93
Views
22
CrossRef citations to date
0
Altmetric
Review

Pharmacoeconomics of antifungal pharmacotherapy – challenges and future directions

, , &
Pages 2617-2632 | Published online: 30 Nov 2005

Bibliography

  • MCNEIL MM, NASH SL, HAJJEH RA et al.: Trends in mortality due to invasive mycotic diseases in the United States, 1980— 1997. Clin. Infect. Dis. (2001) 33(5):641–647.
  • PFALLER MA and DIEKEMA DJ: Role of sentinel surveillance of candidemia: trends in species distribution and antifungal susceptibility. J. Clin. MicrobioL (2002) 40(10):3551–3557.
  • PAPPAS PG, REX JH, SOBEL JD et al.: Guidelines for treatment of candidiasis. Clin. Infect. Dis. (2004) 38(2):161–189.
  • STEVENS DA, KAN VL, JUDSON MA et al.: Practice guidelines for diseases caused by Aspergillus. Infectious Diseases Society of America. Clin. Infect. Dis. (2000) 30(4):696–709.
  • SAAG MS, GRAYBILL RJ, LARSEN RA et al.: Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America. Clin. Infect. Dis. (2000) 30(4):710–718.
  • WHEAT J, SAROSI G, MCKINSEY D et al.: Practice guidelines for the management of patients with histoplasmosis. Infectious Diseases Society of America. Clin. Infect. Dis. (2000) 30(4):688–695.
  • BENNETT JE, KAUFFMAN C, WALSH T et al.: Forum report: issues in the evaluation of diagnostic tests, use of historical controls, and merits of the current multicenter collaborative groups. Clin. Infect. Dis. (2003) 36\(Suppl. 3):5123–5127.
  • REX JH, WALSH TJ, NETTLEMAN M et al.: Need for alternative trial designs and evaluation strategies for therapeutic studies of invasive mycoses. Clin. Infect. Dis. (2001) 33(1):95–106.
  • JOHNSON MD, DODDS ASHLEY ES, KAYE KS, ELY TS, PERFECT JR: Impact of voriconazole on antifungal expenditures at a tertiary care medical center. Program and Abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA (2003) M–986.
  • FORREST G, WEEKES E, STANDIFORD HC: Antimicrobial management program: continual cost savings at a large teaching medical center. Program and Abstracts of the 4Ist Annual Meeting of the Infectious Diseases Society of America, San Diego, CA, USA (2003) 328.
  • OSTROSKY-ZEICHNER L, MARR KA, REX JH, COHEN SH: Amphotericin B: time for a new 'gold standard'. Clin. Infect. Dis. (2003) 37(3):415–425.
  • DIXON S, MCKEEN E, TABBERER M, PAISLEY S: Economic evaluations of treatments for systemic fungal infections: a systematic review of the literature. Pharmacoeconomics (2004) 22(7):421–433.
  • ••Excellent review outlining importantelements in pharmacoeconomic analyses of systemic antifungal therapy.
  • JOLICOEUR LM, JONES-GRIZZLE AJ, BOYER JG: Guidelines for performing a pharmacoeconomic analysis. Am. J. Hosp. Pharm. (1992) 49(716217301741–1747.
  • •Excellent review of pharmacoeconomic study methods.
  • SANCHEZ LA: Applied pharmacoeconomics: evaluation and use of pharmacoeconomic data from the literature. Am. J. Health Syst. Pharm. (1999) 56(16):1630–1638.
  • SANCHEZ LA: Pharmacoeconomic principles and methods: including pharmacoeconomics into hospital pharmacy practice. Hosp. Pharm. (1994) 29(11):1035–1036, 1039–1040.
  • SANCHEZ LA: Pharmacoeconomic principles and methods: an introduction for hospital pharmacists. Hosp. Pharm. (1994) 29(8):774, 777-779.
  • SANCHEZ LA and LEE J: Use and misuse of pharmacoeconomic terms: a definitions primer. Top. Hosp. Pharm. Manage. (1994) 13(4):11–22.
  • WILSON LS, REYES CM, STOLPMAN M et al.: The direct cost and incidence of systemic fungal infections. Value Health (2002) 5(1):26–34.
  • ••Key paper describing costs of managinginvasive fungal infections.
  • WINGARD JR, LEATHER HL, WALSH TJ et al.: Pharmacoeconomic analysis comparing caspofungin to liposomal amphotericin B for empirical therapy for persistently febrile neutropenic patients. Program and Abstracts of the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC (2004) 0–1619.
  • ••First pharmacoeconomic analysis ofcaspofungin versus amphotericin B deoxycholate as empiric therapy for neutropaenic fever.
  • RENTZ AM, HALPERN MT, BOWDEN R: The impact of candidemia on length of hospital stay, outcome, and overall cost of illness. Clin. Infect. Dis. (1998) 27(4):781–788.
  • WENZEL R, DEL FAVERO A, KIBBLER C et al.: Economic evaluation of voriconazole compared with conventional amphotericin B for the primary treatment of aspergillosis in immunocompromised patients. J. Antimimb. Chemother. (2005) 55(3):352–361.
  • ••Key study evaluating costs of voriconazoleversus amphotericin B deoxycholate/other licensed antifungal therapy when managing invasive aspergillosis based on data from a randomised trial.
  • O'CONNELL B, CRAIG JI, MARCUS RE, LUDLAM H: Cost-effective use of liposomal amphotericin B. Clin. Lab. HaematoL (2002) 24(5):317–319.
  • LEWIS JS, BOUCHER HW, LUBOWSKI TJ et al.: Cost advantage of voriconazole over amphotericin B for primary treatment of invasive aspergillosis. Pharmacotherapy (2005) 25(0:839-846. Key study evaluating costs of voriconazole versus other licensed antifungal therapy when managing invasive aspergillosis based on data from a randomised trial.
  • DRANITSARIS G, PHILLIPS P, ROTSTEIN C et al.: Economic analysis of fluconazole versus amphotericin B for the treatment of candidemia in non-neutropenic patients. Pharmacoeconomics (1998) 13(5):509–518.
  • ••Important study evaluating costs oftreating invasive candidiasis with fluconazole or amphotericin B deoxycholate, based data from a randomised clinical trial.
  • DASBACH EJ, DAVIES GM, TEUTSCH SM: Burden of aspergillosis-related hospitalizations in the United States. Clin. Infect. Dis. (2000) 31(6):1524–1528.
  • KUTI JL, KOTAPATI S, WILLIAMS P: Pharmacoeconomic analysis of amphotericin B lipid complex versus liposomal amphotericin B in the treatment of fungal infections. Pharmacoeconomics (2004) 22(5):301–310.
  • ••An important cost-minimisation analysisof two lipid amphotericin B formulations for treatment of invasive fungal infections in one medical centre.
  • FINK JM, LONG JK, GOLDMAN MP: Cost-minimization analysis of lipid amphotericin B products. Program and Abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA (2003) A–1361.
  • MILLER LG, HAJJEH RA, EDWARDS JE JR: Estimating the cost of nosocomial candidemia in the United States. Clin. Infect. Dis. (2001) 32(7):1110.
  • MANSLEY EC, SULLIVAN E, WOOD C, BERGER ML: Caspofitngin versus amphotericin B deoxycholate: do the savings generated from reduced rates of impaired renal function offset the differences in drug cost? Program and Abstracts of the 4Ist Annual Meeting of the Infectious Diseases Society of America, San Diego, CA, USA (2003) 165.
  • REX JH, PAPPAS PG, KARCHMER AW et al.: A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects. Clin. Infect. Dis. (2003) 36(10):1221–1228.
  • HERBRECHT R, DENNING DW, PATTERSON TF et al.: Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl. J. Med. (2002) 347(6):408–415.
  • BUXTON MJ, DUBOIS DJ, TURNER RR et al.: Cost implications of alternative treatments for AIDS patients with cryptococcal meningitis. Comparison of fluconazole and amphotericin B-based therapies. J. Infect. (1991) 23(1):17–31.
  • TOLLEMAR J, HOCKERSTEDT K, ERICZON BG, JALANKO H, RINGDEN 0: Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients. A randomized, placebo-controlled study. Transplantation (1995) 59(1):45–50.
  • SHARPE MD, GHENT C, GRANT D et al.: Efficacy and safety of itraconazole prophylaxis for fungal infections after orthotopic liver transplantation: a prospective, randomized, double-blind study. Transplantation (2003) 76(0:977–983.
  • BIANCOFIORE G, BINDI ML, BALDASSARRI R et al: Antifitngal prophylaxis in liver transplant recipients: a randomized placebo-controlled study. Transpl. Int. (2002) 15(7):341–347.
  • MEKA VG, HADLEY S, DALY J et al.: Molecular epidemiology of invasive candida infection withing 100 days after orthotopic liver transplantation. Program and Abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ii, USA (2003) M–2062.
  • WAKERLY L, CRAIG AM, MALEK M et al.: Fluconazole versus oral polyenes in the prophylaxis of immunocompromised patients: a cost-minimization analysis. J. Hosp. Infect. (1996) 33(1):35–48.
  • SCHAFFNER A, SCHAFFNER M: Effect of prophylactic fluconazole on the frequency of fungal infections, amphotericin B use, and health care costs in patients undergoing intensive chemotherapy for hematologic neoplasias. J. Infect. Dis. (1995) 172(4):1035–1041.
  • SCHARFSTEIN JA, PALTIEL AD, FREEDBERG KA: The cost-effectiveness of fluconazole prophylaxis against primary systemic fungal infections in AIDS patients. Med. Decis. Making (1997) 17(4):373–381.
  • MANFREDI R, MASTROIANNI A. CORONADO OV, CHIODO F: Fluconazole as prophylaxis against fungal infection in patients with advanced HIV infection. Arch. Intern. Med. (1997) 157(1):64–69.
  • POIRIER JM, HARDY S, ISNARD F et al.: Plasma itraconazole concentrations in patients with neutropenia: advantages of a divided daily dosage regimen. Ther. Drug. Monit. (1997) 19(5):525–529.
  • SKINNER JL, HARRIS C, AARON MF et al.: Cost-benefit analysis of extended antifungal prophylaxis in ventricular assist devices. ASAIO Journal (2000) 46(5):587–589.
  • KRUPOVA Y, NOVOTNY J, SABO A, MATEICKA F, KRCMERY V JR: Aetiology, cost of antimicrobial therapy and outcome in neutropenic patients who developed bacteraemia during antimicrobial prophylaxis: a case-control study. Int. J. Antimicrob. Agents (1998) 10(4):313–316.
  • SAJBEN P, MINARIK T, TOMASIK E et al.: Fluconazole plus ofloxacin in prophylaxis of infections in patients with acute leukemia: a comparative study. Support Care Cancer (1993) 1(4):214–216.
  • SCHRODER CP, DE VRIES EG, MULDER NH et al.: Prevention of febrile leucopenia after chemotherapy in high-risk breast cancer patients: no significant difference between granulocyte-colony stimulating growth factor or ciprofloxacin plus amphotericin B. J. Antimicrob. Chemother. (1999) 43(5):741–3.
  • BOOGAERTS M, TORMANS G, MAES E, VAN DOORSLAER B: Cost-effectiveness analysis of AmBisome versus amphotericin B in the empiric treatment of febrile neutropenia in adults and children. Blood (1996) 88\(Suppl. 1):501a.
  • CAGNONI PJ, WALSH TJ, PRENDERGAST MM et al.: Pharmacoeconomic analysis of liposomal amphotericin B versus conventional amphotericin B in the empirical treatment of persistently febrile neutropenic patients. Clin. Oncol (2000) 18(12):2476–2483. Important analysis of costs associated with management of neutropaenic fever with liposomal amphotericin B versus amphotericin B deoxycholate, using data from a large randomised, double-blind trial.
  • WALSH TJ, FINBERG RW, ARNDT C et al.: Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group. N Engl. J. Med. (1999) 340(10):764–771.
  • WALSH TJ, TEPPLER H, DONOWITZ GR et al.: Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia. N Engl. J. Med. (2004) 351(14):1391–1402.
  • DREW RH, JOHNSON MD, DODDS ASHLEY ES, PERFECT JR: Rational use of antifungals for invasive fungal infections in the institutional setting. Antibiotic optimization: concepts and strategies in clinical practice, 1st edn. Marcel Dekker, New York, N.Y. (2005):577–644.
  • WONG-BERINGER A, JACOBS RA, GUGLIELMO BJ: Lipid formulations of amphotericin B: clinical efficacy and toxicities. Clin. Infect. Dis. (1998) 27(3):603–618.
  • BELDEN TL, DREW RH, PERFECT JR: Predicting subsequent infusion-related reactions from responses to initial doses of amphotericin B lipid complex. Program and abstracts of the American College of Clinical Pharmacy 2002 Spring Practice and Research Forum, Savannah, GA, USA (2002).
  • RODEN MM, NELSON LD, KNUDSEN TA et al.: Triad of acute infusion-related reactions associated with liposomal amphotericin B: analysis of clinical and epidemiological characteristics. Clin. Infect. Dis. (2003) 36(10):1213–1220.
  • JOHNSON MD, DREW RH, PERFECT JR: Chest discomfort associated with liposomal amphotericin B: report of three cases and review of the literature. Pharmacotherapy (1998) 18(5):1053–1061.
  • TIMMERS GJ, ZWEEGMAN S, SIMOONS-SMIT AM et al.: Amphotericin B colloidal dispersion (Amphocil) versus fluconazole for the prevention of fungal infections in neutropenic patients: data of a prematurely stopped clinical trial. Bone Marrow Transplant. (2000) 25(8):879–884.
  • DERAY G: Amphotericin B nephrotoxicity. Antimicrob. Chemother. (2002) 49\(Suppl. 0:37–41.
  • BOWDEN R, CHANDRASEKAR P, WHITE MH et al.: A double-blind, randomized, controlled trial of amphotericin B colloidal dispersion versus amphotericin B for treatment of invasive aspergillosis in immunocompromised patients. Clin. Infect. Dis. (2002) 35(4):359–366.
  • JOHNSON PC, WHEAT LJ, CLOUD GA et al.: Safety and efficacy of liposomal amphotericin B compared with conventional amphotericin B for induction therapy of histoplasmosis in patients with AIDS. Ann. Intern. Med. (2002) 137(2):105–109.
  • LEENDERS AC, DAENEN S, JANSEN RL et al.: Liposomal amphotericin B compared with amphotericin B deoxycholate in the treatment of documented and suspected neutropenia-associated invasive fungal infections. Br. J. Haematol (1998) 103(1):205–212.
  • LEENDERS AC, REISS P, PORTEGIES P et al.: Liposomal amphotericin B (AmBisome) compared with amphotericin B both followed by oral fluconazole in the treatment of AIDS-associated cryptococcal meningitis. AIDS (1997) 11(12):1463–1471.
  • SHARKEY PK, GRAYBILL JR, JOHNSON ES et al.: Amphotericin B lipid complex compared with amphotericin B in the treatment of cryptococcal meningitis in patients with AIDS. Clin. Infect. Dis. (1996) 22(2):315–321.
  • MORA-DUARTE J, BETTS R, ROTSTEIN C et al.: Comparison of caspofungin and amphotericin B for invasive candidiasis. N Engl. J. Med. (2002) 347(25):2020–2029.
  • VILLANUEVA A. ARATHOON EG, GOTUZZO E et al.: A randomized double-blind study of caspofungin versus amphotericin for the treatment of candidal esophagitis. Clin. Infect. Dis. (2001) 33(9):1529–1535.
  • ARATHOON EG, GOTUZZO E, NORIEGA LM et al.: Randomized, double-blind, multicenter study of caspofungin versus amphotericin B for treatment of oropharyngeal and esophageal candidiases. Antimicrob. Agents Chemother. (2002) 46(2):451–457.
  • WALSH TJ, PAPPAS P, WINSTON DJ et al.: Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever. N Engl. J. Med. (2002) 346(4):225–234.
  • WALSH T, SABLE C, DEPAUW B et al.: A randomized, double-blind, multicenter trial of caspofungin v liposomal amphotericin B for empirical antifungal therapy of persistently febrile neutropenic patients. Program and Abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA (2003) M–1761.
  • WALSH TJ, GROLL AH: Emerging fungal pathogens: evolving challenges to immunocompromised patients for the twenty-first century. Transpl. Infect. Dis. (1999) 1(4):247–261.
  • GREENBERG RN, CAGNONI PJ, WINGARD JR, PRENDERGAST MM, TONG KB: Factors associated with increased hospital costs in patients treated with lipid-based amphotericin B for empirical therapy. J. Med. Econ. (2002)
  • BATES DW, SU L, YU DT et al.: Mortality and costs of acute renal failure associated with amphotericin B therapy. Clin. Infect. Dis. (2001) 32(5):686–693.
  • HARBARTH S, BURKE JP, LLOYD JF et al.: Clinical and economic outcomes of conventional amphotericin B-associated nephrotoxicity. Clin. Infect. Dis. (2002) 35(12) el 20-el 27.
  • GRYBET S, CRONIN SM, SOBEL JW, BINDLISH V: Arnphotericin B usage evaluation at a university teaching hospital. ASHP Midyear Clinical Meeting, New Orleans, LA, USA (1991).
  • NINNO SD, NINNO MA: Optimizing the use of amphotericin B lipid complex. ASHP Midyear Clinical Meeting, New Orleans, LA, USA (1996).
  • GABARDI S, FIUMARA K, LOWRY C, FANIKOS J: Drug utilization evaluation of liposomal amphotericin B at a large, urban, academic medical center, with a focus on drug dosing over the past six years. ASHP Midyear Clinical Meeting Orlando, FL, USA (2004).
  • SANDERSON B, JONES TA: Assessment of salt-loading in patients receiving amphotericin B preparatons. ASHP Midyear Clinical Meeting New Orleans, LA, USA (2003).
  • KENNEDY LD, CONNELLY JF, KUZMA KM: Two-year longitudinal evaluation of amphotericin B lipid complex injection in a tertiary care medical center. Hosp. Pharm. (2001) 36(2):176–191.
  • CHAN S, FORREST GN, KLEINBERG M, DONNENBERG MS: Significant cost savings with implementation of lipid amphotericin B guidelines at a university cancer center. Program and Abstracts of the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA (2002) 0–999.
  • LOMAESTRO B, ROGLER B: A large teaching hospital's utilization of systemic antifungal therapy. ASHP Midyear Clinical Meeting, New Orleans, LA, USA (2003).
  • COLLINS CD, PEDERSEN CA, SCHNEIDER PJ et al.: Effect on amphotericin B lipid complex use of a clinical decision support system for computerized prescriber order entry. Am. J. Health Syst. Pharm. (2004) 61(13):1395–1399.
  • GALLAGHER JC, LEE KB: Program to restrict use of iv. fluconazole. Am. J. Health Syst. Pharm. (2004) 61(16):1695–1698.
  • BURKIEWICZ JS, KOSTIUK KA, JACOBS RA, GUGLIELMO BJ: Impact of an intravenous fluconazole restriction policy on patient outcomes. Ann. Pharmacotherapy (2001) 35(1):9–13.
  • ARNOLD T, DONEGAN S, KLEINBERG M, FORREST G: Cost-effectiveness of implementing an IV antifungal to oral voriconazole conversion in a cancer center. Program and Abstracts of the 42nd Annual Meeting of the Infectious Diseases Society of America, Boston, MA, USA (2005) 690.
  • PHILLIPS P, SHAFRAN S, GARBER G et al.: Multicenter randomized trial of fluconazole versus amphotericin B for treatment of candidemia in non-neutropenic patients. Canadian Candidemia Study Group. Eur. j Clin. Microbiol Infect. Dis. (1997) 16(5):337–345.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.