Drugs targeting nitric oxide synthase for migraine treatment

Bibliography

• Olesen J. The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache. Pharmacol Ther 2008;120(2):157-71
   PubMed Web of Science ®Google Scholar
• Sarchielli P, Alberti A, Codini M, et al. Nitric oxide metabolites, prostaglandins and trigeminal vasoactive peptides in internal jugular vein blood during spontaneous migraine attacks. Cephalalgia 2000;20(10):907-18
   PubMed Web of Science ®Google Scholar
• Sarchielli P, Alberti A, Floridi A, Gallai V. L-Arginine/nitric oxide pathway in chronic tension-type headache: relation with serotonin content and secretion and glutamate content. J Neurol Sci 2002;198(1-2):9-15
   PubMed Web of Science ®Google Scholar
• D’Amico D, Ferraris A, Leone M, et al. Increased plasma nitrites in migraine and cluster headache patients in interictal period: basal hyperactivity of L-arginine-NO pathway? Cephalalgia 2002;22(1):33-6
   PubMed Web of Science ®Google Scholar
• Toda N, Ayajiki K, Okamura T. Cerebral blood flow regulation by nitric oxide: recent advances. Pharmacol Rev 2009;61(1):62-97
   PubMed Web of Science ®Google Scholar
• Prast H, Philippu A. Nitric oxide as modulators of neuronal function. Prog Neurobiol 2001;64:51-68
   PubMed Web of Science ®Google Scholar
• Luo ZD, Cizkova D. The role of nitric oxide in nociception. Curr Rev Pain 2000;4(6):459-66
   PubMedGoogle Scholar
• Wu J, Fang L, Lin Q, Willis WD. Nitric oxide synthase in spinal cord central sensitization following intradermal injection of capsaicin. Pain 2001;94(1):47-58
   PubMed Web of Science ®Google Scholar
• Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-42
   PubMed Web of Science ®Google Scholar
• Förstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J 2012;33:829-37
   PubMed Web of Science ®Google Scholar
• Zhou L, Zhu DY. Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. Nitric Oxide 2009;20:223-30
   PubMed Web of Science ®Google Scholar
• Messlinger K, Lennerz JK, Eberhardt M, Fischer MJM. CGRP and NO in the trigeminal system: mechanisms and role in headache generation. Headache 2012;52:1411-27
   PubMed Web of Science ®Google Scholar
• Nathan CF, Hibbs JB. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 1991;3:65-70
   PubMed Web of Science ®Google Scholar
• Förstermann U, Münzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006;113(13):1708-14
   PubMed Web of Science ®Google Scholar
• Lassen LH, Sperling B, Andersen AR, Olesen J. The effect of i.v. L-NG methylarginine hydrochloride (L-NMMA: 546C88) on basal and acetazolamide (Diamox) induced changes of blood velocity in cerebral arteries and regional cerebral blood flow in man. Cephalalgia 2005;25(5):344-52
   PubMed Web of Science ®Google Scholar
• Akerman S, Williamson DJ, Kaube H, Goadsby PJ. Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene-related peptide induced dilation of dural meningeal vessels. Br J Pharmacol 2002;137:62-8
   PubMed Web of Science ®Google Scholar
• Fanciullacci M, Alessandri M, Figini M, et al. Increase in plasma calcitonin gene related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack. Pain 1995;60:119-23
   PubMed Web of Science ®Google Scholar
• Booth BP, Tabrizi-Fard MA, Fung H. Calcitonin gene-related peptide-dependent vascular relaxation of rat aorta. An additional mechanism for nitroglycerin. Biochem Pharmacol 2000;59:1603-9
   PubMed Web of Science ®Google Scholar
• Tvedskov JF, Tfelt-Hansen P, Petersen KA, et al. CGRP receptor antagonist olcegepant (BIBN4096BS) does not prevent glyceryl trinitrate-induced migraine. Cephalalgia 2010;30(11):1346-53
   PubMed Web of Science ®Google Scholar
• Garthwaite J. Concepts of neural nitric oxide-mediated transmission. Eur J Neurosci 2008;27:2783-802
   PubMed Web of Science ®Google Scholar
• Greco R, Tassorelli C, Armentero MT, et al. Role of central dopaminergic circuitry in pain processing and nitroglycerin-induced hyperalgesia. Brain Res 2008;1238:215-23
   PubMed Web of Science ®Google Scholar
• Luecher TF, Vanhoutte PM. The endothelium: modulator of cardiovascular functions. CRC Press; Ann Arbor, Michigan: 1990
   Google Scholar
• Ahern GP, Hsu SF, Klyachko VA, Jackson MB. Induction of persistent sodium current by exogenous and endogenous nitric oxide. J Biol Chem 2000;275:28810-15
   PubMed Web of Science ®Google Scholar
• Ahern GP, Klyachko VA, Jackson MB. cGMP and S-nitrosylation: two routes for modulation of neuronal excitability by NO. Trends Neurosci 2002;25:510-17
   PubMed Web of Science ®Google Scholar
• Yuan XJ, Tod ML, Rubin LJ, Blaustein MP. NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels. Proc Natl Acad Sci USA 1996;93:10489-94
   PubMed Web of Science ®Google Scholar
• Gozalov A, Jansen-Olesen I, Klaerke D, Olesen J. Role of BK(Ca) channels in cephalic vasodilation induced by CGRP, NO and transcranial electrical stimulation in the rat. Cephalalgia 2007;27:1120-7
   PubMed Web of Science ®Google Scholar
• Cury Y, Picolo G, Gutierrez VP, Ferreira SH. Pain and analgesia: the dual effect of nitric oxide in the nociceptive system. Nitric Oxide 2011;25(3):243-54
   PubMed Web of Science ®Google Scholar
• Lin Q, Palecek J, Paleckova V, et al. Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons. J Neurophysiol 1999;81(3):1075-85
   PubMed Web of Science ®Google Scholar
• Lambert GA, Hoskin KL, Zagami AS. Nitrergic and glutamatergic neuronal mechanisms at the trigeminovascular first-order synapse. Neuropharmacology 2004;47(1):92-105
   PubMed Web of Science ®Google Scholar
• Jones MG, Lever I, Bingham S, et al. Nitric oxide potentiates response of trigeminal neurons to dural or facial stimulation in the rat. Cephalalgia 2001;21(6):643-55
   PubMed Web of Science ®Google Scholar
• Wu J, Fang L, Lin Q, Willis WD. Nitric oxide synthase in spinal cord central sensitization following intradermal injection of capsaicin. Pain 2001;94(1):47-58
   PubMed Web of Science ®Google Scholar
• Mao J, Price DD, Zhu J, et al. The inhibition of nitric oxide-activated poly(ADP-ribose)synthetase attenuates transsynaptic alteration of spinal cord dorsal horn neurons and neuropathic pain in the rat. Pain 1997;72(3):355-66
   PubMed Web of Science ®Google Scholar
• Hoskin KL, Bulmer DCE, Goadsby PJ. Fos expression in the trigeminocervical complex of the cat after stimulation of the superior sagittal sinus is reduced by L-NAME. Neurosci Lett 1999;266:173-6
   PubMed Web of Science ®Google Scholar
• De Col R, Koulchitsky SV and Messlinger KB. Nitric oxide synthase inhibition lowers activity of neurons with meningeal input in the rat spinal trigeminal nucleus. Neuroreport 2003;14:229-32
   PubMed Web of Science ®Google Scholar
• Schmidtko A, Tegeder I, Geisslinger G. No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing. Trends Neurosci 2009;32(6):339-46
   PubMed Web of Science ®Google Scholar
• Sicuteri F, Delbene E, Poggioni M, Bonazzi A. Unmasking latent dysnociception in healthy-subjects. Headache 1987;27:180-5
   PubMed Web of Science ®Google Scholar
• Olesen J, Iversen HK, Thomsen LL. Nitric oxide supersensitivity: a possible molecular mechanism of migraine pain. Neuroreport 1993;4:1027-30
   PubMed Web of Science ®Google Scholar
• Thomsen LL, Kruuse C, Iversen HK, Olesen J. A nitric oxide donor (nitroglycerin) triggers genuine migraine attacks. Eur J Neurol 1994;1(1):73-80
   PubMedGoogle Scholar
• Christiansen I, Daugaard D, Lykke Thomsen L, Olesen J. Glyceryl trinitrate induced headache in migraineurs – relation to attack frequency. Eur J Neurol 2000;7:405-11
   PubMed Web of Science ®Google Scholar
• Christiansen I, Thomsen LL, Daugaard D, et al. Glyceryl trinitrate induces attacks of migraine without aura in sufferers of migraine with aura. Cephalalgia 1999;19:660-7
   PubMed Web of Science ®Google Scholar
• Afridi SK, Kaube H, Goadsby PJ. Glyceryl trinitrate triggers premonitory symptoms in migraineurs. Pain 2004;110(3):675-80
   PubMed Web of Science ®Google Scholar
• Martelletti P, D’Alò S, Stirparo G, et al. Modulation of nitric oxide synthase by nitric oxide donor compounds in migraine. Int J Clin Lab Res 1998;28(2):135-9
   PubMedGoogle Scholar
• Olesen J, Thomsen LL, Lassen LH, Olesen IJ. The nitric oxide hypothesis of migraine and other vascular headaches. Cephalalgia 1995;15:94-100
   PubMed Web of Science ®Google Scholar
• Tassorelli C, Joseph SA. Systemic nitroglycerin induces Fos immunoreactivity in brainstem and forebrain structures of the rat. Brain Res 1995;682:167-81
   PubMed Web of Science ®Google Scholar
• Tassorelli C, Joseph SA, Nappi G. Neurochemical mechanisms of nitroglycerin-induced neuronal activation in rat brain: a pharmacological investigation. Neuropharmacology 1997;36(10):1417-24
   PubMed Web of Science ®Google Scholar
• Olesen J. Nitric Oxide-related drug targets in headache. Neurotherapeutics 2010;7(2):183-90
   PubMed Web of Science ®Google Scholar
• Lassen LH, Ashina M, Christiansen I, et al. Nitric oxide synthase inhibition in migraine. Lancet 1997;349:401-2
   PubMed Web of Science ®Google Scholar
• Lassen LH, Ashina M, Christiansen I, et al. Nitric oxide synthase inhibition: a new principle in the treatment of migraine attacks. Cephalalgia 1998;18:27-32
   PubMed Web of Science ®Google Scholar
• Palmer JE, Guillard FL, Laurijssens BE, et al. A randomised, single-blind, placebo-controlled, adaptive clinical trial of GW274150, a selective iNOS inhibitor, in the treatment of acute migraine. Cephalalgia 2009;29:124
   Google Scholar
• Van der Schueren BJ, Lunnon MW, Laurijssens BE, et al. Does the unfavorable pharmacokinetic and pharmacodynamic profile of the iNOS inhibitor GW273629 lead to inefficacy in acute migraine? J Clin Pharmacol 2009;49(3):281-90
   PubMed Web of Science ®Google Scholar
• Bhatt DK, Gupta S, Jansen-Olesen I, et al. NXN-188, a selective nNOS inhibitor and a 5-HT1B/1D receptor agonist, inhibits CGRP release in preclinical migraine models. Cephalalgia 2013;33(2):87-100
   PubMed Web of Science ®Google Scholar
• Medve RA, Lategan TW. A phase 2 multicenter, randomized, double-blind, parallel-group, placebo-controlled study of NXN-188 dihydrochloride in acute migraine without aura. J Headache Pain 2010;11(1):S38
   Google Scholar
• Høivik HO, Laurijssens BE, Harnisch LO, et al. Lack of efficacy of the selective iNOS inhibitor GW274150 in prophylaxis of migraine headache. Cephalalgia 2010;30(12):1458-67
   PubMed Web of Science ®Google Scholar
• Lim SS, Vos T, Flaxman AD, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380(9859):2163-96
   PubMed Web of Science ®Google Scholar
• Tfelt-Hansen PC, Pihl T, Hougaard A, Mitsikostas DD. Drugs targeting 5-hydroxytryptamine receptors in acute treatments of migraine attacks. A review of new drugs and new administration forms of established drugs. Expert Opin Investig Drugs 2014;23(3):375-85
   PubMed Web of Science ®Google Scholar
• Hoffmann J, Akerman S, Goadsby PJ. Efficacy and mechanism of anticonvulsant drugs in migraine. Expert Rev Clin Pharmacol 2014;7(2):191-201
   PubMed Web of Science ®Google Scholar
• Hoffmann J, Goadsby PJ. Emerging targets in migraine. CNS Drugs 2014;28(1):11-17
   PubMed Web of Science ®Google Scholar
• Kots AY, Bian K, Murad F. Nitric oxide and cyclic GMP signaling pathway as a focus for drug development. Curr Med Chem 2011;18:3299-305
   PubMed Web of Science ®Google Scholar
• Van Der Kuy PH, Merkus FW, Lohman JJ, et al. Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study. Cephalalgia 2002;22:513-19
   PubMed Web of Science ®Google Scholar
• Edvinsson L, Elsas T, Suzuki N, et al. Origin and co-localization of nitric oxide synthase, CGRP, PACAP, and VIP in the cerebral circulation of the rat. Microsc Res Tech 2001;53:221-8
   PubMed Web of Science ®Google Scholar
• Pardutz A, Krizbai I, Multon S, et al. Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis. Neuroreport 2000;11:3071-5
   PubMed Web of Science ®Google Scholar
• De Felice M, Ossipov MH, Wang R, et al. Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers. Brain 2010;133(8):2475-88
   PubMedGoogle Scholar
• Jackson JL, Kuriyama A, Hayashino Y. Botulinum toxin A for prophylactic treatment of migraine and tension headaches in adults: a meta-analysis. JAMA 2012;307(16):1736-45
   PubMed Web of Science ®Google Scholar
• Barbanti P, Fabbrini G, Pesare M, et al. Unilateral cranial autonomic symptoms in migraine. Cephalalgia 2002;22(4):256-9
   PubMed Web of Science ®Google Scholar
• Barbanti P, Fofi L, Dall’Armi V, et al. Rizatriptan in migraineurs with unilateral cranial autonomic symptoms: a double-blind trial. J Headache Pain 2012;13(5):407-14
   PubMed Web of Science ®Google Scholar