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Long-acting injectable antipsychotics in the treatment of schizophrenia: their role in relapse prevention

, MD, , MD MSc FRCPC & , MD PhD FRCPC
Pages 2301-2317 | Published online: 30 Jun 2010

Bibliography

  • Robinson D, Woerner MG, Alvir JM, Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch Gen Psychiatry 1999;56:241-7
  • Kane JM. Schizophrenia. N Engl J Med 1996;334:34-41
  • Hogarty GE, Goldberg SC, Schooler NR. Drug and sociotherapy in the aftercare of schizophrenic patients. III. Adjustment of nonrelapsed patients. Arch Gen Psychiatry 1974;31:609-18
  • Hogarty GE, Goldberg SC, Schooler NR, Ulrich RF. Drug and sociotherapy in the aftercare of schizophrenic patients. II. Two-year relapse rates. Arch Gen Psychiatry 1974;31:603-8
  • Leff JP, Wing JK. Trial of maintenance therapy in schizophrenia. Br Med J 1971;3:599-604
  • Rifkin A, Quitkin F, Klein DF. Fluphenazine decanoate, oral fluphenazine, and placebo in treatment of remitted schizophrenics. II. Rating scale data. Arch Gen Psychiatry 1977;34:1215-19
  • Davis JM. Overview: maintenance therapy in psychiatry: I. Schizophrenia. Am J Psychiatry 1975;132:1237-45
  • Davis JM, Matalon L, Watanabe MD, Depot antipsychotic drugs. Place in therapy. Drugs 1994;47:741-73
  • Coldham EL, Addington J, Addington D. Medication adherence of individuals with a first episode of psychosis. Acta Psychiatr Scand 2002;106:286-90
  • Kissling W. Guidelines for neuroleptic relapse prevention in schizophrenia. In: Kissling W, editor, Guidelines for neuroleptic relapse prevention in schizophrenia. Springer Verlag, Berlin; 1991. p. 1-6
  • Kissling W. Compliance, quality assurance and standards for relapse prevention in schizophrenia. Acta Psychiatr Scand Suppl 1994;382:16-24
  • Lieberman JA, Stroup TS, McEvoy JP, Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005;353:1209-23
  • Cramer JA, Rosenheck R. Compliance with medication regimens for mental and physical disorders. Psychiatr Serv 1998;49:196-201
  • Carrick, JA. Medical ethics in the ancient world. Georgetown University Press, Washington DC; 2001
  • Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005;353:487-97
  • Dimatteo MR. Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 2004;42:200-9
  • Berg JS, Dischler J, Wagner DJ, Medication compliance: a healthcare problem. Ann Pharmacother 1993;27:S1-24
  • Takemoto SK, Pinsky BW, Schnitzler MA, A retrospective analysis of immunosuppression compliance, dose reduction and discontinuation in kidney transplant recipients. Am J Transplant 2007;7:2704-11
  • Restrepo RD, Alvarez MT, Wittnebel LD, Medication adherence issues in patients treated for COPD. Int J Chron Obstruct Pulmon Dis 2008;3:371-84
  • Haynes RB, Taylor DW, Sackett DL, editors. Compliance in health care. Johns Hopkins University Press, Baltimore; 1979
  • Keith SJ, Kane JM. Partial compliance and patient consequences in schizophrenia: our patients can do better. J Clin Psychiatry 2003;64:1308-15
  • Llorca PM. Partial compliance in schizophrenia and the impact on patient outcomes. Psychiatry Res 2008;161:235-47
  • Fleischhacker WW, Meise U, Gunther V, Kurz M. Compliance with antipsychotic drug treatment: influence of side effects. Acta Psychiatr Scand Suppl 1994;382:11-5
  • Zygmunt A, Olfson M, Boyer CA, Mechanic D. Interventions to improve medication adherence in schizophrenia. Am J Psychiatry 2002;159:1653-64
  • Valenstein M, Ganoczy D, McCarthy JF, Antipsychotic adherence over time among patients receiving treatment for schizophrenia: a retrospective review. J Clin Psychiatry 2006;67:1542-50
  • Weiden P, Rapkin B, Zygmunt A, Postdischarge medication compliance of inpatients converted from an oral to a depot neuroleptic regimen. Psychiatr Serv 1995;46:1049-54
  • Patel MX, David AS. Why aren't depot antipsychotics prescribed more often, and what can be done about it? Adv Psychiatr Treat 2005;11:203-13
  • Budd RJ, Hughes IC, Smith JA. Health beliefs and compliance with antipsychotic medication. Br J Clin Psychol 1996;35:393-7
  • Smith J, Hughes ICT, Budd RJ. Non-compliance with antipsychotic medication. User's view on advantages and disadvantages. J Ment Health 1999;8:287-96
  • Lacro JP, Dunn LB, Dolder CR, Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature. J Clin Psychiatry 2002;63:892-909
  • Tegeler J, Lehmann E. A follow-up study of schizophrenic outpatients treated with depot-neuroleptics. Prog Neuropsychopharmacol 1981;5:79-90
  • Perkins DO. Predictors of noncompliance in patients with schizophrenia. J Clin Psychiatry 2002;63:1121-8
  • Bergiannaki JD, Hatzimanolis J, Liappas J, Relapse prevention in schizophrenia: attitudes of neurologists-psychiatrists. Eur Psychiatry 2001;16:90-8
  • Hughes IH, Budd R. Compliance with antipsychotic medication: from theory to practice. J Ment Health 1997;6:473-89
  • Weiden P, Rapkin B, Mott T, Rating of medication influences (ROMI) scale in schizophrenia. Schizophr Bull 1994;20:297-310
  • Naber D, Karow A. Good tolerability equals good results: the patient's perspective. Eur Neuropsychopharmacol 2001;11(Suppl 4):S391-6
  • Jaeger M, Rossler W. Attitudes towards long-acting depot antipsychotics: a survey of patients, relatives and psychiatrists. Psychiatry Res 2010;175:58-62
  • Diaz E, Levine HB, Sullivan MC, Use of the Medication Event Monitoring System to estimate medication compliance in patients with schizophrenia. J Psychiatry Neurosci 2001;26:325-9
  • Babiker IE. Noncompliance in schizophrenia. Psychiatr Dev 1986;4:329-37
  • Remington G, Kwon J, Collins A, The use of electronic monitoring (MEMS) to evaluate antipsychotic compliance in outpatients with schizophrenia. Schizophr Res 2007;90:229-37
  • Cramer JA, Mattson RH, Prevey ML, How often is medication taken as prescribed? A novel assessment technique. JAMA 1989;261:3273-77
  • Shriqui CL. Neuroleptic dosing and neuroleptic plasma levels in schizophrenia: determining the optimal regimen. Can J Psychiatry 1995;40:S38-48
  • Tauscher J, Kapur S. Choosing the right dose of antipsychotics in schizophrenia: lessons from neuroimaging studies. CNS Drugs 2001;15:671-8
  • Kikkert MJ, Barbui C, Koeter MW, Assessment of medication adherence in patients with schizophrenia: the Achilles heel of adherence research. J Nerv Ment Dis 2008;196:274-81
  • Kane JM. Treatment adherence and long-term outcomes. CNS Spectr 2007;12:21-6
  • Leucht S, Heres S. Epidemiology, clinical consequences, and psychosocial treatment of nonadherence in schizophrenia. J Clin Psychiatry 2006;67(Suppl 5):3-8
  • Perkins DO. Adherence to antipsychotic medications. J Clin Psychiatry 1999;60(Suppl 21):25-30
  • Valenstein M, Copeland LA, Owen R, Adherence assessments and the use of depot antipsychotics in patients with schizophrenia. J Clin Psychiatry 2001;62:545-51
  • Weiden PJ, Kozma C, Grogg A, Locklear J. Partial compliance and risk of rehospitalization among California Medicaid patients with schizophrenia. Psychiatr Serv 2004;55:886-91
  • Docherty J, Mahmoud R, Grogg A, Kozma C. Antipsychotic maintenance in schizophrenia: partial compliance and clinical outcome. In: 9th International Congress on Schizophrenia Research; 29 March – 02 April 2003, Colarado Springs, Colorado; 2003; 60(1):281-2
  • Law MR, Soumerai SB, Ross-Degnan D, Adams AS. A longitudinal study of medication nonadherence and hospitalization risk in schizophrenia. J Clin Psychiatry 2008;69:47-53
  • Carpenter WT Jr, Hanlon TE, Heinrichs DW, Continuous versus targeted medication in schizophrenic outpatients: outcome results. Am J Psychiatry 1990;147:1138-48
  • Gaebel W, Frick U, Kopcke W, Early neuroleptic intervention in schizophrenia: are prodromal symptoms valid predictors of relapse? Br J Psychiatry Suppl 1993;21:8-12
  • Herz MI, Glazer WM, Mostert MA, Intermittent vs maintenance medication in schizophrenia. Two-year results. Arch Gen Psychiatry 1991;48:333-9
  • Jolley AG, Hirsch SR, Morrison E, Trial of brief intermittent neuroleptic prophylaxis for selected schizophrenic outpatients: clinical and social outcome at two years. BMJ 1990;301:837-42
  • Schooler NR, Keith SJ, Severe JB, Relapse and rehospitalization during maintenance treatment of schizophrenia. The effects of dose reduction and family treatment. Arch Gen Psychiatry 1997;54:453-63
  • Goldberg SC, Schooler NR, Hogarty GE, Roper M. Prediction of relapse in schizophrenic outpatients treated by drug and sociotherapy. Arch Gen Psychiatry 1977;34:171-84
  • Carpenter W Jr. Early, targeted pharmacotherapeutic intervention in schizophrenia. J Clin Psychiatry 1986;47(Suppl):23-9
  • Carpenter WT Jr. Maintenance therapy of persons with schizophrenia. J Clin Psychiatry 1996;57(Suppl 9):10-8
  • Remington G, Seeman P, Shammi C, ‘Extended’ antipsychotic dosing: rationale and pilot data. J Clin Psychopharmacol 2005;25:611-13
  • Remington G, Feingold A, ‘Extended’ antipsychotic dosing in the maintenance treatment of schizophrenia: a double-blind trial. J Clin Psychiatry 2010; In press
  • Lindstrom E, Bingefors K. Patient compliance with drug therapy in schizophrenia. Economic and clinical issues. Pharmacoeconomics 2000;18:106-24
  • Haywood TW, Kravitz HM, Grossman LS, Predicting the ‘revolving door’ phenomenon among patients with schizophrenic, schizoaffective, and affective disorders. Am J Psychiatry 1995;152:856-61
  • Sullivan G, Wells KB, Morgenstern H, Leake B. Identifying modifiable risk factors for rehospitalization: a case-control study of seriously mentally ill persons in Mississippi. Am J Psychiatry 1995;152:1749-56
  • Ayuso-Gutierrez JL, Del Rio Vega JM. Factors influencing relapse in the long-term course of schizophrenia. Schizophr Res 1997;28:199-206
  • Kane JM, Rifkin A, Quitkin F, Fluphenazine vs placebo in patients with remitted, acute first-episode schizophrenia. Arch Gen Psychiatry 1982;39:70-3
  • Rabiner CJ, Wegner JT, Kane JM. Outcome study of first-episode psychosis. I: Relapse rates after 1 year. Am J Psychiatry 1986;143:1155-8
  • Gaebel W, Pietzcker A. One-year outcome of schizophrenic patients – the interaction of chronicity and neuroleptic treatment. Pharmacopsychiatry 1985;18:235-9
  • Johnstone EC, Crow TJ, Johnson AL, Macmillan JF. The Northwick Park Study of first episodes of schizophrenia. I. Presentation of the illness and problems relating to admission. Br J Psychiatry 1986;148:115-20
  • The Scottish first episode schizophrenia study. VIII. Five-year follow-up: clinical and psychosocial findings. The Scottish Schizophrenia Research Group. Br J Psychiatry 1992;161:496-500
  • Crow TJ, Macmillan JF, Johnson AL, Johnstone EC. A randomised controlled trial of prophylactic neuroleptic treatment. Br J Psychiatry 1986;148:120-7
  • Geddes J, Mercer G, Frith CD, Prediction of outcome following a first episode of schizophrenia. A follow-up study of Northwick Park first episode study subjects. Br J Psychiatry 1994;165:664-8
  • Rajkumar S, Thara R. Factors affecting relapse in schizophrenia. Schizophr Res 1989;2:403-9
  • Kane JM. Strategies for improving compliance in treatment of schizophrenia by using a long-acting formulation of an antipsychotic: clinical studies. J Clin Psychiatry 2003;64(Suppl 16):34-40
  • Weiden PJ, Olfson M. Cost of relapse in schizophrenia. Schizophr Bull 1995;21:419-29
  • Birnbaum M, Sharif Z. Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ER. Patient Prefer Adherence 2008;2:233-40
  • Davis JM, Chen N, Glick ID. A meta-analysis of the efficacy of second-generation antipsychotics. Arch Gen Psychiatry 2003;60:553-64
  • Lapierre YD, Angus C, Awad AG, The treatment of negative symptoms: a clinical and methodological study. Int Clin Psychopharmacol 1999;14:101-12
  • Simpson GM. A brief history of depot neuroleptics. J Clin Psychiatry 1984;45:3-4
  • Kinross-Wright J, Vogt AH, Charalampous KD. A new method of drug therapy. Am J Psychiatry 1963;119:779-80
  • Chue P, Emsley R. Long-acting formulations of atypical antipsychotics: time to reconsider when to introduce depot antipsychotics. CNS Drugs 2007;21:441-8
  • Johnson DA, Freeman H. Long-acting tranquillizers. Practitioner 1972;208:395-400
  • Curry SH, Whelpton R, De Schepper PJ, Plasma-fluphenazine concentrations after injection of long-acting esters. Lancet 1978;1:1217-18
  • Taylor D. Psychopharmacology and adverse effects of antipsychotic long-acting injections: a review. Br J Psychiatry 2009;195:S13-19
  • Citrome L. Paliperidone palmitate – review of the efficacy, safety and cost of a new second-generation depot antipsychotic medication. Int J Clin Pract 2009;64(2):216-39
  • Glazer WM, Kane JM. Depot neuroleptic therapy: an underutilized treatment option. J Clin Psychiatry 1992;53:426-33
  • Agid O, Kapur S, Remington G. Emerging drugs for schizophrenia. Expert Opin Emerg Drugs 2008;13:479-95
  • Kane JM, Leucht S, Carpenter D, Docherty JP. The expert consensus guideline series. Optimizing pharmacologic treatment of psychotic disorders. Introduction: methods, commentary, and summary. J Clin Psychiatry 2003;64(Suppl 12):5-19
  • Alessi-Severini S, Biscontri RG, Collins DM, Utilization and costs of antipsychotic agents: a Canadian population-based study, 1996 – 2006. Psychiatr Serv 2008;59:547-53
  • Aparasu RR, Bhatara V, Gupta S. U S. national trends in the use of antipsychotics during office visits, 1998 – 2002. Ann Clin Psychiatry 2005;17:147-52
  • IMS health Inc. Marketing Research. In: Geddes J. Generating evidence to inform policy and practice: the example of the second generation “Atypical” antipsychotics. Schizophrenia Bulletin 2003;29(1):105-14
  • Keith S. Use of long-acting risperidone in psychiatric disorders: focus on efficacy, safety and cost-effectiveness. Expert Rev Neurother 2009;9:9-31
  • Ereshefsky L, Mannaert E. Pharmacokinetic profile and clinical efficacy of long-acting risperidone: potential benefits of combining an atypical antipsychotic and a new delivery system. Drugs R D 2005;6:129-37
  • Fleischhacker WW, Eerdekens M, Karcher K, Treatment of schizophrenia with long-acting injectable risperidone: a 12-month open-label trial of the first long-acting second-generation antipsychotic. J Clin Psychiatry 2003;64:1250-7
  • Kane JM, Eerdekens M, Lindenmayer JP, Long-acting injectable risperidone: efficacy and safety of the first long-acting atypical antipsychotic. Am J Psychiatry 2003;160:1125-32
  • Lasser RA, Bossie CA, Gharabawi GM, Baldessarini RJ. Clinical improvement in 336 stable chronically psychotic patients changed from oral to long-acting risperidone: a 12-month open trial. Int J Neuropsychopharmacol 2005;8:427-38
  • Lindenmayer JP, Eerdekens E, Berry SA, Eerdekens M. Safety and efficacy of long-acting risperidone in schizophrenia: a 12-week, multicenter, open-label study in stable patients switched from typical and atypical oral antipsychotics. J Clin Psychiatry 2004;65:1084-9
  • Fleischhacker WW. Second-generation antipsychotic long-acting injections: systematic review. Br J Psychiatry 2009;195(Suppl 52):S29-36
  • Lauriello J, Lambert T, Andersen S, An 8-week, double-blind, randomized, placebo-controlled study of olanzapine long-acting injection in acutely ill patients with schizophrenia. J Clin Psychiatry 2008;69:790-9
  • Kane JM, Detke HC, Naber D, Olanzapine long-acting injection: a 24-week, randomized, double-blind trial of maintenance treatment in patients with schizophrenia. Am J Psychiatry 2010;167:181-9
  • Owen RT. Olanzapine: a review of rapid and long-acting parenteral formulations. Drugs Today (Barc) 2010;46:173-81
  • Gopal S, Hough DW, Xu H, Efficacy and safety of paliperidone palmitate in adult patients with acutely symptomatic schizophrenia: a randomized, double-blind, placebo-controlled, dose-response study. Int Clin Psychopharmacol 2010. [Epub ahead of print]
  • Pandina GJ, Lindenmayer JP, Lull J, A randomized, placebo-controlled study to assess the efficacy and safety of 3 doses of paliperidone palmitate in adults with acutely exacerbated schizophrenia. J Clin Psychopharmacol 2010;30:235-44
  • Nahata T, Saini TR. Formulation optimization of long-acting depot injection of aripiprazole by using D-optimal mixture design. PDA J Pharm Sci Technol 2009;63:113-22
  • Jann MW, Ereshefsky L, Saklad SR. Clinical pharmacokinetics of the depot antipsychotics. Clin Pharmacokinet 1985;10:315-33
  • Dencker SJ. The risk/benefit ratio of depot neuroleptics: a Scandinavian perspective. J Clin Psychiatry 1984;45:22-7
  • Marder SR, Hubbard JW, Van Putten T, Midha KK. Pharmacokinetics of long-acting injectable neuroleptic drugs: clinical implications. Psychopharmacology (Berl) 1989;98:433-9
  • McEvoy JP. Risks versus benefits of different types of long-acting injectable antipsychotics. J Clin Psychiatry 2006;67(Suppl 5):15-8
  • Gerlach J. Depot neuroleptics in relapse prevention: advantages and disadvantages. Int Clin Psychopharmacol 1995;9(Suppl 5):17-20
  • Young JL, Spitz RT, Hillbrand M, Daneri G. Medication adherence failure in schizophrenia: a forensic review of rates, reasons, treatments, and prospects. J Am Acad Psychiatry Law 1999;27:426-44
  • Young JL, Zonana HV, Shepler L. Medication noncompliance in schizophrenia: codification and update. Bull Am Acad Psychiatry Law 1986;14:105-22
  • Shi L, Ascher-Svanum H, Zhu B, Characteristics and use patterns of patients taking first-generation depot antipsychotics or oral antipsychotics for schizophrenia. Psychiatr Serv 2007;58:482-8
  • Tattan TM, Creed FH. Negative symptoms of schizophrenia and compliance with medication. Schizophr Bull 2001;27:149-55
  • Dencker S. Neuroleptic relapse prevention. In Kissling W, editor, Guidelines for neuroleptic relapse prevention in Schizophrenia. Springer, Berlin; 1991. p. 24-5
  • Lee SH, Choi TK, Suh S, Effectiveness of a psychosocial intervention for relapse prevention in patients with schizophrenia receiving risperidone via long-acting injection. Psychiatry Res 2010;175:195-9
  • Kane JM. The use of depot neuroleptics: clinical experience in the United States. J Clin Psychiatry 1984;45:5-12
  • Blackburn HL, Allen JL. Behavioral effects of interrupting and resuming tranquilizing medication among schizophrenics. J Nerv Ment Dis 1961;133:303-8
  • Diamond LS, Marks JB. Discontinuance of tranquilizers among chronic schizophrenic patients receiving maintenance dosage. J Nerv Ment Dis 1960;131:247-51
  • Engelhardt DM, Rosen B, Freedman N, Margolis R. Phenothiazines in prevention of psychiatric hospitalization. IV. Delay or prevention of hospitalization – a reevaluation. Arch Gen Psychiatry 1967;16:98-101
  • Itil T, Keskiner A. Fluphenazine hydrochloride, enanthate, and decanoate in the management of chronic psychosis. Dis Nerv Syst 1970;31(Suppl):37-42
  • Adams CE, Fenton MK, Quraishi S, David AS. Systematic meta-review of depot antipsychotic drugs for people with schizophrenia. Br J Psychiatry 2001;179:290-9
  • Tiihonen J, Wahlbeck K, Lonnqvist J, Effectiveness of antipsychotic treatments in a nationwide cohort of patients in community care after first hospitalisation due to schizophrenia and schizoaffective disorder: observational follow-up study. BMJ 2006;333:224-7
  • Zhu B, Ascher-Svanum H, Shi L, Time to discontinuation of depot and oral first-generation antipsychotics in the usual care of schizophrenia. Psychiatr Serv 2008;59:315-17
  • Conley RR, Kelly DL, Love RC, McMahon RP. Rehospitalization risk with second-generation and depot antipsychotics. Ann Clin Psychiatry 2003;15:23-31
  • Haro JM, Novick D, Suarez D, Remission and relapse in the outpatient care of schizophrenia: three-year results from the Schizophrenia Outpatient Health Outcomes study. J Clin Psychopharmacol 2006;26:571-8
  • Haro JM, Suarez D, Novick D, Three-year antipsychotic effectiveness in the outpatient care of schizophrenia: observational versus randomized studies results. Eur Neuropsychopharmacol 2007;17:235-44
  • Haddad PM, Taylor M, Niaz OS. First-generation antipsychotic long-acting injections v. oral antipsychotics in schizophrenia: systematic review of randomised controlled trials and observational studies. Br J Psychiatry 2009;195:S20-8
  • Denham J, Adamson L. The contribution of fluphenazine enanthate and decanoate in the prevention of readmission of schizophrenic patients. Acta Psychiatr Scand 1971;47:420-30
  • Denham J, Adamson L. Long-acting phenothiazines in the prevention of relapse of schizophrenic patients. Can Psychiatr Assoc J 1973;18:235-7
  • Devito RA, Brink L, Sloan C, Jolliff F. Fluphenazine decanoate vs oral antipsychotics: a comparison of their effectiveness in the treatment of schizophrenia as measured by a reduction in hospital readmissions. J Clin Psychiatry 1978;39:26-34
  • Freeman H. Twelve years' experience with the total use of depot neuroleptics in a defined population. Adv Biochem Psychopharmacol 1980;24:559-64
  • Gottfries CG, Green L. Flupenthixol decanoate – in treatment of out-patients. Acta Psychiatr Scand Suppl 1974;255:15-24
  • Marriott P, Hiep A. A mirror image out-patient study at a depot phenothiazine clinic. Aust NZ J Psychiatry 1976;10:163-7
  • Davis JM, Dysken MW, Haberman SJ, Use of survival curves in analysis of antipsychotic relapse studies. Adv Biochem Psychopharmacol 1980;24:471-81
  • Johnson DA, Pasterski G, Ludlow JM, The discontinuance of maintenance neuroleptic therapy in chronic schizophrenic patients: drug and social consequences. Acta Psychiatr Scand 1983;67:339-52
  • Youssef H. A five year follow-up study of chronic schizophrenics and other psychotics treated in the community: depot haloperidol decanuate versus other neuroleptics. Adv Ther 1989;64:186-95
  • Young CL, Taylor DM. Health resource utilization associated with switching to risperidone long-acting injection. Acta Psychiatr Scand 2006;114:14-20
  • Barnes TR, Curson DA. Long-term depot antipsychotics. A risk-benefit assessment. Drug Saf 1994;10:464-79
  • Heres S, Hamann J, Kissling W, Leucht S. Attitudes of psychiatrists toward antipsychotic depot medication. J Clin Psychiatry 2006;67:1948-53
  • Levine J, Schooler NR, Cassano GB. The role of depot neuroleptics in the treatment of schizophrenic patients. Psychol Med 1979;9:383-6
  • Lehman AF, Lieberman JA, Dixon LB, Practice guideline for the treatment of patients with schizophrenia, second edition. Am J Psychiatry 2004;161:1-56
  • Dencker SJ, Axelsson R. Optimising the use of depot antipsychotics. CNS Drugs 1996;367-81
  • Kane JM, Aguglia E, Altamura AC, Guidelines for depot antipsychotic treatment in schizophrenia. European Neuropsychopharmacology Consensus Conference in Siena, Italy. Eur Neuropsychopharmacol 1998;8:55-66
  • Ereshefsky L, Saklad SR, Jann MW, Future of depot neuroleptic therapy: pharmacokinetic and pharmacodynamic approaches. J Clin Psychiatry 1984;45:50-9
  • Nagy A. Blood and brain concentrations of imipramine, clomipramine and their monomethylated metabolites after oral and intramuscular administration in rats. J Pharm Pharmacol 1977;29:104-7
  • Eerdekens M, Van Hove I, Remmerie B, Mannaert E. Pharmacokinetics and tolerability of long-acting risperidone in schizophrenia. Schizophr Res 2004;70:91-100
  • Yoshimura R, Ueda N, Ikenouch-Sugita A, Fluctuating plasma levels of the active moiety of risperidone is related to occurrence of extrapyramidal symptoms. Int J Psychiatry Clin Pract 2009;13:21-4
  • Kapur S, Zipursky R, Jones C, Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am J Psychiatry 2000;157:514-20
  • Remington GJ, Adams ME. Depot neuroleptic therapy: clinical considerations. Can J Psychiatry 1995;40:S5-11
  • Knox ED, Stimmel GL. Clinical review of a long-acting, injectable formulation of risperidone. Clin Ther 2004;26:1994-2002
  • Nasrallah HA. The case for long-acting antipsychotic agents in the post-CATIE era. Acta Psychiatr Scand 2007;115:260-7
  • Rothbard AB, Kuno E, Foley K. Trends in the rate and type of antipsychotic medications prescribed to persons with schizophrenia. Schizophr Bull 2003;29:531-40
  • Taylor D. Atypical antipsychotics in the treatment of schizophrenia. Pragmatic considerations are important when considering which drug to prescribe. BMJ 2001;322:925
  • Hamann J, Langer B, Leucht S, Medical decision making in antipsychotic drug choice for schizophrenia. Am J Psychiatry 2004;161:1301-4
  • Galletly CA. Antipsychotic drug doses in a schizophrenia inpatient unit. Aust NZ J Psychiatry 1992;26:574-6
  • Johnson DA, Wright NF. Drug prescribing for schizophrenic out-patients on depot injections. Repeat surveys over 18 years. Br J Psychiatry 1990;156:827-34
  • Heres S, Hamann J, Mendel R, Identifying the profile of optimal candidates for antipsychotic depot therapy A cluster analysis. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1987-93
  • Sim K, Su A, Ungvari GS, Depot antipsychotic use in schizophrenia: an East Asian perspective. Hum Psychopharmacol 2004;19:103-9
  • Barnes TR, Paton C, Cavanagh MR, A UK audit of screening for the metabolic side effects of antipsychotics in community patients. Schizophr Bull 2007;33:1397-403
  • Barnes TR, Paton C, Hancock E, Screening for the metabolic syndrome in community psychiatric patients prescribed antipsychotics: a quality improvement programme. Acta Psychiatr Scand 2008;118:26-33
  • Paton C, Barnes TR, Cavanagh MR, High-dose and combination antipsychotic prescribing in acute adult wards in the UK: the challenges posed by p.r.n. prescribing. Br J Psychiatry 2008;192:435-9
  • Johnson D. UK: neuroleptic relapse prevention. In: Kissling W, editor, Guidelines for neuroleptic relapse prevention in schizophrenia. Springer, Berlin; 1991. p. 45-6
  • Fleischhacker WW. The current status of maitenance treatment in schizophrenia. In: Kissling W, editor, Guidelines for neuroleptic relapse prevention in schizophrenia. Springer, Berlin; 1991. p. 13-5
  • West JC, Wilk JE, Olfson M, Patterns and quality of treatment for patients with schizophrenia in routine psychiatric practice. Psychiatr Serv 2005;56:283-91
  • Covell NH, Jackson CT, Evans AC, Essock SM. Antipsychotic prescribing practices in Connecticut's public mental health system: rates of changing medications and prescribing styles. Schizophr Bull 2002;28:17-29
  • Lehman AF, Steinwachs DM. Patterns of usual care for schizophrenia: initial results from the Schizophrenia Patient Outcomes Research Team (PORT) Client Survey. Schizophr Bull 1998;24:11-20; discussion 20-32
  • Callaly T, Trauer T. Patterns of use of antipsychotic medication in a regional community mental health service. Australas Psychiatry 2000;8:220-4
  • Paton C, Lelliott P, Harrington M, Patterns of antipsychotic and anticholinergic prescribing for hospital inpatients. J Psychopharmacol 2003;17:223-9
  • Kane J, Garcia-Ribera C. clinical guideline recommendations for antipsychotic long-acting injections. Br J Psychiatry 2009;195:S63-7
  • Glazer WM. The depot paradox. Behav Healthc 2007;27:44-6
  • NICE (National Institute for Health and Clinical Excellence). Schizophrenia: Full National Clinical Guideline on Core Interventions in Primary and Secondary Care. London: Gaskell/British Psychological Society; 2003
  • Canadian Psychiatric Association. Clinical practice guidelines: treatment of schizophrenia. Can J Psychiatry 2005;50:7-56S
  • Lieberman JA, Perkins D, Belger A, The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches. Biol Psychiatry 2001;50:884-97
  • Patel MX, De Zoysa N, Bernadt M, David A. Depot and oral antipsychotics: patient preferences and attitudes are not the same thing. J Psychopharmacol 2009;23:789-96
  • Patel MX, De Zoysa N, Baker D, David AS. Antipsychotic depot medication and attitudes of community psychiatric nurses. J Psychiatr Ment Health Nurs 2005;12:237-44
  • Glover G, Malcolm G. The prevalence of depot neuroleptic treatment among West Indians and Asians in the London borough of Newham. Soc Psychiatry Psychiatr Epidemiol 1988;23:281-4
  • Price N, Glazer W, Morgenstern H. Demographic predictors of the use of injectable versus oral antipsychotic medications in outpatients. Am J Psychiatry 1985;142:1491-2
  • Cournos F, Mckinnon K, Stanley B. Outcome of involuntary medication in a state hospital system. Am J Psychiatry 1991;148:489-94
  • Walburn J, Gray R, Gournay K, Systematic review of patient and nurse attitudes to depot antipsychotic medication. Br J Psychiatry 2001;179:300-7
  • Waddell L, Taylor M. Attitudes of patients and mental health staff to antipsychotic long-acting injections: systematic review. Br J Psychiatry 2009;195:S43-50
  • Heres S, Schmitz FS, Leucht S, Pajonk FG. The attitude of patients towards antipsychotic depot treatment. Int Clin Psychopharmacol 2007;22:275-82
  • Glazer WM. Depot fluphenazine: risk/benefit ratio. J Clin Psychiatry 1984;45:28-35
  • Marder SR, Van Putten T, Mintz J, Costs and benefits of two doses of fluphenazine. Arch Gen Psychiatry 1984;41:1025-9
  • Patel M, De Zoysa N, Bernadt M, Are depot antipsychotics more coercive than tablets? J Psychopharmacol 2009. [Epub ahead of print]
  • Pereira S, Pinto R. A survey of the attitudes of chronic psychiatric patients living in the community toward their medication. Acta Psychiatr Scand 1997;95:464-8
  • Svedberg B, Backenroth-Ohsako G, Lutzen K. On the path to recovery: patients' experiences of treatment with long-acting injections of antipsychotic medication. Int J Ment Health Nurs 2003;12:110-18
  • Wistedt B. How does the psychiatric patient feel about depot treatment, compulsion or help? Nord J Psychiatry 1995;49:41-6
  • Lieberman JA, Sheitman B, Chakos M, The development of treatment resistance in patients with schizophrenia: a clinical and pathophysiologic perspective. J Clin Psychopharmacol 1998;18:20S-24S
  • Olfson M, Mechanic D, Hansell S, Prediction of homelessness within three months of discharge among inpatients with schizophrenia. Psychiatr Serv 1999;50:667-3
  • Sokal J, Messias E, Dickerson FB, Comorbidity of medical illnesses among adults with serious mental illness who are receiving community psychiatric services. J Nerv Ment Dis 2004;192:421-7
  • Edwards J, Maude D, Herrmann-Doig T, A service response to prolonged recovery in early psychosis. Psychiatr Serv 2002;53:1067-9
  • Kasper S. First-episode schizophrenia: the importance of early intervention and subjective tolerability. J Clin Psychiatry 1999;60(Suppl 23):5-9
  • Kane JM. Review of treatments that can ameliorate nonadherence in patients with schizophrenia. J Clin Psychiatry 2006;67(Suppl 5):9-14
  • Kim B, Lee SH, Choi TK, Effectiveness of risperidone long-acting injection in first-episode schizophrenia: in naturalistic setting. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1231-5
  • Emsley R, Oosthuizen P, Koen L, Remission in patients with first-episode schizophrenia receiving assured antipsychotic medication: a study with risperidone long-acting injection. Int Clin Psychopharmacol 2008;23:325-31
  • Weiden PJ, Schooler NR, Weedon JC, A randomized controlled trial of long-acting injectable risperidone vs continuation on oral atypical antipsychotics for first-episode schizophrenia patients: initial adherence outcome. J Clin Psychiatry 2009;70:1397-406
  • Davis JM, Chen N. Choice of maintenance medication for schizophrenia. J Clin Psychiatry 2003;64(Suppl 16):24-33
  • Adil S, Virani Kzb-B, Jeffries JJ, editors. Clinical handbook of psychotropic drugs. 18th revised edition. Hogrefe & Huber, Ohio; 2009
  • Reynolds JEF. Martindale the extra pharmacopoeia: Anxiolytic Sedatives Hypnotics and Neuroleptics. 30th edition. Pharmaceutical Press, London; 1993
  • Dencker SJ, Malm U, Jorgensen A, Overo KF. Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. IV. Serum levels and clinical outcome. Acta Psychiatr Scand 1980;279(Suppl):55-63
  • Curry SH, Whelpton R, De Schepper PJ, Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man. Br J Clin Pharmacol 1979;7:325-31
  • Beresford R, Ward A. Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis. Drugs 1987;33:31-49
  • Larsson M, Axelsson R, Forsman A. On the pharmacokinetics of perphenazine: a clinical study of perphenazine enanthate and decanoate. Curr Ther Res 1984;36:1071-88
  • Aaes-Jorgensen T. Pharmacokinetics of three different injectable zuclopenthixol preparations. Prog Neuropsychopharmacol Biol Psychiatry 1989;13:77-85
  • Gopal S, Gassmann-Mayer C, Palumbo J, Practical guidance for dosing and switching paliperidone palmitate treatment in patients with schizophrenia. Curr Med Res Opin 2010;26:377-87
  • Samtani MN, Vermeulen A, Stuyckens K. Population pharmacokinetics of intramuscular paliperidone palmitate in patients with Schizophrenia: a novel once-monthly, long-acting formulation of an atypical antipsychotic. Clin Pharmacokinet 2009;48:585-600

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