85
Views
4
CrossRef citations to date
0
Altmetric
Drug Evaluation

Sildenafil for pulmonary arterial hypertension: when blue turns into white

Pages 1801-1810 | Published online: 23 Aug 2006

Bibliography

  • RUBIN LJ: Diagnosis and management of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest (2004) 126(1 Suppl.):4S-6S.
  • SIMONNEAU G, GALIE N, RUBIN LJ et al.: Clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol. (2004) 43(12 Suppl. S):5S-12S.
  • D’ALONZO GE, BARST RJ, AYRES SM et al.: Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann. Intern. Med. (1991) 115(5):343-349.
  • BARST RJ, MCGOON M, TORBICKI A et al.: Diagnosis and differential assessment of pulmonary arterial hypertension. J. Am. Coll. Cardiol. (2004) 43(12 Suppl. S):40S-47S.
  • MCGOON M, GUTTERMAN D, STEEN V et al.: Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest (2004) 126(1 Suppl.):14S-34S.
  • GALIE N, TORBICKI A, BARST R et al.: Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology. Eur. Heart J. (2004) 25(24):2243-2278.
  • HUMBERT M, SITBON O, SIMONNEAU G: Treatment of pulmonary arterial hypertension. N. Engl. J. Med. (2004) 351(14):1425-1436.
  • CHRISTMAN BW, MCPHERSON CD, NEWMAN JH et al.: An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl. J. Med. (1992) 327(2):70-75.
  • GIAID A, SALEH D: Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. (1995) 333(4):214-221.
  • GIAID A, YANAGISAWA M, LANGLEBEN D et al.: Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. (1993) 328(24):1732-1739.
  • RUNO JR, LOYD JE: Primary pulmonary hypertension. Lancet (2003) 361(9368):1533-1544.
  • PROVENCHER S, SITBON O, SIMONNEAU G: Treatment of pulmonary arterial hypertension with bosentan: from pathophysiology to clinical evidence. Expert Opin. Pharmacother. (2005) 6(8):1337-1348.
  • BADESCH DB, ABMAN SH, AHEARN GS et al.: Medical therapy for pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest (2004) 126(1 Suppl.):35S-62S.
  • RICH S, KAUFMANN E, LEVY PS: The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N. Engl. J. Med. (1992) 327(2):76-81.
  • SITBON O, HUMBERT M, JAIS X et al.: Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension. Circulation (2005) 111(23):3105-3111.
  • FUSTER V, STEELE PM, EDWARDS WD et al.: Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation (1984) 70(4):580-587.
  • OGATA M, OHE M, SHIRATO K, TAKISHIMA T: Effects of a combination therapy of anticoagulant and vasodilator on the long-term prognosis of primary pulmonary hypertension. Jpn. Circ. J. (1993) 57(1):63-69.
  • Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Nocturnal Oxygen Therapy Trial Group. Ann. Intern. Med. (1980) 93(3):391-398.
  • Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. Lancet (1981) 1(8222):681-686.
  • RICH S, SEIDLITZ M, DODIN E et al.: The short-term effects of digoxin in patients with right ventricular dysfunction from pulmonary hypertension. Chest (1998) 114(3):787-792.
  • TUDER RM, COOL CD, GERACI MW et al.: Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am. J. Respir. Crit. Care Med. (1999) 159(6):1925-1932.
  • BADESCH DB, TAPSON VF, MCGOON MD et al.: Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial. Ann. Intern. Med. (2000) 132(6):425-434.
  • BARST RJ, RUBIN LJ, LONG WA et al.: A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N. Engl. J. Med. (1996) 334(5):296-302.
  • BARST RJ, RUBIN LJ, MCGOON MD et al.: Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin. Ann. Intern. Med. (1994) 121(6):409-415.
  • MCLAUGHLIN VV, GENTHNER DE, PANELLA MM, RICH S: Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension. N. Engl. J. Med. (1998) 338(5):273-277.
  • SHAPIRO SM, OUDIZ RJ, CAO T et al.: Primary pulmonary hypertension: improved long-term effects and survival with continuous intravenous epoprostenol infusion. J. Am. Coll. Cardiol. (1997) 30(2):343-349.
  • SITBON O, HUMBERT M, NUNES H et al.: Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. J. Am. Coll. Cardiol. (2002) 40(4):780-788.
  • BARST RJ, MCGOON M, MCLAUGHLIN V et al.: Beraprost therapy for pulmonary arterial hypertension. J. Am. Coll. Cardiol. (2003) 41(12):2119-2125.
  • HOEPER MM, SCHWARZE M, EHLERDING S et al.: Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N. Engl. J. Med. (2000) 342(25):1866-1870.
  • OLSCHEWSKI H, SIMONNEAU G, GALIE N et al.: Inhaled iloprost for severe pulmonary hypertension. N. Engl. J. Med. (2002) 347(5):322-329.
  • OPITZ CF, WENSEL R, WINKLER J et al.: Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension. Eur. Heart J. (2005) 26(18):1895-1902.
  • SIMONNEAU G, BARST RJ, GALIE N et al.: Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial. Am. J. Respir. Crit. Care Med. (2002) 165(6):800-804.
  • RUBENS C, EWERT R, HALANK M et al.: Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension. Chest (2001) 120(5):1562-1569.
  • HAYNES WG, WEBB DJ: Endothelin as a regulator of cardiovascular function in health and disease. J. Hypertens. (1998) 16(8):1081-1098.
  • MCLAUGHLIN VV, SITBON O, BADESCH DB et al.: Survival with first-line bosentan in patients with primary pulmonary hypertension. Eur. Respir. J. (2005) 25(2):244-249.
  • GALIE N, BADESCH D, OUDIZ R et al.: Ambrisentan therapy for pulmonary arterial hypertension. J. Am. Coll. Cardiol. (2005) 46(3):529-535.
  • BARST RJ, RICH S, WIDLITZ A et al.: Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension: open-label pilot study. Chest (2002) 121(6):1860-1868.
  • DUNKERN TR, HATZELMANN A: The effect of sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5. Cell. Signal. (2005) 17(3):331-339.
  • WHARTON J, STRANGE JW, MOLLER GM et al.: Antiproliferative effects of phosphodiesterase Type 5 inhibition in human pulmonary artery cells. Am. J. Respir. Crit. Care Med. (2005) 172(1):105-113.
  • MICHELAKIS ED: The role of the NO axis and its therapeutic implications in pulmonary arterial hypertension. Heart Fail. Rev. (2003) 8(1):5-21.
  • LADHA F, BONNET S, EATON F et al.: Sildenafil improves alveolar growth and pulmonary hypertension in hyperoxia-induced lung injury. Am. J. Respir. Crit. Care Med. (2005) 172(6):750-756.
  • TANTINI B, MANES A, FIUMANA E et al.: Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells. Basic Res. Cardiol. (2005) 100(2):131-138.
  • TURKO IV, BALLARD SA, FRANCIS SH, CORBIN JD: Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds. Mol. Pharmacol. (1999) 56(1):124-130.
  • KLINGER JR, THAKER S, HOUTCHENS J et al.: Pulmonary hemodynamic responses to brain natriuretic peptide and sildenafil in patients with pulmonary arterial hypertension. Chest (2006) 129(2):417-425.
  • PRESTON IR, HILL NS, GAMBARDELLA LS, WARBURTON RR, KLINGER JR: Synergistic effects of ANP and sildenafil on cGMP levels and amelioration of acute hypoxic pulmonary hypertension. Experimental Biology and Medicine (2004) 229(9):920-925.
  • ZHAO L, MASON NA, STRANGE JW, WALKER H, WILKINS MR: Beneficial Effects of Phosphodiesterase 5 Inhibition in Pulmonary Hypertension Are Influenced by Natriuretic Peptide Activity. Circulation (2003) 107(2):234-237.
  • PAUL GA, GIBBS JSR, BOOBIS AR, ABBAS A, WILKINS MR: Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension. Br. J. Clin. Pharmacol. (2005) 60(1):107-112.
  • CHEITLIN MD, HUTTER AM Jr, BRINDIS RG et al.: Use of sildenafil (viagra) in patients with cardiovascular disease. Circulation (1999) 99(1):168-177.
  • GILLIES HC, ROBLIN D, JACKSON G: Coronary and systemic hemodynamic effects of sildenafil citrate: from basic science to clinical studies in patients with cardiovascular disease. Int. J. Cardiol. (2002) 86(2-3):131-141.
  • ZHAO L, MASON NA, MORRELL NW et al.: Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation (2001) 104(4):424-428.
  • GHOFRANI HA, VOSWINCKEL R, REICHENBERGER F et al.: Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study. J. Am. Coll. Cardiol. (2004) 44(7):1488-1496.
  • GHOFRANI HA, WIEDEMANN R, ROSE F et al.: Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann. Intern. Med. (2002) 136(7):515-522.
  • GHOFRANI HA, WIEDEMANN R, ROSE F et al.: Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet (2002) 360(9337):895-900.
  • KUHN KP, WICKERSHAM NE, ROBBINS IM, BYRNE DW: Acute effects of sildenafil in patients with primary pulmonary hypertension receiving epoprostenol. Exp. Lung Res. (2004) 30(2):135-145.
  • LEPORE JJ, MAROO A, BIGATELLO LM et al.: Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide. Chest (2005) 127(5):1647-1653.
  • LEUCHTE HH, SCHWAIBLMAIR M, BAUMGARTNER RA et al.: Hemodynamic response to sildenafil, nitric oxide, and iloprost in primary pulmonary hypertension. Chest (2004) 125(2):580-586.
  • MICHELAKIS E, TYMCHAK W, LIEN D et al.: Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide. Circulation (2002) 105(20):2398-2403.
  • WILKENS H, GUTH A, KONIG J et al.: Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation (2001) 104(11):1218-1222.
  • CHOCKALINGAM A, GNANAVELU G, VENKATESAN S et al.: Efficacy and optimal dose of sildenafil in primary pulmonary hypertension. Int. J. Cardiol. (2005) 99(1):91-95.
  • SHETH A, PARK JE, ONG YE, HO TB, MADDEN BP: Early haemodynamic benefit of sildenafil in patients with coexisting chronic thromboembolic pulmonary hypertension and left ventricular dysfunction. Vascul. Pharmacol. (2005) 42(2):41-45.
  • BHARANI A, MATHEW V, SAHU A, LUNIA B: The efficacy and tolerability of sildenafil in patients with moderate-to-severe pulmonary hypertension. Indian Heart J. (2003) 55(1):55-59.
  • SASTRY BK, NARASIMHAN C, REDDY NK, RAJU BS: Clinical efficacy of sildenafil in primary pulmonary hypertension: a randomized, placebo-controlled, double-blind, crossover study. J. Am. Coll. Cardiol. (2004) 43(7):1149-1153.
  • GALIE N, MANES A, FARAHANI KV et al.: Pulmonary arterial hypertension associated to connective tissue diseases. Lupus (2005) 14(9):713-717.
  • GHOFRANI HA, ROSE F, SCHERMULY RT et al.: Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension. J. Am. Coll. Cardiol. (2003) 42(1):158-164.
  • KOTHARI SS, DUGGAL B: Chronic oral sildenafil therapy in severe pulmonary artery hypertension. Indian Heart J. (2002) 54(4):404-409.
  • MICHELAKIS ED, TYMCHAK W, NOGA M et al.: Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Circulation (2003) 108(17):2066-2069.
  • MIKHAIL GW, PRASAD SK, LI W et al.: Clinical and haemodynamic effects of sildenafil in pulmonary hypertension: acute and mid-term effects. Eur. Heart J. (2004) 25(5):431-436.
  • SASTRY BK, NARASIMHAN C, REDDY NK et al.: A study of clinical efficacy of sildenafil in patients with primary pulmonary hypertension. Indian Heart J. (2002) 54(4):410-414.
  • GALIE N, GHOFRANI HA, TORBICKI A et al.: Sildenafil citrate therapy for pulmonary arterial hypertension. N. Engl. J. Med. (2005) 353(20):2148-2157.
  • MACHADO RF, MARTYR S, KATO GJ et al.: Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension. Br. J. Haematol. (2005) 130(3):445-453.
  • HOEPER MM, FAULENBACH C, GOLPON H et al.: Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension. Eur. Respir. J. (2004) 24(6):1007-1010.
  • HOEPER MM, MARKEVYCH I, SPIEKERKOETTER E, WELTE T, NIEDERMEYER J: Goal-oriented treatment and combination therapy for pulmonary arterial hypertension. Eur. Respir. J. (2005) 26(5):858-863.
  • HUMPL T, REYES JT, HOLTBY H, STEPHENS D, ADATIA I: Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension: twelve-month clinical trial of a single-drug, open-label, pilot study. Circulation (2005) 111(24):3274-3280.
  • KARATZA AA, BUSH A, MAGEE AG: Safety and efficacy of Sildenafil therapy in children with pulmonary hypertension. Int. J. Cardiol. (2005) 100(2):267-273.
  • LEE AJ, CHIAO TB, TSANG MP: Sildenafil for pulmonary hypertension. Ann. Pharmacother. (2005) 39(5):869-884.
  • BARST RJ: PDGF signaling in pulmonary arterial hypertension. J. Clin. Invest. (2005) 115(10):2691-2694.

Website

  • http://www.pfizer.com/pfizer/download/uspi_viagra.pdf PFIZER, INC.: Viagra® (sildenafil citrate) prescribing information. Pfizer, Inc. NY, (NY) USA (2006). Accessed 3 August, 2006.
  • http://www.pfizer.com/pfizer/download/uspi_revatio.pdf PFIZER, INC.: Revatio® (sildenafil citrate) prescribing information. Pfizer, Inc. NY, (NY) USA (2006). Accessed 3 August, 2006.
  • http://clinicaltrials.gov/show/NCT00159913 A randomized, double-blind, placebo-controlled study of sildenafil in children with pulmonary arterial hypertension. Accessed 3 August, 2006.
  • http://clinicaltrials.gov/show/NCT00159874 Long term extension study evaluating safety of sildenafil citrate when used to treat PAH in children. Access 3 August, 2006.
  • http://clinicaltrials.gov/show/NCT00159887 Study to assess the longterm safety of sildenafil citrate in patients with pulmonary arterial hypertension. Accessed 3 August, 2006.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.