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Review

Therapeutic benefit of bisphosphonates in the management of prostate cancer-related bone disease

Pages 705-716 | Published online: 02 Mar 2005

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  • •Provides evidence for the cytotoxic activity of bisphosphonates, supporting their expanded role in both prevention and progression of prostate cancer metastases.
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  • •A comprehensive review of the evolving role of zoledronic acid in prostate cancer-associated bone disease.
  • DIEL IJ: Bisphosphonates in the prevention of bone metastases: current evidence Semin. Oncol (2001) 28\(Suppl. 6):75–80.
  • ••Excellent review of current clinical data onadjuvant bisphosphonate therapy.
  • KANIS JA, POWLES TJ,PATERSON AHG et al.: Clodronate decreases the frequency of skeletal metastases in women with breast cancer. Bone (1996) 19:663–667.
  • DIEL IJ, SOLOMAYER EF, COSTA SD et al: Reduction in new metastases in breast cancer with adjuvant clodronate treatment. N Engl. J. Med. (1998) 339:357–363.
  • DIEL IJ, SOLOMAYER EF, BASTERT G etal.: Bisphosphonates in the prevention of 715Expert Op/n. Pharmacother. (2003) 4(5)metastases in breast cancer results of the extended follow-up study. Proc. Am. Soc.CM]. Oncol. (2000) 19:314 (Abstract).
  • SAARTO T, BLOMQVIST C, VIRKKUNEN P, ELOMAA I: Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer: 5-year results of a randomized controlled trial.j. CM]. Oncol. (2001) 19:10–17.
  • •An important negative, randomised trial showing a lack of benefit of clodronate.
  • DEARNALEY DP, SYDES MR: Preliminary evidences that oral clodronate delays symptomatic progression of bone metastases from prostate cancer: first results of the MRC PRO5 trial. the MRC PRO5 collaboration. Proc. Amer Soc. Chit. Oncol. (2001) 20:174a (Abstract 693).
  • •An important preliminary report of a potential role of bisphosphonate therapy in delay of progression of bone metastases using a weak, first-generation agent.
  • JONES J: Bisphosphonates may be useful in treatment of bone metastases.Natl. Cancer Inst. (2001) 93:1052–1053.

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