Growth hormone replacement for adult growth hormone deficiency

Bibliography

• GUISTINA A, VELDHUIS JD: Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr: Rev (1998) 19:717–797.
   PubMed Web of Science ®Google Scholar
• TANNENBAUM GS, LING M: The interrelationship of growth hormone (GH)-releasing factor and somatostatin in the generation of the ultradian rhythm of GH secretion. Endocrinology (1984) 115:1952–1957.
   PubMed Web of Science ®Google Scholar
• KOJIMA M, HOSODA H, DATE Y, NAKAZATO M, MATSUO H, KANGAWA K: Ghrelin is a growth hormone-releasing acylated peptide from stomach. Nature (1999) 402:656–660.
   PubMed Web of Science ®Google Scholar
• DE VOS AM, ULTSCH M,KOSSIAKOFF A: Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science (1992) 255:306–312.
   PubMed Web of Science ®Google Scholar
• STROUS GJ, VAN KERKHOF P: The ubiquitin-proteasome pathway and the regulation of growth hormone receptor availability. Ma Cell. Endocrinol (2002) 197:143–151.
   PubMedGoogle Scholar
• ZADIK Z, CHALEW SA,MCCARTER RJ Jr, MEISTAS M, KOWARSKI AA: The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals.Clin. Endocrinol Metab. (1985) 60:513–515.
   Google Scholar
• IRANMANESH A, LIZARRALDE G, VELDHUIS JD: Age and related obesity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. Clin. Endocrinol Metab. (1991) 73:1081–1088.
   Google Scholar
• FLORINI JR, PRINZ PN, VITIELLO MV, HINTZ RL: Somatomedin-C levels in healthy young and old men: relationship to peak and 24-hour integrated levels of growth hormone.' Cerontol (1985) 40:2–7.
   Google Scholar
• RABEN M: Treatment of a pituitary dwarf with human growth hormone. I Clin. Endocrinol Metab. (1954) 18:901–903.
   Google Scholar
• AUGUST GP, LIPPE BM, BLETHEN L et al.: Growth hormone treatment in the United States: demographic and diagnosticfeatures of 2331 children. Pediatr. (1990) 116:899–903.
   Google Scholar
• FRASIER SD, FOLEY TP Jr: Clinical review 58. Creutzfeldt-Jakob disease in recipients of pituitary hormones. J. Endocrinol Metab. (1994) 78:1277–1279.
   Google Scholar
• DALBOGE H, DAHL H-HM, PEDERSEN J, HANSEN JW, CHRISTENSEN T: A novel enzymatic method for production of authentic hGH from an Escherichia coli produced hGH precursor. Biotechnology (1987) 5:161–164.
   Google Scholar
• DE BOER H, BLOK G-J, VAN DER VEEN EA: Clinical aspects of growth hormone deficiency in adults. Endocr: Rev (1995) 16:63–86.
   PubMed Web of Science ®Google Scholar
• SALOMON F, CUNEO RC, HESP R, SNOKSEN PH: The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N. Engl.' Med. (1989) 321:1797–1803.
   PubMed Web of Science ®Google Scholar
• ••One of the first important studies on GHreplacement in adults, after rhGH became available.
   Google Scholar
• ROSEN T, BOSAEUS I, TOLLI J, LINDSTEDT G, BENGTSSON BA: Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency.Endocrinol (Off). (1993) 38:63–71.
   PubMed Web of Science ®Google Scholar
• BINNERTS A, DEURENBERG P, SWART GR, WILSON JH,LAMBERTS SW: Body composition in growth hormone deficient adults. Am. Nutr. (1992) 55:918–923.
   PubMed Web of Science ®Google Scholar
• CUNEO RC, SALOMON F, WILES CM, SONKSEN PH: Skeletal muscle performance in adults with growth hormone deficiency. Horm. Res. (1990) 33\(Suppl. 4):55–60.
   Google Scholar
• COLAO A, DI SOMMA C, PIVONELLO R et al.: Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism. j. Clin. Endocrinol Metab. (1999) 84:1919–1924.
   PubMed Web of Science ®Google Scholar
• JORGENSEN JOL, THUESEN L, MULLER J, OVESEN P,SKAKKEBAEK NE, CHRISTIANSEN JS: Three years of growth hormone treatment in growth hormone-deficient adults: near normalization of body composition and physical performance. Eur. Endocrinol (1994) 130:224–228.
   Google Scholar
• ROSEN T, BENGTSSON B-A: Premature mortality due to cardiovascular disease inhypopituitarism. Lancet (1990) 336:285–288.
   PubMed Web of Science ®Google Scholar
• TOMLINSON JW, HOLDEN N, HILLS RK et al.: Association between premature mortality and hypopituitarism. Lancet (2001) 357:425–431.
   PubMed Web of Science ®Google Scholar
• ROSEN T, WIREN L, WILHELMSEN L, WIKLUND I, BENGTSSON BA: Decreased psychological well-being in adult patients with growth hormone deficiency. Clin. Endocrinol (Off). (1994) 40:111–116.
   PubMed Web of Science ®Google Scholar
• BURMAN P, BORMAN JE, HETTA J et al.: Quality of life in adults with growth hormone (GH) deficiency: response treatment with recombinant human GH in a placebo-controlled 21-month trial.' Clin. Endocrinol Metab. (1995) 80:3585–3590.
   Google Scholar
• HARTMAN ML, CROWE BJ,BILLER BMK, HO KKY,CLEMMONS DR, CHIPMAN JJ: Which patients do not require a GH stimulation test for the diagnosis of adult GH deficiency? I Gin. Endocrinol Metab. (2002) 87:477–485.
   Google Scholar
• •A large study evaluating the need for diagnosis of GHD in patients with hypopituitarism.
   Google Scholar
• GROWTH HORMONE RESEARCH SOCIETY: Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society workshop on adult growth hormone deficiency. J. Clin. Endocrinol Metab. (1998) 83:379–381.
   PubMed Web of Science ®Google Scholar
• SHALET SM, TOOGOOD A, RAHIM A, BRENNAN BMD: The diagnosis of growth hormone deficiency in children and adults. Endocr. Rev (1998) 19:203–223.
   PubMed Web of Science ®Google Scholar
• BILLER BMK, SAMUELS MH,ZAGAR A et al.: Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. j Clin. Endocrinol Metab. (2002) 87:2067–2079.
   Google Scholar
• BURMAN p, JOHANSSON AG,SIEGBAHN A, VESSBY B, KARLSSON FA: Growth hormone (GH)-deficient men are more sensitive to GH replacement therapy than women. I. Clin. Endorcinol Metab. (1997) 82:550–555.
   PubMedGoogle Scholar
• KEHELY A, BATES PC, FREWER P et al.:Short-term safety and efficacy of human GH replacement therapy in 595 adults with GH deficiency: a comparison of two dosage algorithms. I Clin. Endocrinol Metab. (2002) 87:1974–1979.
   PubMed Web of Science ®Google Scholar
• ••A large, well-designed study evaluating the efficacy and safety of low and higher dose of GH for adult GHD.
   Google Scholar
• EZZAT S, FEARS, GAILLARD R-C et al: Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults. I Cilia. Endocrinol Metab. (2002) 87:2725–2733.
   PubMedGoogle Scholar
• CHAN JM, STAMPFER MJ,GIOVANNUCCI E et al.: Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science (1998) 279:563–566.
   Google Scholar
• FLORAKIS D, HUNG V, KALTSAS G et al.: Sustained reduction in circulating cholesterol in adult hypopituitary patients given low dose titrated growth hormone replacement therapy: a two year study. Cilia. Endocrinol (2000) 53:453–459.
   PubMedGoogle Scholar
• JOHANNSSON G, BJARNASON R, BRAMNERT M et al.: The individual responsiveness to growth hormone (GH) treatment in GH-deficient adults is dependent on the level of GH-binding protein, body mass index, age, and gender.I Cilia. Endocrinol Metab. (1996) 81:1575–1581.
   PubMed Web of Science ®Google Scholar
• DRAKE WM, HOWELL SJ, MONSON JP, SHALET SM: Optimizing GH therapy in adults and children. Endocr. Rev (2001) 22:425–450.
   PubMed Web of Science ®Google Scholar
• ••An excellent review of the physiology,clinical practice and response to GH replacement.
   Google Scholar
• BEX M, ABS R, MAITER D, BECKERS A, LAMBERIGTS G, BOUILLON R: The effects of growth hormone replacement therapy on bone metabolism in adult-onset growth hormone deficiency: 2-year open randomized controlled multicenter trial.J. Bone Mineral. Res. (2002) 17:1081–1094.
   PubMed Web of Science ®Google Scholar
• TOOGOOD AA, O'NEILL PA, SHALET SM: Beyond the somatopause: growth hormone deficiency in adults over the age of 60 years. J. Cilia. Endocrinol Metab. (1996) 81:460–465.
   PubMedGoogle Scholar
• VANCE ML: Can growth hormone preventaging? N Engl. J. Med. (2003) 348:779–780.
   Google Scholar
• CUNEO RC, SALOMON F, WATTS GE HESP R, SONKSEN PH: Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. Metabolism (1993) 42:1519–1523
   PubMed Web of Science ®Google Scholar
• COLAO A, DI SOMMA C,PIVONELLO R et al.: The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study. Cilia. Endocrinol Metab. (2002) 87:1088–1093.
   Google Scholar
• ATTANASIO AF, BATES PC, HO KKY et al.: Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status - 3-year results from the HypoCCS database. J. Cilia. Endocrinol Metab. (2002) 87:1600–1607.
   PubMedGoogle Scholar
• PFEIFER M, VERHOVEC R, ZIZEK B,PREZELJ J, POREDOS P, CLAYTON RN: Growth hormone (GH) treatment reverses early atherosclerotic changes in GH-deficient adults. J. Clin. Endocrinol Metab. (1999) 84:453–457.
   PubMed Web of Science ®Google Scholar
• PORRETTI S, GIAVOLI C, RONCHI C et al.: Recombinant human GH replacement therapy and thyroid function in a large group of adult GH-deficient patients: When does L-T4 therapy become mandatory? I. Cilia. Endocrinol Metab. (2002) 87:2042–2045.
   PubMed Web of Science ®Google Scholar
• GIBNEY J, WALLACE JD, SPINKS T et al.: The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients. I Cilia. Endocrinol Metab. (1999) 84:2596–2602.
   PubMed Web of Science ®Google Scholar
• WIREN L, BENGTSSON B-A, JOHANNSSON G: Beneficial effects of long-term GH replacement therapy on quality of life in adults with GH deficiency. Cilia. Endocrinol OW (1998) 48:613–620.
   PubMedGoogle Scholar
• HERNBERG-STAHL E, LUGER A, ABS R et al.: Healthcare consumption decreases in parallel with improvements in quality of life during GH replacement in hypopituitary adults with GH deficiency. I Clin. Endocrinol Metab. (2001) 86:5277–5281.
   PubMed Web of Science ®Google Scholar
• COOK DM, BILLER BMK, VANCE ML et al.: The pharmacokinetic and pharmacodynamic characteristics of a long-acting growth hormone (GH) preparation (Nutropin depot) in GH-deficient adults. Cilia. Endocrinol Metab. (2002) 87:4508–4514.
   PubMedGoogle Scholar
• REITER EO, ATTIE KM, MOSHANG Jr T et al.: A multicenter study of the efficacy and safety of sustained-release growth hormone in the treatment of naive pediatric patients with growth hormone deficiency. j. Clin. Endocrinol Metab. (2001) 86:4700–4706.
   Google Scholar
• HATRICK AG, BOGHALO P, BINGHAM JB, AYRES AB,SNOKSEN PH, RUSSELL-JONES DL: Does GH replacement therapy in adult GH-deficient patients result in recurrence or increase in size of pituitary tumours?Eur. Endocrinol (2002) 146:807–811.
   Google Scholar
• MURRAY RD, SHALET SM: Future perspective. Adult growth hormone replacement: lessons learned and future direction. I Cilia. Endocrinol Metab. (2002) 87:4427–4428.
   Google Scholar
• NATIONAL INSTITUTE FOR CLINICAL EXCELLENCE: Human growth hormone (somatropin) in adults with growth hormone deficiency. Technology Appraisal 64; August (2003).
   Google Scholar
• •Comprehensive guidelines for treating adult GHD.Affiliation
   Google Scholar