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Research

Inhibition of nitric oxide synthesis as a therapeutic target for arthritis: recent reports

Pages 529-531 | Published online: 03 Mar 2008

References

  • MONCADA S, HIGGS A: The L-arginine-nitric oxide path-way. N. Eng. J. Med. (1993) 329:2002–2012.
  • NATHAN C: Nitric oxide as a secretory product of mam-malian cells. FASEBJ. (1992) 6:3051–3064.
  • BECKMAN JS, BECKMAN TW, CHEN J, MARSHALL PA, FREEMAN BA: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA (1990) 87:1620–1624.
  • JACOB T, MORRELL M, MANZI S, VERDILE V, SIMMONS RL: Elevated nitrates in inflammatory joint disease: nitric oxide in arthritis. Arth. Rheum. (1992) 35\(Suppl. 5):Abstr.R9.
  • FARRELL AJ, BLAKE DR, PALMER RMJ, MONCADA S: In-creased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis Of In rheumatic diseases. Ann. Rheum. Dis. (1992) 5 1:1219–1222.
  • HIBBS JB, WESTENFELDER C, TAINTOR R, VAVRIN Z,KABLLITZ C, BARANOWSKI RI, WARD JH, MENLOVE RI, MCMURRAY MP, ICUSHNER JP, SAMLOWSKI W: Evidence for cytokine-inducible nitric oxide synthesis from L-ar-ginine in patients receiving interieukin-2 therapy. J. Clin. Invest. (1992) 89:967–877.
  • OCHOA JB, UDEKWU AO, BILLIAR TR, CURRAN RD, CERRAFB, SIMMONS RL, PETTZMAN AB: Nitrogen levels in pa-tients after trauma and sepsis. Ann. Surg. (1991) 214:621–626.
  • CHARLES IG, PALMER RMJ, HICKERY MS, BAYLISS MT,CHUBB AP, HALL VS, MOSS DW, MONCADA S: Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc. Natl. Acad. Sci. USA (1993) 90:11419–11423.
  • STEFANOVIC-RACIC M, STADLER J, GEORGESCU HI,EVANS CH: Nitric oxide production by cytokine-stimu-lated synovial fibroblasts. Trans. Orthop. Res. Soc. (1991) 17(Abstr.):228.
  • STEFANOVIC-RACIC M, MYERS K, MESCHTER C, COFFEY JW, HOFFMAN R, EVANS CH: N-monomethylarginine, an Inhibitor of nitric oxide synthase, suppresses the onset of adjuvant arthritis. Arth . Rheum. ( 1 9 9 3) 36 (Suppl.):Abstr. S44.
  • CANNON GW, HIBBS JB, GRIFFITHS MM: Nitric oxide production during adjuvant arthritis. Arth. Rheum. (1993) 36 (Suppl.):Abstr. S45.
  • TALENT' A, MONCADA S, DI ROSA M: Modulation of esadjuvant arthritis by endogenous nitric oxide. Br. JPharmacol. (1993) 110:701–706.
  • MCCARTNEY-FRANCIS N, ALLEN JB, MIZEL DE, ALBINA JE, ESXIExs Q-W, NATHAN CF, WAHL SM: Suppression of arthritisby an inhibitor of nitric oxide synthase. J. Exp. Med. (1993) 178:749–754.
  • WEINBERG JB, GRANGER DL, PISETSKY DS, SELDIN MF, MISUKONIS MA, MASON SN, PLPPEN AM, RLTIZ P, WOODER, GILKESON GS. The role of nitric oxide in the patho-genesis of spontaneous murine autoimmune disease increased nitric oxide production and nitric oxide synthase expression in MRL-fpr//pr mice, and reduc-tion of spontaneous nephritis and arthritis by orally administered N6-monomethyl-L-arginine. J. Exp. Med. (1994) 179:651–660.
  • PETROS A, BENNETT D, VALLANCZ P: Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock Lancet (1991) 338:1557–1558.
  • GROSS SS, LEVI R, MADERA A, PARK KH, VANE J, HATTORI Y: Tetrahydrobiopterin synthesis is induced by LPS in vascular smooth muscle and is rate-limiting for nitric oxide production. Adv. Exp. Med. Biol. (1993) 338:295–300.
  • SCHOEDON G, BLAU N, SCHNEEMANN M, FLURY G, SCHAFFNER A: Nitric oxide production depends on preceding tetrahydorbiopterin synthesis by endothe-Hal cells: selective suppression of induced nitric oxide production by seplapterin reductase inhibitors. Bio-chem. Biophys. Res. Commun. (1994) 199:504–510.
  • SHERMAN MP, AEBERHARD EE, WONG VZ, GRISCAVAGEJM, IGNARRO LJ: Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem. Biophys. Res. Commun. (1993) 191:1301–1308.
  • MARCZIN N, PAPAPETROPOULOS A, PILING T, CATRAVAS JD: Prevention of nitric oxide induction in vascular smooth muscle cells by microtuble depolymerizing agents. Br. J. Phar. (1993) 109:603–605.
  • MARCZIN N, PAPAPETROPOULOS A, CATRAVAS JD: Tyro-sine kinase inhibitors suppress endotoxin- and IL-1113-induced NO synthesis in aortic smooth muscle cells. Am. J. Physiol. (1993) 265:H1014–H1018.
  • BREDT DS, FERRIS CD, SYNDER SH: Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-de-pendent protein kinase, protein kinase C, and cal-cium/calmodulin protein kinase; identification of flavin and cahnodulin binding sites.1 Biol. Chem. (1992) 267:10976–10981.
  • NAKANE M, MITCHELL J, FORSTERMANN U, MURAD F: Phosphorylation by calcium cahnodulin-dependent protein kinase 11 and protein kinase C modulates the activity of nitric oxide synthase. Biochem. Biophys. Res. Commun. (1991) 180:1396–1402.
  • VODOVOTZ Y, BOGDAN C, PALK J, XIE Q-W, NATHAN C: Mechanism of suppression of macrophage nitric oxide release by transforming growth factor 13. I Exp. Med. (1993) 178:605–613.
  • HECK DE, LASKIN DL, GARDNER CR, LASKIN JD: Epider-mal growth factor suppresses nitric oxide and hydro-gen peroxide production by keratinocytes: potential role for nitric oxide in the regulation of wound healing. J. Biol. Chem. (1992) 267:21277–21280.
  • SCHINI VB, DURANTE W, ELIZONDO E, SCOTT-BURDENT, JUNQUERO DC, SCHAFER Al, VANHOUTTE PM: The induction of nitric oxide synthase activity is inhibited by TGF-01, PDGFAs and PDGFRB in vascular smooth muscle cells. Eur. J. Pharmacol. (1992) 216:379–383.
  • MCCALL TB, PALMER RMJ, MONCADA S: Interleukin-8 Inhibits the induction of nitric oxide synthase in rat peritoneal neutrophas. Biochem. Biophys. Res. Commun. (1992) 186:680–685.
  • LIEW FY, LI Y, SEVERN A, MILLOTT S, SCHMIDT J, SALTERM, MONCADA S: A possible novel pathway of regulation by murine T helper type-2 (Th2) of a Ti, 1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages. Eur. J. Immunol. (1991) 21:2489–2494.

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