Intravenous acetylcysteine for the treatment of acetaminophen overdose

Bibliography

• Bronstein AC, Spyker DA, Cantilena LR, 2008 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS). 26th annual report. Clin Toxicol 2009;47:911-1084
   PubMed Web of Science ®Google Scholar
• Larson AM, Polson J, Fontana RJ, Acetaminophen-induced acute liver failure: results of a United States multicenter prospective study. Hepatology 2005;42:1364-72
   PubMed Web of Science ®Google Scholar
• Mour G, Feinfeld DA, Caraccio T, Acute renal dysfunction in acetaminophen poisoning. Ren Fail 2005;27:381-3
   PubMed Web of Science ®Google Scholar
• Larson A. Acetaminophen hepatotoxicity. Clin Liver Dis 2007;11:525-48
   PubMedGoogle Scholar
• James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 2003;31:1499-506
   PubMed Web of Science ®Google Scholar
• Mitchell JR, Jollow DJ, Potter WZ, Acetaminophen-induced hepatic necrosis. I. Role of glutathione. J Pharmacol Exp Ther 1973;187:211-17
   PubMed Web of Science ®Google Scholar
• Dart RC, Erdman AR, Olson KR, Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol 2006;44:1-18
   Web of Science ®Google Scholar
• Food and Drug Administration. Intravenous N-acetylcysteine package insert. Available from: http://www.fda.gov/cder/foi/label/2004/21539_N-acetylcysteine_lbl.pdf [Last accessed 22 August 2010]
   Google Scholar
• Jones AL. Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: a critical review. J Toxicol Clin Toxicol 1998;36:277-85
   PubMed Web of Science ®Google Scholar
• Corcoran GB, Racz WJ, Smith CV, Effects of N-acetycysteine on acetaminophen covalent binding and hepatic necrosis in mice. J Pharmacol Exp Ther 1985:232(3):857-63
   PubMedGoogle Scholar
• Hjelle JJ, Brzeznicka EA, Klaassen CD. Comparison of the effects of sodium sulfate and N-acetylcysteine on the hepatotoxicity of acetaminophen in mice. J Pharmacol Exp Ther 1986;236:526-34
   PubMed Web of Science ®Google Scholar
• Keays R, Harrison PM, Wendon JA, Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. Br Med J 1991;303:1026-9
   PubMed Web of Science ®Google Scholar
• Harrison PM, Wendon JA, Gimson AE, Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 1991;324:1852-7
   PubMed Web of Science ®Google Scholar
• Borgstrom I, Kagedal B, Paulsen O. Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol 1986;31:217-22
   PubMed Web of Science ®Google Scholar
• Olsson B, Johansson M, Gabreilsson J, Bolme P. Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol 1998;34:77-82
   Google Scholar
• Prescott LF, Donovan JW, Jarvie DR, The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol 1989;37:501-6
   PubMed Web of Science ®Google Scholar
• Rumack BH, Peterson RC, Koch GG, Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 1981;141:380-5
   PubMed Web of Science ®Google Scholar
• Prescott LF, Illingsworth RN, Critchley JAJH, Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. Br Med J 1979;2:1097-100
   PubMed Web of Science ®Google Scholar
• Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the National Multicenter Study (1976 – 1985). N Engl J Med 1988;319:1557-62
   PubMed Web of Science ®Google Scholar
• Brok J, Buckley N, Gluud C. Interventions for paracetamol (acetaminophen) overdose [Review]. Cochrane Database Syst Rev 2006;2:CD003328
   Google Scholar
• Smilkstein MJ, Bronstein AC, Linden C, Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med 1991;20:1058-63
   PubMed Web of Science ®Google Scholar
• Kobrinsky NL, Hartfield D, Horner H, Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue. Cancer Invest 1996;14:202-10
   PubMed Web of Science ®Google Scholar
• Buckley NA, Whyte IM, O'Connell DL, Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? J Toxicol Clin Toxicol 1999;37:759-67
   PubMed Web of Science ®Google Scholar
• Kerr F, Dawson A, Whyte IM, The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of Nacetylcysteine. Ann Emerg Med 2005;45:402-8
   PubMed Web of Science ®Google Scholar
• Whyte IM, Francis B, Dawson AH. Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database. Curr Med Res Opin 2007;23:2359-68
   PubMed Web of Science ®Google Scholar
• Doyon S, Klein-Schwartz W. Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Acad Emerg Med 2009;16:34-9
   PubMed Web of Science ®Google Scholar
• Perry HE, Shannon MW. Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial. J Pediatr 1998;132:149-52
   PubMed Web of Science ®Google Scholar
• Dawson AH, Henry DA, McEwan J. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. Med J Aust 1989;150:329-31
   PubMed Web of Science ®Google Scholar
• Prescott LF, Park J, Ballantyne A, Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet 1977;2:432-4
   PubMed Web of Science ®Google Scholar
• Schwartz EA, Hayes BD, Sarmiento KF. Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. Ann Emerg Med 2009;54:421-3
   PubMed Web of Science ®Google Scholar
• Smith SW, Howland MA, Hoffman RS, Nelson LS. Altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy. Ann Pharmacother 2008;42:1333-9
   PubMed Web of Science ®Google Scholar
• Kleinschmidt K, Prueitt R, Shehadeh S. Delayed time to peak acetaminophen and death despite early treatment in a massive Tylenol PM exposure [abstract]. Clin Toxicol 2010;48:611
   Google Scholar
• Dolcourt BA, Morrone WR, Smolinske S. Acetaminophen induced hepatotoxicity despite early individualized treatment [abstract]. Clin Toxicol 2008;46:638
   Google Scholar
• Hendrickson RG, McKeown NJ, West P, Burke CR. Bactrian (‘double hump’) acetaminophen pharmacokinetics: a case series and review of the literature. J Med Toxicol 2010;6:337-44
   PubMedGoogle Scholar
• Levine M, Ruha A-M. Massive acetaminophen ingestion resulting in hepatic injury despite early use of N-Acetylcysteine [abstract]. Clin Toxicol 2010;48:656
   Google Scholar
• Parker D, White JP, Paton D, Safey of late acetylcysteine treatment in paracetamol poisoning. Hum Exp Toxicol 1990;9:25-7
   PubMed Web of Science ®Google Scholar
• Zyoud SH, Awang R, Syed Sulaiman SA, Al-Jabi SW. An analysis of the length of hospital stay after acetaminophen overdose. Hum Exp Toxicol 14 July 2010. [Epub ahead of print]
   Google Scholar
• Offerman SR. The clinical management of acetaminophen poisoning in a community hospital system: factors associated with hospital length of stay. J Med Toxicol 21 September 2010. [Epub ahead of print]
   Google Scholar
• Harrison PM, Keays R, Bray GP, Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine. Lancet 1990;335:1572-3
   PubMed Web of Science ®Google Scholar
• Heard KJ. Acetylcysteine for acetaminophen poisoning. N Engl J Med 2008;359:285-92
   PubMed Web of Science ®Google Scholar
• Daly FF, O'Malley GF, Heard K, Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion. Ann Emerg Med 2004;44:393-8
   PubMed Web of Science ®Google Scholar
• Yarema MC, Johnson DW, Berlin RJ, Comparison of the 20-hour intravenous and 72-hour oral Acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Ann Emerg Med 2009;54:606-14
   PubMed Web of Science ®Google Scholar
• Waring WS, Stephen AF, Robinson OD, Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose. Clin Toxicol 2008;46:496-500
   PubMed Web of Science ®Google Scholar
• Bebarta VS, Kao L, Froberg B, A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose. Clin Toxicol 2010;48:424-30
   PubMed Web of Science ®Google Scholar
• Pakravan N, Waring WS, Sharma S, Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose. Clin Toxicol 2008;46:697-702
   PubMed Web of Science ®Google Scholar
• Zyoud SH, Awang R, Sulaiman SA, Relationship between serum acetaminophen concentration and N-acetylcysteine-induced adverse drug reactions. Basic Clin Pharmacol Toxicol 2010;107:718-23
   PubMed Web of Science ®Google Scholar
• Zyoud SH, Awang R, Sulaiman SA, Effects of delay in infusion of N-acetylcysteine on appearance of adverse drug reactions after acetaminophen overdose: a retrospective study. Pharmacoepidemiol Drug Saf 2010;19:1064-70
   PubMedGoogle Scholar
• Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med 1998;31:710-15
   PubMed Web of Science ®Google Scholar
• Hayes BD, Klein-Schwartz W, Doyon S. Frequency of medication errors with intravenous Acetylcysteine for acetaminophen overdose. Ann Pharmacother 2008;42:766-70
   PubMed Web of Science ®Google Scholar
• Ferner RE, Langford NJ, Anton C, Random and systematic medication errors in routine clinical practice: a multicentre study of infusions, using acetylcysteine as an example. Br J Clin Pharmacol 2001;52:573-7
   PubMed Web of Science ®Google Scholar
• Mant TG, Tempowski JH, Volans GN, Talbot JCC. Adverse reactions to acetylcysteine and effects of overdose. Br Med J 1984;289:217-19
   PubMed Web of Science ®Google Scholar
• Anon. Death after N-acetylcysteine (New and Notes). Lancet 1984;1:1421
   Google Scholar
• Sung L, Simons JA, Dayneka NL. Dilution of intravenous N-acetylcysteine as a cause of hyponatremia. Pediatric 1997;100:389-91
   PubMedGoogle Scholar
• Hershkowitz E, Shorer Z, Levitas A, Tal A. Status epilepticus following intravenous N-acetylcysteine therapy. Isr J Med Sci 1996;32:1102-4
   PubMedGoogle Scholar
• Bailey B, Blais R, Letarte A. Status epilepticus after massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death. Ann Emerg Med 2004;44:401-6
   PubMed Web of Science ®Google Scholar
• Johnston RE, Hawkins HC, Weikel JH. The toxicity of N-acetylcysteine in laboratory animals. Semin Oncol 1983;10:17-24
   PubMed Web of Science ®Google Scholar
• Selvan VA, Calvert SHS, Cavell G, Weight-based N-acetylcysteine dosing chart to minimize the risk of calculation errors in prescribing and preparing N-acetylcysteine infusions for adults presenting with paracetamol overdose in the emergency department. Emerg Med J 2007;24:482-4
   PubMed Web of Science ®Google Scholar
• Thompson TM, Lu JJ, Blackwood L, Computerized N-acetylcysteine physician order entry by template protocol for acetaminophen toxicity. Am J Ther 9 June 2010. [Epub ahead of print]
   Google Scholar
• Zolnierz M, Sesin P, Motha R. Comment: Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose. Ann Pharmacother 2009;43:152
   PubMedGoogle Scholar
• Mullins ME, Dribben WH, Halcomb SE, Comment: Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose. Ann Pharmacother 2008;42:1914-15
   PubMed Web of Science ®Google Scholar
• Clinical Practic Guidelines. Paracetamol poisoning. The Royal Children's Hospital Melbourne. Available from: http://www.rch.org.au/clinicalguide/cpg.cfm?doc_id=5436 [Last accessed 26 October 2010]
   Google Scholar
• Rumack BH, Peterson RG. Acetaminophen overdose: incidence, diagnosis and management in 416 patients. Pediatrics 1978;62(Suppl):898-903
   PubMedGoogle Scholar
• Nelson LS, Lewin NA, Howland MA, (editors). Goldfrank's toxicologic emergencies. 9th edition. McGraw-Hill, New York, NY; 2011
   Google Scholar