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Miscellaneous

Delivery of novel macromolecular drugs against HIV-1

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Pages 949-970 | Published online: 23 Feb 2005

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  • •This paper demonstrates that in spite of the intracellular accumulation of cationic liposome-anti-HIV-1-ribozyme complexes, the inhibitory effect of the ribozyme on HIV-1 production in infected cells is negligible.
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  • •This study utilises exogenous delivery of ribozymes for the inhibition of HIV-1 LTR-driven luciferase expression.
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  • •The authors show that the strong enhancer/promoter CMV severely suppresses the expression of the HIV-1 proviral DNA even when it is not transcribing an anti-HIV-1 construct.
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  • ••This paper demonstrates the role ofsequences appended to Pol III transcripts in intracellular localisation of these transcripts.
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