501
Views
3
CrossRef citations to date
0
Altmetric
Reviews

Contraceptives with novel benefits

, &
Pages 83-90 | Published online: 08 Dec 2011

Bibliography

  • Law ML, Kao FT, Wei Q, ?>The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2. Proc Natl Acad Sci USA 1987;84:2877-81
  • Gadkar-Sable S, Shah C, Rosario G, Progesterone receptors: various forms and functions in reproductive tissues. Front Biosci 2005;10:2118-30
  • Kastner P, Krust A, Turcotte B, Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 1990;9:1603-14
  • Tora L, Gronemeyer H, Turcotte B, The N-terminal region of the chicken progesterone receptor specifies target gene activation. Nature 1988;333:185-8
  • Giangrande PH, McDonnell DP. The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. Recent Prog Horm Res 1999;54:291-313; discussion 313-294
  • Mulac-Jericevic B, Mullinax RA, DeMayo FJ, Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science 2000;289:1751-4
  • Mulac-Jericevic B, Lydon JP, DeMayo FJ, Conneely OM. Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci USA 2003;100:9744-9
  • Schumacher M, Guennoun R, Robert F, Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination. Growth Horm IGF Res 2004;14Suppl(A):S18-33
  • Attardi BJ, Burgenson J, Hild SA, Reel JR. In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol 2004;88:277-88
  • Schindler AE, Campagnoli C, Druckmann R, Classification and pharmacology of progestins. Maturitas 2008;61:171-80
  • Sitruk-Ware R. New progestogens: a review of their effects in perimenopausal and postmenopausal women. Drugs Aging 2004;21:865-83
  • Fuhrmann U, Krattenmacher R, Slater EP, Fritzemeier KH. The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential. Contraception 1996;54:243-51
  • Oelkers W. Drospirenone, a progestogen with antimineralocorticoid properties: a short review. Mol Cell Endocrinol 2004;217:255-61
  • Schindler AE. Differential effects of progestins on hemostasis. Maturitas 2003;46(Suppl 1):S31-7
  • Muhn P, Fuhrmann U, Fritzemeier KH, Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity. Ann N Y Acad Sci 1995;761:311-35
  • Oelkers WK. Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure. Steroids 1996;61:166-71
  • Elger W, Beier S, Pollow K, Conception and pharmacodynamic profile of drospirenone. Steroids 2003;68:891-905
  • Krattenmacher R. Drospirenone: pharmacology and pharmacokinetics of a unique progestogen. Contraception 2000;62:29-38
  • Johansson ED, Sitruk-Ware R. New delivery systems in contraception: vaginal rings. Am J Obstet Gynecol 2004;190:S54-9
  • Keam SJ, Wagstaff AJ. Ethinylestradiol/drospirenone: a review of its use as an oral contraceptive. Treat Endocrinol 2003;2:49-70
  • Endrikat J, Blode H, Gerlinger C, A pharmacokinetic study with a low-dose oral contraceptive containing 20 microg ethinylestradiol plus 100 microg levonorgestrel. Eur J Contracept Reprod Health Care 2002;7:79-90
  • Machado RB, Pompei Lde M, Giribela AG, Giribela CG. Drospirenone/ethinylestradiol: a review on efficacy and noncontraceptive benefits. Womens Health (Lond Engl) 2011;7:19-30
  • Maloney JM, Dietze P Jr, Watson D, Treatment of acne using a 3-milligram drospirenone/20-microgram ethinyl estradiol oral contraceptive administered in a 24/4 regimen: a randomized controlled trial. Obstet Gynecol 2008;112:773-81
  • Koltun W, Lucky AW, Thiboutot D, Efficacy and safety of 3 mg drospirenone/20 mcg ethinylestradiol oral contraceptive administered in 24/4 regimen in the treatment of acne vulgaris: a randomized, double-blind, placebo-controlled trial. Contraception 2008;77:249-56
  • van Vloten WA, van Haselen CW, van Zuuren EJ, The effect of 2 combined oral Contraceptives containing either drospirenone or cyproterone acetate on acne and seborrhea. Cutis 2002;69:2-15
  • Thorneycroft H, Gollnick H, Schellschmidt I. Superiority of a combined contraceptive containing drospirenone to a triphasic preparation containing norgestimate in acne treatment. Cutis 2004;74:123-30
  • Marr J, Niknian M, Shulman LP, Lynen R. Premenstrual dysphoric disorder symptom cluster improvement by cycle with the combined oral contraceptive ethinylestradiol 20 mcg plus drospirenone 3 mg administered in a 24/4 regimen. Contraception 2011;84:81-6
  • Marr J, Heinemann K, Kunz M, Rapkin A. Ethinyl estradiol 20 mug/drospirenone 3 mg 24/4 oral contraceptive for the treatment of functional impairment in women with premenstrual dysphoric disorder. Int J Gynaecol Obstet 2011;113:103-7
  • Foidart JM, Faustmann T. Advances in hormone replacement therapy: weight benefits of drospirenone, a 17alpha-spirolactone-derived progestogen. Gynecol Endocrinol 2007;23:692-9
  • Catherino WH, Jordan VC. Nomegestrol acetate, a clinically useful 19-norprogesterone derivative which lacks estrogenic activity. J Steroid Biochem Mol Biol 1995;55:239-46
  • Lello S. Nomegestrol acetate: clinical pharmacology. Minerva Ginecol 2009;61:459-63
  • Bullock LP, Bardin CW. Androgenic, synandrogenic, and antiandrogenic actions of progestins. Ann N Y Acad Sci 1977;286:321-30
  • Lello S. Nomegestrol acetate: pharmacology, safety profile and therapeutic efficacy. Drugs 2010;70:541-59
  • Christin-Maitre S, Serfaty D, Chabbert-Buffet N, Comparison of a 24-day and a 21-day pill regimen for the novel combined oral contraceptive, nomegestrol acetate and 17beta-estradiol (NOMAC/E2): a double-blind, randomized study. Hum Reprod 2011;26:1338-47
  • Gaussem P, Alhenc-Gelas M, Thomas JL, Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17beta-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study. Thromb Haemost 2011;105:560-7
  • Coutinho EM. One year contraception with a single subdermal implant containing nomegestrol acetate (Uniplant). Contraception 1993;47:97-105
  • Barbosa I, Coutinho E, Hirsch C, Effects of a single contraceptive silastic implant containing nomegestrol acetate on ovarian function and cervical mucus production during 2 years. Fertil Steril 1996;65:724-9
  • Persiani P, Radici E, Lombardi PA, Lombardi PL. Use of nomegestrol acetate in the treatment of menstruation disorders. Our experience in 56 cases. Minerva Ginecol 1997;49:181-5
  • Fraser DI, Padwick ML, Whitehead MI, The effects of the addition of nomegestrol acetate to post-menopausal oestrogen therapy. Maturitas 1989;11:21-34
  • Kumar N, Koide SS, Tsong Y, Sundaram K. Nestorone: a progestin with a unique pharmacological profile. Steroids 2000;65:629-36
  • Diaz S, Schiappacasse V, Pavez M, Clinical trial with Nestorone subdermal contraceptive implants. Contraception 1995;51:33-8
  • Lahteenmaki PL, Diaz S, Miranda P, Milk and plasma concentrations of the progestin ST-1435 in women treated parenterally with ST-1435. Contraception 1990;42:555-62
  • Fraser IS, Weisberg E, Kumar N, An initial pharmacokinetic study with a Metered Dose Transdermal System for delivery of the progestogen Nestorone as a possible future contraceptive. Contraception 2007;76:432-8
  • Fotherby K. Potency and pharmacokinetics of gestagens. Contraception 1990;41:533-50
  • Noe G, Salvatierra A, Heikinheimo O, Pharmacokinetics and bioavailability of ST 1435 administered by different routes. Contraception 1993;48:548-56
  • Prasad PV, Bashir M, Sitruk-Ware R, Kumar N. Single-dose pharmacokinetics of Nestorone, a potential female-contraceptive. Steroids 2010;75:252-64
  • Sivin I, Mishell DR Jr, Alvarez F, Contraceptive vaginal rings releasing Nestorone and ethinylestradiol: a 1-year dose-finding trial. Contraception 2005;71:122-9
  • Sitruk-Ware R, Small M, Kumar N, Nestorone: clinical applications for contraception and HRT. Steroids 2003;68:907-13
  • Massai MR, Diaz S, Quinteros E, Contraceptive efficacy and clinical performance of Nestorone implants in postpartum women. Contraception 2001;64:369-76
  • Nath A, Sitruk-Ware R. Parenteral administration of progestins for hormonal replacement therapy. Eur J Contracept Reprod Health Care 2009;14:88-96
  • Lenzi E, Pluchino N, Begliuomini S, Central modifications of allopregnanolone and beta-endorphin following subcutaneous administration of Nestorone. J Steroid Biochem Mol Biol 2009;116:15-20
  • Liu L, Zhao L, She H, Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo. Endocrinology 2010;151:5782-94
  • Sitruk-Ware R, Nath A. The use of newer progestins for contraception. Contraception 2010;82:410-17
  • Sitruk-ware R. Neuroprotection and meyelin repair using Nestorone. in WIPO Patent Application. The Population Council, Inc; USA: 2011
  • Oettel M, Bervoas-Martin S, Elger W, A 19-norprogestin without 17alpha-ethinyl group II: Dienogest from a pharmacokinetic point of view. Drugs Today 1995;31:499-516
  • Sasagawa S, Shimizu Y, Kami H, Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile. Steroids 2008;73:222-31
  • Foster RH, Wilde MI. Dienogest. Drugs 1998;56:825-33; discussion 834-825
  • Sitruk-Ware R. Pharmacological profile of progestins. Maturitas 2008;61:151-7
  • Teichmann A. Pharmacology of estradiol valerate/dienogest. Climacteric 2003;6(Suppl 2):17-23
  • Zeun S, Lu M, Uddin A, Pharmacokinetics of an oral contraceptive containing oestradiol valerate and dienogest. Eur J Contracept Reprod Health Care 2009;14:221-32
  • Wiegratz I, Stahlberg S, Manthey T, Effect of extended-cycle regimen with an oral contraceptive containing 30 mcg ethinylestradiol and 2 mg dienogest on bleeding patterns, safety, acceptance and contraceptive efficacy. Contraception 2011;84:133-43
  • Palacios S, Wildt L, Parke S, Efficacy and safety of a novel oral contraceptive based on oestradiol (oestradiol valerate/dienogest): a Phase III trial. Eur J Obstet Gynecol Reprod Biol 2010;149:57-62
  • Klipping C, Duijkers I, Parke S, Hemostatic Effects of a Novel Estradiol-Based Oral Contraceptive: An Open-Label, Randomized, Crossover Study of Estradiol Valerate/Dienogest versus Ethinylestradiol/Levonorgestrel. Drugs R D 11 159-70
  • Schneider HP. Androgens and antiandrogens. Ann N Y Acad Sci 2003;997:292-306
  • Fraser IS, Romer T, Parke S, Effective treatment of heavy and/or prolonged menstrual bleeding with an oral contraceptive containing estradiol valerate and dienogest: a randomized, double-blind Phase III trial. Hum Reprod 2011;26:2698-708
  • Fraser IS, Parke S, Mellinger U, Effective treatment of heavy and/or prolonged menstrual bleeding without organic cause: pooled analysis of two multinational, randomised, double-blind, placebo-controlled trials of oestradiol valerate and dienogest. Eur J Contracept Reprod Health Care 2011;16:258-69
  • Petraglia F, Hornung D, Seitz C, Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment. Arch Gynecol Obstet 2011; [Epub ahead of print]
  • Winneker RC, Bitran D, Zhang Z. The preclinical biology of a new potent and selective progestin: trimegestone. Steroids 2003;68:915-20
  • Sitruk-Ware R, Bossemeyer R, Bouchard P. Preclinical and clinical properties of trimegestone: a potent and selective progestin. Gynecol Endocrinol 2007;23:310-19
  • Maillard-Salin DG, Becourt P, Couarraze G. A study of the adhesive-skin interface: correlation between adhesion and passage of a drug. Int J Pharm 2000;200:121-6
  • Bouchard P, De Cicco-Nardone F, Spielmann D, Garcea N. Bleeding profile and endometrial safety of continuous combined regimens 1 mg 17beta-estradiol/trimegestone versus 1 or 2 mg 17beta-estradiol/norethisterone acetate in postmenopausal women. Gynecol Endocrinol 2005;21:142-8
  • Koninckx PR, Spielmann D. A comparative 2-year study of the effects of sequential regimens of 1 mg 17beta-estradiol and trimegestone with a regimen containing estradiol valerate and norethisterone on the bleeding profile and endometrial safety in postmenopausal women. Gynecol Endocrinol 2005;21:82-9
  • Al-Azzawi F, Wahab M, Sami S, Randomized trial of effects of estradiol in combination with either norethisterone acetate or trimegestone on lipids and lipoproteins in postmenopausal women. Climacteric 2004;7:292-300
  • Warming L, Ravn P, Spielman D, Trimegestone in a low-dose, continuous-combined hormone therapy regimen prevents bone loss in osteopenic postmenopausal women. Menopause 2004;11:337-42
  • Chabbert-Buffet N, Ouzounian S, Kairis AP, Bouchard P. Contraceptive applications of progesterone receptor modulators. Eur J Contracept Reprod Health Care 2008;13:222-30
  • Brenner RM, Slayden OD, Nath A, Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques. Contraception 81:336-42
  • Stratton P, Levens ED, Hartog B, Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914. Fertil Steril 2010;93:2035-41
  • Snow SE, Melillo SN, Jarvis CI. Ulipristal acetate for emergency contraception. Ann Pharmacother 2011;45:780-6
  • Nieman LK, Blocker W, Nansel T, Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study. Fertil Steril 2011;95:767-72; e761-762
  • DeManno D, Elger W, Garg R, Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy. Steroids 2003;68:1019-32
  • Chwalisz K, Perez MC, Demanno D, Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Endocr Rev 2005;26:423-38
  • Wilkens J, Chwalisz K, Han C, Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy. J Clin Endocrinol Metab 2008;93:4664-71
  • Safety of Treatment of Uterine Fibroids With Asoprisnil. Vol. 2008. Available from: http://clinicaltrials.gov/archive/NCT00156208, 2005
  • Chwalisz K, Mattia-Goldberg K, Lee M, Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil. Fertil Steril 2004;82:S83
  • Pasqualini JR. Progestins and breast cancer. Gynecol Endocrinol 2007;23(Suppl 1):32-41

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.