Testosterone undecanoate in the treatment of male hypogonadism

Bibliography

• Plymate SR. Hypogonadism in men: an overiew. In: Bagatell CJ, Bremner WJ, editors, Androgens in health and disease. Humana Press, New Jersey; 2003. p. 23-44
   Google Scholar
• Basaria S, Dobs AS. Hypogonadism and androgen replacement therapy in elderly men. Am J Med 2001;110(7):563-72
   PubMedGoogle Scholar
• Schubert M, Minnemann T, Hubler D, Intramuscular testosterone undecanoate: pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism. J Clin Endocrinol Metab 2004;89(11):5429-34
   PubMedGoogle Scholar
• Herz JE, Torres JV, Murillo A, Potential long-acting contraceptive agents: esters and ethers of testosterone with alpha- and/or beta-chain branching. Steroids 1985;46(6):947-53
   PubMedGoogle Scholar
• Behre HM, Handelsman DJ, Nieschlag E. Pharmacology of testosterone preparations. In: Nieschlag E, Behre HM, editors, Cambridge University Press, Cambridge; 2004. p. 405-44
   Google Scholar
• EPG Health Media, Bayer Schering Pharma. Nebido® Testosterone Therapy. 2009; 2009(12/1):10. Available from: http://www.epgonline.org/mens-health/treatment/initiating-treatment/ nebido-testosterone-therapy.cfm [Accessed 10 January 2009]
   Google Scholar
• Harman SM, Metter EJ, Tobin JD, ; Baltimore Longitudinal Study of Aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001;86(2):724-31
   PubMedGoogle Scholar
• Gooren LJ, Bunck MC. Androgen replacement therapy: present and future. Drugs 2004;64(17):1861-91
   PubMedGoogle Scholar
• Bremner WJ, Vitiello MV, Prinz PN. Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 1983;56(6):1278-81
   PubMedGoogle Scholar
• Plymate SR, Tenover JS, Bremner WJ. Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men. J Androl 1989;10(5):366-71
   PubMedGoogle Scholar
• Diver MJ, Imtiaz KE, Ahmad AM, Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle-aged men compared with those in young men. Clin Endocrinol (Oxf) 2003;58(6):710-7
   PubMedGoogle Scholar
• Winters SJ, Clark BJ. Testosterone synthesis, transport, and metabolism. In: Bagatell CJ, Bremner WJ, editors, Androgens in health and disease. Humana Press, New Jersey; 2003. p. 23-44
   Google Scholar
• Behre HM, Abshagen K, Oettel M, Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies. Eur J Endocrinol 1999;140(5):414-9
   PubMedGoogle Scholar
• Nieschlag E, Buchter D, Von Eckardstein S, Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men. Clin Endocrinol (Oxf) 1999;51(6):757-63
   PubMedGoogle Scholar
• von Eckardstein S, Nieschlag E. Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: a phase II study. J Androl 2002;23(3):419-25
   PubMedGoogle Scholar
• Dobs AS, Meikle AW, Arver S, Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men. J Clin Endocrinol Metab 1999;84(10):3469-78
   PubMedGoogle Scholar
• Swerdloff RS, Wang C, Cunningham G, Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. J Clin Endocrinol Metab 2000;85(12):4500-10
   PubMedGoogle Scholar
• Zitzmann MN. Long-term experience of more than 8 years with a novel formulation of testosterone undecanoate (Nebido) in substitution therapy of hypogonadal men ‘aging male’. 5th World Conference on the Aging Male, 9 – 12 February 2006, Salzburg, Austria. Available from: http://www.agingmale2006.com/transcripts/transcript_sag_nebido_hypogonadal_men.asp
   Google Scholar
• Morales A, Nieschlag E, Schubert M, Clinical experience with the new long-acting injectable testosterone undecanoate. Report on the educational symposium on the occasion of the 5th World Congress on the Aging Male, 9 – 12 February 2006, Salzburg, Austria. Aging Male 2006;9(4):221-7
   PubMedGoogle Scholar
• Jacobeit JW, Schulte HM. Long-acting intramuscular testosterone undecanoate (TU, Nebido®) in treatment of aging males with hypogonadism. 8th European Congress of Endocrinology, Glasgow, 1 – 5 April 2006, Poster No. P184
   Google Scholar
• Morgentaler A, Dobs AS, Kaufman JM, Long acting testosterone undecanoate therapy in men with hypogonadism: results of a pharmacokinetic clinical study. J Urol 2008;180(6):2307-13
   PubMedGoogle Scholar
• Gooren LJ, Saad F, Haide A, Yassin A. Decline of plasma 5alpha-dihydrotestosterone (DHT) levels upon testosterone administration to elderly men with subnormal plasma testosterone and high DHT levels. Andrologia 2008;40(5):298-302
   PubMedGoogle Scholar
• Page ST, Amory JK, Bowman FD, Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 2005;90(3):1502-10
   PubMedGoogle Scholar
• Saad F, Kamischke A, Yassin A, More than eight years' hands-on experience with the novel long-acting parenteral testosterone undecanoate. Asian J Androl 2007;9(3):291-7
   PubMedGoogle Scholar
• Harle L, Basaria S, Dobs AS. Nebido: a long-acting injectable testosterone for the treatment of male hypogonadism. Expert Opin Pharmacother 2005;6(10):1751-9
   PubMedGoogle Scholar
• Minnemann T, Schubert M, Freude S, Comparison of a new long-acting testosterone undecanoate formulation vs testosterone enanthate for intramuscular androgen therapy in male hypogonadism. J Endocrinol Invest 2008;31(8):718-23
   PubMedGoogle Scholar
• Jockenhovel F, Minnemann T, Schubert M, Comparison of long-acting testosterone undecanoate formulation versus testosterone enanthate on sexual function and mood in hypogonadal men. Eur J Endocrinol 2009;160(5):815-9
   PubMedGoogle Scholar
• Minnemann T, Schubert M, Hubler D, A four-year efficacy and safety study of the long-acting parenteral testosterone undecanoate. Aging Male 2007;10(3):155-8
   PubMedGoogle Scholar
• Saad F, Gooren LJ, Haider A, Yassin A. A dose-response study of testosterone on sexual dysfunction and features of the metabolic syndrome using testosterone gel and parenteral testosterone undecanoate. J Androl 2008;29(1):102-5
   PubMedGoogle Scholar
• Gooren LJ, Saad F. Recent insights into androgen action on the anatomical and physiological substrate of penile erection. Asian J Androl 2006;8(1):3-9
   PubMedGoogle Scholar
• Traish AM, Guay AT. Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence. J Sex Med 2006;3(3):382-404, discussion 404-7
   PubMedGoogle Scholar
• Yassin AA, Saad F. Dramatic improvement of penile venous leakage upon testosterone administration. A case report and review of literature. Andrologia 2006;38(1):34-7
   PubMedGoogle Scholar
• Yassin AA, Saad F, Traish A. Testosterone undecanoate restores erectile function in a subset of patients with venous leakage: a series of case reports. J Sex Med 2006;3(4):727-35
   PubMedGoogle Scholar
• Sartorius G, Fennell C, Spasevska S, Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate. Asian J Androl 2010;12(2):227-33
   PubMedGoogle Scholar
• Nieschlag E, Swerdloff R, Behre HM, Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. Int J Androl 2005;28(3):125-7
   PubMedGoogle Scholar
• Amory JK, Watts NB, Easley KA, Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone. J Clin Endocrinol Metab 2004;89(2):503-10
   PubMedGoogle Scholar
• Jockenhovel F, Vogel E, Reinhardt W, Reinwein D. Effects of various modes of androgen substitution therapy on erythropoiesis. Eur J Med Res 1997;2(7):293-8
   PubMedGoogle Scholar