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Research Article

Section Review Central & Peripheral Nervous Systems: P2-Purinoceptors: Advances and therapeutic opportunities

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Pages 925-934 | Published online: 03 Mar 2008

References

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  • This overview will appear early in 1996 and is the authoritative source on the history of the purinoceptor field.
  • HARDEN TK, BOYER JL, NICHOLAS RA: P2-purinergic receptors: subtype-associated signaling responses andstructure. Ann. Rev. Pharmacol. Toxicol. (1995) 35:541-579. A thorough overview of the P2 receptor area from a molecular and pharmacological perspective.
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  • An overview of the role of ATP, and related purines and nucleotides as trophic factors in nervous tissue.
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  • The seminal paper in purinergic receptor research.
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  • The paper in which the existence of Pi and P2 receptors was initially proposed.
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  • A seminal paper in the history of P2 receptor nomenclature.
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  • Yet another seminal paper in the history of P2 receptor nomenclature. The use of T' and 'Z' to define receptors continues to perplex those used to A following B and so on.
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  • An important overview that provided the basis to delineate the two main P2 receptor families on the basis of signal transduction mecha-nisms and, eventually, structure.
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  • Yet another seminal paper from the Bumstock camp providing the stimulus to redefine the P2 receptor area. While this paper provided some intriguing pharmacological data as a framework to define the eleven receptors outlined, these have been overtaken by incredibly energetic efforts on the cloning front.
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  • A very nice synthesis of electrophysiological, pharmacological and molecular biological data to support the existence of the P2x purinoceptor superfamily.
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  • A very nice synthesis of electrophysiological, pharmacological and molecular biological data to support the existence of the P2y purinoceptor superfamily.
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  • A detailed account of clinical studies involving over 1000 patients using ATP to reduce anaesthesia usage and improve their safety profile
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  • An overview of the novel Pzr receptor antagonist, ARL 67085. The research program that led to this very interesting molecule was based on the identification of an opportunity to develop an improved antithrombotic agent using available data on structure-activity rela-tionships for stable purine nucleotide ligands and a body of biologi-cal knowledge related to ADP, ATP and platelet function that had been available for over two decades. These comments by no means diminish the significant achievements of the Astra Charnwood group, but this article does point out that the recognition and application of existing knowledge to a specific therapeutic target can be as crucial to a successful outcome for a drug discovery project as enabling technology, i.e., intellect still counts!
  • BURNSTOCK G: Purinoceptor Update Newsletter 2. (Septemesber, 1995).
  • A newsletter produced by Geoff Bumstock and colleagues that provides an on-going 'clearing house' for new information regarding receptor cloning and pharmacological characterisation. This informal newsletter is intended to aid the efforts of the IUPHAR Committee on Receptor Nomenclature by providing a framework to designate P2 receptors in a sequential manner and avoid duplication of designators. The newsletter is available from Professor Bumstock who can be contacted via fax on +44 (0) 171 380 7349 in London, UK. (Additional information about purinoceptors is available at the World Wide Web at http://mgddkl.niddk.nih.gov:8000/).

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