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Drug Evaluation

Anagrelide: a decade of clinical experience with its use for the treatment of primary thrombocythaemia

Pages 1781-1798 | Published online: 25 Feb 2005

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  • •Deals with the early often neglected stages of PT.
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  • •A good overview on childhood essential thrombocythaemia.
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  • •Prolonged use of hydroxyurea may increase the rate of skin tumours.
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  • •These authors cannot detect an increased risk of leukaemic transformation with hydroxyurea therapy.
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  • •These authors do not recommend the use of hydroxurea in younger patients.
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  • •High proportion of 17p deletion in patients with MDS/AML after treatment with hydroxyurea alone or in combination with pipobroman.
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