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Managing the combination of nonalcoholic fatty liver disease and metabolic syndrome

, MD, , MD, , MD & , MD
Pages 2657-2672 | Published online: 01 Nov 2011

Bibliography

  • Grundy SM, Cleeman JI, Daniels SR, Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735-52
  • Alberti KG, Zimmet P, Shaw J. The metabolic syndrome – a new worldwide definition. Lancet 2005;366:1059-62
  • Alberti KG, Eckel RH, Grundy SM, Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation task force on epidemiology and prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009;120:1640-5
  • Kotronen A, Westerbacka J, Bergholm R, Liver fat in the metabolic syndrome. J Clin Endocrinol Metab 2007;92:3490-7
  • Marchesini G, Brizi M, Bianchi G, Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001;50:1844-50
  • Targher G, Marra F, Marchesini G. Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia 2008;51:1947-53
  • Hamaguchi M, Kojima T, Takeda N, The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005;143:722-8
  • Oh SY, Cho YK, Kang MS, The association between increased alanine aminotransferase activity and metabolic factors in nonalcoholic fatty liver disease. Metabolism 2006;55:1604-9
  • Suzuki A, Angulo P, Lymp J, Chronological development of elevated aminotransferases in a nonalcoholic population. Hepatology 2005;41:64-71
  • Liangpunsakul S, Chalasani N. Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the third National Health and Nutrition Survey (NHANES III). Am J Med Sci 2005;329:111-16
  • Marchesini G, Bugianesi E, Forlani G, Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003;37:917-23
  • Fracanzani AL, Valenti L, Bugianesi E, Risk of severe liver disease in NAFLD with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology 2008;48:792-8
  • McMillan KP, Kuk JL, Church TS, Independent associations between liver fat, visceral adipose tissue, and metabolic risk factors in men. Appl Physiol Nutr Metab 2007;32:265-72
  • Day CP, James OFW. Steatohepatitis: a tale of two 'hits'. Gastroenterology 1998;114:842-5
  • Bugianesi E, Manzini P, D'Antico S, Relative contribution of iron burden, HFE mutations and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology 2004;39:179-87
  • Kelley DE, McKolanis TM, Hegazi RA, Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance. Am J Physiol Endocrinol Metab 2003;285:E906-16
  • Fassio E, Alvarez E, Dominguez N, Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 2004;40:820-6
  • Yamaguchi K, Yang L, McCall S, Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007;45:1366-74
  • Wadden TA, Butryn ML, Wilson C. Lifestyle modification for the management of obesity. Gastroenterology 2007;132:2226-38
  • Wing RR; for the Look AHEAD Research Group. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med 2010;170:1566-75
  • Phelan S, Wadden TA, Berkowitz RI, Impact of weight loss on the metabolic syndrome. Int J Obes (Lond) 2007;31:1442-8
  • Case CC, Jones PH, Nelson K, Impact of weight loss on the metabolic syndrome. Diabetes Obes Metab 2002;4:407-14
  • Muzio F, Mondazzi L, Sommariva D, Long-term effects of low-calorie diet on the metabolic syndrome in obese nondiabetic patients. Diabetes Care 2005;28:1485-6
  • Tuomilehto J, Lindstrom J, Eriksson JG, Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-50
  • Orchard TJ, Temprosa M, Goldberg R, The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial. Ann Intern Med 2005;142:611-19
  • Wing RR, Lang W, Wadden TA, Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care 2011;34:1481-6
  • Writing group of the PREMIER Collaborative Research Group. Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA 2003;289:2083-93
  • Romeo S, Kozlitina J, Xing C, Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008;40:1461-5
  • Huang MA, Greenson JK, Chao C, One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study. Am J Gastroenterol 2005;100:1072-81
  • Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology 2009;49:306-17
  • Suzuki A, Lindor K, St Sauver J, Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 2005;43:1060-6
  • Hickman IE, Jonsson JR, Prins JB, Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life. Gut 2004;53:413-19
  • Promrat K, Kleiner DE, Niemeier HM, Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010;51:121-9
  • Moscatiello S, Di Luzio R, Bugianesi E, Cognitive-behavioral treatment of non-alcoholic fatty liver disease: a propensity score-adjusted observational study. Obesity (Silver Spring) 2011;19:763-70
  • Esposito K, Pontillo A, Di Palo C, Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 2003;289:1799-804
  • Rector RS, Warner SO, Liu Y, Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome. Am J Physiol Endocrinol Metab 2007;293:E500-6
  • Tortosa A, Bes-Rastrollo M, Sanchez-Villegas A, Mediterranean diet inversely associated with the incidence of metabolic syndrome: the SUN prospective cohort. Diabetes Care 2007;30:2957-9
  • Lien LF, Brown AJ, Ard JD, Effects of PREMIER lifestyle modifications on participants with and without the metabolic syndrome. Hypertension 2007;50:609-16
  • Zivkovic AM, German JB, Sanyal AJ. Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. Am J Clin Nutr 2007;86:285-300
  • Ryan MC, Abbasi F, Lamendola C, Serum alanine aminotransferase levels decrease further with carbohydrate than fat restriction in insulin-resistant adults. Diabetes Care 2007;30:1075-80
  • Ouyang X, Cirillo P, Sautin Y, Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol 2008;48:993-9
  • Le KA, Tappy L, D'Alessio DA. Mitochondrial dysfunction and insulin resistance: a matter of lifestyle? Curr Opin Clin Nutr Metab Care 2007;10:494-7
  • Johnson JL, Slentz CA, Houmard JA, Exercise training amount and intensity effects on metabolic syndrome (from Studies of a Targeted Risk Reduction Intervention through Defined Exercise). Am J Cardiol 2007;100:1759-66
  • Katzmarzyk PT, Herman KM. The role of physical activity and fitness in the prevention and treatment of metabolic syndrome. Curr Cardiovasc Risk Rep 2007;1:228-36
  • Johnson NA, Sachinwalla T, Walton DW, Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology 2009;50:1105-12
  • St George A, Bauman A, Johnston A, Independent effects of physical activity in patients with nonalcoholic fatty liver disease. Hepatology 2009;50:68-76
  • Buchwald H, Avidor Y, Braunwald E, Bariatric surgery: a systematic review and meta-analysis. JAMA 2004;292:1724-37
  • Meijer RI, van Wagensveld BA, Siegert CE, Bariatric surgery as a novel treatment for type 2 diabetes mellitus: a systematic review. Arch Surg 2011;146:744-50
  • Bray GA, Ryan DH. Drug treatment of the overweight patient. Gastroenterology 2007;132:2239-52
  • Torgerson JS, Hauptman J, Boldrin MN, XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care 2004;27:155-61
  • Assy N, Hussein O, Abassi Z. Weight loss induced by orlistat reverses fatty infiltration and improves hepatic fibrosis in obese patients with non-alcoholic steatohepatitis. Gut 2007;56:443-4
  • Harrison SA, Fecht W, Brunt EM, Orlistat for overweight subjects with nonalcoholic steatohepatitis: a randomized, prospective trial. Hepatology 2009;49:80-6
  • Sabuncu T, Nazligul Y, Karaoglanoglu M, The effects of sibutramine and orlistat on the ultrasonographic findings, insulin resistance and liver enzyme levels in obese patients with non-alcoholic steatohepatitis. Rom J Gastroenterol 2003;12:189-92
  • Wadden TA, Berkowitz RI, Womble LG, Randomized trial of lifestyle modification and pharmacotherapy for obesity. N Engl J Med 2005;353:2111-20
  • Torp-Pedersen C, Caterson I, Coutinho W, Cardiovascular responses to weight management and sibutramine in high-risk subjects: an analysis from the SCOUT trial. Eur Heart J 2007;28:2915-23
  • Despres JP, Golay A, Sjostrom L. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 2005;353:2121-34
  • Despres JP, Ross R, Boka G, Effect of rimonabant on the high-triglyceride/low-HDL-cholesterol dyslipidemia, intraabdominal adiposity, and liver fat: the ADAGIO-Lipids trial. Arterioscler Thromb Vasc Biol 2009;29:416-23
  • Bugianesi E, Gentilcore E, Manini R, A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 2005;100:1082-90
  • DeFronzo RA, Tripathy D, Schwenke DC, Pioglitazone for diabetes prevention in impaired glucose tolerance. N Engl J Med 2011;364:1104-15
  • Xiang AH, Peters RK, Kjos SL, Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes. Diabetes 2006;55:517-22
  • Dormandy JA, Charbonnel B, Eckland DJ, Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005;366:1279-89
  • Promrat K, Lutchman G, Uwaifo GI, A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology 2004;39:188-96
  • Belfort R, Harrison SA, Brown K, A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006;355:2297-307
  • Aithal GP, Thomas JA, Kaye PV, Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology 2008;135:1176-84
  • Sanyal AJ, Chalasani N, Kowdley KV, Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010;362:1675-85
  • Lewis JD, Ferrara A, Peng T, Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study. Diabetes Care 2011;34:916-22
  • Piccinni C, Motola D, Marchesini G, Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting. Diabetes Care 2011;34:1369-71
  • Beydoun MA, Shroff MR, Chen X, Serum antioxidant status is associated with metabolic syndrome among U.S. adults in recent national surveys. J Nutr 2011;141:903-13
  • Younossi ZM, Stepanova M, Rafiq N, Pathologic criteria for nonalcoholic steatohepatitis: interprotocol agreement and ability to predict liver-related mortality. Hepatology 2011;53:1874-82
  • Madan K, Batra Y, Gupta DS, Vitamin E-based therapy is effective in ameliorating transaminasemia in nonalcoholic fatty liver disease. Indian J Gastroenterol 2005;24:251-5
  • Dufour JF, Oneta CM, Gonvers JJ, Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin E in nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2006;4:1537-43
  • Balmer ML, Siegrist K, Zimmermann A, Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis. Liver Int 2009;29:1184-8
  • Bjelakovic G, Nikolova D, Gluud LL, Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2008;CD007176
  • Rosenstock J, Klaff LJ, Schwartz S, Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes. Diabetes Care 2010;33:1173-5
  • Astrup A, Rossner S, Van Gaal L, Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 2009;374:1606-16
  • Gonzalez-Ortiz M, Martinez-Abundis E, Robles-Cervantes JA, Effect of exenatide on fat deposition and a metabolic profile in patients with metabolic syndrome. Metab Syndr Relat Disord 2011;9:31-4
  • Klonoff DC, Buse JB, Nielsen LL, Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin 2008;24:275-86
  • Tushuizen ME, Bunck MC, Pouwels PJ, Incretin mimetics as a novel therapeutic option for hepatic steatosis. Liver Int 2006;26:1015-17
  • Yilmaz Y, Atug O, Yonal O, Dipeptidyl peptidase IV inhibitors: therapeutic potential in nonalcoholic fatty liver disease. Med Sci Monit 2009;15:HY1-5
  • Balaban YH, Korkusuz P, Simsek H, Dipeptidyl peptidase IV (DDP IV) in NASH patients. Ann Hepatol 2007;6:242-50
  • Cariou B. The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis. Diabetes Metab 2008;34:685-91
  • Zhang S, Wang J, Liu Q, Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. J Hepatol 2009;51:380-8
  • Ma K, Saha PK, Chan L, Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 2006;116:1102-9
  • Modica S, Gadaleta RM, Moschetta A. Deciphering the nuclear bile acid receptor FXR paradigm. Nucl Recept Signal 2010;8:e005
  • Alvarez JA, Ashraf A. Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol 2010; 2010:351385
  • Mattila C, Knekt P, Mannisto S, Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care 2007;30:2569-70
  • Chiu KC, Chu A, Go VL, Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004;79:820-5
  • Forouhi NG, Luan J, Cooper A, Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990 – 2000. Diabetes 2008;57:2619-25
  • Pittas AG, Lau J, Hu FB, The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007;92:2017-29
  • Targher G, Bertolini L, Scala L, Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 2007;17:517-24
  • Yin J, Zhang H, Ye J. Traditional chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets 2008;8:99-111
  • Vuddanda PR, Chakraborty S, Singh S. Berberine: a potential phytochemical with multispectrum therapeutic activities. Expert Opin Investig Drugs 2010;19:1297-307
  • Balk EM, Tatsioni A, Lichtenstein AH, Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes Care 2007;30:2154-63
  • Suliburska J, Bogdanski P, Pupek-Musialik D, Dietary intake and serum and hair concentrations of minerals and their relationship with serum lipids and glucose levels in hypertensive and obese patients with insulin resistance. Biol Trace Elem Res 2011;139:137-50
  • Obeid O, Elfakhani M, Hlais S, Plasma copper, zinc, and selenium levels and correlates with metabolic syndrome components of lebanese adults. Biol Trace Elem Res 2008;123:58-65
  • Wijesekara N, Chimienti F, Wheeler MB. Zinc, a regulator of islet function and glucose homeostasis. Diabetes Obes Metab 2009;11(Suppl 4):202-14
  • Li R, Zhang P, Barker LE, Cost-effectiveness of interventions to prevent and control diabetes mellitus: a systematic review. Diabetes Care 2010;33:1872-94
  • Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 2010;363:1341-50
  • Ratziu V, Bellentani S, Cortez-Pinto H, A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol 2010;53:372-84
  • Stepanova M, Rafiq N, Younossi ZM. Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study. Gut 2010;59:1410-15

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