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Plants and cervical cancer: an overview

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Pages 1133-1156 | Published online: 22 Jun 2013

Bibliography

  • Li J, Li Q, Feng T, et al. Aqueous extract of Solanum nigrum inhibit growth of cervical carcinoma (U14) via modulating immune response of tumor bearing mice and inducing apoptosis of tumor cells. Fitoterapia 2008;79:548-56
  • Su JH, Wu A, Scotney E, et al. Immunotherapy for cervical cancer: research status and clinical potential. BioDrugs 2010;24:109-29
  • Kim HG, Song H, Yoon DH, et al. Cordyceps pruinosa extracts induce apoptosis of HeLa cells by a caspase dependent pathway. J Ethnopharmacol 2010;128:342-51
  • Bhutia SK, Mallick SK, Stevens SM, et al. Induction of mitochondria-dependent apoptosis by Abrus agglutinin derived peptides in human cervical cancer cell. Toxicol In Vitro 2008;22:344-51
  • Ferguson PJ, Brisson AR, Koropatnick J, et al. Enhancement of cytotoxicity of natural product drugs against multidrug resistant variant cell lines of human head and neck squamous cell carcinoma and breast carcinoma by tesmilifene. Cancer Lett 2009;274:279-89
  • de Mesquita ML, de Paula JE, Pessoa C, et al. Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines. J Ethnopharmacol 2009;123:439-45
  • Kumar D, Kumar A, Prakash O. Potential antifertility agents from plants: a comprehensive review. J Ethnopharmacol 2012;140:1-32
  • Peng B, Hu Q, Liu X, et al. Duchesnea phenolic fraction inhibits in vitro and in vivo growth of cervical cancer through induction of apoptosis and cell cycle arrest. Exp Biol Med (Maywood) 2009;234:74-83
  • Yong Y, Shin SY, Lee YH, et al. Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: induction of G2/M cell cycle arrest and caspase-dependent apoptosis. Bioorg Med Chem Lett 2009;19:4367-71
  • Feng C, Zhou LY, Yu T, et al. A new anticancer compound, oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. Int J Cancer 2012;131:1445-54
  • Won SJ, Ki YS, Chung KS, et al. 3α,23-Isopropylidenedioxyolean-12-en-27-oic acid, a triterpene isolated from Aceriphyllum rossii, induces apoptosis in human cervical cancer HeLa cells through mitochondrial dysfunction and endoplasmic reticulum stress. Biol Pharm Bull 2010;33:1620-6
  • Abdel WS, Abdul AB, Alzubairi AS, et al. In vitro ultramorphological assessment of apoptosis induced by zerumbone on (HeLa). J Biomed Biotechnol 2009;2009:769568
  • Vidya PR, Senthil MR, Maitreyi S, et al. The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-kappaB inhibition. Eur J Pharmacol 2010;649:84-91
  • Szliszka E, Czuba ZP, Jernas K, et al. Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Int J Mol Sci 2008;9:56-64
  • Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-62
  • Zhang YB, Ye YP, Wu XD, et al. Astilbotriterpenic acid induces growth arrest and apoptosis in HeLa cells through mitochondria-related pathways and reactive oxygen species (ROS) production. Chem Biodivers 2009;6:218-30
  • Kessel D, Luo Y. Cells in cryptophycin-induced cell-cycle arrest are susceptible to apoptosis. Cancer Lett 2000;151:25-9
  • Hu YW, Liu CY, Du CM, et al. Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by flavonoids from Astragalus complanatus. J Ethnopharmacol 2009;123:293-301
  • Shi J, Shen H. Critical role of Bid and Bax in indirubin-3′-monoxime-induced apoptosis in human cancer cells. Biochem Pharmacol 2008;75:1729-42
  • Hernandez-Flores G, Ortiz-Lazareno PC, Lerma-Diaz JM, et al. Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence. BMC Cancer 2011;11:483
  • Li H, Wang LJ, Qiu GF, et al. Apoptosis of HeLa cells induced by extract from Cremanthodium humile. Food Chem Toxicol 2007;45:2040-6
  • Chen SP, Dong M, Kita K, et al. Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells. Mol Med Rep 2010;3:673-8
  • Shi YQ, Zhu CJ, Yuan HQ, et al. Marchantin C, a novel microtubule inhibitor from liverwort with anti-tumor activity both in vivo and in vitro. Cancer Lett 2009;276:160-70
  • Ha SW, Kim YJ, Kim W, et al. Antitumor effects of camptothecin combined with conventional anticancer drugs on the cervical and uterine squamous cell carcinoma cell line SiHa. Korean J Physiol Pharmacol 2009;13:115-21
  • Park I, Park KK, Park JH, et al. Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition. Cancer Lett 2009;277:174-81
  • Ren G, Zhao Y, Yang L, et al. Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis. Cancer Lett 2008;262:190-200
  • Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999;18:6853-66
  • Shafi G, Munshi A, Hasan TN, et al. Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa. Cancer Cell Int 2009;9:29
  • Hu W, Kavanagh JJ. Anticancer therapy targeting the apoptotic pathway. Lancet Oncol 2003;4:721-9
  • Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770-6
  • Lavrik IN, Golks A, Krammer PH. Caspases: pharmacological manipulation of cell death. J Clin Invest 2005;115:2665-72
  • Nicholson DW, Thornberry NA. Caspases: killer proteases. Trends Biochem Sci 1997;22:299-306
  • Green DR. Apoptotic pathways: paper wraps stone blunts scissors. Cell 2000;102:1-4
  • Zhou L, Chan WK, Xu N, et al. Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest. Life Sci 2008;83:394-403
  • Kim SY, An JM, Lee HG, et al. 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one induces cell cycle arrest and apoptosis in HeLa cells by preventing microtubule polymerization. Biochem Biophys Res Commun 2011;408:287-92
  • Ramer R, Merkord J, Rohde H, et al. Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1. Biochem Pharmacol 2010;79:955-66
  • Kim MK, Kim HS, Kim SH, et al. Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment. Biochem Pharmacol 2010;80:1930-5
  • Mahata S, Bharti AC, Shukla S, et al. Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Mol Cancer 2011;10:39
  • Tao X, Hu W, Ramirez PT, et al. Chemotherapy for recurrent and metastatic cervical cancer. Gynecol Oncol 2008;110:S67-71
  • Ng WK, Yazan LS, Ismail M. Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein. Toxicol In Vitro 2011;25:1392-8
  • Ren G, Zhao Y, Yang L, et al. Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis. Cancer Lett 2008;262:190-200
  • Koppikar SJ, Choudhari AS, Suryavanshi SA, et al. Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer 2010;10:210
  • Li Y, Gan G, Zhang H, et al. A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines. J Ethnopharmacol 2007;113:115-24
  • Wang Q, Zheng XL, Yang L, et al. Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells. J Exp Clin Cancer Res 2010;29:159
  • Long MJ, Wu FX, Li P, et al. MicroRNA-10a targets CHL1 and promotes cell growth, migration and invasion in human cervical cancer cells. Cancer Lett 2012;324:186-96
  • Zhang Z, Knobloch TJ, Seamon LG, et al. A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells. Gynecol Oncol 2011;123:401-6
  • Alonso-Castro AJ, Ortiz-Sanchez E, Dominguez F, et al. Antitumor effect of Croton lechleri Mull. Arg. (Euphorbiaceae). J Ethnopharmacol 2012;140:438-42
  • Choudhury D, Das A, Bhattacharya A, et al. Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells. Food Chem Toxicol 2010;48:2872-80
  • Zeng YW, Liu XZ, Lv ZC, et al. Effects of Ficus hirta Vahl. (Wuzhimaotao) extracts on growth inhibition of HeLa cells. Exp Toxicol Pathol 2012;64:743-9
  • Tayarani-Najaran Z, Mousavi SH, Asili J, et al. Growth-inhibitory effect of Scutellaria lindbergii in human cancer cell lines. Food Chem Toxicol 2010;48:599-604
  • Li GL, Jiang W, Xia Q, et al. HPV E6 down-regulation and apoptosis induction of human cervical cancer cells by a novel lipid-soluble extract (PE) from Pinellia pedatisecta Schott in vitro. J Ethnopharmacol 2010;132:56-64
  • Kim H, Kim H, Mosaddik A, et al. Induction of apoptosis by ethanolic extract of mango peel and comparative analysis of the chemical constitutes of mango peel and flesh. Food Chem 2012;133:416-22
  • Kwon H, Bae S, Kim K, et al. Induction of apoptosis in HeLa cells by ethanolic extract of Corallina pilulifera. Food Chem 2007;104:196-201
  • Kim H, Moon JY, Mosaddik A, et al. Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract. Food Chem Toxicol 2010;48:2435-42
  • Rejiya CS, Cibin TR, Abraham A. Leaves of Cassia tora as a novel cancer therapeutic–an in vitro study. Toxicol In Vitro 2009;23:1034-8
  • Kwon HJ, Hong YK, Kim KH, et al. Methanolic extract of Pterocarpus santalinus induces apoptosis in HeLa cells. J Ethnopharmacol 2006;105:229-34
  • Tavakkol-Afshari J, Brook A, Mousavi SH. Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem Toxicol 2008;46:3443-7
  • Wu DC, Li S, Yang DQ, et al. Effects of Pinus massoniana bark extract on the adhesion and migration capabilities of HeLa cells. Fitoterapia 2011;82:1202-5
  • Aparicio-Fernandez X, Reynoso-Camacho R, Castano-Tostado E, et al. Antiradical capacity and induction of apoptosis on HeLa cells by a Phaseolus vulgaris extract. Plant Foods Hum Nutr 2008;63:35-40
  • Ma H, Lai F, Xie H, et al. Involvement of the Bcl-2 family members in Pinus massoniana bark extract induced apoptosis in HeLa cells. Phytother Res 2008;22:1472-6
  • Peng B, Hu Q, Liu X, et al. Duchesnea phenolic fraction inhibits in vitro and in vivo growth of cervical cancer through induction of apoptosis and cell cycle arrest. Exp Biol Med (Maywood) 2009;234:74-83
  • Bonfili L, Amici M, Cecarini V, et al. Wheat sprout extract-induced apoptosis in human cancer cells by proteasomes modulation. Biochimie 2009;91:1131-44
  • Huang WC, Hsu RM, Chi LM, et al. Selective downregulation of EGF receptor and downstream MAPK pathway in human cancer cell lines by active components partially purified from the seeds of Livistona chinensis R. Brown. Cancer Lett 2007;248:137-46
  • Bhutia SK, Mallick SK, Stevens SM, et al. Induction of mitochondria-dependent apoptosis by Abrus agglutinin derived peptides in human cervical cancer cell. Toxicol In Vitro 2008;22:344-51
  • Yu XY, Zeng CQ, Gao S, et al. The study on apoptosis of human cervical cancer HeLa cell induced by Phryma leptostachya L. var. asiatica Hara extract and related molecular mechanism. Cell Mol Immunol 2012;28:608-10
  • Spies L, Koekemoer TC, Sowemimo AA, et al. Caspase-dependent apoptosis is induced by Artemisia afra Jacq. ex Willd in a mitochondria-dependent manner after G2/M arrest. S Afr J Bot 2013;104-9
  • Ad'hiah HA, Al-Bederi ONH, Al-Sammarrae KW. Cytotoxic effects of Agrimonia eupatoria L. against cancer cell lines in vitro. J Assoc Arab Univ Basic Appl Sci 2013. Available from: http://dx.doi.org/10.1016/j.jaubas.2013.01.003
  • Park I, Park KK, Park JH, et al. Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition. Cancer Lett 2009;277:174-81
  • Mandal SK, Biswas R, Bhattacharyya SS, et al. Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Eur J Pharmacol 2010;626:115-22
  • Lv H, Kong Y, Yao Q, et al. Nebrodeolysin, a novel hemolytic protein from mushroom Pleurotus nebrodensis with apoptosis-inducing and anti-HIV-1 effects. Phytomedicine 2009;16:198-205
  • Xiao JX, Huang GQ, Zhang SH. Soyasaponins inhibit the proliferation of HeLa cells by inducing apoptosis. Exp Toxicol Pathol 2007;59:35-42
  • Wang P, Li JC. Trichosanthin-induced specific changes of cytoskeleton configuration were associated with the decreased expression level of actin and tubulin genes in apoptotic HeLa cells. Life Sci 2007;81:1130-40
  • Takaya M, Nomura M, Takahashi T, et al. 23-Hydroxyursolic acid causes cell growth-inhibition by inducing caspase-dependent apoptosis in human cervical squamous carcinoma HeLa cells. Anticancer Res 2009;29:995-1000
  • Yan Q, Li Y, Jiang Z, et al. Antiproliferation and apoptosis of human tumor cell lines by a lectin (AMML) of Astragalus mongholicus. Phytomedicine 2009;16:586-93
  • Mancinelli L, De Angelis PM, Annulli L, et al. A class of DNA-binding peptides from wheat bud causes growth inhibition, G2 cell cycle arrest and apoptosis induction in HeLa cells. Mol Cancer 2009;8:55
  • Chen CY, Liu TZ, Tseng WC, et al. (-)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells. Food Chem Toxicol 2008;46:2694-702
  • Chen SP, Dong M, Kita K, et al. Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells. Mol Med Rep 2010;3:673-8
  • Youn MJ, So HS, Cho HJ, et al. Berberine, a natural product, combined with cisplatin enhanced apoptosis through a mitochondria/caspase-mediated pathway in HeLa cells. Biol Pharm Bull 2008;31:789-95
  • Chung KS, Choi JH, Back NI, et al. Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. Mol Nutr Food Res 2010;54:1318-28
  • Liu RM, Zhong JJ. Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. Phytomedicine 2011;18:349-55
  • Costa LS, Telles CB, Oliveira RM, et al. Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells. Mar Drugs 2011;9:603-14
  • Oh HL, Lim H, Park Y, et al. HY253, a novel compound isolated from Aralia continentalis, induces apoptosis via cytochrome c-mediated intrinsic pathway in HeLa cells. Bioorg Med Chem Lett 2009;19:797-9
  • Abdelwahab SI, Abdul AB, Zain ZN, et al. Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells. Int Immunopharmacol 2012;12:594-602
  • Xu W, Liu J, Li C, et al. Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer Lett 2008;264:229-40
  • Liu C, Wang Y, Xie S, et al. Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in HeLa Cells. Phytother Res 2011;25:277-83
  • Mandal SK, Biswas R, Bhattacharyya SS, et al. Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Eur J Pharmacol 2010;626:115-22
  • Nawrot R, Wolun-Cholewa M, Gozdzicka-Jozefiak A. Nucleases isolated from Chelidonium majus L. milky sap can induce apoptosis in human cervical carcinoma HeLa cells but not in Chinese Hamster Ovary CHO cells. Folia Histochem Cytobiol 2008;46:79-83
  • Hu HZ, Yang YB, Xu XD, et al. Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line. Acta Pharmacol Sin 2007;28:1819-26
  • Singh M, Singh N. Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells. Mol Cell Biochem 2009;325:107-19
  • Liu Z, Liu B, Zhang ZT, et al. A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells. Phytomedicine 2008;15:867-75
  • Ohtsuki T, Tamaki M, Toume K, et al. A novel sesquiterpenoid dimer parviflorene F induces apoptosis by up-regulating the expression of TRAIL-R2 and a caspase-dependent mechanism. Bioorgan Med Chem 2008;16:1756-63
  • Cao W, Li XQ, Wang X, et al. A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway. Phytomedicine 2010;17:598-605
  • Yong Y, Shin SY, Lee YH, et al. Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: induction of G2/M cell cycle arrest and caspase-dependent apoptosis. Bioorg Med Chem Lett 2009;19:4367-71
  • Li Z, Wang J, Jiang B, et al. Benzobijuglone, a novel cytotoxic compound from Juglans mandshurica, induced apoptosis in HeLa cervical cancer cells. Phytomedicine 2007;14:846-52
  • Peng H, Lv H, Wang Y, et al. Clematis montana lectin, a novel mannose-binding lectin from traditional Chinese medicine with antiviral and apoptosis-inducing activities. Peptides 2009;30:1805-15
  • Sukirtha R, Priyanka KM, Antony JJ, et al. Cytotoxic effect of Green synthesized silver nanoparticles using Melia azedarach against in vitro HeLa cell lines and lymphoma mice model. Process Biochem 2012;47:273-9
  • Yang Y, Yue Y, Runwei Y, et al. Cytotoxic, apoptotic and antioxidant activity of the essential oil of Amomum tsao-ko. Bioresour Technol 2010;101:4205-11
  • Yim N, Lee JH, Cho W, et al. Decursin and decursinol angelate from Angelica gigas Nakai induce apoptosis via induction of TRAIL expression on cervical cancer cells. Eur J Integr Med 2011;3:e299-307
  • Siriwan D, Naruse T, Tamura H. Effect of epoxides and α-methylene-γ-lactone skeleton of sesquiterpenes from yacon (Smallanthus sonchifolius) leaves on caspase-dependent apoptosis and NF-κB inhibition in human cervical cancer cells. Fitoterapia 2011;82:1093-101
  • Ren D, Peng G, Huang H, et al. Effect of rhodoxanthin from Potamogeton crispus L. on cell apoptosis in HeLa cells. Toxicol In Vitro 2006;20:1411-18
  • Li HN, Nie FF, Liu W, et al. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Toxicology 2009;257:80-5
  • Gao XM, Yu T, Lai FS, et al. Identification and evaluation of apoptotic compounds from Garcinia paucinervis. Bioorg Med Chem 2010;18:4957-64
  • Sun HX, Zheng QF, Tu J. Induction of apoptosis in HeLa cells by 3β-hydroxy-12-oleanen-27-oic acid from the rhizomes of Astilbe chinensis. Bioorg Med Chem 2006;14:1189-98
  • Bhutia SK, Mallick SK, Stevens SM, et al. Induction of mitochondria-dependent apoptosis by Abrus agglutinin derived peptides in human cervical cancer cell. Toxicol In Vitro 2008;22:344-51
  • Alvarez-Delgado C, Reyes-Chilpa R, Estrada-Muniz E, et al. Coumarin A/AA induces apoptosis-like cell death in HeLa cells mediated by the release of apoptosis-inducing factor. J Biochem Mol Toxicol 2009;23:263-72
  • Jung S, Li C, Lee S, et al. Inhibitory effect and mechanism on antiproliferation of khellactone derivatives from herbal suitable for medical or food uses. Food Chem Toxicol 2012;50:648-52
  • Fedorov S, Dyshlovoy S, Monastyrnaya M, et al. The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus). Toxicon 2010;55:811-17
  • Dall'Acqua S, Linardi MA, Maggi F, et al. Natural daucane sesquiterpenes with antiproliferative and proapoptotic activity against human tumor cells. Bioorg Med Chem 2011;19:5876-85
  • Zhai DD, Supaibulwatana K, Zhong JJ. Inhibition of tumor cell proliferation and induction of apoptosis in human lung carcinoma 95-D cells by a new sesquiterpene from hairy root cultures of Artemisia annua. Phytomedicine 2010;17:856-61
  • Ye JC, Hsiao MW, Hsieh CH, et al. Analysis of caffeic acid extraction from ocimum gratissimum linn. by high performance liquid chromatography and its effects on a cervical cancer cell line. Taiwan J Obstet Gynecol 2010;49:266-71
  • Shi J, Shen H. Critical role of Bid and Bax in indirubin-3′-monoxime-induced apoptosis in human cancer cells. Biochem Pharmacol 2008;75:1729-42
  • Li J, Li Q, Peng Y, et al. Protective effects of fraction 1a of polysaccharides isolated from Solanum nigrum Linne on thymus in tumor-bearing mice. J Ethnopharmacol 2010;129:350-6
  • Kuete V, Wabo HK, Eyong KO, et al. Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants. PLoS One 2011;6:e21762
  • Zhang Y, Ge Y, Chen Y, et al. Cellular and molecular mechanisms of silibinin induce cell-cycle arrest and apoptosis on HeLa cells. Cell Biochem Funct 2012;30:243-8
  • Xu Y, Ge R, Du J, et al. Corosolic acid induces apoptosis through mitochondrial pathway and caspases activation in human cervix adenocarcinoma HeLa cells. Cancer Lett 2009;284:229-37
  • Teh SS, Cheng LEG, Mah SH, et al. Mesua beccariana (Clusiaceae), a source of potential anti-cancer lead compounds in drug discovery. Molecules 2012;17:10791-800
  • Begum S, Syed SA, Siddiqui BS, et al. Carandinol: first isohopane triterpene from the leaves of Carissa carandas L. and its cytotoxicity against cancer cell lines. Phytochem Lett 2013;6:91-5
  • Momtaz S, Hussein AA, Ostad SN, et al. Growth inhibition and induction of apoptosis in human cancerous HeLa cells by Maytenus procumbens. Food Chem Toxicol 2013;51:38-45
  • Wang H, Ao M, Wu J, et al. TNF-α and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G2/M cell cycle arrest. Food Chem Toxicol 2013;55:396-410
  • Hu Y, Qi Y, Liu H, et al. Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography-mass spectrometry based metabolic profiling. Biochim Biophys Acta 2012;1830:2779-89
  • Alonso-Castro AJ, Ortiz-Sanchez E, Garcia-Regalado A, et al. Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects. J Ethnopharmacol 2013;145:476-89
  • Choudhary MI, Hussain A, Adhikari A, et al. Anticancer and α-chymotrypsin inhibiting diterpenes and triterpenes from Salvia leriifolia. Phytochemist Lett 2013;6:139-43
  • Jeyaraj M, Rajesh M, Arun R, et al. An investigation on the cytotoxicity and caspase-mediated apoptotic effect of biologically synthesized silver nanoparticles using Podophyllum hexandrum on human cervical carcinoma cells. Colloids Surf B Biointerfaces 2013;102:708-17
  • Suman TY, Radhika RS, Kanchana A, et al. Biosynthesis, characterization and cytotoxic effect of plant mediated silver nanoparticles using Morinda citrifolia root extract. Colloids Surf B Biointerfaces 2013;106:74-8
  • Ramer R, Merkord J, Rohde H, et al. Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1. Biochem Pharmacol 2010;79:955-66
  • Ying TH, Yang SF, Tsai SJ, et al. Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway. Arch Toxicol 2012;86:263-73
  • You BR, Moon HJ, Han YH, et al. Gallic acid inhibits the growth of HeLa cervical cancer cells via apoptosis and/or necrosis. Food Chem Toxicol 2010;48:1334-40
  • Hsu YL, Chia CC, Chen PJ, et al. Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells. Mol Nutr Food Res 2009;53:826-35
  • Xiao JX, Huang GQ, Geng X, et al. Soy-derived isoflavones inhibit HeLa cell growth by inducing apoptosis. Plant Foods Hum Nutr 2011;66:122-8
  • Al-Hazzani AA, Alshatwi AA. Catechin hydrate inhibits proliferation and mediates apoptosis of SiHa human cervical cancer cells. Food Chem Toxicol 2011;49:3281-6
  • Kniazhanski T, Jackman A, Heyfets A, et al. Methyl jasmonate induces cell death with mixed characteristics of apoptosis and necrosis in cervical cancer cells. Cancer Lett 2008;271:34-46
  • Xin S, Shulan L, Jing Z, et al. Effects of Res on proliferation and apoptosis of human cervical carcinoma cell lines C33A, SiHa and HeLa. J Med Coll PLA 2009;24:148-54
  • Lakshminarayana R, Sathish UV, Dharmesh SM, et al. Antioxidant and cytotoxic effect of oxidized lutein in human cervical carcinoma cells (HeLa). Food Chem Toxicol 2010;48:1811-16
  • Yan J, Wang Q, Zheng X, et al. Luteolin enhances TNF-related apoptosis-inducing ligand's anticancer activity in a lung cancer xenograft mouse model. Biochem Bioph Res Co 2012;417:842-6
  • Yokoyama M, Noguchi M, Nakao Y, et al. Antiproliferative effects of the major tea polyphenol, (-)-epigallocatechin gallate and retinoic acid in cervical adenocarcinoma. Gynecol Oncol 2008;108:326-31
  • Ramesh E, Alshatwi AA. Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells. Food Chem Toxicol 2013;51:97-105
  • Kim J, Kang JW, Kim MS, et al. The apoptotic effects of the flavonoid N101-2 in human cervical cancer cells. Toxicol In Vitro 2012;26:67-73
  • Kuzmich AS, Fedorov SN, Shastina VV, et al. The anticancer activity of 3- and 10-bromofascaplysins is mediated by caspase-8, -9, -3-dependent apoptosis. Bioorg Med Chem 2010;18:3834-40
  • Cárdenas MG, Blank VC, Marder M, et al. 2′-Nitroflavone induces cell cycle arrest and apoptosis in HeLa human cervical carcinoma cells. Cancer Lett 2008;268:146-57
  • Zhang T, Chen X, Qu L, et al. Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in HeLa cells. Bioorgan Med Chem 2004;12:6097-105
  • Moon HJ, Park WH. Butylated hydroxyanisole inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis and GSH depletion. Mol Cell Biochem 2011;349:179-86
  • Han YH, Moon HJ, You BR, et al. Propyl gallate inhibits the growth of HeLa cells via caspase-dependent apoptosis as well as a G1 phase arrest of the cell cycle. Oncol Rep 2010;23:1153-8
  • Yao Z, Shulan Z. Inhibition effect of Guizhi-Fuling-decoction on the invasion of human cervical cancer. J Ethnopharmacol 2008;120:25-35
  • Chae H, Yang S, Kim D, et al. Ge-Jee-Bok-Ryung-Hwan induces apoptosis in human cervical carcinoma HeLa cells: an endoplasmic reticulum stress pathway. Life Sci 2004;75:2997-3016
  • Sun A, Chia JS, Chiang CP, et al. The Chinese herbal medicine Tien-Hsien liquid inhibits cell growth and induces apoptosis in a wide variety of human cancer cells. J Altern Complement Med 2005;11:245-56
  • He DM, Yuan XF, Li JB. Effects of compound matrine capsule on cells proliferation inhibitory and cell cycle in cervical cancer cells. Lishizhen Med Mat Med Res 2012;23:1737-8
  • Chen HL, Han FJ, Gong YQ, et al. Effects of Erhuangsan with complex prescription of traditional Chinese medicine on cells proliferation inhibitory and the expression of Bcl-2 protein in HeLa cells of cervical cancer. Modern oncol 2010;18:2102-4

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