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Review

Haemoglobin-based erythrocyte transfusion substitutes

Pages 831-843 | Published online: 23 Feb 2005

Bibliography

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  • ••Stepwise transfusion with bovine cell-freehaemoglobin, autologous packed red cells or freshly donated red blood cells after profound isovolaemic haemodilution in dogs provided restoration of muscular tissue oxygen tensions with a significantly lower dose of HBOC when compared with cellular haemoglobin indicating a higher oxygenation potential of HBOC.
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  • ••This animal experiment shows withfluoroscopy that cell-free haemoglobin molecules are able to perfuse compressed capffiaries in lung zone I more readily than erythrocytes, offering the oppurtunity of improved gas exchange in critically ill individuals.
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  • KASPER SM, WALTER M, GRUNE F, BISCHOFF A, ERASMI H, BUZELLO W: Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Ariesth. Arialg. (1996) 83(5):921–927.
  • STANDL T, WILHELM S, HORN EP et al.: Preoperative hemodilution with bovine hemoglobin. Acute hemodynamic effects in liver surgery patients. Anaesthetist. (1997) 46(9):763–770.
  • BRAUER E STANDL T, WILHELM S, BURMEISTER MA, SCHULTE AM ESCH J: Transcranial Doppler sonography mean flow velocity during infusion of ultrapurifled bovine hemoglobin. Neurosurg. Anesthesia (1998) 10(3):146–152.
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  • LAMURAGLIA GM, O'HARA PJ, BAKER WH et al: The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution. Vase. &mg. (2000) 31(2):299–308.
  • •In this clinical setting, bovine HBOC could eliminate the need for allogeneic transfusion in 27% of patients undergoing infrarenal aortic reconstruction.

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