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Expert Opinion on Pharmacotherapy Volume 9, 2008 - Issue 14
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Drug Evaluation

Drug evaluation of clevidipine for acute hypertension

Ika Noviawaty University of Minnesota, Zeenat Qureshi Stroke Research Center, Department of Neurology, MMC 295, 420 Delaware St S.E., Minneapolis, MN 55455, USA +1 612 626 8221; +1 612 625 7950;[email protected]
, MD,
Guven Uzun University of Minnesota, Zeenat Qureshi Stroke Research Center, Department of Neurology, MMC 295, 420 Delaware St S.E., Minneapolis, MN 55455, USA +1 612 626 8221; +1 612 625 7950;[email protected]
, MD &
Adnan I Qureshi University of Minnesota, Zeenat Qureshi Stroke Research Center, Department of Neurology, MMC 295, 420 Delaware St S.E., Minneapolis, MN 55455, USA +1 612 626 8221; +1 612 625 7950;[email protected]
, MD
Pages 2519-2529 | Published online: 08 Sep 2008

Bibliography

  • Mason DT, Braunwald E. The effect of nitroglycerin and amyl nitrite on arteriolar and venous tone in the human forearm. Circulation 1965;32:755
  • Zall S, Kirno K, Milocco I, Ricksten S-E. Vasodilation with adenosine or sodium nitroprusside after coronary artery bypass surgery. A comparative study on myocardial blood flow and metabolism. Anesth Analg 1993;76:493-7
  • Kaplan JA, Finlayson DC, Woodward S. Vasodilator therapy after cardiac surgery: a review of the efficacy and toxicity of nitroglycerin and nitroprusside. Can Anaesth Soc J 1980;3:254-9
  • Van Zwieten PA, van Wezel HB. Antihypertensive drug treatment in the perioperative period. J Cardiothorac Vasc Anesth 1993;7:213-26
  • Levy JH. The ideal agent for perioperative hypertension and potential cytoprotective effects. Acta Anaesthesiol Scand Suppl 1993;37:20-5
  • Lawrence CJ, Lestrade A, De Lange S. Comparative study of isradipine and sodium nitroprusside in the control of hypertension in patients following coronary artery-bypass surgery. Acta Anaestesiol Scand Suppl 1993;37:48-52
  • Cook E, Clifton GG, Vargas R, et al. Pharmacokinetics, pharmacodynamics, and minimum effective clinical dose of intravenous nicardipine. Clin Pharmacol Ther 1990;47:706-18
  • Murray MJ. Perioperative hypertension: evaluation and management. Available from: http://www.asahq.org/rcls/ RCLS_SRC/512_Murray.pdf [Accessed June 2008]
  • Levy JH, Huraux C, Nordlander M. Treatment of perioperative hypertension, calcium antagonists in clinical medicine. In: Epstein M, editor. Philadelphia Han and Belf; 1997. p. 345-58
  • Ericsson H, Tholander B, Regårdh CG. In vitro analysis rate and protein binding of clevidipine, a new ultrashort-acting calcium anatagonist metabolized by esterases, in different animal species and man. Eur J Pharm Sci 1999;8:29-37
  • Nordlander M. Antihypertensive potency and effect-duration of H324/38 and reference compounds in anaesthetized normotensive and spontaneously hypertensive rats. Astra Hassle Rep 1994; No. 2220-0846-00
  • Ericsson H, Fakt C, Hoglund L, et al. Pharmacokinetics and pharmacodynamics of clevidipine in healthy volunteers after intravenous infusion. Eur J Clin Pharmacol 1999;55:61-7
  • Ericsson H, Tholander B, Björkman JA, et al. Pharmacokinetics of new calcium channel antagonist clevidipine in the rat, rabbit, and dog and pharmacokinetic/pharmacodynamic relationship in anesthetized dogs. Am Soc Pharmacol Exp Ther 1999;27:558-64
  • Nordlander M, Sjöquist PO, Ericsson H, Rydén L. Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control. Cardiovasc Drug Rev 2004;22(3):227-50
  • Davies B, Morris T. Physiological parameters in laboratory animals and humans. Pharm Res (NY) 1993;10:1093-5
  • Cook E, Clifton GG, Vargas R, et al. Pharmacokinetics, pharmacodynamics and minimum effective clinical dose of intravenous nicardipine. Clin Pharmacol Ther 1990;47:706-18
  • Ericsson H, Bredberg U, Erikson U, et al. Pharmacokinetics and arteriovenous differences in clevidipine concentration following a short- and long-term intravenous infusion in healthy volunteers: Lippincott Williams & Wilkins, Inc., Philadelphia 2000;92:993-1001
  • Hughes M, Glass P, Jacobs J. Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anaesthetic drugs. Anesthesiology 1992;76:334-41
  • Ericsson H, Fakt C, Jolin-Mellgård Å, et al. Clinical and pharmacokinetic results with a new ultrashort-acting calcium antagonist, clevidipine, following gradually increasing intravenous doses to healthy volunteers. Br J Clin Pharmacol 1999;47:531-8
  • Sheiner LB, Stanski DR, Vozeh S, et al. Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin Pharmacol Ther 1979;25:358-71
  • Sharma A, Jusko WJ. Characterization of four basic models of indirect pharmacodynamic responses. J Pharmacokinet Biopharm 1996;24:611-35
  • Greenblatt DJ, Divoll M, Harmatz JS, Shader RI. Oxazepam kinetics: effects of age and sex. J Pharmacol Exp Ther 1980;215:86-91
  • Divoll M, Greenblatt DJ, Harmatz JS, Shader RI. Effect of age and gender on disposition of temazepam. J Pharm Sci 1981;70:1104-7
  • Bonate PL. Gender-related differences in xenobiotic metabolism. J Clin Pharmacol 1991;31:684-90
  • Hansen KT, Stentoft K. Characterization of benzazepine UDP-glucuronosyltransferase in laboratory animals and man. Xenobio1ogy 1995;25:611-22
  • Jacobs JR, Narda D, Croughwell C, et al. Effect of hypothermia and sampling site on blood esmolol concentrations. J Clin Pharmacol 1993;33:360-5
  • Selinger K, Nation RL, Smith A. Enzymatic and chemical hydrolysis of remifentanil. Anesthesiology 1995;83:A385
  • Nadjmabadi MH, Rastan H, Saidi MT, Aftandelian E. Haemodynamic effects of acute intra-operative haemodilution in open heart surgery. Anaesthetist 1978;27:364-9
  • Melandez JA, Stone JG, Delphine E, Quon CY. Influence of temperature on the in vitro metabolism of esmolol. J Cardiothorac Anaesth 1990;4:704-6
  • Mortimer CE. Chemistry. In: Mortimer CE, editor, Chemical kinetics. Volume 6. Wadsworth, Belmont; 1986. p. CA394-9
  • Edgar B, Regaradh CG, Attman PO, et al. Pharmacokinetics of felodipine in patients with impaired renal function. Br J Clin Pharmacol 1989;27:67-74
  • Kieler-Jensen N, Jolin-Mellgard A, Nordlander M, Ricksten SE. Coronary and systemic hemodynamic effects of clevidipine, an ultra-short-acting calcium antagonist, for treatment of hypertension after coronary artery surgery. Acta Anaesth Scand 2000;44(2):186-93
  • Yi X, Vivien B, Lynch C. Clevidipine blockade of L-type Ca2+ currents: steady-state and kinetic electrophysiological studies in guinea pig ventricular myocytes. J Cardiovasc Pharmacol 2000;36(5):592-600
  • Levy JH, Huraux C, Nordlander M. Treatment of perioperative hypertension. In: Epstein M, editor, Calcium antagonists in clinical medicine. Philadelphia: Han & Belf; 1998. p. 45-358
  • Astra Data on file. Effects of H324/38 on the paced rat papillary muscle and on spontaneously myogenic activity and various induced vasomotor responses in the isolated rat portal vein. Astra Hässle Rep 1997; No. 2220-0853-01
  • Ljung B. Vascular selectivity of felodipine. Drugs 1985;29(2):46-58
  • Segawa D, Sjöquist PO, Wang QD, et al. Calcium antagonist protects the myocardium from reperfusion injury by interfering with mechanisms directly related to reperfusion: an experimental study with the ultrashort-acting calcium antagonist clevidipine. J Cardiovasc Pharmacol 2000;36:338-43
  • Segawa D, Sjöquist PO, Wang QD, et al. Time dependent cardioprotection with calcium antagonism and experimental studies with clevidipine in ischemic-reperfused pig hearts. Part II. J Cardiovasc Pharmacol 2002;40(3):339-45
  • Wang QD, Segawa D, Ericsson H, et al. Time-dependent cardioprotection with calcium antagonism and experimental studies with clevidipine in ischemic-reperfused pig hearts. Part I. J Cardiovasc Pharmacol 2002;40:228-34
  • Fakt C, Stenhoff H. Determination of an ultrashort-acting antihypertensive dihydropyridine in blood using capillary gas chromatography mass spectrometry and of the primary metabolite using liquid chromatography and fluorescence detection. J Chromatogr B Biomed Appl 1999;723:211-9
  • Fisher DM. (Almost) everything you learned about pharmacokinetics was (somewhat) wrong. Anesth Analg 1996;83:901-3
  • Chiou WL. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site: implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics. Part I. Clin Pharmacokinet 1989;17:175-99
  • Chiou WL. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site: implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics. Part II. Clin Pharmacokinet 1989;17:275-90
  • Gourine A, Gonon A, Sjöquist PO, Pernow J. Short-acting calcium antagonist clevidipine protects against reperfusion injury via local nitric oxide-related mechanism in the jeopardized myocardium. Cardiovasc Res 2001;51:100-7
  • Goyal M, Jandhyala BS. Splanchnic artery occlusion shock (SAO) in the rats. Effect of clevidipine and sodium nitroprusside on splanchnic hemodynamics. FASEB Exp Biol 1997;97:A285
  • Stephens CT, Jandhyala BS. Effects of fenoldopam, a dopamine D1 agonist, and clevidipine, a calcium channel antagonist, in acute renal failure in anesthetized rats. Clin Exp Hypertens 2002;24:301-13
  • Gray RJ. Postcardiac surgical hypertension. J Cardiothor Anesth 1988;2:678-82
  • Tanaka M, Nishikawa T. Arterial baroreflex function in humans anesthetized with sevoflurane. Anesthesiology 1997;87:A132
  • Kieler-Jensen N, Jolin-Mellgard A, Nordlander M, Ricksten SE. Myocardial circulatory and metabolic effects of clevidipine after coronary artery bypass grafting (CABG). Br J Anesth 1997;78:A12
  • Tinker JH, Michenfelder JD. Sodium nitroprusside: pharmacology, toxicology and therapeutics. Anesthesiology 1976;45:340-54
  • Kaplan JA, Finlayson DC, Woodward S. Vasodilator therapy after cardiac surgery: a review of the efficacy and toxicity of nitroglycerin and nitroprusside. Can Anesth Soc J 1980;27:254-9
  • Amaranath L, Kellermeyer WF Jr. Tachyphylaxis to sodium nitroprusside. Anesthesiology 1976;44:345-8
  • Khambatta HJ, Stone GJ, Khan E. Hypertension during anesthesia on discontinuation of sodium nitroprusside induced hypotension. Anesthesiology 1979;51:127-30
  • Benumof JL. Hypoxic pulmonary vasoconstriction and infusion of sodium nitroprusside. Anesthesiology 1979;50:481-3
  • Bailey JM, Lu W, Levy JH, et al. Clevidipine in adult cardiac surgical patients: a dose-finding study. Anesthesiology 2002;96(5):1086-94
  • Powroznyk AVV, Vuylsteke A, Naughton C, et al. Comparison of clevidipine with sodium nitroprusside in the control of blood pressure after coronary artery surgery. Eur J Anaesthesiol 2003;20:697-703
  • Kotrly KJ, Ebert TJ, Vucins E, et al. Baroreceptor reflex control of heart rate during isoflurane anesthesia in humans. Anesthesiology 1984;60:173-9
  • Schwieler JH, Ericsson H, Lofdahl P, et al. Circulatory effects and pharmacology of clevidipine, a novel ultra short acting and vascular selective calcium antagonist, in hypertensive humans. J Cardiovasc Pharmacol 1999;34(2):268-74
  • Astra Data on file. The dose-antihypertensive effect of clevidipine (H324_38) in hypertensive patients treated with β-blockers. Astra Hässle Rep 1997; SH SAD 0004
  • Astra Data on file. Blood pressure control in cardiac surgical patients. A double-blind comparison between clevidipine and placebo with addition of glyceryl trinitrate. Astra Hässle Rep 2001; SH-SAD-0017
  • Vuylsteke A, Milner Q, Ericsson H, et al. Pharmacokinetics and pulmonary extraction of clevidipine, a new vasodilating ultrashort-acting dihydropyridine, in cardiac surgical patients during cardiopulmonary bypass. Br J Anaesth 2000;85:683-9
  • Levy JH, Mancao M, Gitter R, et al. Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: the results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1. Anesth Analg 2007;105:918-25
  • Singla N, Warltier DC, Gandhi SD, et al. Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double blind, placebo controlled trial. Anesth Analg 2008;107:59-67
  • Data on file, The Medicines Company. Final study report TMC-CLV-03-03. Evaluation of clevidipine in the perioperative treatment of hypertension assessing safety events (with nitroglycerin as active comparator). ECLIPSE-NTG; 2007
  • Data on file, The Medicines Company. Final study report TMC-CLV-03-04. Evaluation of clevidipine in the perioperative treatment of hypertension assessing safety events (with sodium nitroprusside as active comparator). ECLIPSE-SNP; 2007
  • Data on file, The Medicines Company. Final study report TMC-CLV-03-05. Evaluation of clevidipine in the perioperative treatment of hypertension assessing safety events (with nicardipine as active comparator). ECLIPSE-NIC; 2007
  • Pollack CV, Varon J, Garrison NA, et al. Clevidipine, an intravenous dihydropyridine calcium channel blocker, is safe and effective for the treatment of patients with acute severe hypertension. Ann Emerg Med 2008 [Epub ahead of print]
  • Cleviprex™ (Clevidipine Butyrate) rapidly reduced blood pressure and maintained control in study of patients with acute hypertension. Available from: http://www.medicalnewstoday.com/articles/86679.php [Accessed June 2008]
  • Astra Data on file. Effects of clevidipine on neuromuscular transmission and skeletal muscle contractile function in an isolated preparation of diaphragm from the rat. Astra Hässle Rep 1994; No.220-0867-00
  • Ericsson H, Schwieler J, Lindmark B, et al. Enantioselective pharmacokinetics of the enantiomers of clevidipine following intravenous infusion of the racemate in essential hypertensive patient. Chirality 2001;13:130-4
  • Kieler Jensen N, Houltz E, Milocco I, Rickstein SE. Central hemodynamics and right ventricular function after coronary artery bypass surgery. A comparison of prostacyclin, sodium nitroprusside and nitroglycerin for treatment of postcardiac surgical hypertension. Cardio Thorac Anesth 1993;7(5):555-9
  • Efficacy and safety of intravenous nicardipine in the control of postoperative hypertension. IV. Nicardipine Study Group. Chest 1991;99:393-8
  • Drug facts and comparison. Philadelphia, USA: Wolters Kluwer Health; 2008
  • Burggraf GW, Parker JO. Left ventricular volume changes after amyl nitrite and nitroglycerin in man as measured by ultrasound. Circulation 1974;49(1):136-43

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