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Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation

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Pages 1155-1167 | Published online: 14 Jun 2012

Bibliography

  • Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 1987;223:217-22
  • Adams J, Chen ZP, Van Denderen BJ, Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci 2004;13:155-65
  • Xiao B, Sanders MJ, Underwood E, Structure of mammalian AMPK and its regulation by ADP. Nature 2011;472:230-3
  • Hardie DG. AMP-activated protein kinase – an energy sensor that regulates all aspects of cell function. Gene Dev 2011;25:1895-908
  • Cheung PC, Salt IP, Davies SP, Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J 2000;346:659-69
  • Salt I, Celler JW, Hawley SA, AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem J 1998;334:177-87
  • Sakamoto K, Goransson O, Hardie DG, Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am J Physiol Endocrinol Metab 2004;287:E310-17
  • Hawley SA, Pan DA, Mustard KJ, Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2005;2:9-19
  • Woods A, Dickerson K, Heath R, Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab 2005;2:21-33
  • Zmijewski JW, Banerjee S, Bae H, Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase. J Biol Chem 2010;285:33154-64
  • Corton JM, Gillespie JG, Hawley SA, 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 1995;229:558-65
  • Lopez JM, Santidrian AF, Campas C, 5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved. Biochem J 2003;370:1027-32
  • Jhun BS, Jin Q, Oh YT, 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. Biochem Biophys Res Commun 2004;318:372-80
  • Guigas B, Bertrand L, Taleux N, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation. Diabetes 2006;55:865-74
  • Fryer LG, Parbu-Patel A, Carling D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 2002;277:25226-32
  • Hawley SA, Ross FA, Chevtzoff C, Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab 2010;11:554-65
  • Kou R, Sartoretto J, Michel T. Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. J Biol Chem 2009;284:14734-43
  • Xu X, Jhun BS, Ha CH, Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation. Endocrinology 2008;149:4183-92
  • Yamauchi T, Kamon J, Minokoshi Y, Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-95
  • Minokoshi Y, Kim YB, Peroni OD, Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002;415:339-43
  • Cool B, Zinker B, Chiou W, Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab 2006;3:403-16
  • Scott JW, van Denderen BJ, Jorgensen SB, Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol 2008;15:1220-30
  • Pang T, Zhang ZS, Gu M, Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J Biol Chem 2008;283:16051-60
  • Pang J, Pang L, Elliot M, The selectivity of protein kinase inhibitors: a further update. Biochem J 2007;408:297-315
  • Kim YM, Kim MY, Kim HJ, Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo. Atherosclerosis 2011;219:57-64
  • Foretz M, Hebrard S, Leclerc J, Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 2010;120:2355-69
  • Geyer M, Muller-Ladner U. Actual status of antiinterleukin-1 therapies in rheumatic diseases. Curr Opin Rheumatol 2010;22:246-51
  • Ding C, Cicuttini F, Li J, Targeting IL-6 in the treatment of inflammatory and autoimmune diseases. Expert Opin Investig Drugs 2009;18:1457-66
  • Sethi G, Sung B, Kunnumakkara AB, Targeting TNF for treatment of cancer and autoimmunity. Adv Exp Med Biol 2009;647:37-51
  • Grewal IS. Overview of TNF superfamily: a chest full of potential therapeutic targets. Adv Exp Med Biol 2009;647:1-7
  • Wu H, Tschopp J, Lin SC. Smac mimetics and TNFalpha: a dangerous liaison? Cell 2007;131:655-8
  • Karin M, Gallagher E. TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol Rev 2009;228:225-40
  • Bianchi K, Meier P. A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling. Mol Cell 2009;36:736-42
  • Walczak H. TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer. Immunol Rev 2011;244:9-28
  • Liu F, Xia Y, Parker AS, IKK biology. Immunol Rev 2012;246:239-53
  • Natoli G. Control of NF-kappaB-dependent transcriptional responses by chromatin organization. Cold Spring Harb Perspect Biol 2009;1:a000224
  • Siwkowski AM, Madge LA, Koo S, Effects of antisense oligonucleotide-mediated depletion of tumor necrosis factor (TNF) receptor 1-associated death domain protein on TNF-induced gene expression. Mol Pharmacol 2004;66:572-9
  • Micheau O, Lens S, Gaide O, NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol 2001;21:5299-305
  • Brikos C, O'Neill LA. Signaling of toll-like receptors. Handb Exp Pharmacol 2008;183:21-50
  • Lee CC, Avalos AM, Ploegh HL. Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol 2012;12:168-79
  • O'Neill LA. The interleukin-1 receptor/toll-like receptor superfamily: 10 years of progress. Immunol Rev 2008;226:10-18
  • Galic S, Fullerton MD, Schertzer JD, Hematopoietic AMPK beta1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest 2011;121:4903-15
  • Gaskin FS, Kamada K, Zuidema MY, Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions. Am J Physiol Heart Circ Physiol 2011;300:H1352-60
  • Prasad R, Giri S, Nath N, 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction. J Neurosci Res 2006;84:614-25
  • Zhao X, Zmijewski JW, Lorne E, Activation of AMPK attenuates neutrophil pro-inflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol 2008;295:L497-504
  • Bai A, Yong M, Ma AG, Novel anti-inflammatory action of 5-aminoimidazole-4-carboxamide ribonucleoside with protective effect in dextran sulfate sodium-induced acute and chronic colitis. J Pharmacol Exp Ther 2010;333:717-25
  • Terkeltaub R, Yang B, Lotz M, Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to pro-inflammatory cytokines interleukin-1beta and tumor necrosis factor alpha. Arthritis Rheum 2011;63:1928-37
  • Pilon G, Dallaire P, Marette A. Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs. J Biol Chem 2004;279:20767-74
  • Giri S, Nath N, Smith B, 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits pro-inflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci 2004;24:479-87
  • Cacicedo JM, Yagihashi N, Keaney JF Jr, AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun 2004;324:1204-9
  • Caligiuri A, Bertolani C, Guerra CT, Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells. Hepatology 2008;47:668-76
  • Yang Z, Kahn BB, Shi H, Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem 2010;285:19051-9
  • Sag D, Carling D, Stout RD, Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol 2008;181:8633-41
  • Zhang Y, Qiu J, Wang X, AMP-Activated Protein Kinase Suppresses Endothelial Cell Inflammation Through Phosphorylation of Transcriptional Coactivator p300. Arterioscler Thromb Vasc Biol 2011;31:2897-908
  • Bess E, Fisslthaler B, Fromel T, Nitric oxide-induced activation of the AMP-activated protein kinase alpha2 subunit attenuates IkappaB kinase activity and inflammatory responses in endothelial cells. PLoS One 2011;6:e20848
  • Wang S, Zhang M, Liang B, AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res 2010;106:1117-28
  • Chandrasekar B, Boylston WH, Venkatachalam K, Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J Biol Chem 2008;283:24889-98
  • Green CJ, Macrae K, Fogarty S, Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappaB signalling in rat skeletal muscle cells by AMP-activated protein kinase. Biochem J 2011;435:463-74
  • Huang NL, Chiang SH, Hsueh CH, Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation. Int J Cardiol 2009;134:169-75
  • Green CJ, Pedersen M, Pedersen BK, Elevated NF-kappaB activation is conserved in human myocytes cultured from obese type 2 diabetic patients and attenuated by AMP-activated protein kinase. Diabetes 2011;60:2810-19
  • Kuo CL, Ho FM, Chang MY, Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase. J Cell Biochem 2008;103:931-40
  • Peairs A, Radjavi A, Davis S, Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells. Clin Exp Immunol 2009;156:542-51
  • Ruderman NB, Xu XJ, Nelson L, AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab 2010;298:E751-60
  • Chen LF, Mu Y, Greene WC. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J 2002;21:6539-48
  • Yang XD, Tajkhorshid E, Chen LF. Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB. Mol Cell Biol 2010;30:2170-80
  • Thalhamer T, McGrath MA, Harnett MM. MAPKs and their relevance to arthritis and inflammation. Rheumatology 2008;47:409-14
  • Qi D, Hu X, Wu X, Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion. J Clin Invest 2009;119:3807-16
  • Dong Y, Zhang M, Liang B, Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation 2010;121:792-803
  • Jeong HW, Hsu KC, Lee JW, Berberine suppresses pro-inflammatory responses through AMPK activation in macrophages. Am J Physiol Endocrinol Metab 2009;296:E955-64
  • Su RY, Chao Y, Chen TY, 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. Mol Cancer Ther 2007;6:1562-71
  • Schuhmacher S, Foretz M, Knorr M, alpha1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation. Arterioscler Thromb Vasc Biol 2011;31:560-6
  • Sung JY, Choi HC. Aspirin-induced AMP-activated protein kinase activation regulates the proliferation of vascular smooth muscle cells from spontaneously hypertensive rats. Biochem Biophys Res Commun 2011;408:312-17
  • Colombo SL, Moncada S. AMPKalpha1 regulates the antioxidant status of vascular endothelial cells. Biochem J 2009;421:163-9
  • Morrow VA, Foufelle F, Connell JMC, Direct activation of AMP-activated protein kinase stimulates nitric oxide synthesis in human aortic endothelial cells. J Biol Chem 2003;278:31629-39
  • Kelleher ZT, Matsumoto A, Stamler JS, NOS2 regulation of NF-kappaB by S-nitrosylation of p65. J Biol Chem 2007;282:30667-72
  • Handy JA, Saxena NK, Fu P, Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3). J Cell Biochem 2010;110:1195-207
  • Nerstedt A, Johansson A, Andersson CX, AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3). Diabetologia 2010;53:2406-16
  • Kim YD, Kim YH, Cho YM, Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models. Diabetologia 2012;55:1482-94
  • Ewart MA, Kohlhaas CF, Salt IP. Inhibition of TNFalpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase. Arterioscler Thromb Vasc Biol 2008;28:2255-7
  • Wang Q, Zhang M, Liang B, Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. PLoS ONE 2011;6:e25436
  • Grisouard J, Dembinski K, Mayer D, Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation. Diabetol Metab Syndr 2011;3:16
  • Buler M, Aatsinki SM, Skoumal R, Energy sensing factors coactivator PGC-1alpha and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of Interleukin 1 receptor antagonist. J Biol Chem 2012;287:1847-60
  • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007;117:175-84
  • Lumeng CN, DelProposto JB, Westcott DJ, Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 2008;57:3239-46
  • Davies SP, Sim AT, Hardie DG. Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase. Eur J Biochem 1990;187:183-90
  • Kukidome D, Nishikawa T, Sonoda K, Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes 2006;55:120-7
  • Tang XX, Chen H, Yu S, Lymphocytes accelerate epithelial tight junction assembly: role of AMP-activated protein kinase (AMPK). PLoS ONE 2010;5:e12343
  • Momcilovic M, Hong SP, Carlson M. Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J Biol Chem 2006;281:25336-43
  • Steinberg GR, Michell BJ, van Denderen BJ, Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab 2006;4:465-74
  • Zhang Z, Lowry SF, Guarente L, Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J Biol Chem 2010;285:41391-401
  • Kelly M, Keller C, Avilucea PR, AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun 2004;320:449-54
  • Carey AL, Steinberg GR, Macaulay SL, Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 2006;55:2688-97
  • Yuen DY, Dwyer RM, Matthews VB, Interleukin-6 attenuates insulin-mediated increases in endothelial cell signalling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression. Diabetes 2009;58:1086-95
  • Riboulet-Chavey A, Diraison F, Siew LK, Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity. Diabetes 2008;57:415-23
  • Tamas P, Hawley SA, Clarke RG, Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J Exp Med 2006;203:1665-70
  • MacIver NJ, Blagih J, Saucillo DC, The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J Immunol 2011;187:4187-98
  • Mayer A, Denanglaire S, Viollet B, AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function. Eur J Immunol 2008;38:948-56
  • Cao Y, Li H, Liu H, The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression. Cell Res 2010;20:99-108
  • Nath N, Khan M, Paintlia MK, Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. J Immunol 2009;182:8005-14
  • Bai A, Ma AG, Yong M, AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis. Biochem Pharmacol 2010;80:1708-17
  • UK Prospective Diabetes Study Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65
  • Landman GW, Kleefstra N, van Hateren KJ, Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16. Diabetes Care 2010;33:322-6
  • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010;140:883-99
  • Kalender A, Selvaraj A, Kim SY, Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab 2010;11:390-401
  • Timmers S, Konings E, Bilet L, Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011;14:612-22
  • Kubota S, Ozawa Y, Kurihara T, Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation. Invest Ophthalmol Vis Sci 2011;52:9142-8
  • Hawley SA, Fullerton MD, Ross FA. The ancient drug salicylate directly activates AMP-activated protein kinase. Science 2012;336:918-22
  • Dai Y, Ge J. Clinical use of aspirin in treatment and prevention of cardiovascular disease. Thrombosis 2012;2012:245037
  • Algra AM, Rothwell PM. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol 2012;13:518-27
  • Available from: http://clinicaltrials gov/show/NCT00883584 IMD-1041 Chronic Obstructive Pulmonary Disease: Proof of Concept (POC) Study (COPD)
  • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011;12:21-35
  • Goncharova EA, Goncharov DA, Damera G, Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis. Mol Pharmacol 2009;76:766-77
  • Delgoffe GM, Kole TP, Zheng Y, The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 2009;30:832-44
  • Kola B, Korbonits M. Shedding light on the intricate puzzle of ghrelin's effects on appetite regulation. J Endocrinol 2009;202:191-8

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