Review of azelastine nasal spray in the treatment of allergic and non-allergic rhinitis

Bibliography

• DYKEWICZ MS, AND FINEMAN S, SKONER DP et al.: Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology. Ann. Allergy Asthma Immunol. (1998) 81:478-518.
   PubMed Web of Science ®Google Scholar
• BOUSQUET J, VAN CAUWENBERGE P: Allergic rhinitis and its impact on asthma (ARIA). J. Allergy Clin. Immunol. (2001) 108(5):S147-S333.
   PubMed Web of Science ®Google Scholar
• RAY NF, BARANIUK JN, THAMER M et al.: Direct expenditures for the treatment of allergic rhinoconjunctivitis in 1996, including the contributions of related airway illnesses. J. Allergy Clin. Immunol. (1999) 103:401-407.
   PubMed Web of Science ®Google Scholar
• LAFORCE C: Use of nasal steroids in managing allergic rhinitis. J. Allergy Clin. Immunol. (1999) 103:S388-S394.
   PubMed Web of Science ®Google Scholar
• MELTZER EO: Efficacy and patient satisfaction with cromolyn sodium nasal solution in the treatment of seasonal allergic rhinitis: a placebo-controlled study. Clin. Ther. (2002) 24:942-952.
   PubMed Web of Science ®Google Scholar
• BOUSQUET J, LOCKEY RF, MALLING HJ: WHO position paper. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Allergy (1998) 53(Suppl.):1-42.
   Web of Science ®Google Scholar
• CASALE TB: The interaction of azelastine with human lung histamine H1, β, and muscarinic receptor-binding sites. J. Allergy Clin. Immunol. (1989) 83(4):771-776.
   PubMed Web of Science ®Google Scholar
• CIPRANDI G, PRONZATO C, PASALACQUA G et al.: Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity. J. Allergy Clin. Immunol. (1996) 98:1088-1096.
   PubMed Web of Science ®Google Scholar
• KATAYAMA S, TSUNODA H, SAKUMA Y, KAI H, TANAKA I, KATAYAMA K: Effect of azelastine on the release and action of leukotriene C4 and D4. Int. Arch. Allergy Appl. Immunol. (1987) 83:284-289.
   PubMedGoogle Scholar
• MATSUMURA M, MATSUMOTO Y, TAKAHASHI H et al.: Inhibitory effects of azelastine on leukotriene B4, C4, and D4 release and production from asthmatic eosinophils. Respir. Res. (1990) 9(2):206-212.
   Google Scholar
• BUSSE W, RANDLEY B, SEDGWICK J: The effect of azelastine on neutrophil and eosinophil generation of superoxide. J. Allergy Clin. Immunol. (1989) 83:400-405.
   PubMed Web of Science ®Google Scholar
• UMEKI S: Effects of antiallergic drugs on human neutrophil superoxide-generating NADPH oxidase. Biochem. Pharmacol. (1992) 43:1109-1117.
   PubMed Web of Science ®Google Scholar
• SHIN MH, BAROODY F, PROUD D et al.: The effect of azelastine on the early allergic response. Clin. Exp. Allergy (1992) 22:289-295.
   PubMed Web of Science ®Google Scholar
• NIEBER K, BAUMGARTEN C, RATHSACK R et al.: Effect of azelastine on substance P content in bronchoalveolar and nasal lavage fluids of patients with allergic asthma. Clin. Exp. Allergy (1993) 23:69-71.
   PubMed Web of Science ®Google Scholar
• YONEDA K, YAMAMOTO T, UETA E, OSAKI T: Suppression by azelastine hydrochloride of NFκB activation involved in generation of cytokines and nitric oxide. Jpn. J. Pharmacol. (1997) 73:145-153.
   PubMedGoogle Scholar
• RIETHMULLER-WINZEN H, PETER G et al.: Tolerability, pharmacokinetics and dose linearity of azelastine hydrochloride in healthy subjects. Arzneimittelforschung (1994) 44:1136-1140.
   PubMed Web of Science ®Google Scholar
• PETER G, ROMEIS P, BORBE HO, BUKER KM et al.: Tolerability and pharmacokinetics of single and multiple doses of azelastine hydrochloride in elderly volunteers. Arzeimittelforschung (1995) 45(5):576-581.
   PubMedGoogle Scholar
• SALE M, LYNESS W, PERHACH J, WOOSLEY R, ROSENBERG A: Lack of effect of coadministration of erythromycin with azelastine on pharmacokinetic or ECG parameters. Ann. Allergy Asthma Immunol. (1996) 76: Abstr. 91.
   Google Scholar
• MORGANROTH J, PERHACH JL, LYNESS W et al.: Lack of effect of azelastine alone and coadministered with ketaconazole on electrocardiographic parameters. J. Allergy Clin. Immunol. (1995) 95:Abstr. 282.
   Google Scholar
• CHAND N, PILLAR J, DIAMANTIS W, PERHACH JL JR, SOFIA RD: Inhibition of calcium ionophore (A23187)-stimulated histamine release from rat peritoneal mast cells by azelastine: implications for its mode of action. Eur J. Pharmacol. (1983) 96(3-4):227-233.
   PubMed Web of Science ®Google Scholar
• LITTLE MM, CASALE TB: Azelastine inhibits IgE-mediated human basophile histamine release. J. Allergy Clin. Immunol. (1989) 83(5):862-865.
   PubMedGoogle Scholar
• GOLDEN MP, GLEASON MM, TOGIAS A: Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis. Clin. Exp. Allergy (2006) 36(6):689-703.
   PubMed Web of Science ®Google Scholar
• CHAND N, NOLAN K, DIAMANTIS: Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs. Allergy (1986) 41(7):473-478.
   PubMed Web of Science ®Google Scholar
• RAJAKULASINGAM K, POLOSA R, CHURCH MK et al.: Kinins and rhinitis. Clin. Exp. Allergy (1992) 22:734-740.
   PubMedGoogle Scholar
• ITO H, NAKAMURA Y, TAKAGI S, SAKAI K: Effects of azelastine on the level of serum interleukin-4 and soluble CD23 antigen in the treatment of nasal allergy. Arzneimittelforschung (1998) 48:1143-1147.
   PubMed Web of Science ®Google Scholar
• BECK G, MANSUR A, AFZAL M et al.: Effect of azelastine nasal spray on mediators of inflammation in patients with seasonal allergic rhinitis (SAR). Presented at American Academy of Allergy, Asthma, and Immunology 56th Annual Meeting. CA, USA (3 – 8 March 2000).
   Google Scholar
• WEILER JM, MELTZER EO, BENSON PM, WEILER K, WIDLITZ MD, FREITAG J: A dose-ranging study of the efficacy and safety of azelastine nasal spray in the treatment of seasonal allergic rhinitis with an acute model. J. Allergy Clin. Immunol. (1994) 94:972-980.
   PubMed Web of Science ®Google Scholar
• MELTZER EO, WEILER JM, DOCKHORN RJ, WIDLITZ MD, FREITAG JJ: Azelastine nasal spray in the management of seasonal allergic rhinitis. Ann. Allergy (1994) 72:354-359.
   PubMedGoogle Scholar
• HORAK F, ZIEGLMAYER UP, ZIEGLMAYER R et al.: Azelastine nasal spray and desloratadine tablets in pollen induced seasonal allergic rhinitis: a pharmacodynamic study of onset of action and efficacy. Curr. Med. Res. Opin. (2006). 22(1):151-157.
   PubMed Web of Science ®Google Scholar
• BAUMGARTEN CR, PETZOLD U, DOKIE D et al.: Modification of allergen induced symptoms and mediator release by intranasal azelastine. J. Pharmacol. Ther. (1994) 3:43-51.
   Google Scholar
• STORMS WW, PEARLMAN DS, CHERVINSKY P et al.: Effectiveness of azelastine nasal solution in seasonal allergic rhinitis. Ear Nose Throat J. (1994) 73:382-394.
   PubMedGoogle Scholar
• RATNER PH, FINDLAY SR, HAMPEL F, VAN BAVEL J, WIDLITZ MD, FREITAG JJ: A double blind, controlled trial to assess the safety and efficacy of azelastine nasal spray in seasonal allergic rhinitis. J. Allergy Clin. Immunol. (1994) 94:818-825.
   PubMed Web of Science ®Google Scholar
• LAFORCE C, DOCKHORN RJ, PRENNER BM et al.: Safety and efficacy of azelastine nasal spray (Astelin NS) for seasonal allergic rhinitis. Ann. Allergy Asthma Immunol. (1996) 76:181-188.
   PubMed Web of Science ®Google Scholar
• CIPRANDI G, RICCA V, PASSALACQUA G et al.: Seasonal rhinitis and azelastine: long- or short-term treatment? J. Allergy Clin. Immunol. (1997) 99:301-307.
   PubMed Web of Science ®Google Scholar
• BERGER WE, WHITE MV, THE RHINITIS STUDY GROUP: Efficacy of azelastine nasal spray in patients with an unsatisfactory response to loratadine. Ann. Allergy Asthma Immunol. (2003) 91:205-211.
   PubMed Web of Science ®Google Scholar
• LAFORCE CF, CORREN J, WHEELER WJ, BERGER WE, THE RHINITIS STUDY GROUP: Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine. Ann. Allergy Asthma Immunol. (2004) 93:154-159.
   PubMed Web of Science ®Google Scholar
• CORREN J, STORMS WW, BERNSTEIN J et al.: Effectiveness of azelastine nasal spray compared to oral cetirizine in patients with seasonal allergic rhinitis. Clin. Ther. (2005) 27:543-553.
   Google Scholar
• BERGER W, HAMPEL F Jr., BERNSTEIN J et al.: Impact of azelastine nasal spray on symptoms and quality of life compared with cetirizine oral tablets in patients with seasonal allergic rhinitis. Ann. Allergy Asthma Immunol. (2006) 97:375-381.
   PubMed Web of Science ®Google Scholar
• FALSER N, WOBER W, RAHLFS VW, BAEHRE M: Comparative efficacy and safety of azelastine and levocabastine nasal sprays in patients with seasonal allergic rhinitis. Arzeimittelforschung (2001) 51(5):387-393.
   PubMed Web of Science ®Google Scholar
• WANG D, SMITZ J, DE WAELE M, CLEMENT P: Effect of topical applications of budesonide and azelastine on nasal symptoms, eosinophil count and mediator release in atopic patients after nasal allergen challenge during the pollen season. Int. Arch. Allergy Immunol. (1997) 114:185-192.
   PubMed Web of Science ®Google Scholar
• BANOV C, LIEBERMAN P: Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis. Ann. Allergy Asthma Immunol. (2001) 86:28-35.
   PubMed Web of Science ®Google Scholar
• LIEBERMAN P, KALINER MA, WHEELER WJ: Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis. Curr. Med. Res. Opin. (2005) 21:611-618.
   PubMed Web of Science ®Google Scholar
• KANEKO T, KITAHARA A, OZAKI S et al.: Effects of azelastine hydrochloride, a novel anti-allergic drug, on the central nervous system. Arzeimittelforschung (1981) 31:1206-1212.
   PubMedGoogle Scholar
• KAKIUCHI M, OHASHI T, TANAKA K et al.: Central nervous system effects of the novel antiallergic agent HSR-609 and typical antiallergic agents using behavioral and electroencephalographic analyses in dogs. Nihon Shinkei Seishin Yakurigaku Zasshi. (1998) 18(5):189-199.
   PubMedGoogle Scholar
• BRONSKY EA, MELTZER EO, PERHACH JL et al.: Cardiac safety of azelastine following 8 weeks of intra-nasal administration [abstract]. J. Allergy Clin. Immunol. (1997) 99(Pt 2):S445.
   Google Scholar