Ecdysone-controlled expression of transgenes

Bibliography

• XIE X, ZHAO X, LIU Y et al: Adenovirus-mediated tissue-targeted expression of a caspase-9-based artificial death switch for the treatment of prostate cancer. Cancer Res. (2001) 61:6795–6804.
   PubMed Web of Science ®Google Scholar
• HUH WK, GOMEZ-NAVARRO J, ARAFAT WO et al.: Bax-induced apoptosis as a novel gene therapy approach for carcinoma of the cervix. Cynecol Oncol (2001) 83:370–377.
   PubMed Web of Science ®Google Scholar
• LOHR F, HUANG Q, HU K, D,EWHIRST MW, LI CY: Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors. Clin. Cancer Res. (2001) 7:3625–3628.
   PubMed Web of Science ®Google Scholar
• HAVIV YS, CURIEL DT: Conditional gene targeting for cancer gene therapy. Adv. Drug Deily. Rev (2001) 53:135–154.
   PubMed Web of Science ®Google Scholar
• RIVERA VM, YE X, COURAGE NL et al.: Long-term regulated expression of growth hormone in mice after intramuscular gene transfer. Proc. Natl. Acad. Sci. USA (1999) 96:8657–8662.
   PubMed Web of Science ®Google Scholar
• YE X, RIVERA VM, ZOLTICK P et al.: Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer. Science (1999) 283:88–91.
   PubMed Web of Science ®Google Scholar
• DRAGHIA-AKLI R, MALONE PB, HILL LA, ELLIS KM, SCHWARTZ RJ, NORDSTROM JL: Enhanced animal growth via ligand regulated GHRH myogenic injectable vectors. FASEB (2002) 16:426–428.
   PubMed Web of Science ®Google Scholar
• ZOLTICK PW, WILSON JM: Regulated gene expression in gene therapy. Ann. NY Acad. Sci. (2001) 953:53–63.
   PubMed Web of Science ®Google Scholar
• CLACKSON T: Controlling mammalian gene expression with small molecules. Curr: Opin. Chem. Biol. (1997) 1:210–218.
   PubMed Web of Science ®Google Scholar
• HARVEY DM, CASKEY CT: Inducible control of gene expression: prospects for gene therapy. Curi: Opin. Chem. Biol. (1998) 2:512–518.
   PubMed Web of Science ®Google Scholar
• TSAI SY, SCHILLINGER K, YE X: Adenovirus-mediated transfer of regulable gene expression. Curr: Opin. Mol Ther. (2000) 2:515–523.
   PubMed Web of Science ®Google Scholar
• DeMAY0 FJ, TSAI SY: Targeted gene regulation and gene ablation. Trends Endocrinol Metab. (2001) 12:348–353.
   PubMed Web of Science ®Google Scholar
• LEZZI M, BERGMAN T, MOUILLET JF, H,ENRICH VC: The ecdysone receptor puzzle. Arch. Insect Biochem. Physiol. (1999) 41:99–106.
   Web of Science ®Google Scholar
• BILLAS IML, MOULINIER L, ROCHELN, MORAS D: Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects. J. Biol. Chem. (2001) 276:7465–7474.
   PubMed Web of Science ®Google Scholar
• CLAYTON GM, PEAKCHEW SY, EVANS RM, SCHWABE JWR The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation. Proc. Natl. Acad. Sci. USA (2001) 98:1549–1554.
   PubMed Web of Science ®Google Scholar
• CHRISTOPHERSON KS, MARK MR, BAJAJ V, GODOWSKI PD: Ecdysteroid-dependent regulation of genes in mammalian cells by a Drosophila ecdysone receptor and chimeric transactivators. Proc. Natl. Acad. Sci. USA (1992) 89:6314–6318.
   PubMed Web of Science ®Google Scholar
• NO D, YAO T-P, EVANS RE: Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Nail. Acad. Sci. USA (1996) 93:3346–3351.
   PubMed Web of Science ®Google Scholar
• ••Development of the VgEcR/rRXR system,and first demonstration in vivo of ecdysone-controlled transgene expression. Bioavailability of muristerone. Tissue-specific transgene expression in vivo.
   Google Scholar
• LECLERC GM, BOOCKFOR FR, FAUGHT WJ, FRAWLEY LS: Development of a destabilized firefly luciferase enzyme for measurement of gene expression. Biotechniques (2000) 29:590–598.
   PubMed Web of Science ®Google Scholar
• SAEZ E, NELSON MC, ESHELMAN B et al.: Identification of ligands and coligands for the ecdysone-regulated gene switch. Proc. Nail. Acad. Sci. USA (2000) 97:14512–14517.
   PubMed Web of Science ®Google Scholar
• ••Comparison by the Evans laboratory ofvarious ecdysteroid and d,ibenzoylhydrazine inducers of VgEcR/ rRXR system in vitro and in transgenic mice. RXR agonists shown to augment transactivation by EcR ligands. Tissue-specific transgene expression in vivo.
   Google Scholar
• THORMEYER D, TENBAUM SP, RENKAWITZ R, BANIAHMAD A: EcR interacts with corepressors and harbours an autonomous silencing domain functional in both Drosophila and vertebrate cells. Steroid Biochem. Ma Biol. (1999) 68:163–169.
   PubMed Web of Science ®Google Scholar
• ALBANESE C, REUTENS AT, BOUZAHZAH B et al.: Sustained mammary gland-directed, ponasterone A- i,nducible expression in transgenic mice. FASEB (2000) 14:877–884.
   PubMed Web of Science ®Google Scholar
• ••VgEcR/rRXR system used to achieveprolonged and tissue-specific transgene expression in vivo. Bioavailability of ponasterone, including slow-release.
   Google Scholar
• WYBORSKI DL, BAUER JC, V,AILLANCOURT P: Bicistronic expression of ecdysone-inducible receptors in mammalian cells. Biotechniques (2001) 31:618–620.
   PubMed Web of Science ®Google Scholar
• •Expression of VgEcR/rRXR from PERV3 in transiently- and stably-transfected cells.
   Google Scholar
• VAN CRAENENBROECK K, VANHOENACKER P, LEYSEN JE, HAEGEMAN G: Evaluation of the tetracycline- and ecdysone-inducible systems for expression of neurotransmitter receptors in mammalian cells. Eur. Neurosci. (2001) 14:968–976.
   PubMed Web of Science ®Google Scholar
• •Difficulties with stable VgEcR/rRXR transfectants in some cell types.
   Google Scholar
• SAWICKI JA, MONKS B, MORRIS RJ: C,ell-specific ecdysone-inducible expression of FLP recombinase in mammalian cells. Biotechniques (1998) 25:868–875.
   PubMed Web of Science ®Google Scholar
• •VgEcR/rRXR-controlled recombination in vitro, including tissue-specific activity limited to embryonic stem cells that followed a particular differentiation path.
   Google Scholar
• WANG Y, BLANDINO G, OREN M, GIVOL D: Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs. Oncogene (1998) 17: 1923-1930.
   Google Scholar
• DUNLOP J, LOU Z, McILVAIN HB: Steroid hormone-inducible expression of the GLT-1 subtype of high-affinity L-glutamate transporter in human embryonic kidney cells. Biochem. Biophys. Res. Commun. (1999) 265:101–105.
   PubMed Web of Science ®Google Scholar
• DUNLOP J, LOU Z, ZHANG Y, McILVAIN HB: Inducible expression and pharmacology of the human excitatory amino acid transporter 2 subtype of L-glutamate transporter. Br. J. Pharmacol (1999) 128:1485–1490.
   PubMed Web of Science ®Google Scholar
• KARNS LR, KISIELEWSKI A, GULDING KM, SERAJ JM, THEODORESCU D: Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts. BMC Biotechnol (2001) 1:11–22.
   PubMedGoogle Scholar
• •RHeoSwitch (GAL4-EcRNP16-RXR) system transfected stably into adenocarcinoma cell lines. GS-E induced transgene expression in transfectants g,rown as tumours in mice.
   Google Scholar
• STOLAROV J, CHANG K, REINER A et al.: Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proc. Nati Acad. Sci. USA (2001) 98:13043–13048.
   PubMed Web of Science ®Google Scholar
• •In vitro delivery of VgEcR and rRXR on retroviruses. Enrichment using an EGFP transgene and iterative FACS allowed development of highly compliant cell populations (>95% recruitment) from various cell lines.
   Google Scholar
• TRAN HT, ASKARI HB, SHAABAN S et al.: Reconstruction of ligand-dependent transactivation of Choristoneura fumiferana ecdysone receptor in yeast. Mol. Endocrinol. (2001) 15:1140–1153.
   PubMed Web of Science ®Google Scholar
• SUBBARAYAN V, MARK M, M,ESSADEQ N, RUSTIN P, CHAMBON P, KASSTNER P: RXRa overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRa-null fetuses. Clin. Invest. (2000) 105:387–394.
   Google Scholar
• HOPPE UC, MARBAN E, JOHNS DC: Adenovirus-mediated inducible gene expression in vivo by a hybrid ecdysone receptor. Mol. Ther. (2000) 1:159–164.
   PubMed Web of Science ®Google Scholar
• ••Development of the DB-EcR system,which does not need rRXR and reponds well to dibenzoylhydrazines. Properties of the system in vitro and in rat myocardium. Bioavailability of GS-E in rats.
   Google Scholar
• ISSA LL, LEONG GM, BARRY JB, SUTHERLAND RL, EISMAN JA: Glucocorticoid receptor-interacting protein-1 and receptor-associated coactivator-3 differentially interact with the vitamin D receptor (VDR) and regulate VDR-retinoid X receptor transcriptional cross-talk. Endocrinology (2001) 142: 1606-1615.
   Google Scholar
• SUHR ST, GIL EB, SENUT M-C, GAGE FH: High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor. Proc. Nati Acad. Set. USA (1998) 95:7999–8004.
   PubMed Web of Science ®Google Scholar
• ZHANG Y, OCHALSKI R, WARDWELL-SWANSON J, DUNLOP J: Ecdysone inducible expression poorly regulates human 5-HT2A receptor gene expression in CHO cells. Soc. Neurosci. Abstr. (2000) 26:273.
   Google Scholar
• HOPPE UC, MARBAN E, JOHNS DC: Molecular dissection of cardiac repolarization by in vivo Kv4.3 gene t,ransfer. Clin. Invest. (2000) 105:1077–1084.
   Google Scholar
• •Adenoviral delivery in vivo to rat and guinea pig myocardium of ion channel genes under control of DB-EcR system, with induction by GS-E.
   Google Scholar
• OGAWA S, NISHIMOTO N, MATSUDA H: Source and availability of ecdysterones. In: Invertebrate Endocrinology and Hormonal Heterophylly Burdette W (ed.), Springer, New York (1974):218–232.
   Google Scholar
• SIMON P, KOOLMAN J: Ecdysteroids invertebrates: pharmacological aspects. In: Ecdysone: from Chemistry to Mode of Action. Koolman J (ed.), Thieme Medical Publishers, New York (1989):254–259.
   Google Scholar
• •Summarises pre-1990 safety, bioavailability and pharmacological data for ecdysteroids in mammals.
   Google Scholar
• DHADIALLA TS, CARLSON GR, LE DP: New insecticides with ecdysteroidal and juvenile hormone activity. Ann. Rev. Entomol. (1998) 43:545–569.
   PubMed Web of Science ®Google Scholar
• •Includes a review of the properties of dibenzoylhydrazine EcR agonists.
   Google Scholar
• SYROV VN: Mechanism of the anabolic action of phytoecdysteroids in mammals. Nauchnye Doki Vyss Shkoly Biol. Nauki (1984) 11:16–20.
   PubMedGoogle Scholar
• TRENIN DS, VOLODIN VV: 20-hydroxyecdysone as a human lymphocyte and neutrophil modulator: in vitro evaluation. Arch. Insect Biochem. Physiol. (1999) 41:156–161.
   PubMed Web of Science ®Google Scholar
• FOMOVSKAIA GN, BERDYSHEV AG, KHOLODOVA ID: Immunomodulating effect of ecdysterones. Ukr. Biokhim. Zh. (1992) 64:56–61.
   PubMedGoogle Scholar
• SLAMA K: Ecdysteroids - insect hormones, plant defensive factors, or human medicine? Phytoparasitica (1993) 21:3–8.
   Google Scholar
• SLAMA K, LAFONT R: Insect hormones - ecdysteroids - their presence and actions in vertebrates. Eur Entomol. (1995) 92:355–377.
   Web of Science ®Google Scholar
• SLAMA K, KOUDELA K, TEN ORA J, MATHOVA A: Insect hormones in vertebrates: anabolic effects of 20-hydroxyecdysone in Japanese quail. Experientia (1996) 52:702–706.
   PubMedGoogle Scholar
• MYKHAYLYK OM, KOTZURUBA AV, BUCHANEVICH OM, GULA NM, BAKAI EA: Cell surface receptor interactions of C27-steroid hormone ecdysone immobilised on nanodispersed magnetite. I Magnetism Magnetic Mater. (1999) 194:113–119.
   Web of Science ®Google Scholar
• CATALAN RE, MARTINEZ AM, ARAGONES MD, MIGUEL BG, ROBLES A, GODOY JE: Alterations in rat lipid metabolism following ecdysterone treatment. Comp. Biochem. Physiol. (1985) 81B:771–775.
   Google Scholar
• CATALAN RE, ARAGONES MD, GOODY JE, MARTINEZ AM: Ecdysterone induces acetylcholinesterase in mammalian brain. Comp. Biochem. Physiol. (1984) 78C:193–195.
   Google Scholar
• CATALAN RE, MARTINEZ AM, ARAGONES MD, MIGUEL BG, ROBLES A, GODOY JE: Effect of ecdysterone treatment on the cyclic AMP-protein kinase system in adipose tissue. Steroid. Biochem. (1982) 16:573–576.
   PubMedGoogle Scholar
• CONSTANTINO S, SANTOS R, GISSELBRECHT S, GOUILLEUX F: The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells. Eur: Cytokine Netw. (2001) 12:365–367.
   PubMed Web of Science ®Google Scholar
• LAFONT R, GIRAULT JP, KERB U: Excretion and metabolism of injected ecdysone in the white mouse. Biochem. Pharmacol. (1988) 37:1174–1177.
   PubMed Web of Science ®Google Scholar
• GHARIB B, BASWAID S, DOUMBO 0, QUILICI M, DE REGGI M: Ecdysteroid-like compounds in human urine: they can occur in the absence of any parasitic infection. Clin. Chim. Acta (1991) 199:159–166.
   PubMed Web of Science ®Google Scholar
• ISITSIMPIKOU C, TSAMIS GD, SISKOS PA, SPYRIDAKI MH, GEORGAKOPOULOS CG: Study of excretion of ecdysterone in human urine. Rapid Commun. Mass Specmom. (2001) 15:1796–1801.
   PubMed Web of Science ®Google Scholar
• LANSOUD-SOUKATE J, GHARIB B, CAPRON A, BASWAID S, DE REGGI M: Ecdysteroid-like compounds in the serum and urine of African patients infected with Loa loa and/or Mansonella perstans microfilariae. Trans. R. Soc. Bop. Med. Hyg. (1989) 84:269–272.
   Web of Science ®Google Scholar
• BASWAID S, GHARIB B, DOUMBO 0, QUILICI M, DE REGGI M: Ecdysteroids in urine of African patients infected with helminths. Acta Tropica (1990) 47:197–204.
   PubMed Web of Science ®Google Scholar
• CYMBOROWSKI B: Bioassays for ecdysteroids. In: Ecdysone: from Chemistry to Mode of Action. Koolman J (ed.) Thieme Medical Publishers, New York (1989):144–149.
   Google Scholar
• FRISTROM JW, YUND MA: C,haracteristics of the action of ecdysones on Drosophila imaginal discs cultured in vitro. In: In vertebrate Thine Culture Research Applications. Maramorosch K (ed.), Academic Press, New York (1976):161–178.
   Google Scholar
• CLEMENT CY, BRADBROOK DA, LAFONT R, DINAN L: Assessment of a microplate-based bioassay for the detection of ecdysteroid-like or antiecdysteroid activities. Insect Biochem. Ma Biol. (1993) 23:187–192.
   Web of Science ®Google Scholar
• CHERBAS P, CHERBAS L, LEE S-S, NAKANISHI K: 264125Illodoponasterone A is a potent ecdysone and a sensitive radioligand for ecdysone receptors. Proc. Nati Acad. Sci. USA (1988) 85:2096–2100.
   PubMedGoogle Scholar
• DELA CRUZ FE, KIRSCH DR, HEINRICH JN: Transcriptional activity of Drosophila melanogasterecdysone receptor isoforms and ultraspiracle in Saccharomyces cerevisiae.J. Mol. Endocrinol (2000) 24:183–191.
   PubMed Web of Science ®Google Scholar
• NAKAGAWA Y, MINAKUCHI C, TAKAHASHI K, UENO T: Inhibition of PHIponasterone A binding by ecdysone agonists in the intact Kc cell line. Insect Biochem. Ma Biol. (2002) 32:175–180.
   PubMed Web of Science ®Google Scholar
• DINAN L, HORMANN RE, FUJIMOTO T,: An extensive ecdysteroid CoMFA. Comput. Aid. Molec. Design (1999) 13:185–207.
   PubMed Web of Science ®Google Scholar
• WURTZ JM, GUILLOT B, FAGART J, MORAS D, TIETJEN K, SCHINDLER M,: A new model for 20-hydroxyecdysone and dibenzoylhydrazine binding: a homology modeling and docking approach. Protein Sci. (2000) 9:1073–1084.
   PubMed Web of Science ®Google Scholar
• MARTINEZ A, SPARKS C, DRAYTON P, THOMPSON J, GREENLAND A, JEPSON I: Creation of ecdysone receptor chimeras in plants for controlled regulation of gene expression. Ma Gen. Genet. (1999) 261:546–552.
   PubMedGoogle Scholar
• LAMARTINA S, ROSCILLI G, RINAUDO CD et al.: Stringent control of gene expression M vivo by using novel doxycycline-dependent trans-activators. Hum. Gene Ther. (2002) 13:199–210.
   PubMed Web of Science ®Google Scholar
• AKAGI K, KANAI M, SAYA H, KOZU T, BERNS A: A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain. Nucleic Acids Res. (2001) 29:E23.
   PubMed Web of Science ®Google Scholar
• BURCIN MM, SCHIEDNER G, KOCHANEK S, TSAI SY, O'MALLEY BW: Adenovirus-mediated regulable target g,ene expression in vivo. Proc. Nati Acad. Sci. USA (1999) 96:355–360.
   PubMed Web of Science ®Google Scholar
• RAUCH P, GREBE M, ELKE C, SPINDLER KD, SPINDLER-BARTH M: E,cdysteroid receptor and ultraspiracle from Chironomus tentans (Insecta) are phosphoproteins and are regulated differently by molting hormone. Insect Biochem. Ma Biol. (1998) 28:265–275.
   PubMed Web of Science ®Google Scholar
• GRAHAM LD, HAGGETT, KD, JENNINGS PA, LE BROCQUE D, WHITTAKER RG: Random mutagenesis of the substrate binding site of a serine protease can generate enzymes with increased activities and altered primary specificities. Biochemistry (1993) 32:6250–6258.
   PubMed Web of Science ®Google Scholar
• DOYLE DF, BRAASCH DA, JACKSON LK et al.: Engineering orthogonal ligand-receptor pairs from 'near drugs'. Am. Chem. Soc. (2001) 123:11367-11371. A,ffiliation
   Google Scholar