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Research

Recent progress in the clinical development of thromboxane A2 receptor antagonists

Pages 469-480 | Published online: 03 Mar 2008

References

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  • A review of pre-clinical and clinical results in asthma.
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  • Study showing no effect on hypertension in patients with RAS.
  • PTACHCINCKI RJ, LOPATIN W, FINN W, WOMBOLT DG, BENNETT WM, ICLEIN JB, COFFMAN TM: Evaluation of the Interaction between 6R32191 and cyclosporine follow-ing renal transplantation. Pharmacotherapy(1989) 9:193.
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  • Study showing no benefit in cyclosporine-induced nephrotoxity.
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  • RITTER W, WEBER H, KUHLMANN J: Single and multiple dose pharmacokinetics of the thromboxane A2 antago-nist BAY u 3405.J. Chn. Pharmacol. (1990) 30:849.
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  • JOHNSON SL, BARDIN PG, RITTER W, JOUBERT JR, HOL-GATE ST: The effect of BAY u 3405, a thromboxane receptor antagonist, on prostaglandin (PG) and hista-mine (H) bronchial challenge and correlation of effi-cacy with plasma levels. Eur. Resp. J. (1991) 4 (SuppL 14):264s–265s.
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  • Study showing effectiveness in PGD2-induced bronchoconstriction.
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  • Study showing efficacy as an antithrombotic in mature aortic grafts.
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  • Study showing efficacy in reducing protamine-induced hyperten-sion.
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  • Summary of early pre-clinical pharmacology.
  • SCHUMACHER WA, STEINBACHER TE, YOUSSEF S, OGLE- TREE ML: Antiplatelet activity of the long-acting throm-boxane receptor antagonist BMS 180,291 in monkeys. Prostaglandins (1992) 44:389–97.
  • KOSLO RJ, FARINA V, OGLETREE ML, ABERG G: Gastro-protective effect of BMS 180,291: a new thromboxane receptor antagonist. Gastroenterology (1992) 102:A102.
  • GOMOLL AW, GROVER GJ, OGLETREE ML: Myocardial salvage efficacy of the novel thromboxane A2 / pro-staglandin endoperoxide antagonist, BMS 180,291, in the ferret and dog. Submitted.
  • Study showing efficacy in animal models of ischaemia.
  • GROVER GJ, SCHUMACHER WA, OGLETREE ML: The thromboxane receptor antagonist HMS-180291, but not aspirin reduces the severity of pacing-induced ischemia In dogs. Submitted.
  • Study showing benefit over aspirin in dog model of ischaemia.
  • 'WEBB ML, LIU ECK, MONSHIZADEGAN H, HEDBERG A, MISRA RN, GOLDENBERG H, HARRIS DN: Binding and function of a potent new thromboxane receptor an-tagonist, BMS 180,291, in human platelets./ Pharmacol. Exp. Ther. (1993) 264:1387–94.
  • KW-3635. Drugs Future (1992) 17:782–7.
  • KARASAWA A, KAWAKAGE M, SHIRAICURA S, HIGO K, KUBO K, OHSHIMA E, OBASE H: Antiplatekt effects of the novel thromboxane A2 receptor antagonist sodium (e)-11-[2-(5,6-dimethyl-1-benzimidazoly1)- ethyliclene]-6,11-dihydrodlbenz[b,eloxepine-2-carboxylate mono-hydrate. Arzneim.-Forsch . (1991) 41:1230–6.
  • KARASAWA A, SHIRAICURA S, HIGO K, KUBO K: Actions of the novel thromboxane A2 receptor antagonist so-dium (e)-11-[2-(5,6-dimethyl-1- benzimidazoly1)-ethylidene[- 6, 11- dihydro dibenz [b, e[o xepine-2-carlboxylate monohydrate on smooth muscle prepara-tions. Arzneim.- Forsch. (1991) 41:1237–41.
  • SHIRAKURA S, KARASAWA A, KUBO K: Protective effectsof the novel thromboxane A2 receptor antagonist so-dium (e)-11-[2-(5,6-dimethy1-1- benzimidazoly1)-ethylidene[-6, 11- dihydro dibenz [b,e[oxepine-2-carbox-ylate monohydrate a :Rinct 9,11-dideoxy-9a,11a-epoxymethano- prostaglandin F2a-induced sudden death in guinea-pigs and rats. Arzrzeim.-Forsch. (1991) 41:1242–5.
  • KAWAKAGE M, SHIRAICURA S, KARASAWA A, TAICEDA M, MIKI I, ISHII, ICUS° K: Beneficial effect of the novel thromboxane A2 receptor antagonist sodium (e)-1142-(5,6-dimethy1-1-benzimidazoly1)-ethylidene]- 6,11-di-hydrodibenz[b,e]oxepine-2-carboxylate monohydrate on collagen- induced coronary ishemia in guinea-pigs. Arzneim.-Forsch. (1991) 41:1246–50.
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  • TOMIYAMA T, WAKABAYASHI S, KOSAKAI K, YOKOTA M:Azulene derivatives: new non-prostanoid thrombox-ane A2 receptor antagonists. J. Med. Chem. (1990) 33:2323–26.
  • KOSAKAI K, WAKABAYASHI S, SATOH T, TOMIYAMA A, SATAKE N, SHIBATA S: Pharmacological properties of KT2-962, an azukne derivative, a novel TxA2/P6112 antagonist. FASEB J. (1991) 5:A500.
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  • NAKAHATA N, SATO K, ABE MT, NAKANISHI: ONO NT-126 Is a potent and selective thromboxane A2 antagonist in human astrocytoma cells. Eur. J. Pharmacol. (1990) 184:233–8.
  • TAKANO S, ISHIMOTO, NAKAHATA N, NAKANISHI H: Thromboxane A2 receptor characterization in human astrocytoma cells and rabbit platelets by a new throm-boxane antagonist, BRION° NT-126. Res. Commun. Chem. Pathol. Pharmacol. (1992) 76:155–70.
  • SCHENK J, FELLIER H, MITREY Z, SCHMIDT G, SAMHAI3EREM, BREDDIN HK: Effects of a novel selective thrombox-ane receptor antagonist IIN-11500 on platelet function In man. A prospective, randomized phase-1 study. Thromb. Haemostasis (1993) 69:673.
  • ROALD HE, BARSTAD RM, ENGEN A, KLERULF P, SKIORTEN F, SAKARIASSEN KS: Phase I study-HN-11500-a novel thromboxane receptor antagonist with antitbromlbotic activity in humans with arterial blood flow conditions. 7bromb. Haemostasis (1993) 69:639.
  • ROALD HE, BARSTAD RM, ENGEN A, KIERULF P, SKJORTEN F, SAKARIASSEN KS: ELN-11500- a novel thromboxane A2 receptor antagonist with antithrombotic activity in humans at arterial blood flow conditions. Thromb. Haemartasis (1994) 71:103–9.
  • ANTIPLATELET TRIALISTS' COLLABORATION: Collabora- tive overview of randomised trials of antiplatelet ther-apy-l: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various catagories of patients. Br. Med. J. (1994) 308:81–106.
  • Meta-analysis establishing efficacy of aspirin.
  • ANTIPLATELET TRIALISTS' COLLABORATION: Collabora- tive overview of randomised trials of antiplatelet ther-apy-II: maintenance of vascular graft or arterial patency by antiplatelet therapy. Br. Med. J. (1994) 388:159-68. Meta-analysis establishing efficacy of aspirin.
  • ANTIPLATFIFT TRIALISTS' COLLABORATION: Collabora-tive overview of randomised trials of antiplatelet ther-apy-III: reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Br. Med. J. (1994) 308:235–46.
  • Meta-analysis establishing efficacy of aspirin.

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