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Drug Evaluation

Caspofungin: first approved agent in a new class of antifungals

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Pages 807-823 | Published online: 02 Mar 2005

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  • ••A study that demonstrates increasedefficacy of a combination of caspofungin and voriconazole against Aspergillus fumigatus in an animal model of transiently neutropenic, immunosuppressed guinea pigs.
  • VILLANUEVA A, GOTUZZO E, ARATHOON EG etal.: A randomized double-blind study of caspofungin versus fluconazole for the treatment of esophageal candidiasis. Am. j Med. (2002) 113(4):294–299.
  • ••Describes a Phase III, randomised trial inwhich caspofungin was as efficacious as fluconazole for the treatment of esophageal candidiasis.
  • KARTSONIS N, DINUBILE MJ, BARTIZAL K et al: Efficacy of caspofungin in the treatment of esophageal candidiasis resistant to fluconazole. Acquir: Immune Defic. Syndr. (2002) 31(2):183–187.
  • MORA-DUARTE J, BETTS R, ROTSTEIN C et al: Caspofungin versus amphotericin B deoxycholate in the treatment of invasive candidiasis in neutropenic and non-neutropenic patients: a multi-centre, randomized, double-blind study. In: Program and Abstracts of the I Zb European Congress of Clinical Microbiology and Infectious Diseases, Milan, Italy (2002)0237.
  • MAERTENS J, RAAD I, PETRIKKOS G et al.: Update of the multicenter noncomparative study of caspofungin in adults with invasive aspergillosis refractory or intolerant to other antifungal agents: analysis of 90 patients. In: Program and Abstracts of the 42m Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA (2002) M–868.
  • ••Describes outcomes of 83 patients whoreceived 1 dose of caspofungin in a study of invasive aspergillosis infection among patients who were refractory or intolerant to other antifungal therapies.
  • KOSS T, BAGHERI B, ZEANA C, ROMAGNOLI MF, GROSSMAN ME: Amphotericin B-resistant Aspergillus flavus infection successfully treated with caspofungin, a novel antifungal agent. Amer. Acad. Dermatol (2002) 46(6):945–947.
  • RUBIN MA, CARROLL KC, CAHILL BC: Caspofungin in combination with itraconazole for the treatment of invasive aspergillosis in humans. Clin Infect. Dis. (2002) 34(8):1160–1161.
  • •Two case reports of successful therapy with a combination of caspofungin and itraconazole for invasive Aspergillosis.
  • ALIFF TB, MASLAK PG, JURCIC JG et al.: Refractory aspergillus pneumonia in patients with acute leukemia: successful therapy with combination caspofungin and liposomal amphotericin B. In: Program and Abstracts of the 4.7d Annual Meeting of the American Society of Hematology Orlando, FL, USA (2001):1381.
  • KONTOYIANNIS DP, HACHEM R, LEWIS RE et al.: Efficacy and toxicity of the caspofungin/liposomal amphotericin B combination in documented or possible invasive aspergillosis in patients with hematologic malignancies. In: Program and Abstracts of the 42m Interscience Conference on Antimicrobial Agents and Chemotherapy San Diego, CA, USA (2002):M–1820.
  • •Case series describing outcomes among 50 patients with invasive aspergillosis who received combination therapy with caspofungin and liposomal amphotericin B.
  • SAFDAR A: Progressive cutaneous hyalohyphomycosis due to Paecilomyces lilacinus: rapid response to treatment with caspofungin and itraconazole. Clin. Infect. Dis. (2002) 34(10):1415–1417.
  • GOODMAN D, PAMER E, JAKUBOWSKI A, MORRIS C, SEPKOWITZ K: Breakthrough trichosporonosis in a bone marrow transplant recipient receiving caspofungin acetate. Clin Infect. Dis. (2002) 35(3):E35–E36.
  • STONE JA, MIGOYA E, LI S et al: Safety and pharmacokinetics of higher doses of caspofungin. In: Program and Abstracts of the 42m Interscience Conference on Antimicrobial Agents and Chemotherapy San Diego, CA, USA (2002):A–1319.
  • •Describes safety of caspofungin at single doses of up to 210 mg in healthy volunteers.

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