, Karvinen H, Gamma-secretase inhibitor treatment promotes VEGF-A-driven blood vessel growth and vascular leakage but disrupts neovascular perfusion. PLoS One 2011;6(4):e18709
  • Hayashi H, Nakagami H, Takami Y, Involvement of gamma-secretase in postnatal angiogenesis. Biochem Biophys Res Commun 2007;363(3):584-90
  • Cao L, Arany PR, Kim J, Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials 2010;31(34):9048-56
  • Al Haj Zen A, Oikawa A, Bazan-Peregrino M, Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia. Circ Res 2010;107(2):283-93
  • Li X, Zhang X, Leathers R, Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med 2009;15(11):1289-97
  • Wu X, Zou Y, Zhou Q, Role of JAGGED1 in arterial lesions after vascular injury. Arterioscler Thromb Vasc Biol 2011;31(9):2000-6
  • Wang Z, Li Y, Ahmad A, Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta 2010;1806(2):258-67
  • Hoey T, Yen WC, Axelrod F, DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell 2009;5(2):168-77
  • Real PJ, Tosello V, Palomero T, Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med 2009;15(1):50-8
  • Liu Z, Turkoz A, Jackson EN, Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest 2011;121(2):800-8
  • Moellering RE, Cornejo M, Davis TN, Direct inhibition of the NOTCH transcription factor complex. Nature 2009;462(7270):182-8
  • Inui M, Martello G, Piccolo S. MicroRNA control of signal transduction. Nat Rev Mol Cell Biol 2010;11(4):252-63
  • Boucher JM, Peterson SM, Urs S, The miR-143/145 cluster is a novel transcriptional target of Jagged-1/Notch signaling in vascular smooth muscle cells. J Biol Chem 2011;286(32):28312-21
  • Ohnishi Y, Saika S, Yamanaka O, Investigation of mechanism of cell proliferation regulation and its clinical application. Nippon Ganka Gakkai Zasshi 2005;109(12):865-83; discussion 84
  • Nusslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980;287(5785):795-801
  • Jung Y, Witek RP, Syn WK, Signals from dying hepatocytes trigger growth of liver progenitors. Gut 2010;59(5):655-65
  • Soleti R, Martinez MC. Microparticles harbouring Sonic Hedgehog: role in angiogenesis regulation. Cell Adhes Migr 2009;3(3):293-5
  • Dentice M. Hedgehog-mediated regulation of thyroid hormone action through iodothyronine deiodinases. Expert Opin Ther Targets 2011;15(4):493-504
  • Li C, Chi S, Xie J. Hedgehog signaling in skin cancers. Cell Signal 2011;23(8):1235-43
  • Gallet A. Hedgehog morphogen: from secretion to reception. Trends Cell Biol 2011;21(4):238-46
  • Hooper JE, Scott MP. Communicating with Hedgehogs. Nat Rev Mol Cell Biol 2005;6(4):306-17
  • McCarthy RA, Barth JL, Chintalapudi MR, Megalin functions as an endocytic sonic hedgehog receptor. J Biol Chem 2002;277(28):25660-7
  • Izraeli S, Lowe LA, Bertness VL, Genetic evidence that Sil is required for the Sonic Hedgehog response pathway. Genesis 2001;31(2):72-7
  • Callahan CA, Ofstad T, Horng L, MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev 2004;18(22):2724-9
  • Johnson RL, Rothman AL, Xie J, Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996;272(5268):1668-71
  • Taylor MD, Liu L, Raffel C, Mutations in SUFU predispose to medulloblastoma. Nat Genet 2002;31(3):306-10
  • Reifenberger J, Wolter M, Weber RG, Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 1998;58(9):1798-803
  • Reifenberger J, Wolter M, Knobbe CB, Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br J Dermatol 2005;152(1):43-51
  • Takebe N, Harris PJ, Warren RQ, Ivy SP. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol 2011;8(2):97-106
  • Merchant AA, Matsui W. Targeting Hedgehog–a cancer stem cell pathway. Clin Cancer Res 2010;16(12):3130-40
  • Benameur T, Andriantsitohaina R, Martinez MC. Therapeutic potential of plasma membrane-derived microparticles. Pharmacol Rep 2009;61(1):49-57
  • Pola R, Ling LE, Aprahamian TR, Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia. Circulation 2003;108(4):479-85
  • Kusano KF, Allendoerfer KL, Munger W, Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy. Arterioscler Thromb Vasc Biol 2004;24(11):2102-7
  • Surace EM, Balaggan KS, Tessitore A, Inhibition of ocular neovascularization by hedgehog blockade. Mol Ther 2006;13(3):573-9
  • Li F, Duman-Scheel M, Yang D, Sonic hedgehog signaling induces vascular smooth muscle cell proliferation via induction of the G1 cyclin-retinoblastoma axis. Arterioscler Thromb Vasc Biol 2010;30(9):1787-94
  • Passman JN, Dong XR, Wu SP, A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci USA 2008;105(27):9349-54
  • Xu Y, Chenna V, Hu C, A polymeric nanoparticle encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma. Clin Cancer Res. 2011 Aug 25. [Epub ahead of print] (in press)
  • Cooper MK, Porter JA, Young KE, Beachy PA. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 1998;280(5369):1603-7
  • Opgenoorth E, Erblich-Baumhackl E, Lenz G, Motor reactivity during lithium prophylaxis. Bibl Psychiatr 1981(161):152-69
  • Gould A, Missailidis S. Targeting the hedgehog pathway: the development of cyclopamine and the development of anti-cancer drugs targeting the hedgehog pathway. Mini Rev Med Chem 2011;11(3):200-13
  • Low JA, de Sauvage FJ. Clinical experience with Hedgehog pathway inhibitors. J Clin Oncol 2010;28(36):5321-6
  • Tremblay MR, McGovern K, Read MA, Castro AC. New developments in the discovery of small molecule Hedgehog pathway antagonists. Curr Opin Chem Biol 2010;14(3):428-35
  • Lauth M, Toftgard R. Hedgehog signaling and pancreatic tumor development. Adv Cancer Res 2011;110:1-17
  • Kiesslich T, Berr F, Alinger B, Current status of therapeutic targeting of developmental signalling pathways in oncology. Curr Pharm Biotechnol. 2011 May 24. [Epub ahead of print]
  • Von Hoff DD, LoRusso PM, Rudin CM, Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009;361(12):1164-72
  • Dolgin E. Companies race to develop first Hedgehog inhibitor cancer drug. Nat Med 2011;17(5):523
  • Bruggemann LW, Queiroz KC, Zamani K, Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer. Cancer Biol Ther 2010;10(1):79-88

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.