39
Views
14
CrossRef citations to date
0
Altmetric
Miscellaneous

Gene therapy for rheumatoid arthritis

, , , , &
Pages 971-978 | Published online: 23 Feb 2005

Bibliography

  • AREND WP: Cytokines and cellular interactions in inflammatory synovitis. Chh. Invest. (2001) 107:1081–1082.
  • FELDMANN M, BRENNAN FM, MAINIRN: Role of cytokines in rheumatoid arthritis. Ann. Rev Immunol. (1996) 14:397–440.
  • MORELAND LW HECK LW Jr., KOOPMAN WJ: Biologic agents for treating rheumatoid arthritis. Concepts and progress. Arthritis Rheum. (1997) 40:397–409.
  • EVANS CH, GHIVIZZANI SC, KANG R et al.: Gene therapy for rheumatic diseases. Arthritis Rheum. (1999) 42:1–16.
  • GHIVIZZANI SC, OLIGINO TJ, GLORIOSO JC, ROBBINS PD, EVANS CH: Direct gene delivery strategies for the treatment of rheumatoid arthritis. Drug Discos,. Today (2001) 6:259–267.
  • DOUGHTY LA, PATRENE KD, EVANS CH, BOGGS SS, ROBBINS PD: Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL- 6 and IL-10. Gene Ther. (1997) 4:252–257.
  • BOGGS SS, PATRENE KD, MUELLER GM, EVANS CH, DOUGHTY LA, ROBBINS PD: Prolonged systemic expression of human IL-1 receptor antagonist (hIL- lra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-lra cDNA. Gene Ther. (1995) 2:632–638.
  • BESSIS N, BOISSIER MC, FERRARA P, BLANKENSTEIN T, FRADELIZI D, FOURNIER C: Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13. Eur. j Immunol. (1996) 26:2399–2403.
  • FELLOWES R, ETHERIDGE CJ, COADE S et al.: Amelioration of established collagen induced arthritis by systemic IL-10 gene delivery. Gene Ther. (2000) 7:967–977.
  • KIM SH, EVANS CH, KIM S, OLIGINO T, GHIVIZZANI SC, ROBBINS PD: Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin- 4. Arthritis Res. (2000) 2:293–302.
  • KIM SH, KIM S, EVANS CH, GHIVIZZANI SC, OLIGINO T, ROBBINS PD: Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. I Immunol. (2001) 166:3499–505.
  • LE CH, NICOLSON AG, MORALES A, SEWELL KL: Suppression of collagen-induced arthritis through adenovirus-mediated transfer of a modified tumor necrosis factor alpha receptor gene. Arthritis Rheum. (1997) 40:1662–1669.
  • QUATTROCCHI E, DALLMAN MJ, DHILLON AP, QUAGLIA A, BAGNATO G, FELDMANN M: Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver. j Immunol. (2001) 166:5970–5978.
  • HUNG GL, GALEA-LAURI J, MUELLER GM et al.: Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium. Gene Ther. (1994). 1:64–69.
  • OTANI K, NITA I, MACAULAY W, GEORGESCU HI, ROBBINS PD, EVANS CH: Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. Immunol. (1996) 156:3558–3562.
  • MAKAROV SS, OLSEN JC, JOHNSTON WN et al.: Suppression of experimental arthritis by gene transfer of interleukin 1 receptor antagonist cDNA. Proc. Nati Acad. Li. USA (1996) 93:402–406.
  • BAKKER AC, JOOSTEN LA, ARNTZ OJ et al.: Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee. Arthritis Rheum. (1997) 40:893–900.
  • EVANS CH, ROBBINS PD, GHIVIZZANI SC et al.: Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum. Gene Ther. (1996) 7:1261–1280.
  • ••This paper reports the protocol for the first clinical trial for a non-lethal disease. This Phase I study was performed on nine post-menopausal women with end-stage RA. The aims were to assess whether the transfer of gene into human RA joints was safe, feasible and efficient.
  • EVANS CH, GHIVIZZANI SC, OLIGINO TA, ROBBINS PD: Future of adenoviruses in the gene therapy of arthritis. Arthritis Res. (2001) 3:142–146.
  • GHIVIZZANI SC, LECHMAN ER, KANG R et al.: Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc. Natl. Acad. Sci. USA (1998) 95:4613–4618.
  • ••This paper reports for the first time the'contralateral effect' in which bilateral improvement was observed following local gene therapy in one knee. These effects were observed in rabbits with antigen-induced arthritis following the transfer of genes encoding IL-1 and TNF soluble receptors. These observations suggest new beneficial mechanisms triggered by gene therapy.
  • WOODS JM, KATSCHKE KJ, VOLIN MV et al.: IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant- induced arthritis. j Immunal. (2001) 166:1214–1222.
  • LECHMAN ER, JAFFURS D, GHIVIZZANI SC et al.: Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. j Immunal. (1999) 163:2202–2208.
  • LUBBERTS E, JOOSTEN LA, VAN DEN BERSSELAAR L et al.: Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw. Gun. Exp. Immunal. (2000) 120:375–383.
  • MI Z, GHIVIZZANI SC, LECHMAN ER et al.: Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints. Arthritis Rheum. (2000) 43:2563–2570.
  • YAO Q, WANG S, GLORIOSO JC et al.:gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation. Mal. Ther. (2001) 3:901–910.
  • HARTIGAN O CONNOR D, AMALFITANO A, CHAMBERLAIN JS: Improved production of gutted adenovirus in cells expressing adenovirus preterminal protein and DNA polymerase. j Viral. (1999) 73:7835–7841.
  • KOCHANEK S, CLEMENS PR, MITANI K, CHEN HH, CHAN S, CASKEY CT: A new adenoviral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc. Natl. Acad. Li. USA (1996) 93:5731–5736.
  • ROBBINS PD, GHIVIZZANI SC: Viral vectors for gene therapy. Pharmacol. Ther. (1998) 80:35–47.
  • NITA I, GHIVIZZANI SC, GALEA-LAURI J etal.: Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo. Arthritis Rheum. (1996) 39:820–828.
  • OLIGINO T, GHIVIZZANI S, WOLFE D et al.: Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis. Gene Ther. (1999) 6:1713–1720.
  • KRISKY DM, MARCONI PC, OLIGINO TJ et al.: Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications. Gene Ther. (1998) 5:1517–1530.
  • GHIVIZZANI SC, LECHMAN ER, TIO C et al.: Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy. Gene Ther. (1997) 4:977–982.
  • NGUYEN KH, BOYLE DL, MCCORMACK JE, CHADA S, JOLLY DJ, FIRESTEIN GS: Direct synovial gene transfer with retroviral vectors in rat adjuvant arthritis. j Rheumatal. (1998) 25:1118–1125.
  • PAN RY, CHEN SL, XIAO X, LIU DW, PENG HJ, TSAO YP: Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist. Arthritis Rheum. (2000) 43:289–297.
  • •This paper reports the unexpected, but potentially important, finding that AAV-mediated gene expression in arthritic joints can be reactivated by a second inflammatory stimulus.
  • PAN RY, XIAO X, CHEN SL et al.: Disease-inducible transgene expression from a recombinant adeno-associated virus vector in a rat arthritis model. ..J. Viral. (1999) 73:3410–3417.
  • WATANABE S, IMAGAWA T, BOIVIN GP, GAO G, WILSON JM, HIRSCH R: Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium. Mai Ther. (2000) 2:147–152.
  • JENNINGS K, KATAKURA S, BURSTEIN H, GAO G, WILSON JM, HIRSCH R: Adeno-associated virus preferentially transduces human compared to mouse synovium. Arthritis Res. (2001) 3\(Suppl. 1):1.
  • GOATER J, MULLER R, KOLLIAS G etal.: Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis. j Rheumatal. (2000) 27:983–989.
  • OLIGINO TJ, YAO Q, WANG S etal.: Intra-articular expression of the IL-1Ra gene following direct delivery with an adeno-associated virus vector. Gene Ther. (under revision).
  • NALDINI L, BLOMER U, GALLAY P etal.: In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 272:263–267.
  • LEVER AM: Lentiviral vectors: progress and potential. Cum: Opin. Mal. Ther (2000) 2:488–496.
  • BUCHSCHACHER GL Jr., WONG-STAAL F: Development of lentiviral vectors for gene therapy for human diseases. Blood (2000) 95:2499–2504.
  • ORY DS, NEUGEBOREN BA, MULLIGAN RC: A stable human-derived packaging cell line for production of high titer retrovirusivesicular stomatitis virus G pseudotypes. Proc. Natl. Acad. Sri. USA (1996) 93:11400–11406.
  • VIGNA E, NALDINI L: Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy. J. Gene Med. (2000) 2:308–316.
  • GOUZE E, PAWLIUK R, PILAPIL C, GOUZE JN, LEBOULCH P, EVANS CH, GHIVIZZANI SC:In vitro and in vivo gene delivery using a lentiviral vector. Arthritis Res. (2001) 3:(Suppl. 1):34.
  • EVANS CH, ROBBINS PD, GHIVIZZANI SC et al.: Gene transfer to human joints: progress towards a gene therapy of arthritis. (Submitted for publication).
  • WHALEN JD, LECHMAN EL, CARLOS CA etal.: Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and un-injected paws. j Immurrol. (1999) 162:3625–3632.
  • ••This work provides evidence to explain thebeneficial contralateral effect induced by local gene therapy. Macrophages and dendritic cells transduced with vIL-10 can, by adoptive transfer, inhibit DTH reactions when pulsed with the relevant inciting antigen.
  • MIAGKOV AV, KOVALENKO DV, BROWN CE etal.: NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Nati Acad. Sd. USA (1998) 95:13859–13864.
  • BOYLE DL, NGUYEN KH, ZHUANG S et al.: Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced th2activity. Gene Ther. (1999) 6:1911–1918.
  • NAKAJIMA A, SEROOGY CM, SANDORA MR et al.: Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. j Gun. Invest. (2001) 107:1293–1301.
  • MAGEED RA, ADAMS G, WOODROW D, PODHAJCER OL, CHERNAJOVSKY Y: Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. Gene Ther. (1998) 5:1584–1592.
  • DECARIS E, GUINGAMP C, CHAT Met al.: Evidence for neurogenic transmission inducing degenerative cartilage damage distant from local inflammation. Arthritis Rheum. (1999) 42:1951–1960.
  • GOUZE-DECARIS E, PHILIPPE L, MINN A et al.: Neurophysiological basis for neurogenic-mediated articular cartilage anabolism alteration. Am. j Physiol. Regul. Integr. Comp. Physiol. (2001) 280:R115–122.
  • DAY CS, KASEMKIJWATTANA C, MENETREY J et al.: Myoblast-mediated gene transfer to the joint. _J. Orthop. Res.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.