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Pharmacotherapy for women's sexual dysfunction

, MD FRCP (UK)
Pages 1631-1648 | Published online: 15 Jun 2009

Bibliography

  • Leiblum SR, Koochaki PE, Rodenberg CA, et al. Hypoactive sexual desire disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHeS). Menopause 2006;13:46-56
  • Dennerstein L, Koochaki P, Barton I, et al. Hypoactive sexual desire disorder in menopausal women: a survey of western European women. J Sex Med 2006;3:212-22
  • West SL, D'Aloisio AA, Agans RP, et al. Prevalence of low sexual desire and hypoactive sexual desire disorder in a nationally representative sample of US women. Arch Intern Med 2008;168:1441-9
  • Cain VS, Johannes CB, Avis NE, et al. Sexual functioning and practices in a multi-ethnic study of midlife women: baseline results from SWAN. J Sex Res 2003;40(3):266-76
  • Laumann EL, Paik A, Rosen RC. Sexual dysfunction in United States: Prevalence and predictors. J Am Med Assoc 1999;10:537-45
  • Fugl-Meyer AR, Sjögren Fugl-Meyer K. Sexual disabilities, problems and satisfaction in 18 to 74-year-old Swedes. Scand J Sexology 1999;2(2):79-105
  • Ventegodt S. Sex and the quality of life in Denmark. Arch Sex Behav 1998;27:295-307
  • Fisher WA, Boroditsky R, Bridges M. Measures of sexual and reproductive health among Canadian women. Can J Hum Sexuality 1999;8(3):175-82
  • Harlow BL, Stewart EG. The population-based assessment of chronic unexplained vulval pain: have we underestimated the prevalence of vulvodynia? J Med Wom Assoc 2003;58:82-8
  • Meston CM, Buss DM. Why humans have sex. Arch Sex Behav 2007;36:477-507
  • Klusmann D. Sexual motivation and the duration of partnership. Arch Sex Behav 2002;31(3):275-87
  • McCall K, Meston C. Differences between pre and postmenopausal women in cues for sexual desire. J Sex Med 2007;4:364-71
  • Carvalheira A, Brotto L, Leal I. Women's arousability determines the access to sexual desire: a community study of Portuguese women. Abstract presented at Annual Meeting of the International Society of Women's Sexual Health 2009
  • Basson R. Female sexual response: the role of drugs in the management of sexual dysfunction. Obstet Gynecol 2001;98(2):350-2
  • Basson R. Pharmacotherapy for sexual dysfunction in women. Expert Opin Pharmacother 2004;5(5):1045-59
  • Kaplan HS. Hypoactive sexual desire. J Sex Marital Ther 1979;3:3-9
  • Janssen E, Evereard W, Spiering M, Janssen J. Automatic processes and the appraisal of sexual stimuli toward an information processing model of sexual arousal. J Sex Res 2000;37:8-23
  • Graham CA, Sanders SA, Milhausen R. The sexual excitation and sexual inhibition inventory for women psychometric properties. Arch Sex Behav 2006;35(4):397-410
  • Bancroft J, Loftus J, Long JS. Distress about sex: A national survey of women in heterosexual relationships. Arch Sex Behav 2003;32:193-211
  • Cyranowski JM, Bromberge J, Youk A, et al. Lifetime depression history and sexual function in women at midlife. Arch Sex Behav 2004;33(6):539-48
  • Hartmann U, Philippsohn S, Heiser K, Rüffer-Hesse C. Low desire in mid life and older women: personality factors, psychosocial development, present sexuality. Menopause 2004;11(6):726-40
  • Peng YS, Chiang CK, Kao TW. Sexual dysfunction in female hemodialysis patients: a multicenter study. Kidney Int 2005;68:760-5
  • Zivadinov R, Zorzon M, Locatelli L, et al. Sexual dysfunction in multiple sclerosis: a MRI neurophysiological and urodynamic study. J Neurol Sci 2003;210:73-6
  • Enzlin P, Mathieu C, Van Den Bruel A, et al. Sexual dysfunction in women with type I diabetes. Diabetes Care 2002;25:672-7
  • Basson R, Weijmar Schultz W. Sexual sequelae of common medical conditions. Lancet 2007;369:409-24
  • Segraves R, Balon R, Clayton A. Proposal for changes in diagnostic criteria for sexual dysfunctions. J Sex Med 2007;4:567-80
  • Mitchell K, Graham CA. Two challenges for the classification of sexual dysfunction. J Sex Med 2008;5:1552-8
  • Laan E, Van Driel EM, Van Lunsen RHW. Genital responsiveness in healthy women with and without sexual arousal disorder. J Sex Med 2008;5:1424-35
  • Basson R, Leiblum S, Brotto L, et al. Definitions of women's sexual dysfunction reconsidered: advocating expansion and revision. J Psychosom Obstet Gynecol 2003;24:221-9
  • Van der Nadem F, Bloemers J, Yassem WE, et al. The influence of testosterone combined with a PDE5-inhibitor on cognitive, effective, and physiological sexual functioning in women suffering from sexual dysfunction. J Sex Med 2009;6(3):777-90
  • Segraves RT. Buproprion sustained release for the treatment of hypoactive sexual desire disorder in premenopausal women. J Clin Psychopharmacol 2004;24(3):339-42
  • Wilson CA. Pharmalogical targets for the control of male and female sexual behavior. In: Riley AJ, Peet M, Wilson C, editors, Sexual Pharmacology. Clarendon Press, Oxford; 1993. p. 1-58
  • Hull EM, Du J, Lorrain DS, Matuszewich L. Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation. J Neuro Sci 1995;15:7465-71
  • Wikberg JES, Muceniece R, Mandrika I, et al. New aspects of melanocortins and their receptors. Pharm Res 2000;42:393-420
  • McKenna KE. Some proposals regarding the organization of the central nervous system control of penile erection. Neuro Sci Bio Behav Rev 2000;24:535-40
  • Lorrain DS, Matuszewich L, Hull EM. 8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats. Brain Res 1998;790:217-23
  • Franks S, Jacobs HS. Hyperprolactinaemia. Clin Endocrinol Metab 1983;12:641-68
  • Bitran D, Miller SA, McQuade DB, et al. Inhibitions of sexual reflexes by lumbosacral injections of GABAB agonist in the male rat. Pharm Biochem Behav 1989;31:657-66
  • Karama S, Lecours AR, Leroux JM, et al. Areas of brain activation in males and females during viewing of erotic film excerpts. Hum Brain Mapp 2002;16:1-13
  • Mani SK, Allen JMC, Clark JH, et al. Convergent pathways for steroid hormone-and neurotransmitter-induced rat sexual behaviour. Science 1995;265:1246-8
  • Blaustein JD. Progestin receptors: neuronal integrators of hormonal and environmental stimulation. Ann NY Acad Sci 2003;1007:1-13
  • Dennerstein L, Lehert P, Guthrie J. The effects of the menopausal transition and biopsychosocial factors on well-being. Arch Women Ment Health 2002;5:15-22
  • Braunstein G, Sundwall DA, Katz M, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual disorder in surgically menopausal women: a randomized, placeo-controlled trial. Arch Intern Med 2005;165:1582-9
  • Buster JE, Kingsberg SA, Aguirre O, et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 2005;105:944-52
  • Simon J, Braunstein G, Nachtigall L, et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2005;90:5226-33
  • Davis SR, Van der Mooren MJ, Van Lunsen RHW, et al. Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo controlled-trial. Menopause 2006;30(3):387-96
  • Shifren JL, Davis SR, Moreau M, et al. Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM ONE STUDY. Menopause 2006;13(5):770-9
  • Arlt W. Androgen therapy in women. Eur J Endocrinol 2006;154:1-11
  • Davis S, Moreau M, Kroll R, et al. Testosterone for low libido in postmenopausal women not taking estrogen. N Eng J Med 2008;359:2005-17
  • Barton DL, Wender DB, Sloan JA, et al. Randomized controlled trial to evaluate transdermal testosterone in female cancer survivors with decreased libido: North Central Cancer Treatment Group Protocol N02C3. J Nat Cancer Inst 2007;99:672-9
  • Davis S, Papalia MA, Norman RJ, et al. Safety and efficacy of a testosterone metered-dose transdermal spray for treatment of decreased sexual satisfaction in premenopausal women: a placebo-controlled randomized, dose ranging study. Ann Int Med 2008;148:569-77
  • Goldstat R, Briganti E, Tran J, et al. Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women. Menopause 2003;10(5):390-8
  • Basson R. Editorial: testosterone supplementation to improve women's sexual satisfaction: complexities and unknowns. Ann Intern Med 2008;148(8):620-1
  • Davis SR, Nijland FA, Weijmar Schultz W. Tibolone vs. transdermal continuous combined estrogen plus progestin in the treatment of female sexual dysfunction in naturally menopausal women: results from the NETA trial. Maturitas 2006;554S:S1-S112
  • Braunstein GD. Management of female sexual dysfunction in postmenopausal women by testosterone administration: safety issues and controversies. J Sex Med 2007;4(4 Pt 1):859-66
  • Schover LR. Androgen therapy for loss of desire in women: is the benefit worth the breast cancer risk? Fertil Steril 2008;90(1):129-40
  • Wild RA. Endogenous androgens and cardiovascular risk. Menopause 2007;14(4):609-10
  • Wierman ME, Basson R, Davis SR, et al. Androgen therapy in women: an Endocrine Society Clinical Practice Guideline. J Clin Enocrinol Metab 2006;91:3697-710
  • Aziz A, Brannstrom M, Bergquist C, Silfverstolpe G. Perimenopausal androgen decline after oophorectomy does not influence sexuality or psychological well-being. Fertil Steril 2005;83:1021-8
  • Farquar CM, Harvey SA, Yu Y, et al. A prospective study of three years of outcomes after hysterectomy with and without oophorectomy. Obstet Gynecol 2006;194:714-7
  • Teplin V, Vittinghoff E, Lin F, et al. Oophorectomy in premenopausal women: health-related quality of life and sexual functioning. Obstet Gynecol 2007;109:347-54
  • Labrie F, Bélanger A, Bélanger P, et al. Androgen Glucuronides, instead of testosterone, as the new markers of androgenic activity in women. J Steroid Biochem 2006;99:182-8
  • Santoro A, Torrens J, Crawford S, et al. Correlates of circulating androgens in midlife women: The Study of Women's Health Across the Nation. J Clin Endocrinol Metab 2005;90(7):2004-63
  • Davis SR, Davison SL, Donath S, Bell RJ. Circulating androgen levels in self-reported sexual function in women. JAMA 2005;294:91-6
  • Arlt W. Dehydroepiandrosterone and ageing. Best Pract Res Clin Endocrinol Metab 2004;18:363-80
  • Arlt W, Callies F, Van Vlijmen JC, et al. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 1999;341(14):1013-20
  • Løovås K, Gebre-medhin G, Trovik TS, et al. Replacement of dehydroepiandrosterone in adrenal failure: no benefit for subjective health status and sexuality in a 9-month randomized parallel group clinical trial. J Clin Endocrinol Metab 2003;3:1112-8
  • Gurnell EN, Hunt PJ, Curran SE, et al. Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial. J Clin Endocrinol Metab 2008;93:400-9
  • Hunt P, Gurnell E, Huppert F. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial. J Clin Endocrinol Metab 2000;85:4650-6
  • Barnhart K, Freeman E, Grisso JA, et al. The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. J Clin Endocrinol Metab 1999;84(11):3896-902
  • Baulieu E, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: Contribution to the DHEAge study to a sociobiomedical issue. Proc Nat Acad Sci 2000;97(8):4279-84
  • Meston CM, Heiman JR. Acute dehydroepiandrosterone effects on sexual arousal in premenopausal women. J Sex Marital Ther 2002;28:53-60
  • Arnold JT, Blackman MR. Does DHEA exert direct effects on androgen and estrogen receptors, and does it promote or prevent prostate cancer? Endocrinol 2005;146(12):4565-7
  • Arlt W. Dehydroepiandrosterone replacement therapy. Semin Reprod Med 2004;22:379-88
  • Melcangi RC, Garcia-Segura LM, Mensah-Nygran AG. Neuroactive steroids: state of the art and new perspectives. Cell Mol Life Sci 2008;65:777-97
  • Ishunina TA, Swaab DF. Alterations in the human brain in menopause. Maturitas 2007;57(1):20-2
  • Modelska K, Litwack S, Ewing SK, Yaffe K. Endogenous estrogen levels affect sexual function in elderly post-menopausal women. Maturitas 2004;49(2):124-33
  • Archer JS, Love-Geffen TE, Herbst-Damm KL, et al. Effect of estradiol vs. estradiol and testosterone on brain-activation patterns in postmenopausal women. Menopause 2006;13(3):528-37
  • Davis SR, Goldstat R, Papalia M, et al. Effects of aromatase inhibition on sexual function and well-being in postmenopausal women treated with testosterone: a randomized, placebo-controlled trial. Menopause 2006;13(1):37-45
  • Burnett AI, Calvin TC, Silver RI, et al. Immuno-chemical description of nitric oxide synthase isoforms in human clitoris. J Urol 1997;158(75):278
  • O'Connell HE, Hutson JM, Anderson CR, Plenter RJ. Anatomical relationship between urethra and clitoris. J Urol 1998;159:1892-7
  • Ziessen T, Moncada S, Cellek S. Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall. Br J Pharmacol 2002;135:546-54
  • Ottesen B, Pedersen B, Neilsen J, et al. Vasoactive intestinal polypeptide (VIP) provokes vaginal lubrication in normal women. Peptides 1987;8:797-800
  • Yucel S, De Souza JRA, Baskin LS. Neuroanatomy of the human female lower urogenital tract. J Urol 2004;172:191-195
  • Gerhard M, Walsh BW, Tawakol A, et al. Estradiol therapy combined with progesterone and endothelium-dependent vasodilatation in postmenopausal women. Circulation 1998;98:1158-63
  • Laan E, Van Lunsen RHW. Hormones and sexuality in postmenopausal women: a psychophysiological study. J Psychom Obstet Gynecol 1997;18:126-33
  • Maravilla KR, Heiman JR, Garland PA, et al. Dynamic MR imaging of the sexual arousal response in women. J Sex Marital Ther 2003;29(Suppl 1):71-6
  • Freedman MA. Estrogen, vaginal pH, and genital atrophy. Menopause 2006;13(6)S11:987
  • Valadares ALR, Pinto Neto AM, Osis MJD, et al. Dyspareunia: a population based study with Brazilian women between 40 and 65 years old. Menopause 2006;13(6)P-98:1016
  • Bachmann G, Lobo RA, Gut R, et al. Efficacy of low-dose estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial. Obstet Gynecol 2008;111(1):67-76
  • Hodis HN, Mack WJ. Postmenopausal hormone therapy and cardiovascular disease in perspective. Clin Obstet Gynecol 2008;51(3):564-80
  • Lobo R. Evidence-based medicine and the management of menopause. Clin Obstet Gynecol 2008;51(3):534-8
  • Vankrunkelsven P, Kellen E, Lousbergh D, et al. Reduction in hormone replacement therapy use and declining breast cancer incidence in the Belgian province of Limburg. Breast Cancer Res Treat Online: 24 February 2009
  • Simon J, Gass M, Cagen R, et al. Lasofoxifene affectively treats dyspareunia in postmenopausal women with vaginal atrophy. Obstet Gynecol 2005;105(Suppl 4):A3423
  • Modungo F, Ness RB, Ewing S, Cauley JA. Effect of raloxifene on sexual function in older postmenopausal women with osteoporosis. Obstet Gynecol 2003;101(2):353-61
  • Fallowfield L, Fleissig R, Edwards A, et al. Tamoxifen for the prevention of breast cancer: psychosocial impact on women participating in two randomized controlled trials. J Clin Oncol 2001;19(7):1885-92
  • Pickar JH. Tissue selective estrogen complexes (TSECs): a new direction for menopausal health Care. Abstract presented at 13thIinternational Congress on Hormomal Steroids and Cancer Sep 2008 Quebec City
  • Nijland EA, Weijmar Schultz WC, Davis SR. Effects of tibolone and raloxifene on health-related quality of life and sexual function. Maturitas 2007;58(2):164-73
  • Basson R, Brotto L. Sexual psychophysiology and effects of sildenafil citrate in oestrogenized women with acquired genital arousal disorder and impaired orgasm. BJOG: An International J Obstet Gynecol 2003;110:1014-24
  • Maravilla KR, Yang CC. Magnetic resonance imaging and the female sexual response: overview of results, techniques and future directions. J Sex Med 2008;5:1559-1571
  • Caruso S, Intelisano G, Lupo L, Agnello C. Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, crossover, placebo-controlled study. Br J Obstet Gynecol 2001;108:623-8
  • Basson R, McInnes R, Smith MD, et al. Efficacy and safety of sildenafil citrate in women with sexual dysfunction associated with female sexual arousal. J Womens Health Gend Based Med 2002;11:367-77
  • Laan E, Van Lunsen RHW, Everaerd W. The effects of tibolone on vaginal blood flow, sexual desire and arousability in postmenopausal women. Climacteric 2001;4:28-41
  • Dasgupta R, Wiseman OJ, Kanabar G, et al. Efficacy of sildenafil in the treatment of female sexual dysfunction due to multiple sclerosis. J Urol 2004;171:1189-93
  • Caruso S, Rugolo S, Agnello C, et al. Sildenafil improves sexual functioning in premenopausal women with Type I diabetes who are affected by sexual arousal disorder: double-blind, crossover, placebo-controlled pilot study. Fertil Steril 2006;85:1496-501
  • Berman JR, Berman LA, Toler SM, et al. Sildenafil Study Group. Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal disorder: a double-blind, placebo controlled study. J Urol 2003;170(6pt1):2333-8
  • Maw GN, Stobie A, Planken S, et al. The structure of small molecule inhibitors of neutral endopeptidase. Structure-activity studies on functionalised glutaramides. Chem Biol Drug Des 2006;67(1):74-7
  • Ito TY, Polan ML, Whipple B, Trant AS. The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status. J Sex Marital Ther 2006;32(5):369-78
  • Labrie F, Cusan L, Gomez JL, et al. Effect of intravaginal DHEA on serum DHEA and 11 of its metabolites in postmenopausal women. J Steroid Biochem Mol Biol 2008;111:178-94
  • Labrie F, Archer D, Bouchard C, et al. Intravaginal Prasterone (DHEA), the physiological and a highly efficient treatment of vaginal atrophy. Menopause In press
  • Labrie F, Archer D, Bouchard C, et al. Effect of Intravaginal Prasterone (DHEA) on libido and sexual dysfunction in postmenopausal women. Menopause In press
  • Diamond LE, Earle DC, Heiman JR, et al. An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist. J Sex Med 2006;3(4):626-83
  • Beral V. Million women study collaborators. Breast cancer and hormone-replacement therapy in the million women study. Lancet 2003;362:419-27
  • Cummings SR. LIFT study is discontinued. BMJ 2006;332:667
  • Goldfischer ER, Breux J, Katz M, et al. Efficacy of continued flibanserin treatment in premenopausal women with hypoactive sexual desire disorder: results from the Rose Study. J Sex Med 2009;6(2):45
  • Safarinejad MR. Evaluation of safety and efficacy of bremelanotide, a melanocortin receptor agonist, in female subjects with arousal disorder: a double- blind placebo- controlled fixed dose randomized study. J Sex Med 2008;5:887-97
  • Nurnberg HG, Hensley PL, Heiman JR, et al. Sildenafil treatment of women with antidepressant-associated sexual dysfunction. JAMA 2008;300(4):395-404
  • Basson R, Weijmar Schultz CM, Brotto L, et al. Second international consultation on sexual medicine: men and women's sexual dysfunction. Paris: Health Publications Limited, 2004
  • Gerber S, Bongiovanni AM, Ledger WJ, Witkin SS. Interleukin-1 beta gene polymorphism in women with vulvar vestibulitis syndrome. Eur J Obstet Gynecol Reprod Biol 2003;104:74-7
  • Babula O, Linhares IM, Bongiovanni AM, et al. Association between primary vulvar vestibulitis syndrome, defective induction of tumor necrosis factor –α, and carriage of the mannose-binding lectin codon 54 gene polymorphism. Am J Obstet Gynecol 2008;198(1):101.e1-4
  • Brotto L, Basson R, Gehring D. Psychological profiles among women with vulvar vestibulitis syndrome: a chart review. J Psychosom Obstet Gynecol 2003;24:3
  • Gunter J. Vulvodynia: new thoughts on a devastating condition. Obstet Gynecol Surv 2007;62(12):812-9
  • Adler J, Zanetti R, Wight E, et al. Sexual dysfunction after premenopausal stage I and II breast cancer: Do androgens play a role? J Sex Med 2008;5:1898-906
  • Basson R, Brotto L, Labrie F, Petkau J. Androgen metabolites and women's sexual function. Abstract presented at the Annual Scientific Meeting of the International Society of the Study of Women's Sexual Health. Florence, 2009

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