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Drug Evaluation

Levosimendan for the treatment of acute heart failure syndromes

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Pages 2741-2751 | Published online: 30 Nov 2005

Bibliography

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  • •The first in vivo study demonstrating anti-inflammatory and anti-apoptotic effects of levosimendan in advanced heart failure.
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  • ••Multi-centre trial demonstrating survivalbenefits of levosimendan versus placebo in patients with acute heart failure in the post-infarction setting.
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  • ••The first randomised multi-centre trialdemonstrating superiority of levosimendan versus dobutamine in haemodynamic improvement and survival benefit of patients with decompensated heart failure.
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Websites

  • http://www.orion.fi/english/investors/ stockreleases.shtml/a05?23290 Orion stock exchange release: Abbott reports improved clinical course with Orion's levosimendan (Simdax(D) when added to standard therapy in acute decompensated heart failure trial (REVIVE-2). Accessed 16 November, 2005.
  • http://www.orion.fi/english/investors/ stockreleases.shtml/a05?23304 Orion stock exchange release: Abbott reports levosimendan (Simdax(D) results from large mortality trial in patients with acute decompensated heart failure (SURVIVE). Accessed 16 November, 2005.

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