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Research

Glycylcyclines - Third generation tetracycline analogues

Pages 191-193 | Published online: 03 Mar 2008

References

  • CHOPRA I, HAWKEY PM, IIINTON M: Tetraclines, molecu-lar and clinical aspects. J. Antimicrob. Chemother. (1992) 29:245–277.
  • Recent comprehensive review, co-authored by the present author, detailing all aspects of tetracycline antibiotics.
  • BURDETT V: tRNA modification activity is necessary for Tet(M)-mediated tetracycline resistance. J. Bacteriol. (1993) 175:7209–7215.
  • A research paper describing recent advances in our understanding of the molecular basis of ribosomal resistance to tetracyclines.
  • SAM P-E, LEE VJ, TESTA RT, HLAUKA JJ, ELLESTAD GA, BLOOM JD, GLUZMAN Y, TALLY FP: The discovery of a new generation of tetracycline antibacterial agents, the `glycylcyclines'. Program and Abstracts of the 33rd Inter-science Conference on Antimicrobial Agents and Chemother-apy (ICAAC) (1993) Abstr. 431 p198.
  • TESTA RT, PETERSEN PJ, JACOBUS NV, SAM P-E, LEE VJ, TALLY FP: In vitro and in vivo antibacterial activities of the gylcylcyclines, a new class of semisynthetic tetracy- clines. Antimicrob. Agents Chemother. (1993) 37:2270–2277.
  • First detailed report on the new tetracyclines.
  • ROGALSKI W: Chemical modification of the tetracycli-nes. In: The Tetracyclines (1985), Hlavka JJ, Boothe JH (Eds), Springer-Verlag, Berlin p179–316.

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