488
Views
9
CrossRef citations to date
0
Altmetric
Drug Evaluations

Recombinant human follicular stimulating hormone and recombinant human luteinizing hormone in a 2:1 ratio combination. Pharmacological characteristics and clinical applications

, MD
Pages 1001-1009 | Published online: 23 Apr 2010

Bibliography

  • The European Recombinant Human LH Study Group. Recombinant human luteinizing hormone (LH) to support recombinant follicle stimulating hormone (FSH)-induced follicular development in LH- and FSH –deficient anovulatory women: a dose finding study. J Clin Endocrinol Metab 1998;83:1507-14
  • Kolibianakis EM, Collins J, Tarlatzis B, Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review. Hum Reprod Update 2006;12:3-12
  • Coomarasamy A, Afnan M, Cheema D, Urinary hMG versus recombinant FSH for controlled ovarian hyperstimulation following an agonist long down-regulation protocol in IVF or ICSI treatment: a systematic review and meta-analysis. Hum Reprod 2008;23:310-15
  • Available from: http://www.emea.europa.eu/humandocs/PDFs/EPAR/pergoveris/H-714-PI-en.pdf
  • Ryan RJ, Charlesworth MC, McCormick DJ, The glycoprotein hormones: recent studies of structure-function relationships. FASEB J 1988;2:2661-9
  • Driebergen R, Baer G. Quantification of follicle stimulating hormone (follitropin alfa): is in vivo bioassay still relevant in the recombinant age? Curr Med Res Opin 2003;19:41-6
  • Bassett RM, Driebergen R. Continued improvements in the quality and consistency of follitropin alfa, recombinant human FSH. Reprod Biomed Online 2005;10:169-77
  • Liu HC, He Z, Rosenwaks Z. In vitro culture and in vitro maturation of mouse preantral follicles with recombinant gonadotropins. Fertil Steril 2002;77:373-83
  • Karnitis VJ, Townson DH, Friedman CI, Danforth DR. Recombinant human follicle-stimulating hormone stimulates multiple follicular growth, but minimal estrogen production in gonadotropin-releasing hormone antagonist-treated monkeys: examining the role of luteinizing hormone in follicular development and steroidogenesis. J Clin Endocrinol Metab 1994;79:91-7
  • Porchet HC, le Cotonnec JY, Loumaye E. Clinical pharmacology of recombinant human follicle-stimulating hormone. III. Pharmacokinetic-pharmacodynamic modeling after repeated subcutaneous administration. Fertil Steril 1994;61:687-95
  • Le Cotonnec JY, Porchet HC, Beltrami V, Clinical pharmacology of recombinant human follicle-stimulating hormone (FSH). I. Comparative pharmacokinetics with urinary human FSH. Fertil Steril 1994;61:669-78
  • Le Cotonnec JY, Porchet HC, Beltrami V, Munafo A. Clinical pharmacology of recombinant human luteinizing hormone: Part I. Pharmacokinetics after intravenous administration to healthy female volunteers and comparison with urinary human luteinizing hormone. Fertil Steril 1998;69:189-94
  • Le Cotonnec JY, Porchet HC, Beltrami V, Munafo A. Clinical pharmacology of recombinant human luteinizing hormone: Part II. Bioavailability of recombinant human luteinizing hormone assessed with an immunoassay and an in vitro bioassay. Fertil Steril 1998;69:195-200
  • Le Cotonnec JY, Loumaye E, Porchet HC, Pharmacokinetic and pharmacodynamic interactions between recombinant human luteinizing hormone and recombinant human follicle-stimulating hormone. Fertil Steril 1998;69:201-9
  • Picard M, Rossier C, Papasouliotis O, Lugan I. Bioequivalence of recombinant human FSH and recombinant human LH in a fixed 2:1 combination: two phase I, randomised, crossover studies. Curr Med Res Opin 2008;24:1199-208
  • Centralised procedure for the marketing authorisation application for Pergoveris, European Medicines Agency, London, UK; 2007. Available from: http://www.emea.europa.eu/humandocs/PDFs/EPAR/pergoveris/H-714-en6.pdf [Last accessed 14 April 2010]
  • Couzinet B, Lestrat N, Brailly S, Stimulation of ovarian follicular maturation with pure follicle stimulating hormone in women with gonadotropin deficiency. J Clin Endocrinol Metab 1988;66:552-556
  • Balasch J, Miró F, Burzaco I, The role of luteinizing hormone in human follicle development and oocyte fertility: evidence from in-vitro fertilization in a woman with long-standing hypogonadotrophic hypogonadism and using recombinant human follicle stimulating hormone. Hum Reprod 1995;10:1678-83
  • Mochtar MH, Van der Veen F, Ziech M, van Wely M. Recombinant luteinizing hormone (rLH) for controlled ovarian hyperstimulation in assisted reproductive cycles. Cochrane Database Syst Rev 2007;18:2
  • Chappel SC, Howles C. Reevaluation of the roles of luteinizing hormone and follicle-stimulating hormone in the ovulatory process. Hum Reprod 1991;6:1206-12
  • Marrs R, Meldrum D, Muasher S, Randomized trial to compare the effect of recombinant human FSH (follitropin alfa) with or without recombinant human LH in women undergoing assisted reproduction treatment. Reprod Biomed Online 2004;8:175-82
  • Humaidan P, Bungum M, Bungum L, Yding Andersen C. Effects of recombinant LH supplementation in women undergoing assisted reproduction with GnRH agonist down-regulation and stimulation with recombinant FSH: an opening study. Reprod Biomed Online 2004;8:635-43
  • Fábregues F, Creus M, Peñarrubia J, Effects of recombinant human luteinizing hormone supplementation on ovarian stimulation and the implantation rate in down-regulated women of advanced reproductive age. Fertil Steril 2006;85:925-31
  • Nyboeandersen A, Humaidan P, Fried G, Recombinant LH supplementation to recombinant FSH during the final days of controlled ovarian stimulation for in vitro fertilization. A multicentre, prospective, randomized, controlled trial. Hum Reprod 2008;23:427-34
  • Griesinger G, Schultze-Mosgau A, Dafopoulos K, Recombinant luteinizing hormone supplementation to recombinant follicle-stimulating hormone induced ovarian hyperstimulation in the GnRH-antagonist multiple-dose protocol. Hum Reprod 2005;20:1200-6
  • Cédrin-Durnerin I, Grange-Dujardin D, Laffy A, Recombinant human LH supplementation during GnRH antagonist administration in IVF/ICSI cycles: a prospective randomized study. Hum Reprod 2004;19:1979-84
  • Levi-Setti PE, Cavagna M, Bulletti C. Recombinant gonadotrophins associated with GnRH antagonist (cetrorelix) in ovarian stimulation for ICSI: comparison of r-FSH alone and in combination with r-LH. Eur J Obstet Gynecol Reprod Biol 2006;126:212-16
  • Bosch E, Labarta E, Simón C, The impact of luteinizing hormone supplementaion in gonadotropin releasing hormone antagonist cycles. An age adjusted randomized trail. (personal communication) ASRM 2008. O-111
  • Lisi F, Rinaldi L, Fishel S, Use of recombinant follicule-stimulating hormone (Gonal F) and a recombinant luteinizing hormone (Luveris) in multiple follicular stimulation in patients with a suboptimal response to in vitro fertilization. Fertil Steril 2003;79:1037-8
  • Ferraretti AP, Gianaroli L, Magli MC, Exogenous luteinizing hormone in controlled ovarian hyperstimulation for assisted reproduction techniques. Fertil Steril 2004;82:1521-6
  • De Placido G, Alviggi C, Perino A, Recombinant human LH supplementation versus recombinant human FSH (rFSH) step-up protocol during controlled ovarian stimulation in normogonadotrophic women with initial inadequate ovarian response to rFSH. A multicentre, prospective, randomized controlled trial. Hum Reprod 2005;20:390-6
  • Ruvolo G, Bosco L, Pane A, Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro fertilization procedures. Fertil Steril 2007;87:542-6
  • Alviggi C, Clarizia R, Pettersson K, Suboptimal response to GnRHa long protocol is associated with a common LH polymorphism. Reprod Biomed Online 2009;18:9-14
  • Reame NE, Sauder ED, Case GD, Pulsatile gonadotropin secretion in women with hypothalamic amenorrhea: evidence that reduced frequency of gonadotropin releasing hormone secretion is the mechanism of persistant anovulation. J Clin Endocrinol Metab 1985;61:851-858
  • Kolibianakis EM, Kalogeropoulou L, Griesinger G, Among patients treated with FSH and GnRH analogues for in vitro fertilization, is the addition of recombinant LH associated with the probability of live birth? A systematic review and meta-analysis. Hum Reprod Update 2007;13:445-52
  • Klein NA, Battaglia DE, Fujimoto VY, Reproductive aging: accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women. J Clin Endocrinol Metab 1996;81:1038-45
  • Davison SL, Bell R, Donath S, Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 2005;90:3847-53
  • Bosch E, Pau E, Albert C, Impact of LH administration on oocyte quality and embryo morphology. Fertil Steril 2006;86:(Suppl 2):S425

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.