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Drug Evaluations

Topical capsaicin. The fire of a ‘hot’ medicine is reignited

, MD PhD & , MD
Pages 1359-1371 | Published online: 06 May 2010

Bibliography

  • Spath E, Darling SF. Synthesis of capsaicin. Ber Chem Ges 1930;63B:737-40
  • Szallasi A, Blumberg PM. Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 1999;51:159-212
  • Li D, Ren Y, Xu X, Sensitization of primary afferent nociceptors induced by intradermal capsaicin involves the peripheral release of calcitonin gene-related peptide driven by dorsal root reflexes. J Pain 2008;9:1155-68
  • Gamse R, Petsche U, Lembeck F, Jancso G. Capsaicin applied to the peripheral nerve inhibits axoplasmic transport of substance P and somatostatin. Brain Res 1982;238:447-62
  • Miller MS, Buck SH, Sipes IG, Regulation of substance P by nerve growth factor: disruption by capsaicin. Brain Res 1982;250:193-6
  • Taylor DCM, Pierau Fr-K, Szolcsanyi J. Long-lasting inhibition of horseradish peroxidase (HRP) transport in sensory nerves induced by capsaicin pretreatment of the receptive field. Brain Res 1984;298:45-9
  • Gilchrist CA, Morrison CF, Chapman KE, Harmar AJ. Identification of nerve growth factor-responsive sequences within the 5′ region of the bovine preprotachy-kiningene. DNA Cell Biol 1991;10:743-9
  • Zhang H, Cang CL, Kawasaki Y, Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKC epsilon: a novel pathway for heat hyperalgesia. J Neurosci 2007;27:12067-77
  • Vyklický L, Nováková-Tousová K, Benedikt J, Calcium dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin. Physiol Res 2008;57:S59-68
  • Mohapatra DP, Nau C. Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem 2005;280:13424-32
  • Tominaga M, Numazaki M, Iida T, Regulation mechanisms of vanilloid receptors. Novartis Found Symp 2004;261:4-12; discussion 12-8,47-54
  • Szallasi A, Blumberg PM. Vanilloid receptor loss in rat sensory neurons associated with long term desensitization to resiniferatoxin. Neurosci Lett 1992;136:51-4
  • Nolano M, Simone DA, Wendelschafer-Crabb G, Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation. Pain 1999;81:135-45
  • Simone DA, Nolano M, Johnson T, Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory function. J Neurosci 1998;18:8947-59
  • Nagy I, Sántha P, Jancsó G, Urbán L. The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. Eur J Pharmacol 2004;500:351-69
  • Liu L, Simon SA. Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: relationship to functional VR1 receptors. Physiol Behav 2000;69:363-78
  • De Petrocellis L, Di Marzo V. Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels. Life Sci 2005;77:1651-66
  • Dhaka A, Uzzell V, Dubin AE, TRPV1 is activated by both acidic and basic pH. J Neurosci 2009;29:153-8
  • Khairatkar-Joshi N, Szallasi A. TRPV1 antagonists: the challenges for therapeutic targeting. Trends Mol Med 2008;15:14-22
  • Maggi CA, Borsini F, Santicioli P, Cutaneous lesions in capsaicin-treated rats. A trophic role of capsaicin-sensitive afferents? Naunyn-Schmiedeberg's Arch Pharmacol 1987;336:538-45
  • Carrillo P, Camacho M, Manzo J, Cutaneous wounds produced by capsaicin treatment of newborn rats are due to trophic disturbances. Neurotoxicol Teratol 1998;20:75-81
  • Gamse R, Holzer P, Lembeck P. Decrease of substance P in primary sensory neurons and impairment of neurogenic plasma extravasation by capsaicin. Br J Pharmacol 1980;68:207-13
  • Gamse R, Molnar A, Lembeck F. Substance P release from spinal cord slices. Life Sci 1981;25:629-36
  • Rossi R, Del Bianco E, Isolani D, Possible involvement of neuropeptidergic sensory nerves in alopecia areata. Neuroreport 1997;8:1135-8
  • Hordinsky M, Ericson M. Autoimmunity: alopecia areata. J Investig Dermatol Symp Proc 2004;9:73-8
  • Ehsani A, Toosi S, Seirafi H, Capsaicin vs. clobetasol for the treatment of localized alopecia areata. J Eur Acad Dermatol Venereol 2009;23(12):1451-3
  • Paus R, Heinzelmann T, Schultz KD, Hair growth induction by substance P. Lab Invest 1994;71:134-40
  • Roberts LA, Connor M. TRPV1 antagonists as a potential treatment for hyperalgesia. Recent Pat CNS Drug Discov 2006;1:65-76
  • Willis WD Jr. The role of TRPV1 receptors in pain evoked by noxious thermal and chemical stimuli. Exp Brain Res 2009;196:5-11
  • Knotkova H, Pappagallo M, Szallasi A. Capsaicin (TRPV1 agonist) therapy for pain relief: farewell or revival? Clin J Pain 2008;24:142-54
  • Lambert DG. Capsaicin receptor antagonists: a promising new addition to the pain clinic. Br J Anaesth 2009;102:153-5
  • Gavva NR. Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1. Trends Pharmacol Sci 2008;29:550-7
  • Leung FW. Capsaicin-sensitive intestinal mucosal afferent mechanism and body fat distribution. Life Sci 2008;83:1-5
  • Geppetti P, Materazzi S, Nicoletti P. The transient receptor potential vanilloid 1: role in airway inflammation and disease. Eur J Pharmacol 2006;533:207-14
  • Takemura M, Quarcoo D, Niimi A, Is TRPV1 a useful target in respiratory diseases? Pulm Pharmacol Ther 2008;21:833-9
  • Hu CP, Li NS, Peng J, Involvement of vanilloid receptors in heat stress-induced delayed protection against myocardial ischemia-reperfusion injury. Neuropeptides 2003;37:233-8
  • Hu CP, Li NS, Xiao L, Involvement of capsaicin-sensitive sensory nerves in cardioprotection of rutaecarpine in rats. Regul Pept 2003;114:45-9
  • Nozawa Y, Nishihara K, Yamamoto A, Distribution and characterization of vanilloid receptors in the rat stomach. Neurosci Lett 2001;309:33-6
  • Wang L, Wang DH. TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice. Circulation 2005;112:3617-23
  • Babbar S, Marier JF, Mouksassi MS, Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain. Ther Drug Monit 2009;31:502-10
  • Fang J-Y, Wu P-C, Huang YB, Tsai YH. In vitro permeation study of capsaicin and its synthetic derivatives from ointment bases using various skin types. Int J Pharm 1995;126:119-28
  • Chanda S, Bashir M, Babbar S, In vitro hepatic and skin metabolism of capsaicin. Drug Metab Dispos 2008;36:670-5
  • Carter RB. Topical capsaicin in the treatment of cutaneous disorders. Drug Dev Res 1991;22:109-23
  • Hergenhahn M, Adolf W, Hecker E. Resiniferatoxin and other esters of novel polyfunctional diterpenes from Euphorbia resinifera and unispina. Tetrahedron Lett 1975;19:1595-8
  • De Vries DJ, Blumberg PM. Thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin. Life Sci 1989;44:711-15
  • Szallasi A, Blumberg PM. Minireview. Resiniferatoxin and analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sci 1990;47:1399-408
  • Szallasi A, Blumberg PM. Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes. Brain Res 1990;524:106-11
  • Szallasi A, Blumberg PM. [3H]Resiniferatoxin binding by the vanilloid receptor: species-related differences, effects of temperature and sulfhydryl reagents. Naunyn Schmiedeberg's Arch Pharmacol 1993;347:84-91
  • Deng PY, Ye F, Cai WJ, Stimulation of calcitonin gene-related peptide synthesis and release: mechanisms for a novel antihypertensive drug, rutaecarpine. J Hypertens 2004;22:1819-29
  • Hu CP, Xiao L, Deng HW, Li YJ. The cardioprotection of rutaecarpine is mediated by endogenous calcitonin related-gene peptide through activation of vanilloid receptors in guinea-pig hearts. Planta Med 2002;68:705-9
  • Santos ARS, Calixto JB. Antinociceptive actions of tachykinin and capsaicin antagonists on neurogenic pain induced by formalin and capsaicin in mice. In: Abstracts of Tachykinins 1995: From Basic Science to Clinical Applications. Fondazione Internazionale Menarini, Florence, Italy; 1995. p. 163
  • Progress in pain research and management. In: Jensen TS, editor. Proceedings of the 8th world congress on pain. (Volume 8); 17-22 August. Turner and Zsuzsanna Wiesenfeld-Hallin, IASP Press, Vancouver, BC, Canada; 1997
  • Szallasi A, Cortright DN, Blum CA, Eid SR. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 2007;6:357-72
  • Jancso G, Ambrus A. Capsaicin sensitivity of primary sensory neurones and its regulation. In: Besson JM, Guilbaud G, Ollat H, editors, Peripheral neurons in nociception: physio-pharmacological aspects. John Libbey Eurotext, Paris; 1994. p. 71-87
  • Cortright DN, Szallasi A. TRP channels and pain. Curr Pharm Des 2009;15:1736-49
  • Oaklander AL. The density of remaining nerve endings in human skin with and without postherpetic neuralgia after shingles. Pain 2001;92:139-45
  • Binder A, Koroschetz J, Baron R. Disease mechanisms in neuropathic itch. Nat Clin Pract Neurol 2008;4:329-37
  • Backonja M, Wallace MS, Blonsky ER, NGX-4010 C116 Study Group. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol 2008;7:1106-12
  • Turnbull A. Tincture of capsaicin as a remedy for chilblains and toothache. Dublin Free Press 1850;1:95-6
  • Ohkubo T, Kitamura K. Eugenol activates Ca-permeable currents in rat dorsal root ganglion cells. J Dent Res 1997;76:1737-44
  • Ohkubo T, Shibata M. The selective capsaicin antagonist capsazepine abolishes the antinociceptive action of eugenol and guaiacol. J Dent Res 1997;76:848-51
  • Vickers ER, Cousins MJ, Walker S, Chisholm K. Analysis of 50 patients with atypical odontalgia. A preliminary report on pharmacological procedures for diagnosis and treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:24-32
  • Huang W, Rothe MJ, Grant-Kels JM. The burning mouth syndrome. J Am Acad Dermatol 1996;34:91-8
  • LaCroix JS, Buvelot JM, Bolla BS, Lundberg JM. Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin. Clin Exp Allergy 1991;21:595-600
  • Marabini S, Ciabatti PG, Polli G, Beneficial effects of intranasal applications of capsaicin in patients with vasomotor rhinitis. Eur Arch Otorhinolaryngol 1991;248:191-4
  • Filiaci F, Zambetti G, Ciofalo A, A local treatment of aspecific nasal hyperreactivity with capsaicin. Allergol Immunopathol 1994;22:264-8
  • Filiaci F, Zambetti G, LuceMand Ciofalo A. Local treatment of nasal polyposis with capsaicin: preliminary findings. Allergol Immunopathol 1996;24:13-8
  • Sicuteri F, Fusco BM, Marabini S, Beneficial effect of capsaicin application to the nasal mucosa in cluster headache. Clin J Pain 1989;5:49-53
  • Fusco BM, Geppetti P, Fanciullacci M, Sicuteri F. Local application of capsaicin for the treatment of cluster headache and idiopathic trigeminal neuralgia. Cephalalgia 1991;11:234-5
  • Marks DR, Rapoport A, Padla D, A double-blind, placebo-controlled trial of intranasal capsaicin for cluster headache. Cephalalgia 1993;13:114-6
  • Stjärne P, Lundblad L, änggård A, Lundberg JM. Local capsaicin treatment of the nasal mucosa reduces symptoms in patients with nonallergic nasal hyperreactivity. Am J Rhinol 1991;5:145-51
  • Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 1988;24:739-68
  • Szolcsányi J, Pintér E, Helyes Z, Systemic anti-inflammatory effect induced by counter-irritation through a local release of somatostatin from nociceptors. Br J Pharmacol 1998;125:916-22
  • Bernstein JE, Bickers DR, Dahl MV, Roshal JY. Treatment of chronic postherpetic neuralgia with topical capsaicin. J Am Acad Dermatol 1987;17:93-6
  • Bucci FA, Gabriels CF, Krohel GB. Succesful treatment of postherpeticneuralgia with capsaicin. Am J Ophthalmol 1988;106:758-9
  • Oaklander AL. Mechanisms of pain and itch caused by herpes zoster (shingles). J Pain 2008;9(1 Suppl 1):S10-18
  • Watson CP, Oaklander AL. Postherpetic neuralgia. Pain Pract 2002;2:295-307
  • Ross DR, Varipapa RJ. Treatment of diabetic neuropathy with topical capsaicin. N Engl J Med 1989;321:474-5
  • Basha KM, Whitehouse FW. Capsaicin: a therapeutic option for painful diabetic polyneuropathy. Henry Ford Hosp Med J 1991;39:138-40
  • Watson CPN, Evans RJ. The postmastectomy pain syndrome and topical capsaicin: a randomized trial. Pain 1992;51:375-9
  • Watson CPN, Evans RJ, Watt VR. The postmastectomy pain syndrome and the effect of topical capsaicin. Pain 1989;38:177-86
  • Deal CL, Schnitzer TJ, Lipstein E, Treatment of arthritis with topical capsaicin: a double-blind trial. Clinic Ther 1991;13:383-95
  • Matucci-Cerinic M, McCarthy G, Lombardi A, Editorial. Neurogenic influences in arthritis: potential modification by capsaicin. J Rheumatol 1995;22:1447-9
  • Simpson DM, Brown S, Tobias J. NGX-4010 C107 Study Group. Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy. Neurology 2008;70:2305-13
  • Ellison N, Loprinzi CL, Kugler J, Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients. J Clin Oncol 1997;15:2974-80
  • McCarty GM, McCarty DJ. Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands. J Rheumatol 1992;19:604-7
  • Schmelz M. Itch and pain. Neurosci Biobehav Rev 2010;34:171-6
  • Handwerker HO, Schmelz M. Pain: itch without pain – a labeled line for itch sensation? Nat Rev Neurol 2009;5:640-1
  • Sikand P, Shimada SE, Green BG, LaMotte RH. Similar itch and nociceptive sensations evoked by punctuate cutaneous application of capsaicin, histamine and cowhage. Pain 2009;144:66-75
  • Simone DA, Zhang X, Li J, Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli. J Neurophysiol 2004;91:213-22
  • Yosipovitch G, Greaves MW, Fleischer AB Jr, McGlone F (eds). Neuropathic pruritus in “Itch. Basic Mechanism and Therapy”. New York, Marcel Dekker, 2004;231-9
  • Yosipovitch G, Samuel LS. Neuropathic and psychogenic itch. Dermatol Ther 2008;21:32-41
  • Wallengren J. Treatment of notalgia paresthetica with topical capsaicin. J Am Acad Dermatol 1991;24:286-8
  • Leibsohn E. Treatment of notalgia paresthetica with capsaicin. Cutis 1992;49:335-6
  • Wallengren J, Klinker M. Successful treatment of notalgia paresthetica with topical capsaicin: vehicle-controlled, double-blind, crossover study. J Am Acad Dermatol 1995;32:287-9
  • Tarng D-C, Cho Y-L, Liu H-N, Huang T-P. Hemodialysis-related pruritus: a double-blind, placebo-controlled, crossover study of capsaicin 0.025% cream. Nephron 1996;72:617-22
  • Breneman DL, Cardone JS, Blumsack RF, Topical capsaicin for treatment of hemodialysis-related pruritus. J Am Acad Dermatol 1992;26:91-4
  • Kantor GR, Resnik KS. Treatment of lichen simplex chronicus with topical capsaicin cream. Acta Derm Venereol (Stockh) 1996;76:161
  • Stander S, Luger T, Metze D. Treatment of prurigo nodularis with topical capsaicin. J Am Acad Dermatol 2001;44:471-8
  • Bernstein JE. Capsaicin in dermatologic diseases. Semin Dermatol 1988;7:304-9
  • Ellis CN, Berberian B, Sulica VI, A double-blind evaluation of topical capsaicin in pruritic psoriasis. J Am Acad Dermatol 1993;29:438-42
  • Yosipovitch G, Mengesha Y, Facliaru D, David M. Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis. J Dermatolog Treat 2005;16:178-80
  • Tuerk MJ, Koo J. A practical review and update on the management of pruritus sine materia. Cutis 2008;82:187-94
  • Lysy J, Sistiery-Ittah M, Israelit Y, Topical capsaicin - a novel and effective treatment for idiopathic intractable pruritus ani: a randomised, placebo controlled, crossover study. Gut 2003;52:1323-6
  • Steinberg AC, Oyama IA, Rejba AE, Capsaicin for the treatment of vulvar vestibulitis. Am J Obstet Gynecol 2005;192:1549-53
  • Lotti T, Teofoli P, Tsampau D. Treatment of aquagenic pruritus with topical capsaicin cream. J Am Acad Dermatol 1994;30:232-5
  • Rumsfield JA, West DP. Topical capsaicin in dermatologic and peripheral pain disorders. DIPC Ann Pharmacother 1991;25:381-7
  • Watson CPN. Topical capsaicin as an adjuvant analgesic. J Pain Symptom Manag 1994;9:425-33
  • Rains C, Bryson HM. Topical capsaicin. A review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy and osteoarthritis. Drugs Aging 1995;7:317-28
  • Yosipovitch G, Maibach HI, Rowbotham MC. Effect of EMLA pre-treatment on capsaicin-induced burning and hyperalgesia. Acta Derm Venereol 1999;79:118-21
  • Robbins WR, Staats PS, Levine J, Treatment of intractable pain with topical large-dose capsaicin: preliminary report. Anesth Analg 1998;86:579-83
  • Noto C, Pappagallo M, Szallasi A. NGX-4010, a high-concentration capsaicin dermal patch for lasting relief of peripheral neuropathic pain. Curr Opin Investig Drugs 2009;10:702-10
  • Paice JA, Ferrans CE, Lashley FR, Topical capsaicin in the management of HIV-associated peripheral neuropathy. J Pain Symptom Manage 2000;19:45-52
  • Wang H, Papoiu AD, Coghill RC, Ethnic differences in pain, itch and thermal detection in response to topical capsaicin: African Americans display a notably limited hyperalgesia and neurogenic inflammation. Br J Dermatol 2010. [Epub ahead of print]
  • Murray JA, Ahujaa KD, Geraghtya DP. Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. Thromb Res 2009;124:721-3
  • Miller CH, Zhang Z, Hamilton SM, Teel RW. Effects of capsaicin on liver microsomal metabolism of the tobacco-specific nitrosamine NNK. Cancer Lett 1993;75:45-52
  • Morré DJ, Chueh PJ, Morré DM. Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture. Proc Natl Acad Sci USA 1995;92:1831-5
  • Mori A, Lehmann S, O'Kelly J, Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p-53 mutant prostate cancer cells. Cancer Res 2006;66:3222-29
  • Scheffler NM, Sheitel PL, Lipton MN. Treatment of painful diabetic neuropathy with capsaicin. J Am Podiatr Med Assoc 1991;81:288-93
  • Ellis JL, Sham JSK, Undem BJ. Tachykinin-independent effects of capsaicin on smooth muscle in human isolated bronchi. Am J Respir Crit Care Med 1997;155:751-5
  • Marciniak BH, Brown B, Peterson B, Adverse consequences of capsaicin exposure in health care workers. J Am Geriatr Soc 1995;43:1181-2
  • Olajos E, Salem H. Riot control agents: pharmacology, toxicology, biochemistry and chemistry. J Appl Toxicol 2001;21:355-91
  • Busker RW, van Helden HP. Toxicologic evaluation of pepper spray as a possible weapon for the Dutch police force: risk assessment and efficacy. Am J Forensic Med Pathol 1998;19:309-16
  • Capsaicin MSDS, Sciencelab.com, Inc. Houston, Texas. Available from: http://www.sciencelab.com/xMSDS-Capsaicin_Natural-9923296
  • Surh Y-J, Lee SS. Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential. Life Sci 1995;56:1845-55
  • Surh Y-J, Lee SS. Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen? Food Chem Toxicol 1996;34:313-16
  • Dasgupta P, Chandiramani V, Parkinson MC, Treating the human bladder with capsaicin: Is it safe? Eur J Urol 1998;33:28-31
  • Dubois JM. Capsaicin blocks one class of K1 channels in the frog node of Ranvier. Brain Res 1982;245:372-5
  • Petersen M, LaMotte RH. Effects of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 1993;54:37-42
  • Kehl SJ. Block by capsaicin of voltage-gated K1 currents in melanotrophs of the rat pituitary. Br J Pharmacol 1994;112:616-24
  • Kuenzi FM, Dale N. Effect of capsaicin and analogues on potassium and calcium currents in Xenoupus embryo spinal neurones. Br J Pharmacol 1996;119:81-90
  • Shimomura Y, Kawada T, Suzuki M. Capsaicin and its analogs inhibit the activity of NADH-Coenzyme Q oxidoreductase of the mitochondrial respiratory chain. Arch Biochem Biophys 1989;270:573-7
  • Meddings JB, Hogaboam CM, Tran K, Capsaicin effects on non-neuronal plasma membrane. Biochim Biophys Acta 1991;1070:43-50
  • Aranda F, VillalaIn J, Gomez-Fernandez JC. Capsaicin affects the structure and phase organization of phospholipid membranes. Biochim Biophys Acta 1995;1234:225-34
  • Hogaboam CM, Wallace JL. Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons. Eur J Pharmacol 1991;202:129-31
  • Cochereau C, Sanchez D, Bourhaoui A, Creppy EE. Capsaicin, a structural analog of tyrosine, inhibits the aminoacylation of tRNA(Tyr). Toxicol Appl Pharmacol 1996;141:133-7
  • Cochereau C, Sanchez D, Creppy EE. Tyrosine prevents capsaicin-induced protein synthesis inhibition in cultured cells. Toxicology 1997;117:133-9
  • Ritter S, Dinh TT. Capsaicin-induced degeneration in rat brain and retina. In: Wood JN, editor, Capsaicin in the study of pain. Academic Press, San Diego, CA; 1993. p. 105-38
  • Morgenlander JC, Hurwitz BJ, Massey EW. Capsaicin for the treatment of pain in Guillain-Barré syndrome. Ann Neurol 1990;28:199
  • Kroenke K, Krebs EE, Bair MJ. Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews. Gen Hosp Psychiatry 2009;31:206-19
  • Rayner HC, Atkins RC, Westerman RA. Relief of local stump pain by capsaicin cream. Lancet 1989;2:1276-7
  • Weintraub M, Golik A, Rubio A. Capsaicin for treatment of post-traumatic amputation stump pain. Lancet 1990;336:1003-4

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