127
Views
7
CrossRef citations to date
0
Altmetric
Drug Evaluation

Capecitabine in carcinoma of the pancreas

&
Pages 1633-1639 | Published online: 28 Jul 2006

Bibliography

  • JEMAL A, MURRAY T, WARD E et al.: Cancer statistics 2005. CA Cancer J. Clin. (2005) 55:10-30.
  • BRAMHALL SR, ALLUMWH, JONES AG, ALLWOOD A, CUMMINS C, NEOPTOLEMOS JP: Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br. J. Surg. (1995) 82(1):111-115.
  • PLATH T, PETERS M, DETJEN K et al.: Overexpression of pRB in human pancreatic carcinoma cells: function in chemotherapy-induced apoptosis. J. Natl. Cancer Inst. (2002) 94:129-142.
  • CARTER SK, COMIS RL: The integration of chemotherapy into a combined modality approach for cancer treatment. VI. Pancreatic adenocarcinoma. Cancer Treat. Rev. (1975) 2:193-214.
  • CROWN J, CASPER ES, BOTET J et al.: Lack of efficacy of high-dose leucovorin and fluorouracil in patients with advanced pancreatic adenocarcinoma. J. Clin. Oncol. (1991) 9:1682-1686.
  • DECAPRIO JA, MAYER RJ, GONIN R, ARBUCK SG: Fluorouracil and high-dose leucovorin in previously untreated patients with advanced adenocarcinoma of the pancreas: results of a Phase II trial. J. Clin. Oncol. (1991) 9:2128-2133.
  • VAN RIJSWIJK RE, JEZIORSKI K, WAGENER DJ et al.: Weekly high-dose 5-fluorouracil and folinic acid in metastatic pancreatic carcinoma: a Phase II study of the EORTC Gastro-Intestinal Tract Cancer Cooperative Group. Eur. J. Cancer (2004) 40:2077-2081.
  • CASPER ES, GREEN MR, KELSEN DP et al.: Phase II trial of gemcitabine (2,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest. New Drugs (1994) 12:29-34.
  • CARMICHAEL J, FINK U, RUSSELL RC et al.: Phase II study of gemcitabine in patients with advanced pancreatic cancer. Br. J. Cancer (1996) 73:101-105.
  • ROTHENBERG ML, MOORE MJ, CRIPPS MC et al.: A Phase II trial of gemcitabine in patients with 5-FU-refractory pancreas. Ann. Oncol. (1996) 7:347-353.
  • BURRIS HA III, MOORE MJ, ANDERSEN J et al.: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J. Clin. Oncol. (1997) 15:2403-2413.
  • THIRION. P, MICHIELS S, PIGNON JP et al.: Meta-Analysis Group in Cancer. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis. J. Clin. Oncol. (2004) 22(18):3766-3775.
  • MIWA M, URA M, NISHIDA M et al.: Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Eur. J. Cancer (1998) 34:1274-1281.
  • ISHIKAWA T, UTOH M, SAWADA N et al.: Tumor selective delivery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts. Biochem. Pharmacol. (1998) 55(7):1091-1097.
  • SCHULLER J, CASSIDY J, DUMONT E et al.: Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chemother. Pharmacol. (2000) 45:291-297.
  • REIGNER B, BLESCH K, WEIDEKAAM E: Capecitabine; a review of its clinical pharmacokinetics. Clin. Pharmacokinet. (2001) 40:85-104.
  • NAKAYAMA Y, INOUE Y, NAGASHIMA N et al.: Expression levels of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) in patients with gastrointestinal cancer. Anti-Cancer Res. (2005) 25(6A):3755-3761.
  • PASSANTINO L, AMATI L, CIANCIOTTA A et al.: Thymidine phosphorylase profiles in nonmalignant and malignant pancreatic tissue. Potential therapeutic role of capecitabine on tumoral and endothelial cells and tumor-infiltrating macrophages. Immunopharmacol. Immunotoxicol. (2005) 27(1):95-107.
  • JUDSON I, BEALE P, TRIGO J et al.: A human capecitabine excretion balance and pharmacokinetic study after administration of asingle oral dose of 14C-labelled drug. Invest. New Drugs (1999) 17:49-56.
  • TWELVES C, GLYNNE-JONES R, CASSIDY J et al.: Effect of hepatic dysfunction due to liver metastases on the pharmacokinetics of capecitabine and its metabolites. Clin. Cancer Res. (1999) 5:1696-1702.
  • POOLE C, GARDINER J, TWELVES C et al.: Effect of renal impairment on the pharmacokinetics and tolerability of capecitabine (Xeloda) in cancer patients. Cancer Chemother. Pharmacol. (2002) 49:225-234.
  • CAMIDGE R, REIGNER B, CASSIDY J et al.: Significant effect of capecitabine on the pharmacokinetics and pharmacodynamics of warfarin in patients with cancer. J. Clin. Oncol. (2005) 23(21):4719-4125.
  • BRICKELL K, PORTER D, THOMPSON P: Phenytoin toxicity due to fluoropyrimidines (5-FU/capecitabine): three case reports. Br. J. Cancer (2003) 89:615-616.
  • REIGNER B, CLIVE S, CASSIDY J et al.: Influence of the antacid maalox on the pharmacokinetics of capecitabine in cancer patients. Cancer Chemother. Pharmacol. (1999) 43:309-315.
  • BUDMAN DR, MEROPOL NJ, REIGNER B: Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabine. J. Clin. Oncol. (1998) 16:1795-1802.
  • SCHEITHAUER W, MCKENDRICK J, BEGBIE S et al.: X-ACT Study Group. Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, Phase III trial. Ann. Oncol. (2003) 14(12):1735-1743.
  • VAN CUTSEM E, HOFF PM, BLUM JL et al.: Incidence of cardiotoxicity with the oral fluoropyrimidine capecitabine is typical of that reported with fluorouracil. Ann. Oncol. (2002) 13(3):484-485.
  • SCHULL B, SCHEITHAUER W, KORNEK GV: Capecitabine as salvage therapy for a breast cancer patient with extensive liver metastases and associated impairment of liver function. Onkologie (2003) 26(6):578-580.
  • CARTWRIGHT TH, COHN A, VARKEY JA et al.: Phase II study of oral capecitabine in patients with advanced or metastatic pancreatic cancer. J. Clin. Oncol. (2002) 20(1):160-164.
  • SAWADA N, FUJIMOTO-OUCHI K, ISHIKAWA T et al.: Antitumour activity of combination therapy with capecitabine plus vinorelbine, and capecitabine plus gemcitabine in human tumor xenograft models. Proc. Am. Assoc. Cancer Res. (2002). (Abstract 5388.)
  • HESS V, SALZBERG M, BORNER M et al.: Combining capecitabine and gemcitabine in patients with advanced pancreatic carcinoma: a Phase I/II trial. J. Clin. Oncol. (2003) 21(1):66-68.
  • HEINEMANN V, HOEHLER T, SEIPELT G et al.: Capecitabine plus oxaliplatin (CapOx) versus capecitabine plus gemcitabine (GemCap) versus gemcitabine plus oxaliplatin (GemOx): a randomised Phase II trial in advanced pancreatic cancer. Proc. Am. Assoc. Clin. Oncol. (2005) 23. (Abstract 4030).
  • SCHEITHAUER W, SCHULL B, ULRICH-PUR H et al.: Biweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: a randomized Phase II trial. Ann. Oncol. (2003) 14(1):97-104.
  • HERRMANN R, BODOKY G, RUHSTALLER T et al.: Gemcitabine (G) plus capecitabine versus G alone in locally advanced or metastatic pancreatic cancer. A randomized Phase III study of the Swiss Group for Clinical Cancer Research (SAKK) and the Central European Cooperative Oncology Group (CECOG). Proc. Am. Assoc. Clin. Oncol. (2005). (Abstract 4010.)
  • CUNNINGHAM D, CHAU I, STOCKEN D et al.: Phase III randomised comparison of gemcitabine (GEM) versus gemcitabine plus capecitabine (GEM-CAP) in patients with advanced pancreatic cancer. Eur. J. Cancer (2005) 3(Suppl.):4.
  • CRANE CH, ELLIS LM, ABBRUZZESE JL et al.: Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer. J. Clin. Oncol. (2006) 24(7):1145-1151.
  • BEN-JOSEF E, SHIELDS AF, VAISHAMPAYAN U et al.: Intensity-modulated radiotherapy (IMRT) and concurrent capecitabine for pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. (2004) 59(2):454-459.
  • ITAKURA J, ISHIWATA T, SHEN B et al.: Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int. J. Cancer (2000) 85:27-34.
  • BRUNS CJ, SOLORZANO CC, HARBISON MT et al.: Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. (2000) 60:2926-2935.
  • MOORE M, GOLDSTEIN D, HAMM J et al.: Erlotinib plus compared to gemcitabine alone in patients with advanced pancreatic cancer: a Phase III trial of the National Cancer Institute of Canada Clinical Trials Group (NCNC-CTG). Proc. Am. Assoc. Clin. Oncol. (2005). (Abstract 1).
  • JAVLE R, IYER R, YU J et al.: Gemcitabine, capecitabine and bevacizumab: a Phase II study for advanced pancreatic cancer (APC) patients with good performance status. Proc. Am. Assoc. Clin. Oncol. Gastrointest. Cancer Symp. (2006). (Abstract 117).
  • NEOPTOLEMOS JP, STOCKEN DD, FRIESS H et al.: A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N. Engl. J. Med. (2004) 350(12):1200-1210.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.