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Therapeutic potential of serum and glucocorticoid inducible kinase inhibition

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Pages 701-714 | Published online: 19 Mar 2013

Bibliography

  • Firestone GL, Giampaolo JR, O'Keeffe BA. Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 2003;13:1-12
  • Lang F, Gorlach A, Vallon V. Targeting SGK1 in diabetes. Expert Opin Ther Targets 2009;13:1303-11
  • Burton TJ, Cope G, Wang J, et al. Expression of the epithelial Na(+) channel and other components of an aldosterone response pathway in human adrenocortical cells. Eur J Pharmacol 2009;613:176-81
  • Lang F, Bohmer C. Palmada M et al. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 2006;86:1151-78
  • Salker MS, Christian M, Steel JH, et al. Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nat Med 2011;17:1509-13
  • Raikwar NS, Liu KZ, Thomas CP. A regulated NH2-terminal Sgk1 variant with enhanced function is expressed in the collecting duct. Am J Physiol Renal Physiol 2012;303:F1527-33
  • Lang F, Eylenstein A, Shumilina E. Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK. Cell Calcium 2012;52:347-54
  • Lang F, Artunc F, Vallon V. The physiological impact of the serum and glucocorticoid-inducible kinase SGK1. Curr Opin Nephrol Hypertens 2009;18:439-48
  • Lang F, Gorlach A. Heterocyclic indazole derivatives as SGK1 inhibitors, WO2008138448. Expert Opin Ther Pat 2010;20:129-35
  • Lang F, Huang DY, Vallon V. SGK, renal function and hypertension. J Nephrol 2010;23(Suppl 16):S124-S129
  • Lang F, Perrotti N, Stournaras C. Colorectal carcinoma cells--regulation of survival and growth by SGK1. Int J Biochem Cell Biol 2010;42:1571-5
  • Luca F, Kashyap S, Southard C, et al. Adaptive variation regulates the expression of the human SGK1 gene in response to stress. PLoS Genet 2009;5:e1000489
  • Maranville JC, Luca F, Richards AL, et al. Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes. PLoS Genet 2011;7:e1002162
  • Melhem A, Yamada SD, Fleming GF, et al. Administration of glucocorticoids to ovarian cancer patients is associated with expression of the anti-apoptotic genes SGK1 and MKP1/DUSP1 in ovarian tissues. Clin Cancer Res 2009;15:3196-204
  • Mongrain V, Hernandez SA, Pradervand S, et al. Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis. Sleep 2010;33:1147-57
  • Reiter MH, Vila G, Knosp E, et al. Opposite effects of serum- and glucocorticoid-regulated kinase-1 and glucocorticoids on POMC transcription and ACTH release. Am J Physiol Endocrinol Metab 2011;301:E336-41
  • Wallace K, Long Q, Fairhall EA, et al. Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes. J Cell Sci 2011;124:405-13
  • Fernandes-Rosa FL, Hubert EL, Fagart J, et al. Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1. J Clin Endocrinol Metab 2011;96:E519-27
  • Pant A, Lee II, Lu Z, et al. Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin. PLoS ONE 2012;7:e41593
  • Rusai K, Prokai A, Szebeni B, et al. Role of serum and glucocorticoid-regulated kinase-1 in the protective effects of erythropoietin during renal ischemia/reperfusion injury. Biochem Pharmacol 2010;79:1173-81
  • Cho YM, Pu HF, Huang WJ, et al. Role of serum- and glucocorticoid-inducible kinase-1 in regulating torsion-induced apoptosis in rats. Int J Androl 2011;34:379-89
  • Feng B, Chen S. George B et al. miR133a regulates cardiomyocyte hypertrophy in diabetes. Diabetes Metab Res Rev 2010;26:40-9
  • Kitada K, Nakano D, Liu Y, et al. Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats. PLoS One 2012;7:e41896
  • Nasrallah R, Paris G, Hebert RL. Hypertonicity increases sodium transporters in cortical collecting duct cells independently of PGE2. Biochem Biophys Res Commun 2012;418:372-7
  • Tokuyama H, Wakino S, Hara Y, et al. Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury. Int J Obes (Lond) 2012;36:1062-71
  • Pessoa BS, Peixoto EB, Papadimitriou A, et al. Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat. J Renin Angiotensin Aldosterone Syst 2012;13:56-66
  • Naito Y, Fujii A, Sawada H, et al. Effect of iron restriction on renal damage and mineralocorticoid receptor signaling in a rat model of chronic kidney disease. J Hypertens 2012;30:2192-201
  • Singh BK, Singh A, Mascarenhas DD. A nuclear complex of rictor and insulin receptor substrate-2 is associated with albuminuria in diabetic mice. Metab Syndr Relat Disord 2010;8:355-63
  • Harries LW, Fellows AD, Pilling LC, et al. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech Ageing Dev 2012;133:556-62
  • Notch EG, Chapline C, Flynn E, et al. Mitogen activated protein kinase 14-1 regulates serum glucocorticoid kinase 1 during seawater acclimation in Atlantic killifish, Fundulus heteroclitus. Comp Biochem Physiol A Mol Integr Physiol 2012;162:443-8
  • Pelzl L, Tolios A, Schmidt EM, et al. Translational regulation of the serum- and glucocorticoid-inducible kinase-1 (SGK1) in platelets. Biochem Biophys Res Commun 2012;425:1-5
  • Dibble CC, Asara JM, Manning BD. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol 2009;29:5657-70
  • Fang Z, Zhang T, Dizeyi N, et al. Androgen receptor enhances p27 degradation in prostate cancer cells through rapid and selective TORC2 activation. J Biol Chem 2012;287:2090-8
  • Hall BA, Kim TY, Skor MN, et al. Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression. Breast Cancer Res Treat 2012;135:469-79
  • Heise CJ, Xu BE, Deaton SL, et al. Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. J Biol Chem 2010;285:25161-7
  • Lyo D, Xu L, Foster DA. Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway. Biochem Biophys Res Commun 2010;396:562-5
  • Pearce LR, Sommer EM, Sakamoto K, et al. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem J 2011;436:169-79
  • Peterson TR, Laplante M, Thoreen CC, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 2009;137:873-86
  • Rosner M, Dolznig H, Fuchs C, et al. CDKs as therapeutic targets for the human genetic disease tuberous sclerosis? Eur J Clin Invest 2009;39:1033-5
  • Treins C, Warne PH, Magnuson MA, et al. Rictor is a novel target of p70 S6 kinase-1. Oncogene 2010;29:1003-16
  • Miyata S, Koyama Y, Takemoto K, et al. Plasma corticosterone activates SGK1 and induces morphological changes in oligodendrocytes in corpus callosum. PLoS One 2011;6:e19859
  • Lee SM, Lee YJ, Yoon JJ, et al. Effect of Poria cocos on hypertonic stress-induced water channel expression and apoptosis in renal collecting duct cells. J Ethnopharmacol 2012;141:368-76
  • Gao D, Wan L, Inuzuka H, et al. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell 2010;39:797-808
  • Gao D, Wan L, Wei W. Phosphorylation of Rictor at Thr1135 impairs the Rictor/Cullin-1 complex to ubiquitinate SGK1. Protein Cell 2010;1:881-5
  • Renauld S, Tremblay K, Ait-Benichou S, et al. Stimulation of ENaC activity by rosiglitazone is PPARgamma-dependent and correlates with SGK1 expression increase. J Membr Biol 2010;236:259-70
  • Soundararajan R, Wang J, Melters D, et al. Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J Biol Chem 2010;285:39905-13
  • Banz VM, Medova M, Keogh A, et al. Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta. Biochim Biophys Acta 2009;1793:1597-603
  • McCaig C, Potter L, Abramczyk O, et al. Phosphorylation of NDRG1 is temporally and spatially controlled during the cell cycle. Biochem Biophys Res Commun 2011;411:227-34
  • Eylenstein A, Schmidt S, Gu S, et al. Transcription factor NF-kappaB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions. J Biol Chem 2012;287:2719-30
  • Na T, Wu G, Zhang W, et al. Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites. Am J Physiol Renal Physiol 2013;304(1):F8-F18
  • Won M, Park KA, Byun HS, et al. Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration. J Hepatol 2009;51:67-76
  • Mo JS, Ann EJ, Yoon JH, et al. Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. J Cell Sci 2011;124:100-12
  • Amato R, D'Antona L, Porciatti G, et al. Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation. J Mol Med (Berl) 2009;87:1221-39
  • Dehner M, Hadjihannas M, Weiske J, et al. Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1. J Biol Chem 2008;283:19201-10
  • Borst O, Schmidt EM, Munzer P et al. The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. Blood 2012;119:251-61
  • Rotte A, Pasham V, Eichenmuller M, et al. Influence of dexamethasone on Na+/H+ exchanger activity in dendritic cells. Cell Physiol Biochem 2011;28:305-14
  • Terada Y, Kuwana H, Kobayashi T, et al. Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium. J Am Soc Nephrol 2008;19:298-309
  • Murakami Y, Hosoi F, Izumi H, et al. Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells. Biochem Biophys Res Commun 2010;396:376-81
  • Lang F, Shumilina E. Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1. FASEB J 2013;27(1):3-12
  • Diakov A, Nesterov V, Mokrushina M, et al. Protein kinase B alpha (PKBalpha) stimulates the epithelial sodium channel (ENaC) heterologously expressed in Xenopus laevis oocytes by two distinct mechanisms. Cell Physiol Biochem 2010;26:913-24
  • Ke Y, Butt AG, Swart M, et al. COMMD1 downregulates the epithelial sodium channel through Nedd4-2. Am J Physiol Renal Physiol 2010;298:F1445-56
  • Krueger B, Haerteis S, Yang L, et al. Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1. Cell Physiol Biochem 2009;24:605-18
  • Lu M, Wang J. Jones KT et al. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol 2010;21:811-18
  • Lu M, Wang J. Ives HE et al. mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel. J Biol Chem 2011;286:30647-54
  • Menniti M, Iuliano R, Foller M, et al. 60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC. Cell Physiol Biochem 2010;26:587-96
  • Pao AC. SGK regulation of renal sodium transport. Curr Opin Nephrol Hypertens 2012;21:534-40
  • Pavlov TS, Imig JD, Staruschenko A. Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors. PPAR Res 2010;2010:703735
  • Reisenauer MR, Anderson M, Huang L, et al. AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha. J Biol Chem 2009;284:35659-69
  • Reisenauer MR, Wang SW, Xia Y, et al. Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels. Am J Physiol Renal Physiol 2010;299:F63-76
  • Soundararajan R, Ziera T, Koo E, et al. Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem 2012;287:33014-25
  • Soundararajan R, Lu M, Pearce D. Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol 2012;47:349-59
  • Soundararajan R, Pearce D, Ziera T. The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport. Mol Cell Endocrinol 2012;350:242-7
  • Thomas SV, Kathpalia PP, Rajagopal M, et al. Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1. J Biol Chem 2011;286:32074-85
  • Watt GB, Ismail NA, Caballero AG, et al. Epithelial Na(+) channel activity in human airway epithelial cells: the role of serum and glucocorticoid-inducible kinase 1. Br J Pharmacol 2012;166:1272-89
  • Wesch D, Miranda P, Afonso-Oramas D, et al. The neuronal-specific SGK1.1 kinase regulates {delta}-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling. Am J Physiol Cell Physiol 2010;299:C779-90
  • Wiemuth D, Lott JS, Ly K, et al. Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS ONE 2010;5:e12163
  • Cheng CJ, Huang CL. Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1. J Am Soc Nephrol 2011;22:460-71
  • Lin DH, Yue P, Rinehart J, et al. Protein phosphatase 1 modulates the inhibitory effect of With-no-Lysine kinase 4 on ROMK channels. Am J Physiol Renal Physiol 2012;303:F110-19
  • Yue P, Lin DH, Pan CY, et al. Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels. Proc Natl Acad Sci USA 2009;106:15061-6
  • Yue P, Sun P, Lin DH, et al. Angiotensin II diminishes the effect of SGK1 on the WNK4-mediated inhibition of ROMK1 channels. Kidney Int 2011;79:423-31
  • Wang L, Zhou C, Zhu Q, et al. Up-regulation of serum- and glucocorticoid-induced protein kinase 1 in the brain tissue of human and experimental epilepsy. Neurochem Int 2010;57:899-905
  • Seebohm G, Strutz-Seebohm N, Ureche ON, et al. Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels. Circ Res 2008;103:1451-7
  • Strutz-Seebohm N, Henrion U, Steinke K, et al. Serum- and glucocorticoid-inducible kinases (SGK) regulate KCNQ1/KCNE potassium channels. Channels (Austin) 2009;3:88-90
  • Eylenstein A, Gehring EM, Heise N, et al. Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1). FASEB J 2011;25:2012-21
  • Shin SH, Lee EJ, Hyun S, et al. Phosphorylation on the Ser 824 residue of TRPV4 prefers to bind with F-actin than with microtubules to expand the cell surface area. Cell Signal 2012;24:641-51
  • Caohuy H, Jozwik C, Pollard HB. Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway. J Biol Chem 2009;284:25241-53
  • Gehring EM, Lam RS, Siraskar G, et al. PIKfyve upregulates CFTR activity. Biochem Biophys Res Commun 2009;390:952-7
  • Notch EG, Shaw JR, Coutermarsh BA, et al. Morpholino gene knockdown in adult Fundulus heteroclitus: role of SGK1 in seawater acclimation. PLoS ONE 2011;6:e29462
  • Shaw JR, Bomberger JM, VanderHeide J, et al. Arsenic inhibits SGK1 activation of CFTR Cl- channels in the gill of killifish, Fundulus heteroclitus. Aquat Toxicol 2010;98:157-64
  • Arroyo JP, Lagnaz D, Ronzaud C, et al. Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway. J Am Soc Nephrol 2011;22:1707-19
  • Rotin D, Staub O. Nedd4-2 and the regulation of epithelial sodium transport. Front Physiol 2012;3:212
  • Rozansky DJ, Cornwall T, Subramanya AR, et al. Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. J Clin Invest 2009;119:2601-12
  • Vallon V, Schroth J, Lang F, et al. Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. Am J Physiol Renal Physiol 2009;297:F704-12
  • Voelkl J, Lin Y, Alesutan I, et al. Sgk1 sensitivity of Na(+)/H(+) exchanger activity and cardiac remodeling following pressure overload. Basic Res Cardiol 2012;107:236
  • Dynia DW, Steinmetz AG, Kocinsky HS. NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase. Am J Physiol Renal Physiol 2010;298:F745-53
  • He P, Lee SJ, Lin S, et al. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell 2011;22:3812-25
  • Panchapakesan U, Pollock C, Saad S. Renal epidermal growth factor receptor: its role in sodium and water homeostasis in diabetic nephropathy. Clin Exp Pharmacol Physiol 2011;38:84-8
  • Pao AC, Bhargava A, Di Sole F, et al. Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Am J Physiol Renal Physiol 2010;299:F1496-506
  • Rexhepaj R, Alesutan I, Gu S, et al. SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D. Pflugers Arch 2011;462:489-94
  • Bohmer C, Sopjani M, Klaus F, et al. The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. Cell Physiol Biochem 2010;25:723-32
  • Gehring EM, Zurn A, Klaus F, et al. Regulation of the glutamate transporter EAAT2 by PIKfyve. Cell Physiol Biochem 2009;24:361-8
  • Klaus F, Gehring EM, Zurn A, et al. Regulation of the Na(+)-coupled glutamate transporter EAAT3 by PIKfyve. Neurochem Int 2009;54:372-7
  • Alesutan IS, Ureche ON, Laufer J, et al. Regulation of the glutamate transporter EAAT4 by PIKfyve. Cell Physiol Biochem 2010;25:187-94
  • Rexhepaj R, Rotte A, Kempe DS, et al. Stimulation of electrogenic intestinal dipeptide transport by the glucocorticoid dexamethasone. Pflugers Arch 2009;459:191-202
  • Rexhepaj R, Rotte A, Pasham V, et al. PI3 kinase and PDK1 in the regulation of the electrogenic intestinal dipeptide transport. Cell Physiol Biochem 2010;25:715-22
  • Andrukhova O, Zeitz U, Goetz R, et al. FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway. Bone 2012;51:621-8
  • Chandran S, Li H, Dong W, et al. Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem 2011;286:37830-40
  • Ohashi T, Uchida K, Uchida S, et al. Dexamethasone increases the phosphorylation of nephrin in cultured podocytes. Clin Exp Nephrol 2011;15:688-93
  • Chen L, Wei TQ, Wang Y, et al. Simulated bladder pressure stimulates human bladder smooth muscle cell proliferation via the PI3K/SGK1 signaling pathway. J Urol 2012;188:661-7
  • Amato R, Menniti M, Agosti V, et al. IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney cancer cells. J Mol Med 2007;85:707-21
  • Schmidt EM, Kraemer BF, Borst O, et al. SGK1 sensitivity of platelet migration. Cell Physiol Biochem 2012;30:259-68
  • Schmidt EM, Gu S, Anagnostopoulou V, et al. Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor. FEBS J 2012;279:1231-42
  • Lang F, Vallon V. Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport. Clin Exp Nephrol 2012;16:73-80
  • Faresse N, Lagnaz D, Debonneville A, et al. Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype. Am J Physiol Renal Physiol 2012;302:F977-85
  • Rotte A, Bhandaru M, Ackermann TF, et al. Role of PDK1 in regulation of gastric acid secretion. Cell Physiol Biochem 2008;22:725-34
  • Rotte A, Mack AF, Bhandaru M, et al. Pioglitazone induced gastric acid secretion. Cell Physiol Biochem 2009;24:193-200
  • Artunc F, Ebrahim A, Siraskar B, et al. Responses to diuretic treatment in gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1. Kidney Blood Press Res 2009;32:119-27
  • Bhandaru M, Kempe DS, Rotte A, et al. Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC. Am J Physiol Regul Integr Comp Physiol 2009;297:R571-5
  • Lang F, Cohen P. Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci STKE 2001;2001:RE17
  • Resch M, Bergler T, Fredersdorf S, et al. Hyperaldosteronism and altered expression of an SGK1-dependent sodium transporter in ZDF rats leads to salt dependence of blood pressure. Hypertens Res 2010;33:1082-8
  • Umbach AT, Pathare G, Foller M, et al. SGK1-dependent salt appetite in pregnant mice. Acta Physiol (Oxf) 2011;202:39-45
  • Shanmugam I, Cheng G, Terranova PF, et al. Serum/glucocorticoid-induced protein kinase-1 facilitates androgen receptor-dependent cell survival. Cell Death Differ 2007;14:2085-94
  • Kawarazaki H, Ando K, Shibata S, et al. Mineralocorticoid receptor--Rac1 activation and oxidative stress play major roles in salt-induced hypertension and kidney injury in prepubertal rats. J Hypertens 2012;30:1977-85
  • Nakano M, Hirooka Y, Matsukawa R et al. Mineralocorticoid receptors/epithelial Na(+) channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. Hypertens Res 2013;36(3):277-84
  • Nakagaki T, Hirooka Y, Matsukawa R, et al. Activation of mineralocorticoid receptors in the rostral ventrolateral medulla is involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. Hypertens Res 2012;35:470-6
  • Rao AD, Sun B, Saxena A et al. Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake. J Hum Hypertens 2013;27(3):176-80
  • Di Pietro N, Panel V, Hayes S, et al. Serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1. Mol Endocrinol 2010;24:370-80
  • Dahlberg J, Smith G, Norrving B, et al. Genetic variants in serum and glucocortocoid regulated kinase 1, a regulator of the epithelial sodium channel, are associated with ischaemic stroke. J Hypertens 2011;29:884-9
  • Gao S, Alarcon C, Sapkota G, et al. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell 2009;36:457-68
  • Cheng J, Truong LD, Wu X, et al. Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int 2010;78:668-78
  • Okazaki A, Mori Y, Nakata M, et al. Peritoneal mesothelial cells as a target of local aldosterone action: upregulation of connective tissue growth factor expression via serum- and glucocorticoid-inducible protein kinase 1. Kidney Blood Press Res 2009;32:151-60
  • Szebeni B, Vannay A, Sziksz E, et al. Increased expression of serum- and glucocorticoid-regulated kinase-1 in the duodenal mucosa of children with coeliac disease. J Pediatr Gastroenterol Nutr 2010;50:147-53
  • Yamahara H, Kishimoto N, Nakata M, et al. Direct aldosterone action as a profibrotic factor via ROS-mediated SGK1 in peritoneal fibroblasts. Kidney Blood Press Res 2009;32:185-93
  • Feng Y, Wang Q, Wang Y, et al. SGK1-mediated fibronectin formation in diabetic nephropathy. Cell Physiol Biochem 2005;16:237-44
  • Yang M, Zheng J, Miao Y, et al. Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arterioscler Thromb Vasc Biol 2012;32:1675-86
  • Das S, Aiba T, Rosenberg M, et al. Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation 2012;126:2208-19
  • Lister K, Autelitano DJ, Jenkins A, et al. Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: a possible role for SGK1. Cardiovasc Res 2006;70:555-65
  • Nagase T, Akase T, Sanada H et al. Aging-like skin changes in metabolic syndrome model mice are mediated by mineralocorticoid receptor signaling. Aging Cell 2013;12(1):50-7
  • Fagerli UM, Ullrich K, Stuhmer T, et al. Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells. Oncogene 2011;30:3198-206
  • Yoon JW, Gilbertson R, Iannaccone S, et al. Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes. Int J Cancer 2009;124:109-19
  • Szmulewitz RZ, Chung E, Al Ahmadie H, et al. Serum/glucocorticoid-regulated kinase 1 expression in primary human prostate cancers. Prostate 2012;72:157-64
  • Abbruzzese C, Mattarocci S, Pizzuti L, et al. Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas. J Exp Clin Cancer Res 2012;31:4
  • Zhang L, Cui R, Cheng X, et al. Antiapoptotic effect of serum and glucocorticoid-inducible protein kinase is mediated by novel mechanism activating I{kappa}B kinase. Cancer Res 2005;65:457-64
  • Baskin R, Sayeski PP. Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1. Cell Signal 2012;24:435-42
  • Zou JX, Guo L, Revenko AS, et al. Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer. Cancer Res 2009;69:3339-46
  • Gu S, Papadopoulou N, Gehring EM, et al. Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo. Mol Cancer 2009;8:114
  • Papadopoulou N, Charalampopoulos I, Anagnostopoulou V, et al. Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells. Mol Cancer 2008;7:88
  • Amato R, Scumaci D, D'Antona L et al. Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells. Oncogene 2012. [ Epub ahead of print]
  • Boiteux A, Hess B. Design of glycolysis. Philos Trans R Soc Lond B Biol Sci 1981;293:5-22
  • Ronchi CL, Sbiera S, Leich E et al. Low SGK1 Expression in Human Adrenocortical Tumors Is Associated with ACTH-Independent Glucocorticoid Secretion and Poor Prognosis. J Clin Endocrinol Metab 2012;97(12):E2251-60
  • Ronchi CL, Leich E, Sbiera S, et al. Single nucleotide polymorphism microarray analysis in cortisol-secreting adrenocortical adenomas identifies new candidate genes and pathways. Neoplasia 2012;14:206-18
  • Segditsas S, Sieber O, Deheragoda M, et al. Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. Hum Mol Genet 2008;17:3864-75
  • Nasir O, Wang K, Foller M, et al. Relative resistance of SGK1 knockout mice against chemical carcinogenesis. IUBMB Life 2009;61:768-76
  • Schmid E, Gu S, Yang W, et al.. Serum- and glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation. Am J Physiol Cell Physiol 2012;(e. ahead of print): doi: 10.1152/ajpcell.00179.2012
  • Sobiesiak M, Shumilina E, Lam RS, et al. Impaired mast cell activation in gene-targeted mice lacking the serum- and glucocorticoid-inducible kinase SGK1. J Immunol 2009;183:4395-402
  • Mansley MK, Wilson SM. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption. Br J Pharmacol 2010;161:571-88
  • Mansley MK, Wilson SM. Dysregulation of epithelial Na+ absorption induced by inhibition of the kinases TORC1 and TORC2. Br J Pharmacol 2010;161:1778-92
  • McTavish N, Getty J, Burchell A, et al. Glucocorticoids can activate the alpha-ENaC gene promoter independently of SGK1. Biochem J 2009;423:189-97
  • Wilson SM, Mansley MK, Getty J, et al. Effects of peroxisome proliferator-activated receptor gamma agonists on Na+ transport and activity of the kinase SGK1 in epithelial cells from lung and kidney. Br J Pharmacol 2010;159:678-88
  • Deng W, Li CY, Tong J, et al. Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury. Respir Res 2012;13:29
  • Zhu T, Zhang W, Wang DX. Insulin up-regulates epithelial sodium channel in LPS-induced acute lung injury model in rats by SGK1 activation. Injury 2012;43:1277-83
  • Catela C, Kratsios P, Hede M, et al. Serum and glucocorticoid-inducible kinase 1 (SGK1) is necessary for vascular remodeling during angiogenesis. Dev Dyn 2010;239:2149-60
  • Li D, Lu Z, Jia J et al. Changes in microRNAs associated with podocytic adhesion damage under mechanical stress. J Renin Angiotensin Aldosterone Syst 2012. [ Epub ahead of print]
  • Artunc F, Amann K, Nasir O, et al. Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1. J Mol Med 2006;84:737-46
  • Fisher SJ, Giudice LC. SGK1: a fine balancing act for human pregnancy. Nat Med 2011;17:1348-9
  • Piechota M, Korostynski M, Solecki W, et al. The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum. Genome Biol 2010;11:R48
  • Peng HY, Chen GD, Hsieh MC, et al. Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund's adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats. Pain 2012;153:2380-92
  • Lang F, Strutz-Seebohm N, Seebohm G, et al. Significance of SGK1 in the regulation of neuronal function. J Physiol 2010;588:3349-54
  • Ma YL, Tsai MC, Hsu WL, et al. SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons. Learn Mem 2006;13:114-18
  • Yang YC, Ma YL, Liu WT, et al. Laminin-beta1 impairs spatial learning through inhibition of ERK/MAPK and SGK1 signaling. Neuropsychopharmacology 2011;36:2571-86
  • Nuber UA, Kriaucionis S, Roloff TC, et al. Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet 2005;14:2247-56
  • Tsai V, Parker WE, Orlova KA et al. Fetal Brain mTOR Signaling Activation in Tuberous Sclerosis Complex. Cereb Cortex 2012. [ Epub ahead of print]
  • Mo JS, Yoon JH, Hong JA, et al. Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways. PLoS ONE 2012;7:e37111
  • Hsu WL, Chiu TH, Tai DJ, et al. A novel defense mechanism that is activated on amyloid-beta insult to mediate cell survival: role of SGK1-STAT1/STAT2 signaling. Cell Death Differ 2009;16:1515-29
  • Rangone H, Poizat G, Troncoso J, et al. The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin. Eur J Neurosci 2004;19:273-9
  • Stichel CC, Schoenebeck B. Foguet M et al. sgk1, a member of an RNA cluster associated with cell death in a model of Parkinson's disease. Eur J Neurosci 2005;21:301-16
  • Iwata S, Nomoto M, Morioka H, et al. Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice. Synapse 2004;51:279-86
  • Busjahn A, Aydin A, Uhlmann R, et al. Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Hypertension 2002;40:256-60
  • von Wowern F, Berglund G, Carlson J, et al. Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. Kidney Int 2005;68:2164-72
  • Friedrich B, Weyrich P, Stancakova A, et al. Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies. PLoS One 2008;3:e3506
  • Sherk AB, Frigo DE, Schnackenberg CG, et al. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res 2008;68:7475-83
  • Ackermann TF, Boini KM, Beier N, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem 2011;28:137-46
  • Hammond M, Washburn DG, Hoang HT, et al. Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors. Bioorg Med Chem Lett 2009;19:4441-5
  • Mulle C, Sailer A, Perez-Otano I, et al. Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature 1998;392:601-5
  • Smolders I, Bortolotto ZA, Clarke VR, et al. Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures. Nat Neurosci 2002;5:796-804
  • Chun J, Kwon T, Lee EJ, et al. 14-3-3 Protein mediates phosphorylation of microtubule-associated protein tau by serum- and glucocorticoid-induced protein kinase 1. Mol Cells 2004;18:360-8
  • Yang YC, Lin CH, Lee EH. Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau. Mol Cell Biol 2006;26:8357-70
  • Meng F, Yamagiwa Y, Taffetani S, et al. IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway. Am J Physiol Cell Physiol 2005;289:C971-81
  • Wu W, Chaudhuri S, Brickley DR, et al. Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res 2004;64:1757-64
  • Tangir J, Bonafe N, Gilmore-Hebert M, et al. SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis 2004;21:477-83

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