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Clinical Trial Evaluation

Losartan: the dose does it

Evaluation of: Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomized, double-blind trial. Lancet 2009;374(9704):1840-8

, MD PhD, , MD PhD & , MD PhD
Pages 2117-2119 | Published online: 25 May 2010

Bibliography

  • Konstam MA, Neaton JD, Dickstein K, ; For the HEAAL investigators. Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial. Lancet 2009;374(9704):1840-8
  • Pitt B, Poole-Wilson PA, Segal R, ; on behalf of the ELITE II investigators. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II. Lancet 2000;355:1582-7
  • Dickstein K, Kjekshus J; the OPTIMAAL Steering Committee for the OPTIMAAL Study Group. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Lancet 2002;360:752-60
  • Dahlöf B, Devereux RB, Kjeldsen SE, ; LIFE Study Group. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002;359:995-1003
  • Ludwig M, Stapff M, Ribeiro A, Comparison of the effects of losartan and atenolol on common carotid artery intima-media thickness in patients with hypertension: results of a 2-year, double-blind, randomized, controlled study. Clin Ther 2002;24:1175-93
  • Brenner BM, Cooper ME, de Zeeuw D, ; RENAAL Study Investigators. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001;345:861-9
  • Granger CB, McMurray JJ, Yusuf S, ; CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet 2003;362:772-6

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