The therapeutic potential of neuropeptide Y in central nervous system disorders with special reference to pain and sympathetically maintained pain

Bibliography

• TATEMOTO K, CARLQUIST M, MUTT V: Neuropeptide Y: a novel brain peptide with structural similarities topeptide YY and pancreatic polypeptide. Nature (1982) 296:659-660. The first description of neuropeptide Y.
   Google Scholar
• MCDONALD JK: NPY and related substances. Grit. Rev.Neurobiol (1988) 4:97–135.
   PubMed Web of Science ®Google Scholar
• LARHAMMAR D: Evolution of neuropeptide Y, peptideYY and pancreatic polypeptide. Regul Pept (1996) 62:1–11.
   PubMed Web of Science ®Google Scholar
• MUNGLANI R, HUDSPITH M, HUNT SP: The therapeutic potential of NPY: analgesic, anxiolytic and antihyper-tensive. Drugs (1996) 52:371-389. A recent comprehensive overview of NPY with emphasis on its role in chronic pain.
   Google Scholar
• SODERBERG C, PIERIBONE VA, DAHLSTRAND J et al.: Neuropeptide role of both peptide YY and neuropep-tide Yin vertebrates suggested by abundant expression of their mRNAs in a cyclostome brain. J. Neurosci. Res. (1994) 37:633–640.
   PubMed Web of Science ®Google Scholar
• BLOMQVIST AG, SODERBERG C, LUNDELL I et al.: Strong evolutionary conservation of neuropeptide Y: se-quences of chicken, goldfish, and Torpedo marmorata DNA clones. Proc. Natl. Acad. Sri. USA (1992) 89:2350–2354.
   PubMed Web of Science ®Google Scholar
• BRODIN L, SODERBERG C, PIERIBONE V etal: Peptidergic neurons in the vertebrate spinal cord: evdutionary trends. In: Progress in Brain Research - Neuropeptides in the Spinal Cord. Nyberg F, Sharma HS, Wiesenfeld-Hallin Z (Eds.), Elsevier (1995):61–74.
   Google Scholar
• GIBSON SJ, POLAK JM, ALLEN JM et al.: The distribution and origin of a novel brain peptide, neuropeptide Yin the spinal cord of several mammals. J. Comp. Neurol (1984) 227:78–91.
   PubMed Web of Science ®Google Scholar
• DOYLE CA, MAXWELL DJ: Neuropeptide Y-immunoreac-tive terminals from axo-axonic synaptic arrangements in the substantia gelatinosa (lamina IO of the cat spinal dorsal horn. Brain Res. (1993) 603:157–161.
   PubMed Web of Science ®Google Scholar
• DOYLE CA, MAXWELL DJ: light and electron-micro-scopic analysis of neuropeptide Yimmunoreactive pro-files in the cat spinal dorsal horn. Neuroscience (1994) 61:107–121.
   PubMed Web of Science ®Google Scholar
• GHILARDI JR, ALLEN CJ, VIGNA SR et al: Cholecystokininand neuropeptide Y receptors on single rabbit vagal afferent ganglion neurons: site of prejunctional modu-lation of visceral sensory neurons. Brain Res. (1994) 633:33–40.
   PubMed Web of Science ®Google Scholar
• EVERITT BJ, HOKFELT T, TERENIUS L et al.: Differentialcoexistence of neuropeptide Y (NPY)-like immunoreac-tivity with catecholamines in the central nervous sys-tem. Neuroscience (1984) 11:443–462.
   PubMed Web of Science ®Google Scholar
• OKITA M, INUI A, HIROSUE Y et al.: Brain peptide YY receptors: highly conserved characteristics throughout vertebrate evolution. Endocrinology (1991) 129:2512–2520.
   PubMed Web of Science ®Google Scholar
• MCVEY DC, RITTSCHOF D, MANNON PJ etal.: Localization and characterization of neuropeptide Y/peptide YY receptors in the brain of the smooth dogfish (Mustelis canis). Regul. Peg. (1996) 61:167–173.
   Google Scholar
• LUNDBERGJM, MODIN A, MALSTROM RE: Recent developments in neuropeptide Y receptor antagonists. Trends Pharmacol Sc]. (1996) 17:301-304. A useful update on the current state of NPY Y1 antagonist develop-ment.
   Google Scholar
• PLAYFORD RJ, COX HM: Peptide YY and neuropeptide Y: two peptides intimately involved in electrolyte ho-meostasis. Trends Pharmacol Sc]. (1996) 17:436–438.
   PubMed Web of Science ®Google Scholar
• WAHLESTEDT C, REIS DJ: Neuropeptide Y-related peptides and their receptors-are the receptors potential therapeutic drug targets? Ann. Rev. Pharmacol. Toxicol (1993) 32:309-352. A major review from one of the leading groups on NPY receptor pharmacology.
   Google Scholar
• GRUNDEMAR L, HAKANSON R: Neuropeptide Y effector systems: perspectives for drug development. TrendsPharmacol Sci. (1994) 15:153-159. Useful review.
   Google Scholar
• HERZOG H, HORT YJ, BALL HJ et al.: Cloned humanneuropeptide Y receptor couples to two different sec-ond messenger systems. Proc. Nat. Acad. Sc]. USA (1992) 89:5794–5798.
   PubMed Web of Science ®Google Scholar
• LARHAMMAR D, BLOMQVIST AG, YEE F eta].: Cloning andfunctional expression of a human neuropeptide Y/pep-tide YY receptor of the Y1 type. J. Biol. Chem. (1992) 267:10935–10938.
   Google Scholar
• GERALD C, WALKER MW, VAYSSE PJ et al.: Expression cloning and pharmacological characterization of a hu-man hippocampal neuropeptide Y/peptide YY Y2 re-ceptor subtype. J. Biol. Chem. (1995) 270:26758–26761.
   PubMed Web of Science ®Google Scholar
• ROSE PM, FERNANDES P, LYNCH JS eta].: Cloning and functional expression of a cDNA encoding a human Type 2 neuropeptide Y receptor. J. Biol. Chem. (1995) 270:22661–22664.
   Google Scholar
• GEHLERT DR, BEAVERS LS, JOHNSON D eta].: Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol. Pharmacol (1996) 49:224–228.
   Google Scholar
• BARD JA, WALKER MW, BRANCHEK TA eta].: Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and pep-tide YY. j BioL Chem. (1995) 270:26762–26765.
   Google Scholar
• GERALD C, WALKER MW, CRISCIONE L eta].: A receptor subtype involved in neuropeptide-Y-induced food in-take. Nature (1996) 382:168-171. Fundamental involvement of NPY in food intake regulation.
   Google Scholar
• VVEINBERG DH, SIRINATHSINGHJI DJ, TAN CP eta].: Clon-ing and expression of a novel neuropeptide Y receptor. J. Biol. Chem. (1996) 271:16435–16438.
   Google Scholar
• RIMLAND J, XIN W, SVVEETNAM P et al.: Sequence and expression of a neuropeptide Y receptor cDNA. Mol. Pharmacol (1991) 40:869–875.
   PubMed Web of Science ®Google Scholar
• JAZIN EE, Y00 H, BLOMQVIST AG et al.: A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells. Regul Pep. (1993) 47:247–258.
   Google Scholar
• HIGUCHI H, COSTA E, YANG HYT: Neuropeptide Y in-hibits the nicotine-mediated release of catecholamines from bovine adrenal chromothin cells. J. Pharmacol. Exp. Ther. (1988) 244:468–474.
   PubMed Web of Science ®Google Scholar
• JAQUES D, CADIEUX A, DUMONT Y et al.: Apparent affinity and potency of BIBP3226, a non-peptide neuropeptide Y receptor antagonist, on purported neuropeptide Y Yl, Y2 andY3 receptors. Eur. J. Pharma-col. (1995) 278:R3–R5.
   PubMed Web of Science ®Google Scholar
• FUXE K, AGNATI LF, HARFSTRAND A eta].: On the role of neuropeptide Yin information handling in the central nervous system in normal and physiopathological states. Focus on volume transmission and neuropep-tide Y/alpha2 receptor interactions. Ann. NY Acad. Sc]. (1990) 579:28-67. Useful review on the role of NPY in the nervous system.
   Google Scholar
• TABARIN A, CASSIEDE P, MINOT AP eta].: Heterogeneity of neuropeptide Y immunoreactivity in patients with pheochromocytoma: influence on the diagnostic power of measuring plasma NPY using antisera with different specificities. Acta Endocrinologica (1993) 128:243–250.
   Google Scholar
• WESTLINDDANIELSSON A, UNDEN A, ABENS J et al.: Neuropeptide Y receptors and the inhibition of adeny-late cydase in the human frontal and temporal cortex. Neurosci. Lett. (1987) 74:237–242.
   PubMed Web of Science ®Google Scholar
• AAKERLUND L, GETHER U, FUHLENDORFF J et al.: Y1receptors for neuropeptide Y are coupled to mobiliza-tion of intracellular calcium and inhibition of adenylate cycla se. FEBS Lett. (1990) 260:73–78.
   PubMed Web of Science ®Google Scholar
• MICHEL MC, BUSCHAUER A: Neuropeptide Y and its antagonists. Drugs Future (1992) 17:39–45.
   Google Scholar
• COLMERS WF, BLEAKMAN D: Effects of neuropeptide Y on the electrical properties of neurons. Trends Neurosci. (1994) 17:373-379. A comprehensive overview of the electrophysiological effects of Yl, Y2, Y3 receptor activation in neurones.
   Google Scholar
• DEQUIDT ME, EMSON PC: Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system - II. immunohistochemical analysis. Neurosci-ence (1986) 18:545–618.
   PubMed Web of Science ®Google Scholar
• MORRIS BJ: Neuronal localisation of neuropeptide Y gene expression in the rat brain. J. Comp. Neurol (1989) 290:358–368.
   PubMed Web of Science ®Google Scholar
• DOYLE CA, MAXWELL DJ: Direct catecholaminaergicinnervation of the spinal dorsal ham with axons as-cending in the dorsal columns in the cat. J. Comp. Neurol (1993) 331:434–444.
   PubMed Web of Science ®Google Scholar
• ADRIAN TE, ALLEN JM, BLOOM SR eta].: Neuropeptide Y distribution in human brain. Nature (1983) 306:584–586.
   Google Scholar
• ALLEN J, GIBSON SJ, ADRIAN TE eta].: Neuropeptide Yin the human spinal cord. Brain Res. (1984) 308:145–148.
   Google Scholar
• ROWAN S, TODD AJ, SPIKE RC: Evidence that Neuropep-tide Y is present in GABAergic neurons in thesuperficial dorsal horn of the rat spinal cord. Neuroscience (1993) 53:537–545.
   PubMed Web of Science ®Google Scholar
• DUMONT Y, FOURNIER A, STPIERRE S et al: Comparative characterization and autoradiographic distribution of neuropeptide Y receptor subtypes in the rat brain./ Neurosci. (1993) 13:73–86.
   PubMed Web of Science ®Google Scholar
• MICHEL MC, LEWELJOHANN K, FARKE W eta': Regulation of NPY/NPY Y1 rece ptor/G-prote in system in rat brain cortex. Am. J. PhysioL Regul. mt. Comp. Physiol. (1995) 268:R192–R200.
   PubMed Web of Science ®Google Scholar
• GLAUM SR, MILLER RJ, RHIM H et al: Characterization of Y3-receptor mediated synaptic inhibition by chimaeric neuropeptide Y-peptide YY peptides in the rat brain-stem. Br. J. Pharm. (1997) 120:481–487.
   PubMed Web of Science ®Google Scholar
• BARD JA, WALKER MW, BRANCHEK TA et al: Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and pep-tide YY. J. Biol. Chem. (1995) 270:26762–26765.
   PubMed Web of Science ®Google Scholar
• MANTYH PW, ALLEN CJ, ROGERS S et al: Some sensory neurones express neuropeptide Y receptors; potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury. J. Neurosci. (1994) 14:3958-3968. NPY as inhibitory neurotransmitter in pain.
   Google Scholar
• ZHANG X, BAO L, XU ZQ et al: Localization of neuropep- tide Y Y1 receptors in the rat nervous system with special reference to somatic receptors on small dorsal root ganglion neurons. Proc. Natl. Acad. Sci. USA (1994) 91:11738–11742.
   PubMed Web of Science ®Google Scholar
• ZHANG X, WIESENFELD-HALLIN Z, HOKFELT T: Effects of peripheral axotomy on expression of neuropeptide Y receptor mRNA in rat lumbar dorsal root ganglia. Eur. Neurosci. (1994) 6:43–57.
   PubMed Web of Science ®Google Scholar
• HUA XY, BOUBLIK JH, SPICER MA et al.: The antinocicep - tive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relation-ship.j Pharmacol Exp. Ther. (1991) 258:243–248.
   PubMed Web of Science ®Google Scholar
• MELLADO ML, GIBERT RAHOLA J, CHOVER AJ et al.: Effect on nociception of intracerebroventricular administra-tion of low doses of neuropeptide Y in mice. Life Sci. (1996) 58:2409–2414.
   PubMed Web of Science ®Google Scholar
• WAKISAKA S, KAJANDER KC, BENNETT GJ: Increased neuropeptide Y (NPY)-like immunoreactivity in rat sensory neurons following peripheral axotomy. Neuro-sci. Lett (1991) 124:200-203. Demonstration that NPY expression can be modulated by nerve injury in the spinal cord.
   Google Scholar
• FRISEN J, RISLING M, THEODORSSON E et al.: NPY-like immunoreactivity in sensory nerve fibers in rat sciatic neuroma. Brain Res. (1992) 577:142–146.
   PubMed Web of Science ®Google Scholar
• ZHANG X, MEISTER B, ELDER eta': Large calibre primary afferent neurons projecting to the gracile nucleus ex-press neuropeptide Y: an immunohistochemical and in situ hybridisation study in rats. Eur. J. Neurosci. (1993) 5:1510–1519.
   PubMed Web of Science ®Google Scholar
• LI JY, HOU XE, DAHLSTROM A: GAP-43 and its relation to autonomic and sensory neurons in sciatic nerve and gastrocnemius muscle in the rat. J. Auton. Nervous System (1995) 50:299–309.
   PubMedGoogle Scholar
• MUNGLANI R, BOND A, SMITH GD et al.: Changes in neuronal markers in a mononeuropathic rat modelrelationship between neuropeptide Y, pre-emptive drug treatment and long-term mechanical hyperalgesia. Pain (1995) 63:21-31. Demonstration of a correlation between hyperalgesia and NPY expression in spinal cord.
   Google Scholar
• MUNGLANI R, HARRISON S, SMITH G et al.: Effect ofdifferent pre-emptive treatments on long-term neuropeptide expression in the dorsal root ganglia in a model of neuropathic pain. Br. J. Anaesth. (1995) 74:482P.
   Web of Science ®Google Scholar
• MUNGLANI R, FLEMING B, HUNT SP: Remembrance oftimes past: the role of c-fos in pain. Br. J. Anaesth. (1996) 76:1–4.
   PubMed Web of Science ®Google Scholar
• MUNGLANI R, HARRISON S, SMITH G et al: Neuropeptide changes persist in spinal cord despite resolving hyp er-algesia in a rat model of mononeuropathy. Brain Res. (1996) 743:102-108. An underlying hyperalgesic state is possibly masked by the persistent NPY increase.
   Google Scholar
• YAMAMOTO T, YAKSH TL: Effects of colchicine appliedto the peripheral nerve onthermalhyperalgesia evoked with chronic nerve constriction. Pain (1993) 55:227–233.
   PubMed Web of Science ®Google Scholar
• WATKINS LR, MAIER SF, GOEHLER LE: Immune activation:the role of pro-inflammatory cytokines in inflamma-tion, illness responses and pathological pain states. Pain (1995) 63:289–302.
   PubMed Web of Science ®Google Scholar
• SATO J, PERL ER: Adrenergic excitation of cutaneouspain receptors induced by peripheral nerve injury. Science (1991) 251:1608–1610.
   PubMed Web of Science ®Google Scholar
• DEVOR M, JANIG W: Activation of myelinated afferents ending in a neuroma by stimulation of the sympathetic supply in a rat. Neurosci. Lett (1981) 24:43–47.
   PubMed Web of Science ®Google Scholar
• EDVINSSON L, EKBLAD E, HAKANSON R et al.: Neuropep-tide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br. J. Pharmacol. (1984) 83:519–525.
   PubMed Web of Science ®Google Scholar
• ROBERTS W: A hypothesis on the physiological basis of causalgia and related pains. Pain (1986) 24:297–311.
   PubMed Web of Science ®Google Scholar
• TRACEY DJ, ROMM MA, YAO NNL: Peripheral hyperalgesia in experimental neuropathy: exacerbation byneuropeptide Y. Brain Res. (1995) 669:245-254. Relationship between NPY and SMP.
   Google Scholar
• LINDH B, HOKFELT T, ELFVIN LG et al.: Topography ofNPY-, somatostatin-, and VIP-immunoreactive, neuro-nal subpopulations in the guinea-pig celiac-superior mesenteric ganglion and their projection to the pylo-rus. J. Neurosci. (1986) 6:2371–2383.
   PubMed Web of Science ®Google Scholar
• BASBAUM Al, FIELDS HL: Endogenous pain control sys-tems: brainstem spinal pathways and endorphin cir-cuitry. Ann. Rev. Neurosci. (1984) 7:309–388.
   PubMed Web of Science ®Google Scholar
• DOYLE CA, MAXWELL DJ: Catecholaminergic innerva-tion of the spinal dorsal horn: a correlated light and electron microscopic analysis of tyrosine hydroxylase-immunore active fibres in the cat. Neuroscience (1991) 45:161–176.
   PubMed Web of Science ®Google Scholar
• ANAND P: Nerve growth factor regulates nociception inhuman health and disease. Br. J. Anaesth. (1995) 75:201–208.
   PubMed Web of Science ®Google Scholar
• LEWIN GR, MENDELL LM: Nerve growth factor and no-ciception. Trends Neurosci. (1993) 16:353–359.
   PubMed Web of Science ®Google Scholar
• ANDREEV NY, DIMITRIEVA N, KOLTZENBURG M et al.: Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones. Pain (1995) 63:109–115.
   PubMed Web of Science ®Google Scholar
• LEVINE JD, TAIWO YO, COLLINS SD et al.: Noradre naline hype ralgesia is mediated through interaction with sym-pathetic. Nature (1986) 323:158–160.
   PubMed Web of Science ®Google Scholar
• VANOS DN, RAMAMURTHY S, HOFFMAN J: Intravenous regional block using ketorolac: preliminary results in the treatment of reflex sympathetic dystrophy. Anaesth. Analges. (1992) 74:139–141.
   PubMed Web of Science ®Google Scholar
• OHARA S, TANTUVVAYA V, DISTEFANO PS et al.: Exoge-nous NT-3 mitigates the transganglionic neuropeptide Y response to sciatic nerve injury. Brain Res. (1995) 699:143–148.
   PubMed Web of Science ®Google Scholar
• VERGE VMK, RICHARDSON PM, WIESENFELDHALLIN Z etal.: Differential influence of nerve growth factor on neuropeptide expression in vivo: a novel role in peptide suppression in adult sensory neurons. J. Neurosci. (1995) 15:2081–2096.
   Google Scholar
• JI RR, ZHANG Q, PETTERSSON RF et al: aFGF, bFGF and NGF differentially regulate neuropeptide expression in dorsal root ganglia after axotomy and induce autotomy. Reg& PepL (1996) 66:179–189.
   PubMed Web of Science ®Google Scholar
• COUGNON N, HUNT SP, MUNGLANI R: Effect of col-chicine on NPY expression in dorsal root ganglia. Brain Res. Assoc. Absfr. (1997) 14:15.
   Google Scholar
• CHAUVET N, DRIAN MJ, PRIVAT A: Immunocytochemical study of phenotypic plasticity of cultured dorsal root ganglion neurons during development. Int J. Dev. Neurosci. (1995) 13:673–683.
   PubMed Web of Science ®Google Scholar
• MULDERRY PK, DOBSON SP: Regulation of VIP and other neuropeptides by c-Jun in sensory neurons: implica-tion for the neuropeptide response to axotomy. Eur. Neurosci. (1996) 8:2479-2491. C-Jun could regulate NPY expression in DRG neurones in vitro.
   Google Scholar
• COUGNON N, BOND A, HUNT SP et al: Neuropeptide Y expression in isolated sensory neurones. Eur. j Neuro-sci. (1996) 9. Abstract 108.08.
   Google Scholar
• JENKINS R, HUNT S: Long-term increases in the levels of c:jun mRNA and Jun protein like immunoreactivity in motor and sensory neurons following axon damage. Neurosci. Lett. (1991) 129:107–111.
   PubMed Web of Science ®Google Scholar
• SABOL SL, HIGUCHI H: Transcriptional regulation of the neuropeptide Y gene by nerve growth factor: antago-nism by adenosine 3',5'-monophosphate and phorbol ester. Mol. EndocrinoL (1990) 4:384–392.
   PubMed Web of Science ®Google Scholar
• RAO MS, TYRRELL S, LANDIS SC et al.: Effects of ciliary neurotrophic factor (CNTF) and depolarization on neuropeptide expression in cultured sympathetic neu-rons. Dev. Biol (1992) 150:281–293.
   PubMed Web of Science ®Google Scholar
• BARNEA A, AGUILA-MANSILLA N, CHUTE HT et al: Com-parison of neurotrophin regulation of human and rat neuropeptide Y (NPY) neurons: induction of NPY pro-duction in aggregate cultures derived from rat but not human fetal brains. Brain Res. (1996) 732:52–60.
   PubMed Web of Science ®Google Scholar
• TAKEI N, SASAOKA K, HIGUCHI H et al.: BDNF increases the expression of neuropeptide Y mRNA and promotes differentiation/maturation of neuropeptide Y-positive cultured cortical neurons from embryonic and postna-tal rats. Mol Brain Res. (1996) 37:283–289.
   PubMedGoogle Scholar
• WAHLESTEDT C, EKMAN R, WIDERLOV E: Neuropeptide Y (NPY) and the central net-Nous system: distribution effects and possible relationship to neurological and psychiatric disorders. Prog. Neuropsychopharmacol Biol. Psych. (1989) 13:31–54.
   PubMed Web of Science ®Google Scholar
• HEILIG M, MCLEOD S, KOOB GK et al: Amdolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test. Regul. PepL (1992) 41:61–69.
   PubMed Web of Science ®Google Scholar
• HEILIG M, MCLEOD S, BROT M et al: Amdolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology (1993) 8:357–363.
   PubMed Web of Science ®Google Scholar
• WAHLESTEDT C, PICH EM, KOOB GF etal.: Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science (1993) 259:528-531. Evidence that NPY is involved in anxiety.
   Google Scholar
• GABRIEL SM, DAVIDSON M, HAROUTUNIAN V et al: Neuropeptide deficits in schizophrenia versus Alzhe-imer's disease cerebral cortex. Biol. Psych. (1996) 39:82–
   PubMed Web of Science ®Google Scholar
• FREDERIKSEN SO, EKMAN R, GOTTFRIES CG et al.: Re-duced concentrations of galanin, arginine vasopressin, neuropeptide Y and peptide YY in the temporal cortex but not in the hypothalamus of brains from schizo-phrenics. Ada. Psychiafr. Scand. (1991) 83:273–277.
   PubMed Web of Science ®Google Scholar
• SAKAI K, MAEDA K, CHIHARA K etal: Increases in corticalneuropeptide Y and somatostatin concentrations fol-lowing haloperidol-depot treatment in rats. Neuropep-tides (1995) 29:157–161.
   PubMed Web of Science ®Google Scholar
• FLOOD JF, BAKER ML, HERNANDEZ EN et al: Modulation of memory processing by neuropeptide Y varies with brain injection site. Brain Res. (1989) 503:73–82.
   PubMed Web of Science ®Google Scholar
• MORLEY JE, FLOOD JF: Neuropeptide Y and memory processing. Ann. NY Acad. Sci (1990) 611:226-231. Useful article.
   Google Scholar
• THOMAS JR, AHLERS ST: Neuropeptide-Y both improves and impairs delayed matching-to-sample performance in rats. Pharmacol. Biochem. Behav. (1991) 40:417–422.
   PubMed Web of Science ®Google Scholar
• CLEARY J, SEMOTUK M, LEVINE AS: Effects of neuropep-tide Y on short-term memory. Brain Res. (1994) 653:210–214.
   PubMed Web of Science ®Google Scholar
• MINAMI S, KAMAGAI J, SUGIHARA H etal: Central glucose privation evoked by the administration of 2-deoxy-D-glucose induces expression of the c-fos gene in a sub population of neuropeptide Y neurones in the rat hypothalamus. Mol. Brain Res. (1995) 33:305–310.
   PubMedGoogle Scholar
• KANATANI A, ISHIHARA A, ASAHI S et al.: Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake. Endocrinology (1996) 137:3177-3182. Evidence that NPY is involved in feeding.
   Google Scholar
• ERICKSON JC, HOLLOPETER G, PALMITER RD: Attenu-
   Google Scholar
• ?ation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science (1996) 274:1704-1707. Evidence that NPY might influence obesity.
   Google Scholar
• CURRIE PJ, COSCINA DV: Regional hypothalamic differ-ences in neuropeptide Y-induced feeding and energy substrate utilization. Brain Res. (1996) 737:238–242.
   PubMed Web of Science ®Google Scholar
• CHANCE WT, BALASUBRAMANIAM A, THOMPSON H et ai.: Assessment of feeding response of tumor-bearing rats to hypothalamic injection and infusion of neuropep-tide Y. Peptides (1996) 17:797–801.
   Google Scholar
• GRUENEWALD DA, MARCK BT, MATSUMOTO AM: Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in ageing male brown Norway rats. Endocrinology (1996) 137:4460–4467.
   PubMed Web of Science ®Google Scholar
• LADURON PM: Towards genomic pharmacdogy: from membranal to nuclear receptors. Adv. Drug Res. (1992) 22:107–148.
   Google Scholar