676
Views
13
CrossRef citations to date
0
Altmetric
Drug Evaluations

Eltrombopag in patients with chronic liver disease

, MD PhD FACG FRSM &
Pages 669-678 | Published online: 04 Mar 2013

Bibliography

  • Giannini EG, Savarino V. Thrombocytopenia in liver disease. Curr Opin Hematol 2008;15:473-80
  • Louie KS, Micallef JM, Pimenta JM, Forssen UM. Prevalence of thrombocytopenia among chronic hepatitis C patients: a systematic review. J Viral Hepat 2011;18:1-7
  • Giannini EG, Savarino V. Epidemiology of thrombocytopenia in patients with chronic hepatitis C: more than meets the eye. J Viral Hepat 2011;18:8-10
  • Qamar MM, Grace ND, Groszmann RJ, Incidence, prevalence, and clinical significance of abnormal hematologic indices in compensated cirrhosis. Clin Gastroenterol Hepatol 2009;7:689-95
  • Giannini EG, Marenco S, Fazio V, Peripheral blood cytopaenia limiting initiation of treatment in chronic hepatitis C patients otherwise eligible for antiviral therapy. Liver Int 2012;32:1113-19
  • Lin KH, Hsu PI, Lin CK, Factors linked to severe thrombocytopenia during antiviral therapy in patients with chronic hepatitis C and pretreatment low platelet counts. BMC Gastroenterol 2012;12:7
  • Giannini EG, Greco A, Marenco S, Incidence of bleeding following invasive procedures in patients with thrombocytopenia and advanced liver disease. Clin Gastroenterol Hepatol 2010;8:899-902
  • Peck-Radosavljevic M, Zacherl J, Meng YG, Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver? J Hepatol 1997;27:127-31
  • Giannini E, Borro P, Botta F, Serum thrombopoietin levels are linked to liver function in untreated patients with hepatitis C virus-related chronic hepatitis. J Hepatol 2002;37:572-7
  • Giannini E, Botta F, Borro P, Relationship between thrombopoietin serum levels and liver function in patients with chronic liver disease related to hepatitis C virus infection. Am J Gastroenterol 2003;98:2516-20
  • Giannini EG, Savarino V. Further insights into the causes of thrombocytopenia in chronic hepatitis C. J Gastrointestin Liver Dis 2010;19:357-8
  • Wolber EM, Jelkmann W. Thrombopoietin: the novel hepatic hormone. News Physiol Sci 2002;17:6-10
  • Nichol JL. Endogenous TPO (eTPO) level in health and disease: possible clues for therapeutic intervention. Stem Cells 1998;16(Suppl 2):165-75
  • Martin TG, Somberg KA, Meng YG, Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation. Ann Intern Med 1997;127:285-8
  • Peck-Radosavljevic M, Wichlas M, Zacherl J, Thrombopoietin induces rapid resolution of thrombocytopenia after orthotopic liver transplantation through increased platelet production. Blood 2000;95:795-801
  • Stroncek DF, Rebulla P. Platelet transfusions. Lancet 2007;370:427-38
  • de Boer MT, Christensen MC, Asmussen M, The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth Analg 2008;106:32-44
  • Pereboom IT, de Boer MT, Haagsma EB, Platelet transfusion during liver transplantation is associated with increased postoperative mortality due to acute lung injury. Anesth Analg 2009;108:1083-91
  • Kuter DJ. New thrombopoietic growth factors. Blood 2007;109:4607-16
  • Romiplostim. Summary of product characteristics. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_Product_Information/human/000942/WC500039537.pdf [Accessed 5 November 2012]
  • Eltrombopag. Summary of product characteristics. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_Product_Information/human/001110/WC500089964.pdf [Accessed 5 November 2012]
  • Afdhal N, Giannini EG, Tayyab G, Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia. N Engl J Med 2012;367:716-24
  • Afdhal NH, Dusheiko G, Giannini EG, Final results of ENABLE 1, a phase 3, multicenter study of eltrombopag as an adjunct for antiviral treatment of hepatitis C virus-related chronic liver disease associated with thrombocytopenia. Hepatology 2011;54(Suppl 1):1427-8
  • Dusheiko G, Afdhal N, Giannini EG, Results of ENABLE 2, a phase 3, multicenter study of eltrombopag and peginterferon alfa-2b treatment in patients with hepatitis C and thrombocytopenia. J Hepatol 2012;56(Suppl 2):S27
  • Luengo JI, Duffy KJ, Shaw AN, Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia. Blood 2004;104:795A
  • Erickson-Miller CL, DeLorme E, Tian SS, Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol 2005;33:85-93
  • Erickson Miller CL, Delorme E, Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells 2009;27:424-30
  • Erhardt JA, Erickson-Miller CL, Aivado M, Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function. Exp Hematol 2009;37:1030-7
  • Jenkins JM, Williams D, Deng Y, Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007;109:4739-41
  • Deng Y, Madatian A, Wire MB, Metabolism and disposition of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, in healthy human subjects. Drug Metab Disp 2011;39:1734-46
  • Williams DD, Peng B, Bailey CK, Effects of food and antacids on the pharmacokinetics of eltrombopag in healthy adult subjects: two single-dose, open-label, randomized-sequence, crossover studies. Clin Ther 2009;31:764-76
  • Deng Y, Rogers M, Sychterz C, Investigations of hydrazine cleavage of eltrombopag in humans. Drug Metab Dispos 2011;39:1747-54
  • Jenkins J, Williams D, Deng Y, Eltrombopag, an oral thrombopoietin receptor agonist, has no impact on the pharmacokinetic profile of probe drugs for cytochrome P450 isoenzymes CYP3A4, CYP1A2, CYP2C9 and CYP2C19 in healthy men: a cocktail analysis. Eur J Clin Pharmacol 2010;66:67-76
  • Bauman JW, Vincent CT, Peng B, Effect of hepatic or renal impairment on eltrombopag pharmacokinetics. J Clin Pharmacol 2011;51:739-50
  • Pugh RNH, Murray-Lyon IM, Dawson JL, Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-9
  • Matthys G, Park JW, McGuire S, Eltrombopag does not affect cardiac repolarization: results from a definitive QTc study in healthy subjects. Br J Clin Pharmacol 2010;70:24-33
  • McHutchison JG, Dusheiko G, Shiffman ML, Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007;357:2227-36
  • Gibiansky E, Zhang J, Williams D, Population pharmacokinetics of eltrombopag in healthy subjects and patients with chronic idiopathic thrombocytopenic purpura. J Clin Pharmacol 2011;51:842-56
  • Kawaguchi T, Komori A, Seike M, Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, phase II study. J Gastroenterol 2012;47:1342-51
  • Kamath PS, Wiesner RH, Malinchoc M, A model to predict survival in patients with end-stage liver disease. Hepatology 2001;33:464-70
  • Botta F, Giannini E, Romagnoli P, MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is correlated with residual liver function: a European study. Gut 2003;52:134-9
  • Poynard T, Imbert-Bismut F, Munteanu M, Ratziu V. FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis? Expert Rev Mol Diagn 2005;5:15-21
  • Pegasys (peginterferon alfa-2a). Complete prescribing information. Genentech, Inc, South San Francisco, CA; 2011
  • PegIntron (peginterferon alfa-2b). Complete prescribing information. Schering Corp., a subsidiary of Merck & Co., Inc, Whitehouse Station, NJ; 2011
  • Giannini EG, Afdhal NH, Campbell FM, Exploratory analyses of predictors of thrombotic events in the ELEVATE study. Hepatology 2010;52(Suppl 1):1071A
  • Violi F, Pignatelli P. Comment on: eltrombopag before procedures in patients with cirrhosis and thrombocytopenia. N Engl J Med 2012;367:2055-6
  • Lisman T, Bongers TN, Adelmeijer J, Elevated levels of von Willebrand factor in cirrhosis support platelet adhesion despite reduced functional capacity. Hepatology 2006;44:53-61
  • Tripodi A, Primignani M, Chantarangkul V, An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology 2009;137:2105-11
  • Tripodi A, Mannucci PM. The coagulopathy of chronic liver disease. N Engl J Med 2011;365:147-56
  • Dusheiko G, Afdhal NH, Giannini E, Final results of open-label treatment with eltrombopag during ENABLE 1: a study of eltrombopag as an adjunct for antiviral treatment of hepatitis C virus associated with thrombocytopenia. Blood 2011;118:972
  • Giannini E, Dusheiko G, Afdhal N, Eltrombopag raises platelet counts prior to antiviral therapy in patients with chronic hepatitis C virus infection associated with thrombocytopenia. Haematologica 2012;97(Suppl 1):O0609
  • Saleh MN, Bussel JB, Cheng G, Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia (ITP): results of the long-term, open-label EXTEND study. Blood 2013;121:537-45

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.