Block copolymeric biotransport carriers as versatile vehicles for drug delivery

Bibliography

• Physical Pharmacy. Martin A, Bustamante P, Chun AHC (Eds.), Lea & Febiger, Philadelphia, USA (1993).
   Google Scholar
• Introduction to Modern Colloid Science. Hunter RJ (Ed.), Oxford University Press, Oxford, UK (1993).
   Google Scholar
• The Pharmacological Basis of Therapeutics. Gilman A, Goodman LS, Rail TW, Murad W (Eds.), Macmillan Publish-ing Company, New York USA (1985).
   Google Scholar
• OLSON RD, MUSHLIN PS: Doxorubicin cardiotoxicity: analysis of prevailing hypotheses. FASEB 1 (1990) 4: 3078.
   Google Scholar
• Implications of the Blood-brain Barrier and its Manipula-tion (Vols. 1, 2). Neuwelt EA (Ed.), Plenum Medical Book Company, New York, USA (1989).
   Google Scholar
• DURAND RE: Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage? Can-cer Chemoth. Pharmacol (1990) 26:198.
   Web of Science ®Google Scholar
• KABANOV AV, ALAKHOV VY: New approaches to target-ing of bioactive compounds. J. Contr. Release (1994) 28:15.
   Web of Science ®Google Scholar
• HAMM-ALVAREZ SF: Microtubule-based motor pro-teins: new targets for enhancing drug delivery? Pharm. Res. (1996)13:489.
   Google Scholar
• HIGGINS CF, GOTTESMAN MM: Is the multidrug trans-porter a flippase? TIBS (1992) 17:18.
   PubMed Web of Science ®Google Scholar
• SOLLNER T, ROTHMAN JE: Neurotransmission: harness-ing fusion machinery at the synapse. Trends Neurosci. (1994) 17:344.
   PubMed Web of Science ®Google Scholar
• BRADBURY NA, BRIDJES RJ: Role of membrane traffick-ing in plasma membrane solute transport. Am. J. Physiol. (1994) 267:C 1 .
   Google Scholar
• SHUURHUIS GJ, BROXTERMAN H, CERVANTES A: Quanti-tative determination of factors contributing to doxoru-bicin resistance in multidrug-resistant cells. J. Natl. Cancer. Inst. (1989) 81:1887.
   PubMed Web of Science ®Google Scholar
• Controlled Drug Delivery. Robinson JR, Lee VHL (Eds.), Mar-cel Dekker, New York, USA (1987).
   Google Scholar
• Pharmacokinetics. Gibaldi M, Perrier D (Eds.), Marcel Dekker, New York, USA (1982).
   Google Scholar
• KABANOV AV, BATRAKOVA EV, MELIK-NUBAROV NS et al.: A new class of drug carriers: micelles of poly(oxyethylene)-poly(oxypropylene) block copoly-mers as microcontainers for drug targeting from blood in brain. J. Contr. Release (1992) 22:141.
   Web of Science ®Google Scholar
• KATAOKA K: Site specific drug-carriers: micelles as high potential vehicles for biologically active mole-cules. In: Proc. 2'1 Taniguchi Conference on Polymer Re-search. Imanishi Y (Ed.), Kagalen-Dojin Press, Kyoto, Japan (1991).
   Google Scholar
• Surfactants in Solution, (Vols. 1-3). Mittal KL, Lindman B (Eds.), Plenum Press, New York, USA (1991).
   Google Scholar
• LASIC DD: Mixed micelles in drug delivery. Nature (Lon-don) (1992) 355:279.
   PubMed Web of Science ®Google Scholar
• KARARLI TT, GUPTA VW: Solubilization and dissolution properties of a leukotriene-D4 antagonist in micellar solutions. J. Pharm. Sci. (1992) 81:483.
   PubMed Web of Science ®Google Scholar
• SWABRICK J, SIVERLY JR: The influence of liquid crystal-line phases on drug percutaneous absorption. II. Per-meation studies through excised human skin. Pharm. Res. (1992) 9:1546.
   Google Scholar
• YAMAMOTO K, SHACH AC, NISHIHATA T: Enhanced rec-tal absorption of itazigrel formulated with polysorbate 80 micelle vehicle in rat: role of co-administered es-terase. J. Pharm. Pharmacol (1994) 46:608.
   PubMed Web of Science ®Google Scholar
• CHUBB C, DRAPER P: Efficacy of perfluorodecalin as anoxygen carrier for mouse and rat testes perfused in vi-tro. Proc. Soc. Exp. Biol. Med. (1987) 184:489.
   PubMed Web of Science ®Google Scholar
• NOGATA Y, MONDON CE, COOPER AD: The effect ofperfluorochemical artificial blood on lipoprotein me-tabolism in rats. Metabolism (1990) 39:682.
   PubMed Web of Science ®Google Scholar
• MORIKAWA K, OKADA F, HOSOKAWA M et al.: Enhance-ment of therapeutic effects of recombinant inter-leukin 2 on a transplantable rat fibrosarcoma by the use of a sustained release vehicle, pluronic gel. Cancer Res. (1987) 47:37.
   PubMed Web of Science ®Google Scholar
• LOWE KC, ARMSTRONG FH: Oxygen-transport fluid based on perfluorochemicals: effects on liver bio-chemistry. Adv. Exp. Med. Biol. (1990) 277:267.
   PubMedGoogle Scholar
• ALLISON AC, BYARS NE: Immunological adjuvants: de-sirable properties and side-effects. Mot. Immunol. (1991) 28:279.
   Web of Science ®Google Scholar
• TOPCHIEVA IN, EROKHIN VN, OSIPOVA SV et al.: Blockcopolymers of ethylene oxide and propylene oxide (pluronics) as immunomodulators and antitumour agents. Biomed. Sci. (1991) 2:38.
   PubMedGoogle Scholar
• CHAPLIN DJ, HORSMAN MR, AOKI DS: Nicotinamide, fluosol DA and carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo. Br. J. Cancer (1991) 63:109.
   PubMed Web of Science ®Google Scholar
• CHEN-CHOW PC, FRANK SG: Comparison of lidocainerelease from Pluronic F-127 gels and other formula-tions. Int. J. Pharm. (1981) 8:89.
   Google Scholar
• KODAMA T, ARIMA K, SAKAMOTO H et al.: Pharma-cological and clinical studies on lipiodol emulsion for hepatocellular carcinoma. Pharm. Res. (1988) 15:2544.
   Google Scholar
• WEETAL HH, BOZICHEVICH J: Effect of surfactants onantigen-antibody reactions. Nature (London) (1967) 215:1479.
   PubMed Web of Science ®Google Scholar
• MOORE AR, PATON BC, EISEMAN B: Reduction of splenic vascular resistance during perfusion by plu-ronic F68. J. Surg. Res. (1968) 8:563.
   PubMed Web of Science ®Google Scholar
• GROVER FL, KAHN RS, HERON MW et al.: A nonionic sur-factant and blood viscosity. Experimental observa-tions. Arch. Surg. (1973) 106:307.
   PubMed Web of Science ®Google Scholar
• GERLOWSKI LE, JAIN RK: Microvascular permeability ofnormal and neoplastic tissues. Microvas. Res. (1986) 31:288.
   PubMed Web of Science ®Google Scholar
• CASSEL DM, YOUNG SW, BRODY WR et al.: Radiographicblood pool contrast agents for vascular and tumor im-aging with projection radiography and computed to-mography. J. Comput. Assist. Tomogr. (1982) 6:141.
   PubMed Web of Science ®Google Scholar
• SILK M, SIGMAN E: Effect of Pluronic-F68 on the devel-opment of tumor metastasis. Cancer (1972) 25:171.
   Web of Science ®Google Scholar
• PRANCAN AV, ECANOW B, BERNARDONI RJ et al.: Polox-amer 188 as vehicle for injectable diazepam. J. Pharm. Sci. (1980) 60:970.
   Web of Science ®Google Scholar
• SASKI W, SHAH SG: Effect of a nonionic surface-active polymer on passage of hydrocortisone across rat in-testine in vitro. J. Pharm. Sci. (1965) 54:277.
   PubMed Web of Science ®Google Scholar
• BRANDER WT, ROSE WC, SCHURINGET JE et al: Antitu-mor activity and toxicity in animals of BMY-25282, a new mitomycin derivative. Cancer Res. (1985) 45:6475.
   PubMed Web of Science ®Google Scholar
• UN SY, KAWASHIMA Y: Kinetic studies on the stability of indomethacin in alkaline aqueous solution contain-ing poly(oxyethylene)poly(oxypropylene) surface-active block copolymers. Pharm. Acta. Helv. (1985) 60:339.
   PubMedGoogle Scholar
• UN SY, KAWASHIMA Y, PARENTER J: Pluronic surfac-tants affecting diazepam solubility, compatibility, and adsorption from iv. admixture solutions. Sci. Technol (1987) 41:83.
   Google Scholar
• KABANOV AV, CHEKHONIN VP, ALAKHOV VY et al.: The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. Micelles as mi-crocontainers for drug targeting. FEBS Lett. (1989) 258:343.
   Google Scholar
• YOKOYAMA M, MIYAUCHI M, YAMADA N et al: Charac-terization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. J. Contr. Ref (1990) 11:269.
   Web of Science ®Google Scholar
• PRATTEN MK, LIOYD JB, HORPEL G et al.: Micelle-forming block copolymers: pinocytosis by macro-phages and interaction with model membranes. Mak-romol Chem. (1985) 186:725.
   Web of Science ®Google Scholar
• DUNCAN R, SPREAFICO F: Polymer conjugates. Pharma-cokinetic considerations for design and development. Clin. Pharmacokinet. 27 (1994) 290.
   PubMed Web of Science ®Google Scholar
• YOKOYAMA M, OKANO T, SAKURAI Y eta].: Stabilization of disulfide linkage in drug-polymer-immunoglobulin conjugate by microenvironmental control. Biochem. Biophys. Res. Commun. (1989) 51:1234.
   Google Scholar
• YOKOYAMA M, MIYAUCHI M, YAMADA N et al: Charac-terization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res. (1990) 50:1693.
   PubMed Web of Science ®Google Scholar
• YOKOYAMA M, MIYAUCHI M, YAMADA N et al: Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res. (1991) 51:3229.
   PubMed Web of Science ®Google Scholar
• YOKOYAMA M, KWON GS, OKANO T eta].: Synthesis of poly (ethylene oxide) with heterobifunctional reactive groups at its terminals by an anionic initiator. Biocon-jugate Chem. (1992) 3:295.
   Google Scholar
• YOKOYAMA M, SUGIYAMA T, OKANO T et al.: Analysis of micelle formation of an adriamycin-conjugated poly(ethylene glycol) -poly (aspartic acid) block copolymer by gel permeation chromatography. Pharm. Res. (1993) 10:895.
   PubMed Web of Science ®Google Scholar
• KWON GS, YOKOYAMA M, OKANO T et al.: Biodistribu-tion of micelle-forming polymer-drug conjugates. Pharm. Res. (1993) 10:970.
   PubMed Web of Science ®Google Scholar
• TRUBETSKOY VS, TORCHILIN VP, GAZELLE GS et al.: Am-phiphilic vinyl polymers effectively prolong liposome circulation time in vivo. Proc. Intl. Symp. Contr. Rel. Bio-act. Mater. (1994) 21:676.
   Google Scholar
• YOKOYAMA M: Block copolymers as drug carriers. Crit. Rev. Ther. Drug Carrier Syst (1992) 9:213.
   PubMed Web of Science ®Google Scholar
• MORGAN PL, HARDING SE, PETRAK K: Interactions of amodel block copolymer drug delivery system with two serum proteins and myoglobin. Biochem. Soc. Trans. (1990) 18:1021.
   PubMed Web of Science ®Google Scholar
• SLEPNEV VI, KUZNETSOVA LE, GUBIN AN et al.: Micellesof poly(oxyethylene)-poly(oxypropylene) block co-polymer (pluronic) as a tool for low-molecular com-pound delivery into a cell: phosphorylation of intracellular proteins with micelle incorporated gamma-[32P]ATP. Biochem. Internat. (1992) 26: 587.
   PubMedGoogle Scholar
• KABANOV AV, SLEPNEV VI, KUZNETSOVA LE eta].: Plu-ronic micelles as a tool for low-molecular compound vector delivery into a cell: effect of Staphylococcus au-reus enterotoxin B on cell loading with micelle incor-porated fluorescent dye. Biochem. Internat. (1992) 26: 1035.
   Google Scholar
• ROLLAND A, O'MULLANE J, GODDARD P et al.: R-N-acetylleglin c:poly(oxyethylene) conjugates: prepara-tion, plasma persistence, and urinary excretion. J. Appl. Polym. Sci. (1992) 44: 853.
   Google Scholar
• DUNN SE, BRINDLEY A, DAVIS SS eta].: Polystyrene-poly (ethylene glycol) (PS-PEG2000) particles as model sys-tems for site specific drug delivery. 2. The effect of PEG surface density on the in vitro cell interaction and in vivo biodistribution. Pharm. Res. (1994) 11:1016.
   Google Scholar
• KABANOV AV, NAZAROVA IR, ASTAFIEVA IV et al.: Mi-celle formation and solubilisation Of fluorescent probes in poly(oxyethylene-b-oxypropylene-b-oxyet-hylene) solutions. Macromolecules (1995) 28:2303.
   Web of Science ®Google Scholar
• KWON GS, NAITO M, YOKOYAMA M eta].: Physical en-trapment of adriamycin in AB block copolymer mi-celles. Pharm. Res. (1995) 12:192.
   Google Scholar
• ROLLAND A, PAUL F, SCOTT K.M et al.: Determination of the surface tension of block copolymer micelles by phagocytosis. Pharm. Res. (1995) 12:1435.
   Google Scholar
• DARAPER M, SAVAGE M, COLLETT JH et al: Solubilisa-tion of drugs in micellar systems studied by eluent gel permeation chromatography. Pharm. Res. (1995) 12:1231.
   PubMed Web of Science ®Google Scholar
• ALAKHOV VY, MOSKALEVA EY., BATRAKOVA EV et al.:Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copoly-mer. Bioconjugate Chem. (1996) 7:209.
   Google Scholar
• LA SB, OKANO T, KATAOKA K: Preparation and charac-terization of the micelle-forming polymeric drug indomethacin-incorporated poly(ethylene ox-ide)-poly(beta-benzyl L-aspartate) block copolymer micelles. J. Pharm. Sci. (1996) 85:85.
   PubMed Web of Science ®Google Scholar
• ZHANG X, JACKSON JK, BURT HM: Preparation and characterization of the micelle-forming polymeric drug indomethacin-incorporated poly(ethylene ox-ide)-poly(beta-benzyl L-aspartate) block copolymer micelles. Int. J. Pharm. (1996) 132:195.
   Web of Science ®Google Scholar
• BATRAKOVA EV, DORODNYCH TY, KLINSKII EY et al.:Anthracycline antibiotics non-covalently incorpo-rated into the block copolymer micelles: in vivo evaluation of anti-cancer activity. Br. J. Cancer (1996) 74:1545.
   PubMed Web of Science ®Google Scholar
• VENNE A, LI S, MANDEVILLE R et al.: Hypersensitizing ef-fect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multi-ple drug-resistant cells. Cancer Res. (1996) 56:3626.
   PubMed Web of Science ®Google Scholar
• ASTAFIEVA I, MAKSIMOVA I, LUKANIDIN E et al.: En-hancement of the polycation-mediated DNA uptake and cell transfection with Pluronic P85 block copoly-mer. FEBS Lett. (1996) 389:278.
   PubMed Web of Science ®Google Scholar
• KABANOV AV, VINOGRADOV SV, SUZDALTSEVA UG et al.: Water-soluble block polycations as carriers for oli-gonucleotide delivery. Bioconjugate Chem. (1995) 6:639.
   PubMed Web of Science ®Google Scholar
• WOLFERT MA, SCHAHT EH, TONCEVA V et al: Charac-terization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. Human Gene Ther. (1996) 7:2123.
   PubMed Web of Science ®Google Scholar
• SCHMOLKA IR: Physical basis for poloxamer interac-tions../. Am. Oil Chem. Soc. (1977) 54:110.
   Web of Science ®Google Scholar
• BASF Performance Chemicals. BASF Co., Parsipany, NJ, (1991).
   Google Scholar
• NAGARAJAN R, GANESH K: Synthesis and antibacterial evaluation of N-alkyl vancomycins. Macromolecules (1989) 22:4312.
   Web of Science ®Google Scholar
• HURTER PN, SCHEUTJENS JMHM, HATTON TA: Molecu-lar modeling of micelle formation and solubilization in block copolymer micelles. 1. A self-consistent mean-field lattice theory. Macromolecules (1993) 26:5592.
   Google Scholar
• HURTER PN, SCHEUTJENS JMHM, HATTON TA: Molecu-lar modeling of micelle formation and solubilization in block copolymer micelles. 2. Lattice theory for monomers internal degrees of freedom. Macromole-cules (1993) 26:5030.
   Google Scholar
• LINSE P: Micellization of poly(ethylene ox-ide)-poly (propylene oxide) block copolymers in aque-ous solutions. Macromolecules (1993) 26:4437.
   Web of Science ®Google Scholar
• ALEXANDRIDIS P, ATHANASSIOU V, FUKUDA S et al.: Sur-face activity of poly(ethylene oxide)-block-poly(pro-py len e oxide)-block-poly(ethylene oxide) copolymers. Langmuir (1994) 10:2604.
   Web of Science ®Google Scholar
• ALEXANDRIDIS P, HOLZWARTH JF, HATTON TA: Micelli-zation of poly(ethylene oxide)-poly(propylene oxide) triblock copolymers in aqueous solutions: thermody-namics of copolymer association. Macromolecules (1994) 10:2604.
   Google Scholar
• ASTAFIEVA I, ZHONG XF, EISENBERG A: Critical micelli-zation phenomena in block polyelectrolites. Macro-molecules (1993) 26:7339.
   Web of Science ®Google Scholar
• GAO Z, EISENBERG A: A model of micellization forblock copolymer in solutions. Macromolecules (1993) 26:7353.
   Web of Science ®Google Scholar
• SCHLILLEN K, BROWN W, JOHNSON RM: Micellar sphere-to rod transition in an aqueous triblock co-polymer system. A dynamic light scattering study of translational and rotational diffusion. Macromolecules (1994) 27:4825.
   Google Scholar
• MALMSTEN M, LINDMAN B: Self-assambly in aqueousblock copolymer solutions. Macromolecules (1992) 25:5440.
   Web of Science ®Google Scholar
• WILHELM M, ZHAO C-L, WANG Y et al.: Poly(sterene-ethylene oxide). Block copolymer micelle formation in water: a fluorescence probe study. Macromolecules (1991) 28: 2303.
   Google Scholar
• KWON GS, KATAOKA K: Block copolymer micelles as long-circulating drug vehicles. Adv. Drug. Delivery Rev. (1995) 16:295.
   Web of Science ®Google Scholar
• HORNE DW, REED KA: Transport of methotrexate in ba-solateral membrane vesicles from rat liver. Arch. Bio-chem. Biophys. (1992) 298:121.
   PubMed Web of Science ®Google Scholar
• POSCHET JF, HAMMOND SM, FAIRCLOUGH PD: Charac-terisation of penicillin-G uptake in rabbit small-intestinal brush-border membrane vesicles. Biochem. Biophys. Acta. (1996) 1278:223.
   PubMed Web of Science ®Google Scholar
• CASCALHEIRA JF, SEBASTIAO AM: Adenine nucleotide analogues, including gamma-phosphate-substituted analogues, are metabolised extracellularly in inner-vated frog sartorius muscle. Eur. J. Pharmacol (1992) 222:49.
   PubMed Web of Science ®Google Scholar
• BRUTOVETSKY N, BACKER A, KLINGENBERG M et al.: Electrical currents associated with nucleotide trans-port by the reconstituted mitochondrial ADP/ATP car-rier. Proc. Natl. Acad. Sci. USA (1996) 93:664.
   PubMed Web of Science ®Google Scholar
• GOLDSTEIN LJ, GOTTESMAN MM, PASTAN I: Expression of the MDR1 gene in human cancers. Cancer Treat. Res. (1991) 57:101.
   PubMedGoogle Scholar
• GOLDSTEIN LJ, GOTTESMAN MM, PASTAN I: Multidrug resistance in human cancer. Crit. Rev. Oncol. Hematol (1992) 12:243.
   PubMed Web of Science ®Google Scholar
• LEPAGE P, GROSS P: Structural and functional aspects of P-glycoproteins and related transport proteins. Curr. Opin. Nephrol. Hypertens. (1993) 2:735.
   PubMedGoogle Scholar
• ALAKHOV VY, BATRAKOVA EV, DORODNICH TY et al.:Block copolymeric drug carriers: 1. Delivery of antineoplastic drugs. In: Proceedings of 1st International Symposium on Polymer Therapeutics. London, UK (1996)72.
   Google Scholar
• ALAKHOV VY, BATRAKOVA EV, LI S et al: Block copoly- mer drug carriers. 1. Hypersensitization of MDR can-cers and in vivo activity. Pharm. Res. (1996) 13:S214.
   Google Scholar
• SHUURHUIS GJ, BROXTERMAN HJ, DE LANGE JHM et al: Early multidrug resistance, defined by changes in in-tracellular doxorubicin distribution, independent of P-glycoprotein. Br. J. Cancer (1991) 64:857.
   PubMed Web of Science ®Google Scholar
• SOGNIER MA, ZHANG Y, EBERLE RL et al.: Sequestration of doxorubicin in vesicles in a multidrug-resistant cell line (LZ-100). Biochem. Pharmacol (1994) 48:391.
   PubMed Web of Science ®Google Scholar
• SCHINDLER M, SHARON G, HOFF E et al.: Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells MCF-7adr). Biochemistry (1996) 35:2811.
   PubMed Web of Science ®Google Scholar
• WOODCOCK DM, JEFFERSON S, LINSENMEYER ME et al:Reversal of the multidrug resistance phenotype with cremophor EL, a common vehicle for water-insoluble vitamins and drugs. Cancer Res. (1990) 50:4199.
   PubMed Web of Science ®Google Scholar
• COON JS, KNUDSON W, CLODFELTER K et al: Solutol HS15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance. Cancer Res. (1991) 51:897.
   PubMed Web of Science ®Google Scholar
• WOODCOCK DM, LINSENMEYER ME, CHOJNOWSKI G etal.: Reversal of multidrug resistance by surfactants. Br. J. Cancer (1992) 51:62.
   Google Scholar
• ZORDAN-NUDO T, LING V, LIU Z et al.: Effects of non-ionic detergents on P-glycoprotein drug binding and reversal of multidrug resistance. Cancer Res. (1993) 53:5994.
   PubMed Web of Science ®Google Scholar
• DUDEJA PK, ANDERSON KM, HARRIS JS et al: Reversal of multidrug resistance phenotype by surfactants: rela-tionship to membrane lipid fluidity. Arch. Biochem. Biophys. (1995) 319:309.
   PubMed Web of Science ®Google Scholar
• BUCKINGHAM LE, BALASUBRAMANIAN M, SAFA AR et al: Reversal of multi-drug resistance in vitro by fatty acid-PEG-fatty acid diesters. Int. J. Cancer (1996) 65:74.
   PubMed Web of Science ®Google Scholar
• SUGAWARA I, KATAOKA I, MORISHITA Y et al.: Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. Can. Res. (1988) 48:1926.
   PubMed Web of Science ®Google Scholar
• FARDEL 0, RATANASAVANH D, LOYER P et al.: Overex-pression of the multidrug resistance gene product in adult rat hepatocytes during primary culture. Eur. J. Biochem. (1991) 205:847.
   Google Scholar
• SCHINKEL AH, SMIT JJM, VAN TELLINGEN 0 et al.: Disrup-tion of the mouse mdr la P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell (1994) 77:491.
   Google Scholar
• NERURKAR MM, BURTON PS, BORCHARDT RT: The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polar-ized efflux system. Pharm. Res. (1996) 13:528.
   PubMed Web of Science ®Google Scholar
• WANG Q, YANG H, MILLER DW et al.: Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribu-tion of rhodamine-123 to the brain: an in vivo micro-dialysis study in freely moving rats. Biochem. Biophys. Res. Commun. (1995) 211:719.
   PubMed Web of Science ®Google Scholar
• FONTANE M, ELMQUIST WF, MILLER DW: Use of rho-damine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers. Life. Sci. (1996) 59:1521.
   PubMed Web of Science ®Google Scholar
• MILLER DW, BATRAKOVA EV, WALTNER TO et al.: Inter-actions of Pluronic block copolymers with brain microvessel endothelial cells: evidence of two poten-tial pathways for drug absorption. Bioconjugate Chem. (1997) 8:649.
   PubMed Web of Science ®Google Scholar
• AUDUS KL, CHIKHALE PJ, MILLER DW et al.: Brain uptake of drugs: the influence of chemical and biological fac-tors. Adv. Drug Res. (1992) 23:3.
   Google Scholar
• BICKEL U, YOSHIKAWA T, PARDRIDGE WM: Delivery of peptides and proteins through the blood-brain bar-rier. Adv. Drug Del. Rev. (1993) 10:205.
   Web of Science ®Google Scholar
• SMITH KR, BORCHARDT RT: Permeability and mecha-nism of albumin, cationized albumin, and glycosy-lated albumin transcellular transport across monolayers of cultured bovine brain capillary endo-thelial cells. Pharm. Res. (1989) 6:466.
   PubMed Web of Science ®Google Scholar
• BICKEL U, LEE WMY, TROJANOWSKI JQ et al: Develop-ment and in vitro characterization of a cationized monoclonal antibody against beta A4 protein: a poten-tial probe for Alzheimer's disease. Bioconjugate Chem. (1994) 5:119.
   PubMed Web of Science ®Google Scholar
• MILLER DW, KELLER BT, BORCHARDT RT: Identification and distribution of insulin receptors on cultured bo-vine brain microvessel endothelial cells: possible function in insulin processing in the blood-brain bar-rier. J. Cell. Physic)]. (1994) 161:333.
   PubMed Web of Science ®Google Scholar
• HUET RJ, CHAPEY BS: Comparison of a new MDR modu-lator, S9788, to eleven other MDR modulating agents in a model of doxorubicin-resistant rat glioblastoma cells in vitro. 12th Biennial Meeting of the European Association for Cancer Research (1993) Brussels, Belgium.
   Google Scholar
• HUET S, CHAPEY C, ROBERT J: Reversal of multidrug re-sistance by a new lipophilic cationic molecule, S9788. Comparison with 11 other MDR-modulating agents in a model of doxorubicin-resistant rat glioblastoma cells. Eur. J. Cancer (1993) 29:1377.
   Google Scholar
• JACHEZ B, LOOR F: Atypical multi-drug resistance (MDR): low sensitivity of a P-glycoprotein-expressing human T lymphoblastoid MDR cell line to classical P-glycoprotein-directed resistance-modulating agents. Anticancer Drugs (1993) 4:605.
   PubMed Web of Science ®Google Scholar