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Review

Pharmacotherapy of first-episode psychosis

, , &
Pages 717-750 | Published online: 02 Mar 2005

Bibliography

  • POWER P, MCGORRY PD: Initial assessment in first-episode psychosis. In:The Recognition and Management of early Psychosis. A preventive Approach, McGorry PD, Jackson HJ (Eds),Cambridge University Press, UK (1999):155–184.
  • NORDENTOFT M, JEPPESEN P,ABEL M: Suicidal behaviour, suicidal ideation and hopelessness among patients with first-episode psychosis. One-year follow-up of a randomised controlled trial. OPUS study. Br. I Psychiatry (2002) 43:98–106.
  • SAND OR A, COURTENAY K: First-episode psychosis. Patients must be asked about suicidal ideation and substance misuse. BMJ(2002) 324(7343):976.
  • BIRCHWOOD M, TODD P, JACKSON C: Early intervention inpsychosis. The critical period hypothesis. Br. J. Psychiatry (1998) 172(33):53–59.
  • GUT-FAYAND A, DERVAUX A, OLIE JP, LOO H, POIRIER ME KREBS MO: Substance abuse and suicidality in schizophrenia: a common risk factor linked to impulsivity. Psychiatry Res. (2001) 102(1):65–72.
  • JOHNSTONE EC, CROW TJ, JOHNSON AL, MACMILLAN JF: The Northwick Park Study of first-episodes of schizophrenia I. Presentation of the illness and problems relating to admission. Br. J. Psychiatry (1986) 148:115–120.
  • FENNIG S, BROMET E, JANDORF L: Differences in clinical characteristics of first-admission psychotic depression. Am. J. Psychiatry(1993) 150(11):1734–1736.
  • LAMBERT M, CONUS P, EIDE P, WARD J, YUEN HP, MCGORRY PD: Treatment of early psychosis with olanzapine or risperidone (TEPOR study): methodology and first results of a medical record study in 786 first-episode psychosispatients treated at early psychosisprevention and intervention centre (EPPIC)between 1998 — 2000. Schizophr. Res. (2002) 53\(Suppl. 3):B66.
  • MATTANAH JJ, BECKER DE LEVY KN, EDELL WS, MCGLASHAN TH: Diagnostic stability in adolescents followed up 2 years after hospitalization. Am. J. Psychiatry (1995) 152(6):889–894.
  • STRAKOWSKI SM, TOHEN M, STOLL AL et al.: Comorbidity in psychosis at first hospitalization. Am. j Psychiatry (1993) 150(5):752–757.
  • MCGORRY PD, COPOLOV DL, SINGH BS: Royal park multidiagnostic instrument for psychosis: Part I. Rationale and review. Schizophr. Bull. (1990) 16(3):501–515.
  • MCGORRY PD, SINGH BS,COPOLOV DL, KAPLAN I, DOSSETOR CR, VAN RIEL RJ:Royal park multidiagnostic instrument forpsychosis: part II: development, reliability,and validity. Schizophr. Bull. (1990) 16(3):517–536.
  • SPITZER RL, WILLIAMS JB,GIBBON M, FIRST MB: The structuredclinical interview for DSM-III-R (SCID)I: history, rationale, and description. Arch. Gen. Psychiatry(1992) 49(8):624–629.
  • Schedules for clinical assessment in neuropsychiatry. WHO, SCAN. World Health Organization, Division of Mental Health, Geneva (1992).
  • Early Psychosis Prevention and Intervention Group. Psychoeducation in early psychosis. University of Melbourne Press, Melbourne Australia (1998).
  • DILLING H MOMBOUR W, SCHMIDT GH: International classification of psychotic disorders ICD-10. Hans Huber, Bern Gottingen, Toronto, Canada (1991).
  • Diagnostic Criteria from DSM-IV. Washington, American Psychiatric Association. American Psychiatric Press (1994).
  • ADDINGTON J, ADDINGTON D: Cognitive functioning in first-episode schizophrenia. j Psychiatry Neurosci (2002) 27(3):188–192.
  • BILDER RM, GOLDMAN RS, ROBINSON D etal.: Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates. Am. J. Psychiatry (2000) 157(4):549–559.
  • •This study has shown that first-episode at the initial presentation already have severe cognitive deficits, especially in memory, attention span and executive functioning. These results are important for early recognition, early intervention and adaptation of treatment (see also refs [18, 20–221).
  • FRITS S, SUNDET K, RUND BR, VAGLUM P, MCGLASHAN TH: Neurocognitive dimensions characterising patients with first-episode psychosis. Br. J. Psychiatry (2002) 43:85–90.
  • RILEY EM, MCGOVERN D,MOCKLER D et al: Neuropsychological functioning in first-episode psychosis-evidence of specific deficits. Schizophr. Res. (2000) 43(1):47–55.
  • SAYKIN AJ, SHTASEL DL, GUR RE et al.: Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch. Gen Psychiatry (1994) 51(2):124–131.
  • ROBINSON DG, WOERNER MG, ALVIR JM, BILDER RM,HINRICHSEN GA, LIEBERMAN JA: Predictors of medication discontinuation by patients with first-episode schizophrenia and schizoaffective disorder. Schizophr. Res. (2002) 57(2-3):209–219.
  • MORITZ S, KRAUSZ M, GOTTWALZ E, LAMBERT M, PERRO C, NABER D: Cognitive dysfunctions at baseline predicts symptomatic one year outcome in first-episode schizophrenics. Psychopathology (2000) 33:48–51.
  • BUHLER B, HAMBRECHT M, LOFFLER W, AN DER HEIDEN W, HAFNER H: Precipitation and determination of the onset and course of schizophrenia by substance abuse - a retrospective and prospective study of 232 population-based first illness episodes. Schizophr. Res. (2002) 54(3):243–251.
  • ADDINGTON D, ADDINGTON J, PATTEN S: Depression in people with first-episode schizophrenia. Br j Psychiatry (1998) 172(33):90–92.
  • KOREEN AR, SIRIS SG, CHAKOS M, ALVIR J, MAYERHOFF D,LIEBERMAN J: Depression in first-episodeschizophrenia. Am. j Psychiatry (1993) 150(11):1643–1648.
  • WASSINK TH, FLAUM M,NOPOULOS P, ANDREASEN NC: Prevalence of depressive symptoms early in the course of schizophrenia. Am. J. Psychiatry (1999) 156(2):315–316.
  • •This study assessed the prevalence (up to 35%) of depressive symptoms in first-episode schizophrenia showing that depression is an important co-current syndrome even at the first presentation (see also refs 126,271).
  • MCGORRY PD, CHANEN A, MCCARTHY E, VAN RIEL R, MCKENZIE D, SINGH BS: Post-traumatic stress disorder following recent-onset psychosis. An unrecognized postpsychotic syndrome. Nerv. Merit. Dis. (1991) 179(5):253–258.
  • EDWARDS J, MCGORRY PD: Implementing early intervention in psychosis. Martin Dunitz Publisher (2002).
  • •This book provides an excellent overview about current concepts and service requirements in the treatment in early psychosis. Its includes actual standards of care and comprise research overviews as well as developments and experiences ofthe Early Psychosis Prevention and Intervention Centre in Melbourne Australia (see also ref [1381).
  • FITZGERALD P, KULKARNI J: Home-oriented management programme for people with early psychosis. Br. I Psychiatry (1998) 171(Suppl.):39–44.
  • MCGORRY PD, EDWARDS J, MIHALOPOULOS C: EPPIC: an evolving system of early detection and optimal management. Schizophr. Bull. (1996) 22:305–322.
  • MCGORRY PD, KILLACKEY E, ELKINS K, LAMBERT M, LAMBERT T: Summary of the clinical practice guidelines for the treatment of schizophrenia.The Schizophrenia Clinical Guidelines Development Team. Australasian Psychiatry (Submitted).
  • DE HAAN L, VAN RAAIJ B, VAN DEN BERG R: Preferences for treatment during a first psychotic episode. Eur. Psychiatry (2001) 16(2):83–89.
  • Schizophrenia: core interventions in the treatment and management of schizophrenia in primary and secondary care. National Institute for Clinical Excellence (NICE). Clinical Guideline 1, National Collaborating Centre for Mental Health (2002).
  • ZIPURSKY RB: Optimal pharmacologic management of the first-episode of schizophrenia. In: The early stages of schizophrenia, Kapur S, Zipursky RB (Eds), HarperCollins, NY, USA (2001).
  • HARRIGAN SM, MCGORRY PD, KRSTEV H: Does treatment delay in first-episode psychosis really matter? Psycho]. Med (2003) 33(1):97–110.
  • MALLA AK, NORMAN RM, MANCHANDA R etal.: One year outcome in first-episode psychosis: influence of DUP and other predictors. Schizophr. Res. (2002) 54(3):231–242.
  • BALDESSARINI R, COHEN B, TEICHER M: Significance of neuroleptic dose and plasma level in the pharmacological treatment of psychoses. Arch. Gen. Psychiatry (1988) 45:79–91.
  • LIEBERMAN J, JODY D, GEISLER S, VITAL-HERNE J, ALVIR JM, WALSLEBEN J, WOERNER MG: Treatment outcome of first-episode schizophrenia. Psychopharmacol Bull. (1989) 25(1):92–96.
  • LIEBERMAN J, JODY D, GEISLER S et al: Time course and biologic correlates oftreatment response in first-episode schizophrenia. Arch. Gen. Psychiatry (1993) 50(5)369–376.
  • The Scottish First-Episode Schizophrenia Study II: Treatment: pimozide versus flupenthixol. The Scottish Schizophrenia Research Group. Br j. Psychiatry (1987) 150:334–338.
  • MCEVOY JP, HOGARTY GE, STEINGARD S: Optimal dose of neuroleptic in acute schizophrenia. A controlled study of the neuroleptic threshold and higher haloperidol dose. Arch. Gen. Psychiatry (1991) 48(8):739–745.
  • ZHANG-WONG J, ZIPURSKY RB, BEISER M, BEAN G: Optimal haloperidol dosage in first-episode psychosis. Carr J. Psychiatry (1999) 44(2):164–167.
  • •After studies from Baldessarirti 1988 and McEvoy 1991, the authors focused on the optimal haloperidol dose for a sufficient response in first-episode psychosis showing that higher doses are correlated with a lower response rate compared to low doses (see also refs [39-43,46–49,63,64,711).
  • KAY SR, OPLER LA,LINDENMAYER JP: Reliability and validity of the positive and negative syndrome scale for schizophrenics. Psychiatry Res. (1988) 23(1):99–110.
  • OOSTHUIZEN P, EMSLEY RA, TURNER J, KEYTER N: Determining the optimal dose of haloperidol in first-episode psychosis. j. Psychopharmacol (2001) 15(4):251–255.
  • MERLO MC, HOFER H, GEKLE W et al: Risperidone, 2 mg/d vs 4 mg/d, in first-episode, acutely psychotic patients: treatment efficacy and effects on fine motor functioning. j. CM]. Psychiatry (2002) 63(10):885–891.
  • YAP HL, MAHENDRAN R, LIM D et al.: Risperidone in the treatment of first-episode psychosis. Singapore Med. 1 (2001) 42(4):170–173.
  • MCGORRY PD: Recommended haloperidol and risperidone doses in first-episode psychosis. I OM. Psychiatry (1999) 60(11):794–795.
  • GUTIERREZ FRAILE M, SEGARRA ECHEVARRIA R, GONZALEZ-PINTO ARRILLAGA A, MARTINEZJUN QUERA G: Risperidone in the early treatment of first-episode psychosis: a two-year follow-up study. Actas Esp. Psiquiatr (2002) 30(3):142–152.
  • SANGER TM, LIEBERMAN JA, TOHEN M, GRUNDY S, BEASLEY C Jr, TOLLEFSON GD: Olanzapine versus haloperidol treatment in first-episode psychosis. Am. J. Psychiatry (1999) 156(1):79–87.
  • GOOD KP, KISS I, BUITEMAN C et al.: Improvement in cognitive functioning in patients with first-episode psychosis during treatment with quetiapine: an interim analysis. Br. I Psychiatry (2002) 43(Suppl.):S45–S49.
  • NABER D, LAMBERT M, KRAUSZ M, HAASEN C, PICKAR D: Atypical neuroleptic s in the treatment of schizophrenic patients 2ri edit under special consideration of atypical antipsychotics in kids- and youth psychiatry. UNI-MED publisher (2002).
  • AGUILAR EJ, KESHAVAN MS, MARTINEZ-QUILES MD, HERNANDEZ J,GOMEZ-BENEYTO M,SCHOOLER NR: Predictors of acute dystonia in first-episode psychotic patients. Am. j. Psychiatry (1994) 151(12):1819–1821.
  • LAMBERT M: Treatment non-response in schizophrenia. In: Atypical neuroleptic s in the treatment of schizophrenic patients, 2ri edit, Naber D, Lambert M, Krausz M, Haasen C, Pickar D, UNI-MED (2002):81–100.
  • RICHARDSON MA, HAUGLAND G, CRAIG TJ: Neuroleptic use, parkinsonian symptoms, tardive dyskinesia, and associated factors in child and adolescent psychiatric patients. Am. J. Psychiatry (1991) 148(10):1322–1328.
  • DUKE PJ, PANTELIS C, BARNES TR: South Westminster schizophrenia survey. Alcohol use and its relationship to symptoms, tardive dyskinesia and illness onset. Br. J. Psychiatry (1994) 164(5):630–636.
  • CHOUINARD G, ANNABLE L, ROSS-CHOUINARD A, MERCIER P: A 5-year prospective longitudinal study of tardive dyskinesia: factors predicting appearance of new cases. j. CM]. Psychopharmacol. (1988) 8\(Suppl. 4):21–26.
  • ROBINSON D, WOERNER M, ALVIR J et al.: Predictors of treatment response from a first-episode of schizophrenia of schizoaffective disorder. Am. j. Psychiatry (1999) 156:544–549.
  • •This article examined relapse after response to a first-episode of schizophrenia or schizoaffective disorder showing thatthere is a high rate of relapse within 5 years of recovery from a first-episode and that this risk is diminished by maintenance antipsychotic drug treatment (see also refs [26,271).
  • FENTON WS, BLYLER C, HEINSSEN R: Determinants of medication compliance in schizophrenia: empirical and clinical findings. Schizophr. Bull. (1997) 23:637–651.
  • •Compliance is a very important issue in psychotic patients. Determinants, influences of non-compliance on the course of illness and guidelines for dealing with this problem are reviewed in this article (see also refs [61,761).
  • KAMPMAN 0, LAIPPALA P, VAANANEN J et al.: Indicators of medication compliance in first-episode psychosis. Psychiatry Res. (2002) 110 (1):39–48.
  • MCEVOY JP, SCHEIFLER PL, FRANCES A: The expert consensus guideline series: treatment of schizophrenia.OM. Psychiatry (1999) 60\(Suppl. 10:3–80.
  • KAPUR S, ZIPURSKY R, JONES C, REMINGTON G, HOULE S: Relationship between dopamine D2 occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am. I Psychiatry (2000) 157(4):514–520.
  • KAPUR S, ZIPURSKY R, ROY P et al: The relationship between D2 receptor occupancy and plasma levels on low dose oral haloperidol: a PET study. Psychopharmacology (1997) 131(2):148–152.
  • JANICAK PG, KECK PE Jr, DAVIS JM et al.: A double-blind, randomized, prospective evaluation of the efficacy and safety of risperidone versus haloperidol in the treatment of schizoaffective disorder. Psychopharmacol. (2001) 21(4):360–368.
  • STONE CK, GARVER DL, GRIFFITH J et al.: Further evidence of s dose response threshold for haloperidol in psychosis. Am. j. Psychiatry (1995) 152:1210–1212.
  • LEUCHT S, PITSCHEL-WALZ G, ABRAHAM D, TUSSLING W: Efficacy and extrapyramidal side effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials. Schizophr. Res. (1999) 35(1):51–68.
  • LEUCHT S, PITSCHEL-WALZ G, ENGEL RR, TUSSLING W: Amisulpride, an unusual 'atypical' antipsychotic: a meta-analysis of randomized controlled trials. Am. J. Psychiatry (2002) 159(2):180–190.
  • EMSLEY RA: Risperidone in the treatment of first-episode psychotic patients: a double-blind multicenter study. Risperidone Working Group. Schizophr. Bull. (1999) 25(4)721–729.
  • KESHAVAN MS, SCHOOLER NR, SWEENEY JA, HAAS GL,PETTEGREW JW: Research and treatment strategies in first-episode psychoses. The Pittsburgh experience. Br J. Psychiatry (1998) 172(33):60–65.
  • KONTAXAKIS VP, HAVAKI-KONTAXAKI BJ, STAMOULI SS, CHRISTODOULOU GN: Optimal risperidone dose in drug-naive, first-episode schizophrenia. Am. J. Psychiatry (2000) 157(7):1178–1179.
  • KOPALA LC, FREDRIKSON D, GOOD KP HONER WG: Symptoms in neuroleptic-naive, first-episode schizophrenia: response to risperidone. Biol. Psychiatry (1996) 39(4):296–298.
  • MALLA AK, NORMAN RIVI, SCHOLTEN DJ, ZIRUL S,KOTTEDA V: A comparison of long-term outcome in first-episode schizophrenia following treatment with risperidone or a typical antipsychotic. j Clin. Psychiatry (2001) 62(3):179–184.
  • ALVAREZ E, BOBES J, GOMEZ JC et al.: Safety of olanzapine versus conventional antipsychotics in the treatment of patients with acute schizophrenia. A naturalistic study. Eur. Neuropsychopharmacol. (2003) 13(1):39–48.
  • HELLEWELL JS: Patients subjective experiences of antipsychotics: clinical relevance. CNS Drugs (2002) 16(7):457–471.
  • YOUNG J, ZONANA H, SHEPLER L: Medication non-compliance in schizophrenia: codification and update. Bull. Am. Acad. Psychiatry Law (1986) 14:105–122.
  • BOWDEN CL, BRUGGER AM, SWANN AC et al.: Efficacy of divalproex vs lithium and placebo in the treatment of mania. The Depakote Mania Study Group. JAMA (1994) 271(12):918–924.
  • KELLEHER JP, CENTORRINO F, ALBERT MJ, BALDESSARINI RJ: Advances in atypical antipsychotics for thetreatment of schizophrenia: new formulations and new agents. CNS Drugs (2002) 16(4):249–261.
  • CALABRESE JR, SHELTON MD, RAPPORT DJ, KIMMEL SE: Bipolar disorders and the effectiveness of novel anticonvulsants. I Clin. Psychiatry (2002) 63\(Suppl. 3):5–9.
  • GLICK RL, GHAEMI SN: The emergency treatment of depression complicated by psychosis or agitation. J. Clin. Psychiatry (2000) 61\(Supp1.14):43–48.
  • MCELROY SL, KECK PE JR,POPE HG Jr, HUDSON JI: Valproate in the treatment of bipolar disorder: literature review and clinical guidelines.v ?Clin. Psychopharmacol (1992) 12\(Suppl. 1):542–552.
  • MCELROY SL, KECK PE Jr,STRAKOWSKI SM: An overview of the treatment of schizoaffective disorder. ?Clin. Psychiatry (1999) 60\(Suppl. 5):16–21.
  • MCELROY SL, KECK PE Jr:Pharmacologic agents for the treatment of acute bipolar mania. Bid. Psychiatry (2000) 48(6):539–557.
  • •Pharmacological treatment ofschizoaffective disorder has not been well studied. The authors review studies of pharmacological agents, present pharmacological treatment guidelines for the disorder (see also refs [88, 89, 96, 102]).
  • CONUS P, MCGORRY PD: First-episodemania: a neglected priority for early intervention. Aust. NZ J. Psychiatry (2002) 36:158–172.
  • •This article gives an excellent overview on first-episode mania showing that when functional, as well as symptomatic variables are considered, outcome of these patients is not as good as formerly believed and that specialised services, as well as intensive research, is needed to improve outcome of these patients.
  • OKUMA T, YAMASHITA I,TAKAHASHI R et al: Clinical efficacy of carbamazepine in affective, schizoaffective, and schizophrenic disorders. Pharmacupsychiatry (1989) 22(2):47–53.
  • Practice guideline for the treatment of patients with major depressive disorder (revision). American Psychiatric Association. Am. J. Psychiatry (2000) 157(4):1–45.
  • •Gives an important overview of the treatment of patients with depressivedisorder (see also refs [104, 105, 107–109,111,114]).
  • Practice guideline for the treatment ofpatients with bipolar disorder (revision). American Psychiatric Association. Am. J. Psychiatry (2002) 159(4):4–50.
  • •Gives an important overview of the treatment of patients with bipolar disorder (see also refs [81, 83, 89-91,93-95,97-99,102,1061).
  • KECK PE Jr, MCELROY SL, STRAKOWSKI SM: Schizoaffective disorder: role of atypical antipsychotics. Schizophr. Res. (1999) 35:S5–S12.
  • MILLER DS, LAKSHMI NY, LAM RW: Comparative efficacy of typical and atypical antipsychotics as add-on therapy to mood-stabilizers in the treatment of acute mania. Clin. Psychiatry (2001) 62:975–980.
  • STRAKOWSKI SM, DELBELLO MP, ADLER CM: Comparative efficacy and tolerability of drug treatments for bipolar disorder. CNS Drugs (2001) 15(9):701–718.
  • SUPPES T, DENNEHY EB, SWANN AC eta].: Report of the Texas consensus conference panel on medication treatment of bipolar disorder 2000.1 Clin. Psychiatry (2002) 63(4):288–299.
  • YATHAM LN: Mood stabilization and the role of antipsychotics. ?Clin. Psychopharmacol (2002) 17\(Suppl. 3):21–27.
  • FRYE MA, KETTER TA,ALTSHULER LL et al: Clozapine in bipolar disorder: treatment implications for other atypical antipsychotics. J. Affect. Disorder (1998) 48(2-3):91–104.
  • SANGER TM, GRUNDY SL, GIBSON PJ, NAMJOSHI MA, GREANEY MG, TOHEN MF: Long-term olanzapine therapy in the treatment of bipolar I disorder: an open-label continuation phase study. Clin. Psychiatry (2001) 62(4):273–281.
  • TOHEN M, SANGER TM,MCELROY SL et al.: Olanzapine versus placebo in the treatment of acute mania. Olanzapine HGEH Study Group. Am. J. Psychiatry (1999) 156(5):702–709.
  • TOHEN M, ZHANG F, KECK PE etal.: Olanzapine versus haloperidol in schizoaffective disorder, bipolar type. J. Affect. Disorder (2001) 67(1–3):133–140.
  • TOHEN M, CHENGAPPA KN, SUPPES T et al.: Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partiallynonresponsive to valproate or lithium monotherapy. Arch. Gen. Psychiatry (2002) 59(1):62–69.
  • TOHEN M, BAKER RW,ALTSHULER LL et al.: Olanzapine versus divalproex in the treatment of acute mania. Am. J. Psychiatry (2002) 159(6):1011–1017.
  • VIETA E, REINARES M, CORBELLA B et al: Olanzapine as long-term adjunctive therapy in treatment-resistant bipolar disorder. j Chi]. Psychopharmacol. (2001) 21(5):469–473.
  • JANICEK PG, JAVAID JI, SHARMA RP et al: A two-phase, double-blind randomized study of three haloperidol plasma levels for acute psychosis with reassignment of initial non-responders. Acta Psychiatr. Scam/. (1997) 95:343–350.
  • SACHS GS, GROSSMAN F,GHAEMI SN, OKAMOTO A, BOWDEN CL: Combination of a mood-stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety. Am. I Psychiatry (2002) 159(7):1146–1154.
  • VIETA E, GOIKOLEA JM,CORBELLA B et al.: Risperidone safety and efficacy in the treatment of bipolar and schizoaffective disorders: results from a 6-month, multicenter, open study. Chi]. Psychiatry (2001) 62(10):818–825.
  • BROWN ES, NEJTEK VA, PERANTIE DC, BOBADILLA L: Quetiapine in bipolar disorder and cocaine dependence. Bipolar Disorder (2002) 4(6):406–411.
  • ROCCA P, MARCHIARO L, RASETTI R, RIVOIRA E, BOGETTO F: A comparison of paroxetine versus paroxetine plus amisulpride in the treatment of dysthymic disorder: efficacy and psychosocial outcomes. Psychiatry Res. (2002) 112(2):145–152.
  • ROCCA P, FONZO V, RAVIZZA L et al.: A comparison of paroxetine and amisulpride in the treatment of dysthymic disorder. j Affect. Disord. (2002) 70(3):313–317.
  • VIETA E, PARRAMON G, PADRELL E et al: Quetiapine in the treatment of rapid cycling bipolar disorder. Bipolar Disord. (2002) 4(5):335–340.
  • CASSANO GB, JORI MC: Efficacy and safety of amisulpride 50 mg versus paroxetine 20 mg in major depression: a randomized, double-blind, parallel groupstudy. BIL Chi]. Psychopharmacol. (2002) 17(1):27–32.
  • SAJATOVIC M, MULLEN JA,SWEITZER DE: Efficacy of quetiapine and risperidone against depressive symptoms in outpatients with psychosis.Chi]. Psychiatry (2002) 63(12):1156–1163.
  • FRYE MA, KETTER TA, KIMBRELL TA etal.: A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders.Chi]. Psychopharmacol. (2000) 22:241–247.
  • ICHIM L, BERK M, BROOKS: Lamotrigine compared with lithium in mania: a double-blind randomized controlled trial. Ann. Clin. Psychiatry (2000) 12:5–10.
  • MENDLEWICZ J: Optimising antidepressant use in clinical practice: towards criteria for antidepressant selection. Br. I Psychiatry (2001) 42:S1–S3.
  • MATTHEWS JD, BOTTONARI KA, POLANIA LM et al.: An open study of olanzapine and fluoxetine for psychotic major depressive disorder: interim analyses.Chi]. Psychiatry (2002) 63 (12):1164-1170.
  • MYERS JE, THASE ME: Risperidone: review of its therapeutic utility in depression. Psychopharmacol. Bull. (2001) 35(4):109–129.
  • ADLI M, BERGHOFER A, LINDEN M et al.: Effectiveness and feasibility of a standardized stepwise drug treatment regimen algorithm for inpatients with depressive disorders: results of a 2-year observational algorithm study.Chi]. Psychiatry (2002) 63(9):782–790.
  • EBERT D, JASPERT A, MURATA H, KASCHKA WP: Initial lithium augmentation improves the antidepressant effects of standard TCA treatment in non-resistant depressed patients.Psychopharmacology (1995) 118(2):223–225.
  • HEIT S, NEMEROFF CB: Lithium augmentation of antidepressants in treatment-refractory depression.Chi]. Psychiatry (1998) 59 (Suppl. 6):28-33; Discussion 34.
  • DILSAVER SC, SWANN SC, CHEN YW etal.: Treatment of bipolar depression with carbamazepine: results of an open study. Bid. Psychiatry (1996) 40(9):935–937.
  • LOEBEL AD, LIEBERMAN JA,ALVIR JM, MAYERHOFF DI,GEISLER SH, SZYMANSKI SR: Duration of psychosis and outcome in first-episodeschizophrenia. Am. I Psychiatry (1992) 149(9):1183–1188.
  • CALABRESE JR, DELUCCHI GA: Spectrum of efficacy of valproate in 55 patients with rapid-cycling bipolar disorder. Am. I Psychiatry (1990) 147(4):431–434.
  • ALLEN MH, CURRIER GW,HUGHES DH, REYES-HARDE M, DOCHERTY JP: The expert consensus guideline series. Treatment of behavioral emergencies. Postgrad. Med. (2001) (Spec. No.):1-88; Quiz 89–90 (Review).
  • •Provides an overview and treatment guidelines of psychiatric emergencies. These recommendations are important, especially to offer appropriate interventions to prevent traumatic experiences for patients and caregivers.
  • BREIER A, MEEHAN K, BIRKETT M et al.: A double-blind, placebo-controlled dose-response comparison of intramuscular olanzapine and haloperidol in the treatment of acute agitation in schizophrenia. Arch. Gen. Psychiatry (2002) 59(5):441–448.
  • •This study assessed efficacy and tolerability of intramuscular formulation of olanzapine for treating acute agitation in patients with schizophrenia. This study has shown that intramuscular olanzapine 2.5-10.0 mg per injection exhibits a dose-response relationship and demonstrates a favourable safety profile compared to haloperidol (see also references 1122-120.
  • JONES B, TAYLOR CC, MEEHAN K: The efficacy of a rapid-acting intramuscular formulation of olanzapine for positive symptoms. I Chi]. Psychiatry (2001) 62\(Suppl. 2):22–24.
  • MEEHAN K, ZHANG F, DAVID S et al.: A double-blind, randomized comparison of the efficacy and safety of intramuscular injections of olanzapine, lorazepam, or placebo in treating acutely agitated patients diagnosed with bipolar mania.Chi]. Psychopharmacol. (2001) 21(4):389–397.
  • WRIGHT P, BIRKETT M, DAVID SR et al.: Double-blind, placebo-controlled comparison of intramuscular olanzapine and intramuscular haloperidol in the treatment of acute agitation in schizophrenia. Am. J. Psychiatry (2001) 158(7):1149–1151.
  • BROOK S: A pilot study of intramuscular ziprasidone in the short-term treatment of patients with acute exacerbation ofschizophrenia. Hum. Psychopharmacol. (2000) 15(7):521–524.
  • LESEM MD, ZAJECKA JM, SWIFT RH, REEVES KR, HARRIGAN EP: Intramuscular ziprasidone, 2 mg versus 10 mg, in the short-term management of agitated psychotic patients.Gbh. Psychiatry(2001) 62(1):12–18.
  • TANDON R, HARRIGAN E, ZORN SH: Ziprasidone: a novel antipsychotic with unique pharmacology and therapeutic potential. j Serotortin Research (1997) 4:159–177.
  • EDWARDS J, MCGORRY PD, WADDELL FM, HARRIGAN SM: Enduring negative symptoms in first-episode psychosis: comparison of six methods using follow-up data.Schizophr. Res. (1999) 40(2):147–158.
  • •A study of negative symptoms in first-episode psychosis. The negative symptom group had significantly lower scores on quality of life, poorer premorbid adjustment, and longer durations of prodrome and untreated psychosis showing that intensive research is needed in this field.
  • HO BC, NOPOULOS E FLAUM M, ARNDT S, ANDREASEN NC: Two-year outcome in first-episode schizophrenia: predictive value of symptoms for quality of life. Am. J. Psychiatry (1998) 155(9):1196–1201.
  • LINSZEN D, DINGEMANS P, LENIOR M: Early intervention and a five year follow up in young adults with a short duration of untreated psychosis: ethical implications. Schizophr. Res. (2001) 51(1):55–61.
  • WATT DC, KATZ K, SHEPHERD M: The natural history of schizophrenia: a 5-year prospective follow-up of a representative sample of schizophrenics by means of a standardized clinical and social assessment. Psycho]. Med. (1993) 13:663–670.
  • WESTERMEYER JF, HARROW M: Prognosis and outcome using broad (DSM-II) and narrow (DSM-III) concepts of schizophrenia. Schizophr. Bull. (1984) 10:624–637.
  • BRAMBILLA P, BARALE ECAVERZASI E, TOGNONI G,BARBUI C: Clozapine-treated subjects with treatment-resistant schizophrenia: a systematic review of experimental and observational studies.Int. Chit. Psychopharmacol. (2002) 17(4):189–195.
  • LAMBERT M, CONUS P, EIDE P, KAROW A, KRAUSZ M, NABER D: Impact of present and past side effects on the attitude towards typical antipsychotic treatment. Eur. Psychiatry (Submitted).
  • SZYMANSKI SR, CANNON TD, GALLACHER E ERWIN RJ, GUR RE: Course of treatment response in first-episode and chronic schizophrenia. Am. J. Psychiatry (1996) 153(4):519–525.
  • CONLEY RR: Risperidone side effects. Chit. Psychiatry (2000) 61\(Suppl. 8):52–61.
  • SEVY S, ROBINSON DG,HOLLOWAY S et al: Correlates of substance misuse in patients with first-episode schizophrenia and schizoaffective disorder. Acta Psychiatr. Scand. (2001) 104(5):367–374.
  • Systematic Treatment of Persistent Psychosis (STOPP). A psychological approach to facilitating recovery in young people with first-episode psychosis. Herrmann-Doig T, Maude D, Edwards J (Eds), Martin Dunitz, UK (2003).
  • BREIER A, MALHORTA A,TUNG-PING S et al.: Clozapine and risperidone in chronic schizophrenia: effects on symptoms, parkinsonian side effects, and neuroendocrine response. Am. j Psychiatry (1999) 156:294–298.
  • LINDENMAYER JP, VOLAVKA J, LIEBERMAN J et al.: Olanzapine for schizophrenia refractory to typical and atypical antipsychotics: an open-label, prospective trial. I Chu. Psychopharmacol (2001) 21(4):448–453.
  • TOLLEFSON GD, BIRKETT MA, KIESLER GM, WOOD AJ: Double-blind comparison of olanzapine versus clozapine in schizophrenic patients clinically eligible for treatment with clozapine.Biol. Psychiatry (2001) 49(1):52–63.
  • ZHANG XY, ZHOU DE CAO LY, ZHANGPY, WU GY, SHEN YC: Risperidone versus haloperidol in the treatment of acute exacerbations of chronic inpatients with schizophrenia: a randomized double-blind study. Int. Chit. Psychopharmacol (2001) 16(6):325–330.
  • MOLLER HJ: Amisulpride: efficacy in the management of chronic patients with predominant negative symptoms of schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. (2001) 251(5):217–224.
  • NABER D, LAMBERT M: Amisulpride: a safe and effective option for the long-term treatment of patients with schizophrenia. Chu. Psych. Practice (In Press).
  • NARENDRAN R, YOUNG CM, VALENTI AM, PRISTACH CA, PATO MT, GRACE JJ: Olanzapine therapy in treatment-resistant psychotic mood disorders: a long-term follow-up study.Chu. Psychiatry (2001) 62(7):509–516.
  • PEUSKENS J, SIENAERT M,DE HERT M: Sexual dysfunction: the unspoken side-effect of antipsychotics. Eur. Psychiatry (1998) 13\(Suppl. 1):23–30.
  • TAYLOR DM, DUNCAN-MCCONNELL D: Refractory schizophrenia and atypical antipsychotics. Psychopharmacol (2000) 14(4):409–418.
  • LANE HY, CHANG YC, CHANG WH, LIN SK, TSENG YT, JANN MW: Effects of gender and age on plasma levels of clozapine and its metabolites: analyzed by critical statistics. j Chu. Psychiatry (1999) 60(1):36–40.
  • KRONIG M, MUNNE R, SZYMANSKI S et al.: Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients. Am. j Psychiatry (1995) 152:179–182.
  • LLORCA PM, CHEREAU I, BAYLE FJ, LANCON C: Tardive dyskinesias and antipsychotics: a review. Eur. Psychiatry (2002) 17(3):129–138.
  • POTKIN SG, BERA R,GULASEKARAM B et al.: Plasma clozapine concentrations predict clinical response in treatment-resistant schizophrenia. j Clin. Psychiatry (1994) 55:133–136.
  • SPINA E, AVENOSO A, FACCIOLA G et al.: Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics. Psychopharmacology (2000) 148:83–89.
  • VAN DER ZWAAG C, MCGEE M, MCEVOY J, FREUDENREICH 0, WILSON W, COOPER T: Response of patients with treatment-refractory schizophrenia to clozapine within three serum level ranges. Am. j Psychiatry (1996) 153:1579–1584.
  • CASEY D: Motor and mental aspects of acute extrapyramidal syndromes. Acta Psychiatc Scand. (1994) 89 (Suppl. 380) :14–20.
  • WHITWORTH AB,FLEISCHHACKER W: Adverse effects of antipsychotic drugs. Int. OM. Psychopharmacol (1995) 9 (Suppl. 5):21–27.
  • REMINGTON G, KAPUR S,ZIPURSKY R: Pharmacotherapy of first-epsiode schizophrenia. Br j Psychiatry (1998) 172\(Suppl. 33):66–70.
  • FRIEDMAN JH: Atypical antipsychotics in the EPS-vulnerable patient. Psychorieuroendocrinology (2003) 28\(Suppl. 1):39–51.
  • LAMBERT M: Adverse neuroleptic effects and their treatment. In: Atypical rieuroleptics in the treatment of schizophrenic patients, 2m edri, Naber D, Lambert M, Krausz M, Haasen C, Pickar D (Eds), UNI-MED publisher, Germany (2002):101–130.
  • ARATO M, O'CONNOR R,MELTZER HY: A 1-year, double-blind, placebo-controlled trial of ziprasidone 40, 80 and 160 mg/day in chronic schizophrenia: the ziprasidone extended use in schizophrenia (ZEUS) study. OM. Psychopharmacol (2002) 17(5):207–215.
  • GOODNICKPJ, JERRY JM: Aripiprazole: profile on efficacy and safety. Expert Opiri. Pharmacother. (2002) 3(12):1773–1781.
  • VAN PUTTEN T, MAY P, MARDER SR, WITTMANN L: Subjective response to antipsychotic drugs. Arch. Gen. Psychiatry (1981) 38:187–190.
  • KRAUSZ M, MORITZ SH, NABER D, LAMBERT M, ANDRESEN B: Neuroleptic-induced extrapyramidal symptoms are accompanied by cognitive dysfunction in schizophrenia. Eur. Psychiatry (1999) 14(2):84–88.
  • SPOHN HE, STRAUSS ME: Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia. Abriorm. Psychology (1989) 98:367–380.
  • BARNES TRE, MCPHILLIPS MA: Antipsychotic-induced extrapyramidal symptoms: role of anticholinergic drugs in treatment. CNS Drugs (1996) 6:315–30.
  • STANILLA JK AND SIMPSON GM: Drugs to treat extrapyramidal side effects, In: The American psychiatric press textbook of psychopharmacology, Schatzberg A,Nemeroff C (Eds), American Psychiatric Press,WA, USA (1995):281–299.
  • GLAZER WM: Review of incidence studies of tardive dyskinesia associated with typicalantipsychotics. j Clin. Psychiatry (2000) 61 (Suppl. 4):15–20.
  • GLAZER WM: Expected incidence of tardive dyskinesia associated with atypical antipsychotics. j OM. Psychiatry (2000) 61 (Suppl. 4):21–26.
  • LLORCA PM, LANCON C, DISDIER B, FARISSE J, SAPIN C, AUQUIER P: Effectiveness of clozapine in neuroleptic-resistant schizophrenia: clinical response and plasma concentrations. Psychiatry Neurosci. (2002) 27(1):30–37.
  • TOLLEFSON GD, BEASLEY CM Jr, TAMURA RN, TRAN PV, POTVIN JH: Blind, controlled, long-term study of the comparative incidence of treatment-emergent tardive dyskinesia with olanzapine or haloperidol. Am. I Psychiatry (1997) 154(9):1248–1254.
  • JESTE DV, CALIGIURI MP, PAULSEN JS eta].: Risk of tardive dyskinesia in older patients. A prospective longitudinal study of 266 outpatients. Arch. Gen. Psychiatry (1995) 52(9):756–765.
  • KANE JM, WOERNER M, BORENSTEIN M, WEGNER J, LIEBERMAN J: Integrating incidence and prevalence of tardive dyskinesia. Psychopharmacol Bull. (1986) 22(1):254–258.
  • WOERNER MG, ALVIR JM, SALTZ BL, LIEBERMAN JA, KANE JM: Prospective study of tardive dyskinesia in the elderly: rates and risk factors. Am. I Psychiatry (1998) 155(11):1521–1528.
  • YASSA R, NAIR N, ISKANDAR H, SCHWARZT G: Factors in the development of severe forms of tardive dyskinesia. Am. I Psychiatry (1990) 147:1156–1163.
  • BERGEN J, KITCHIN R, BERRY G: Predictors of the course of tardive dyskinesia in patients receiving neuroleptics. Biol. Psychiatry (1992) 32(7):580–594.
  • EGAN MF, APUD J, WYATT RJ: Treatment of tardive dyskinesia. Schizophr. Bull. (1997) 23(4):583–609.
  • •A review of literature concerning tardive dyskinesia, showing that despite treatment developments, this disorder remains a significant clinical problem for patients and physicians. The article gives advice for pharmacological interventions (see also refs [166, 167, 169,170–174,176]).
  • SIMPSON GM: The treatment of tardive dyskinesia and tardive dystonia. Cliri. Psychiatry (2000) 61\(Suppl. 4):39–44.
  • BARNETT AA: Safety concerns over antipsychotic drug, sertindole. Lancet (1996) 348:256–257.
  • FDA Briefing document for Zeldox capsules (Ziprasidone), Pfizer Inc., NY, USA, July 18, (2000):16.
  • GLASSMAN AH, BIGGER JT Jr: Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am. J Psychiatry (2001) 158(11):1774–1782.
  • •Provides a good and actual review of QTc prolongation under various antipsychotics (see also ref [180]).
  • MELTZER HY, DAVIDSON M, GLASSMAN AH, VIEWEG WV: Assessing cardiovascular risks versus clinical benefits of atypical antipsychotic drug treatment. I OM. Psychiatry (2002) 63 (Suppl. 9):25–29.
  • BAPTISTA T: Body weight gain induced by antipsychotic drugs: mechanisms and management. Acta Psychiatr. Scarid (1999) 100(1):3–16.
  • GREEN A, PATEL J, GOISMAN R, ALLISON D, BLACKBURN G: Weight gain from novel antipsychotic drugs: need for action. Gen. Hosp. Psychiatry (2000) 22(4):224–235.
  • NASRALLAH H: A review of the effect of atypical antipsychotics on weight. Psychorieuroendocrinology (2003) 28:83–96.
  • •Provides a review of the effect of atypical antipsychotics on weight. The authors concluded that the weight-gain profile of an antipsychotic should be a factor to consider when constructing an algorithm for treatment (see also refs [181, 182, 184–187,189–193,201]).
  • SUSSMAN N: Review of atypical antipsychotics and weight gain. Clin. Psychiatry (2001) 62\(Suppl. 23):5–12.
  • BASILE VS, MASELLIS M,MCINTYRE RS, MELTZER HY, LIEBERMAN JA, KENNEDY JL: Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle. I OM. Psychiatry (2001) 62\(Suppl. 23):45–66.
  • MCINTYRE RS, MANCINI DA,BASILE VS: Mechanisms of antipsychotic-induced weight gain. I OM. Psychiatry (2001) 62\(Suppl. 23):23–29.
  • ARONNE LJ: Epidemiology, morbidity, and treatment of overweight and obesity. OM. Psychiatry (2001) 62\(Suppl. 23):13–22.
  • NEWMAN SC, BLAND RC: Mortality in a cohort of patients with schizophrenia: a record linkage study. Can. I Psychiatry (1991) 36(4):239–245.
  • ALLISON DB, MENTORE JL, HEO M et al.: Antipsychotic-induced weight gain: a comprehensive research synthesis. Am. J. Psychiatry (1999) 156(11):1686–1696.
  • LEVY E, MARGOLESE HC,CHOUINARD G: Topiramate produced weight loss following olanzapine-induced weight gain in schizophrenia. Clin. Psychiatry (2002) 63(11):1045.
  • WIRSHING DA, WIRSHING WC, KYSAR L et al.: Novel antipsychotics: comparison of weight gain liabilities. Clin. Psychiatry (1999) 60(6):358–363.
  • JAMES WP ASTRUP A, FINER N et al.: Effect of sibutramine on weight maintenance after weight loss: a randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance. Lancet (2000) 356(9248):2119–2125.
  • SJOSTROM L, RISSANEN A,ANDERSEN T et al: Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group. Lancet (1998) 352(9123):167–172.
  • SACCHETTI E, GUARNERI L, BRAVI D: H2 antagonist nizatidine may control olanzapine-associated weight gain in schizophrenic patients. Biol. Psychiatry (2000) 48(2):167–168.
  • CARO JJ, WARD A, LEVINTON C, ROBINSON K: The risk of diabetes during olanzapine use compared with risperidone use: a retrospective database analysis. Clin. Psychiatry (2002) 63(12):1135–1139.
  • HEDENMALM K, HAGG S, STAHL M, MORTIMER 0, SPIGSET 0: Glucose intolerance with atypical antipsychotics. Drug Safety (2002) 25(15):1107–1116.
  • SERNYAK MJ, LESLIE DL,ALARCON RD, LOS ONCZY ME ROSENHECK R: Association of diabetes mellitus with use of atypical neuroleptics in the treatment of schizophrenia. Am. J. Psychiatry (2002) 159(4):561–566.
  • DIXON L, WEIDEN P, DELAHANTY J et al.: Prevalence and correlates of diabetes in national schizophrenia samples. Schizophr. Bull. (2000) 26(4):903–912.
  • FLETCHER PJ: Increased food intake in satiated rats induced by the 5-HT antagonists methysergide, metergoline and ritanserin. Psychopharmacology (1988) 96(2):237–242.zoo. GARATTINI S, MENNINI T,SAMANIN R: Reduction of food intake by manipulation of central serotonin. Current experimental results. Br I Psychiatry (1989) 8:S41–S51.
  • WETTERLING T, MUSSIGBRODT HE: Weight gain: side effect of atypical neuroleptics? I Clin. Psychopharmacol (1999) 19(4):316–321.zoz. WIRSHING DA, SPELLBERG BJ, ERHART SM, MARDER SR, WIRSHING W: Novel antipsychotics and new onset diabetes. Biol. Psychiatry (1998) 44(8):778–783.
  • BROMEL T, BLUM WE ZIEGLER A et al: Serum leptin levels increase rapidly after initiation of clozapine therapy. Malec. Psychiatry (1998) 3(1):76–80.
  • OSSER DN, NAJARIAN DM, DUFRESNE RL: Olanzapine increases weight and serum triglyceride levels. Clin. Psychiatry (1999) 60(10:767-770.zos. PEUSKENS J, MOLLER HJ, PUECH A: Amisulpride improves depressive symptoms in acute exacerbations of schizophrenia: comparison with haloperidol and risperidone. Eur. Neuropsychopharmacol. (2002) 12(4):305–310.
  • SIGUSCH V: Sexual dysfunctions and their treatment. Thieme Medical Publishers, NY, USA (1997).
  • BREIER A, HAMILTON SH: Comparative efficacy of olanzapine and haloperidol for patients with treatment-resistant schizophrenia. Biol. Psychiatry (1999) 45(4):403–411.
  • CONLEY RR, KELLY DL: Management of treatment resistance in schizophrenia. Biol. Psychiatry (2001) 50(11):898–911.zos. HALBREICH U, KINON BJ,GILMORE JA, KAHN LS: Elevated prolactin levels in patients with schizophrenia: mechanisms and related adverse effects. Psychoneuroendocrinology (2003) 28\(Suppl. 1):53–67.
  • REIN W, TURJANSKI S, FAVENNEC-MEIDINGER C: Amisulpride, an atypical antipsychotic - safety profile. In: Xth WPA Congress, Madrid, Spain (1996).
  • TURRONE E KAPUR S, SEEMAN MV, FLINT AJ: Elevation of prolactin levels byatypical antipsychotics. Am. j Psychiatry (2002) 159(1):133–135.
  • WUDARSKY M, NICOLSON R, HAMBURGER SD et al.: Elevated prolactin in pediatric patients on typical and atypical antipsychotics. I Child Adolesc. Psychopharmacol (1999) 9(4):239–245.
  • DAVID SR, TAYLOR CC, KINON BJ, BREIER A: The effects of olanzapine, risperidone, and haloperidol on plasma prolactin levels in patients with schizophrenia. Clin Ther (2000) 22(9):1085–1096.
  • MEATS P: Quetiapine (Seroquel), an effective and well-tolerated atypical antipsychotic. mt. I Psychiatry Chia. Pic. (1997) 1:231–239.
  • WEIDEN PJ, NAVEED I, MENDELOWITZ TANDON R, ZIMBROFF DL, ROSS R: Best clinical practice with ziprasidone: update after one year experience. I Psych. Practice (2002) 8:81–98.
  • VIGUERA AC, BALDESSARINI RJ, HEGARTY JD, VAN KAMMEN DP, TOHEN M: Clinical risk following abrupt and gradual withdrawal of maintenance neuroleptic treatment. Arch. Gen. Psychiatry (1997) 54(1):49–55.
  • BOSVELD-VAN HAANDEL LJ, SLOOFF CJ, VAN DEN BOSCH RJ: Reasoning about the optimal duration of prophylactic antipsychotic medication in schizophrenia: evidence and arguments. Acta Psychiam Scam/. (2001) 103(5):335–346.
  • •This article provides a review of evidence-based literature regarding the necessary duration of antipsychotic relapse prevention in schizophrenia and related psychoses.
  • GITLIN M, NUECHTERLEIN K, SUBOTNIK KL et al: Clinical outcome following neuroleptic discontinuation in Patients with remitted recent-onset schizophrenia. Am. I Psychiatry (2001) 158(10:1835–1842.
  • WIERSMA D, NIENHUIS FJ,SLOOFF CJ, GIEL R: Natural course of schizophrenic disorders: a 15-year follow-up of a Dutch incidence cohort. Schizophr. Bull. (1998) 24:75-65.zzo.
  • HOGARTY GE, GOLDBERG SC, SCHOOLER NR, ULRICH RF: Drug and sociotherapy in the aftercare of schizophrenic patients: two year relapse rates. Arch. Gen. Psychiatry (1974) 31:603–608.
  • ZIPURSKY RB: Optimal pharmacologic management of the first-episode of schizophrenia. In: The early stages of schizophrenia. Kapur S, Zipursky RB (Eds), American Psychiatric Publishing Inc. Washington DC, USA (2001).

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