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Key Paper Evaluation

Inhaled corticosteroids in COPD: systemic effects of a local therapy?

Evaluation of Sin DD, Man SF, Marciniuk DD, et al. The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;177(11):1207-14

, MD PhD
Pages 3271-3273 | Published online: 19 Nov 2008

Bibliography

  • Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. The GOLD Workshop Report (updated 2007). Available from: www.goldcopd.com (October 2008)
  • Antoniu SA, Mihaescu T, Donner CF. Inhaled therapy for stable chronic obstructive pulmonary disease. Expert Opin Pharmacother 2007;8(6):777-85
  • Antoniu S, Donner CF. Fluticasone propionate in COPD airway inflammation: there is a partial effect? Expert Rev Pharmacoecon Outcomes Res 2002;2(5):415-7
  • Calverley PM, Anderson JA, Celli B, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 2007;356(8):775-89
  • Sin DD, Man SF, Marciniuk DD, et al. The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;177(11):1207-14
  • Hattotuwa KL, Gizycki MJ, Ansari TW, et al. The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study. Am J Respir Crit Care Med 2002;165(12):1592-6
  • Gizycki MJ, Hattotuwa KL, Barnes N, et al. Effects of fluticasone propionate on inflammatory cells in COPD: an ultrastructural examination of endobronchial biopsy tissue. Thorax 2002;57(9):799-803
  • Barnes NC, Qiu YS, Pavord ID, et al. Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease. Am J Respir Crit Care Med 2006;173(7):736-43
  • Sin DD, Lacy P, York E, et al. Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004;170(7):760-5

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