Advanced search
Publication Cover
Expert Opinion on Biological Therapy Volume 9, 2009 - Issue 8
Submit an article Journal homepage
294
Views
39
CrossRef citations to date
0
Altmetric
Reviews

Treating autoimmune disease by targeting CD8+ T suppressor cells

Christine Konya Emory University School of Medicine, Lowance Center for Human Immunology and Rheumatology, 101 Woodruff Circle #1003, Atlanta, GA 30322, USA +1 404 727 7310; +1 404 727 7371; [email protected]
,
Jőrg J Goronzy Emory University School of Medicine, Lowance Center for Human Immunology and Rheumatology, 101 Woodruff Circle #1003, Atlanta, GA 30322, USA +1 404 727 7310; +1 404 727 7371; [email protected]
&
Cornelia M Weyand Emory University School of Medicine, Lowance Center for Human Immunology and Rheumatology, 101 Woodruff Circle #1003, Atlanta, GA 30322, USA +1 404 727 7310; +1 404 727 7371; [email protected]
Pages 951-965 | Published online: 12 Jun 2009

Bibliography

  • Nishizuka Y, Sakakura T. Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science 1969;166(906):753-5
  • Gershon RK, Cohen P, Hencin R, Liebhaber SA. Suppressor T cells. J Immunol 1972;108(3):586-90
  • Cantor H, Hugenberger J, McVay-Boudreau L, et al. Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition. J Exp Med 1978;148(4):871-7
  • Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155(3):1151-64
  • Belkaid Y, Piccirillo CA, Mendez S, et al. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002;420(6915):502-7
  • Kapp JA, Bucy RP. CD8 + suppressor T cells resurrected. Hum Immunol 2008;69(11):715-20
  • Kapp JA, Honjo K, Kapp LM, et al. TCR transgenic CD8+ T cells activated in the presence of TGFβ express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. Int Immunol 2006;18(11):1549-62
  • Karlsson I, Malleret B, Brochard P, et al. FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. J Virol 2007;81(24):13444-55
  • Shao L, Jacobs AR, Johnson VV, Mayer L. Activation of CD8+ regulatory T cells by human placental trophoblasts. J Immunol 2005;174(12):7539-47
  • Sugita S, Futagami Y, Horie S, Mochizuki M. Transforming growth factor β-producing Foxp3+CD8+CD25+ T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions. Exp Eye Res 2007;85(5):626-36
  • Cosmi L, Liotta F, Lazzeri E, et al. Human CD8+ CD25+ thymocytes share phenotypic and functional features with CD4+ CD25+ regulatory thymocytes. Blood 2003;102(12):4107-14
  • Rifa'i M, Shi Z, Zhang SY, et al. CD8+ CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-αβTCR interaction and become IL-10-producing active regulatory cells. Int Immunol 2008;20(7):937-47
  • Filaci G, Fravega M, Negrini S, et al. Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+ CD28– T cells and inhibit both T-cell proliferation and CTL function. Hum Immunol 2004;65(2):142-56
  • Groux H, Bigler M, de Vries JE, Roncarolo MG. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med 1996;184(1):19-29
  • Fenoglio D, Ferrera F, Fravega M, et al. Advancements on phenotypic and functional characterization of non-antigen-specific CD8+ CD28- regulatory T cells. Hum Immunol 2008;69(11):745-50
  • Mahic M, Henjum K, Yaqub S, et al. Generation of highly suppressive adaptive CD8+CD25+FOXP3+ regulatory T cells by continuous antigen stimulation. Eur J Immunol 2008;38(3):640-6
  • Fan TM, Kranz DM, Flavell RA, Roy EJ. Costimulatory strength influences the differential effects of transforming growth factor β1 for the generation of CD8+ regulatory T cells. Mol Immunol 2008;45(10):2937-50
  • Herold KC, Gitelman SE, Masharani U, et al. A single course of anti-CD3 monoclonal antibody hOKT3γ1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005;54(6):1763-9
  • Bisikirska B, Colgan J, Luban J, et al. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest 2005;115(10):2904-13
  • Joosten SA, van Meijgaarden KE, Savage ND, et al. Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4. Proc Natl Acad Sci USA 2007;104(19):8029-34
  • Uss E, Rowshani AT, Hooibrink B, et al. CD103 is a marker for alloantigen-induced regulatory CD8+ T cells. J Immunol 2006;177(5):2775-83
  • Uss E, Yong SL, Hooibrink B, et al. Rapamycin enhances the number of alloantigen-induced human CD103+ CD8+ regulatory T cells in vitro. Transplantation 2007;83(8):1098-106
  • Allez M, Brimnes J, Dotan I, Mayer L. Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. Gastroenterology 2002;123(5):1516-26
  • Yio XY, Mayer L. Characterization of a 180-kDa intestinal epithelial cell membrane glycoprotein, gp180. A candidate molecule mediating T cell–epithelial cell interactions. J Biol Chem 1997;272(19):12786-92
  • Jarvis LB, Matyszak MK, Duggleby RC, et al. Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function. Eur J Immunol 2005;35(10):2896-908
  • Gilliet M, Liu YJ. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med 2002;195(6):695-704
  • Wei S, Kryczek I, Zou L, et al. Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma. Cancer Res 2005;65(12):5020-6
  • Ciubotariu R, Colovai AI, Pennesi G, et al. Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CD8+ CD28– regulatory T cells. J Immunol 1998;161(10):5193-202
  • Li J, Liu Z, Jiang S, et al. T suppressor lymphocytes inhibit NF-κB-mediated transcription of CD86 gene in APC. J Immunol 1999;163(12):6386-92
  • Chang CC, Ciubotariu R, Manavalan JS, et al. Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 2002;3(3):237-43
  • Vlad G, Cortesini R, Suciu-Foca N. CD8+ T suppressor cells and the ILT3 master switch. Hum Immunol 2008;69(11):681-6
  • Vlad G, D'Agati VD, Zhang QY, et al. Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice. Diabetes 2008;57(7):1878-86
  • Chess L, Jiang H. Resurrecting CD8+ suppressor T cells. Nat Immunol 2004;5(5):469-71
  • Lu L, Werneck MB, Cantor H. The immunoregulatory effects of Qa-1. Immunol Rev 2006;212:51-9
  • Sarantopoulos S, Lu L, Cantor H. Qa-1 restriction of CD8+ suppressor T cells. J Clin Invest 2004;114(9):1218-21
  • Czesnikiewicz-Guzik M, Lee WW, et al. T cell subset-specific susceptibility to aging. Clin Immunol 2008;127(1):107-18
  • Chung CP, Avalos I, Raggi P, Stein CM. Atherosclerosis and inflammation: insights from rheumatoid arthritis. Clin Rheumatol 2007;26(8):1228-33
  • Kaplan MJ. Cardiovascular disease in rheumatoid arthritis. Curr Opin Rheumatol 2006;18(3):289-97
  • Weyand CM. Immunopathologic aspects of rheumatoid arthritis: who is the conductor and who plays the immunologic instrument? J Rheumatol Suppl 2007;79:9-14
  • Weyand CM, Goronzy JJ. Ectopic germinal center formation in rheumatoid synovitis. Ann NY Acad Sci 2003;987:140-9
  • Knedla A, Neumann E, Muller-Ladner U. Developments in the synovial biology field 2006. Arthritis Res Ther 2007;9(2):209
  • Goronzy JJ, Weyand CM. Rheumatoid arthritis. Immunol Rev 2005;204:55-73
  • Weyand CM, Goronzy JJ. T-cell-targeted therapies in rheumatoid arthritis. Nat Clin Pract Rheumatol 2006;2(4):201-10
  • Colmegna I, Diaz-Borjon A, Fujii H, et al. Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis. Arthritis Rheum 2008;58(4):990-1000
  • Davila E, Kang YM, Park YW, et al. Cell-based immunotherapy with suppressor CD8 + T cells in rheumatoid arthritis. J Immunol 2005;174(11):7292-301
  • Klimiuk PA, Goronzy JJ, Weyand CM. IL-16 as an anti-inflammatory cytokine in rheumatoid synovitis. J Immunol 1999;162(7):4293-9
  • Seo SK, Choi JH, Kim YH, et al. 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat Med 2004;10(10):1088-94
  • Filaci G, Bacilieri S, Fravega M, et al. Impairment of CD8+ T suppressor cell function in patients with active systemic lupus erythematosus. J Immunol 2001;166(10):6452-7
  • Singh RR, Ebling FM, Sercarz EE, Hahn BH. Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus. J Clin Invest 1995;96(6):2990-6
  • Hahn BH, Singh RR, Wong WK, et al. Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus. Arthritis Rheum 2001;44(2):432-41
  • Hahn BH, Singh RP, La Cava A, Ebling FM. Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFβ-secreting CD8+ T cell suppressors. J Immunol 2005;175(11):7728-37
  • Singh RP, La Cava A, Wong M, et al. CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression. J Immunol 2007;178(12):7649-57
  • Ferrera F, Hahn BH, Rizzi M, et al. Protection against renal disease in (NZB × NZW)F1 lupus-prone mice after somatic B cell gene vaccination with anti-DNA immunoglobulin consensus peptide. Arthritis Rheum 2007;56(6):1945-53
  • Kang HK, Michaels MA, Berner BR, Datta SK. Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets. J Immunol 2005;174(6):3247-55
  • Kang HK, Liu M, Datta SK. Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells. J Immunol 2007;178(12):7849-58
  • Weber MS, Hohlfeld R, Zamvil SS. Mechanism of action of glatiramer acetate in treatment of multiple sclerosis. Neurotherapeutics 2007;4(4):647-53
  • Tennakoon DK, Mehta RS, Ortega SB, et al. Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis. J Immunol 2006;176(11):7119-29
  • Correale J, Villa A. Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis. J Neuroimmunol 2008;195(1-2):121-34
  • Menager-Marcq I, Pomie C, Romagnoli P, van Meerwijk JP. CD8+ CD28– regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice. Gastroenterology 2006;131(6):1775-85
  • Ho J, Kurtz CC, Naganuma M, et al. A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. J Immunol 2008;180(4):2573-80
  • Brimnes J, Allez M, Dotan I, et al. Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease. J Immunol 2005;174(9):5814-22
  • James EA, Kwok WW. CD8+ suppressor-mediated regulation of human CD4+ T cell responses to glutamic acid decarboxylase 65. Eur J Immunol 2007;37(1):78-86
  • Chatenoud L. OKT3-induced cytokine-release syndrome: prevention effect of anti-tumor necrosis factor monoclonal antibody. Transplant Proc 1993;25(2 Suppl 1):47-51
  • Chatenoud L. Humoral immune response against OKT3. Transplant Proc 1993;25(2 Suppl 1):68-73
  • Alegre ML, Peterson LJ, Xu D, et al. A non-activating “humanized” anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation 1994;57(11):1537-43
  • Xu D, Alegre ML, Varga SS, et al. In vitro characterization of five humanized OKT3 effector function variant antibodies. Cell Immunol 2000;200(1):16-26
  • Ablamunits V, Bisikirska BC, Herold KC. Human regulatory CD8 T cells. Ann NY Acad Sci 2008;1150:234-8
  • Wang R, Han G, Song L, et al. CD8+ regulatory T cells are responsible for GAD-IgG gene-transferred tolerance induction in NOD mice. Immunology 2009;126(1):123-31

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.