321
Views
57
CrossRef citations to date
0
Altmetric
Reviews

Novel targeted immunotherapy approaches for staphylococcal infection

, PhD
Pages 1049-1059 | Published online: 09 Jun 2010

Bibliography

  • Lowy FD. Staphylococcus aureus infections. N Engl J Med 1998;339:520-32
  • Lowy FD. Antimicrobial resistance: the example of Staphylococcus aureus. J Clin Invest 2003;111:1265-73
  • Kirby WM. Extraction of a highly potent penicillin inactivator from penicillin resistant Staphylococci. Science 1944;99:452-3
  • Novick RP. Staphylococcal penicillinase and the new penicillins. Biochem J 1962;83:229-35
  • Stewart GT, Holt RJ. Evolution of natural resistance to the newer penicillins. Br Med J 1963;1:308-11
  • DeLeo FR, Chambers HF. Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. J Clin Invest 2009;119:2464-74
  • Wertheim HF, Verbrugh HA. Global prevalence of meticillin-resistant Staphylococcus aureus. Lancet 2006;368:1866; author reply-1867
  • Grundmann H, Aires-de-Sousa M, Boyce J, Tiemersma E. Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat. Lancet 2006;368:874-85
  • Chambers HF, DeLeo FR. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol 2009;7:629-41
  • Moran GJ, Krishnadasan A, Gorwitz RJ, Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med 2006;355:666-74
  • Witte W, Strommenger B, Cuny C, Methicillin-resistant Staphylococcus aureus containing the panton-valentine leucocidin gene in Germany in 2005 and 2006. J Antimicrob Chemother 2007;60:1258-63
  • Ruppitsch W, Stoger A, Schmid D, Occurrence of the USA300 community-acquired Staphylococcus aureus clone in Austria. Euro Surveill 2007;12(43):E0710251
  • Klevens RM, Morrison MA, Nadle J, Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 2007;298:1763-71
  • Otto M. Staphylococcal biofilms. Curr Top Microbiol Immunol 2008;322:207-28
  • Diep BA, Chambers HF, Graber CJ, Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann Intern Med 2008;148:249-57
  • Voss A, Milatovic D, Wallrauch-Schwarz C, Methicillin-resistant Staphylococcus aureus in Europe. Eur J Clin Microbiol Infect Dis 1994;13:50-5
  • Molstad S, Cars O, Struwe J. Strama – a Swedish working model for containment of antibiotic resistance. Euro Surveill 2008;13(46):19041
  • Sabuncu E, David J, Bernede-Bauduin C, Significant reduction of antibiotic use in the community after a nationwide campaign in France, 2002-2007. PLoS Med 2009;6:e1000084
  • Wertheim HF, Melles DC, Vos MC, The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis 2005;5:751-62
  • Williams RE. Healthy carriage of Staphylococcus aureus: its prevalence and importance. Bacteriol Rev 1963;27:56-71
  • Takahashi N, Kato H, Imanishi K, Immunopathophysiological aspects of an emerging neonatal infectious disease induced by a bacterial superantigen. J Clin Invest 2000;106:1409-15
  • Nomura Y, Yoshinaga M, Masuda K, Maternal antibody against toxic shock syndrome toxin-1 may protect infants younger than 6 months of age from developing Kawasaki syndrome. J Infect Dis 2002;185:1677-80
  • Jensen K. A normally occurring Staphylococcus antibody in human serum. Acta Pathol Microbiol Scand 1958;44:421-8
  • Wertheim HF, van Leeuwen WB, Snijders S, Associations between Staphylococcus aureus genotype, infection, and in-hospital mortality: a nested case-control study. J Infect Dis 2005;192:1196-200
  • Loffler B, Hussain M, Grundmeier M, Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for human neutrophils. PLoS Pathog 2010;6(1):e1000715
  • Etz H, Minh DB, Henics T, Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus. Proc Natl Acad Sci USA 2002;99:6573-8
  • Kuklin NA, Clark DJ, Secore S, A novel Staphylococcus aureus vaccine: iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S. aureus sepsis model. Infect Immun 2006;74:2215-23
  • Torres VJ, Pishchany G, Humayun M, Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization. J Bacteriol 2006;188:8421-9
  • Johri AK, Paoletti LC, Glaser P, Group B Streptococcus: global incidence and vaccine development. Nat Rev Microbiol 2006;4:932-42
  • O'Riordan K, Lee JC. Staphylococcus aureus capsular polysaccharides. Clin Microbiol Rev 2004;17:218-34
  • Fattom AI, Sarwar J, Ortiz A, Naso R. A Staphylococcus aureus capsular polysaccharide (CP) vaccine and CP-specific antibodies protect mice against bacterial challenge. Infect Immun 1996;64:1659-65
  • Lee JC, Park JS, Shepherd SE, Protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide in a modified model of endocarditis in rats. Infect Immun 1997;65:4146-51
  • Shinefield H, Black S, Fattom A, Use of a Staphylococcus aureus conjugate vaccine in patients receiving hemodialysis. N Engl J Med 2002;346:491-6
  • Schaffer AC, Lee JC. Staphylococcal vaccines and immunotherapies. Infect Dis Clin North Am 2009;23:153-71
  • Bhakdi S, Tranum-Jensen J. Alpha-toxin of Staphylococcus aureus. Microbiol Rev 1991;55:733-51
  • Liang X, Ji Y. Alpha-toxin interferes with integrin-mediated adhesion and internalization of Staphylococcus aureus by epithelial cells. Cell Microbiol 2006;8:1656-68
  • Bubeck Wardenburg J, Bae T, Otto M, Poring over pores: alpha-hemolysin and panton-valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med 2007;13(12):1405-6
  • Callegan MC, Engel LS, Hill JM, O'Callaghan RJ. Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis. Infect Immun 1994;62:2478-82
  • Bramley AJ, Patel AH, O'Reilly M, Roles of alpha-toxin and beta-toxin in virulence of Staphylococcus aureus for the mouse mammary gland. Infect Immun 1989;57:2489-94
  • Patel AH, Nowlan P, Weavers ED, Foster T. Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement. Infect Immun 1987;55:3103-10
  • Poole-Warren LA, Hallett MD, Hone PW, Vaccination for prevention of CAPD associated staphylococcal infection: results of a prospective multicentre clinical trial. Clin Nephrol 1991;35:198-206
  • Adlam C, Ward PD, McCartney AC, Effect immunization with highly purified alpha- and beta-toxins on staphylococcal mastitis in rabbits. Infect Immun 1977;17:250-6
  • Menzies BE, Kernodle DS. Site-directed mutagenesis of the alpha-toxin gene of Staphylococcus aureus: role of histidines in toxin activity in vitro and in a murine model. Infect Immun 1994;62:1843-7
  • Bubeck Wardenburg J, Schneewind O. Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med 2008;205:287-94
  • Szmigielski S, Prevost G, Monteil H, Leukocidal toxins of staphylococci. Zentralbl Bakteriol 1999;289:185-201
  • Diep BA, Otto M. The role of virulence determinants in community-associated MRSA pathogenesis. Trends Microbiol 2008;16:361-9
  • Vandenesch F, Naimi T, Enright MC, Community-acquired methicillin-resistant Staphylococcus aureus carrying panton-valentine leukocidin genes: worldwide emergence. Emerg Infect Dis 2003;9:978-84
  • Gillet Y, Issartel B, Vanhems P, Association between Staphylococcus aureus strains carrying gene for panton-valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet 2002;359:753-9
  • Chheng K, Tarquinio S, Wuthiekanun V, Emergence of community-associated methicillin-resistant Staphylococcus aureus associated with pediatric infection in Cambodia. PLoS One 2009;4:e6630
  • Lee SS, Kim YJ, Chung DR, Invasive infection caused by community-associated methicillin-resistant Staphylococcus aureus strain not carrying panton-valentine leukocidin in Korea. J Clin Microbiol 2009;48:311-3
  • Nimmo GR, Coombs GW. Community-associated methicillin-resistant Staphylococcus aureus (MRSA) in Australia. Int J Antimicrob Agents 2008;31:401-10
  • Rollason J, Bastin L, Hilton AC, Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region. J Hosp Infect 2008;70:314-20
  • Brown EL, Dumitrescu O, Thomas D, The panton-valentine leukocidin vaccine protects mice against lung and skin infections caused by Staphylococcus aureus USA300. Clin Microbiol Infect 2008;15:156-64
  • Bubeck Wardenburg J, Palazzolo-Ballance AM, Otto M, Panton-valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease. J Infect Dis 2008;198:1166-70
  • Voyich JM, Otto M, Mathema B, Is panton-valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis 2006;194:1761-70
  • Hongo I, Baba T, Oishi K, Phenol-soluble modulin alpha3 enhances the human neutrophil lysis mediated by panton-valentine leukocidin. J Infect Dis 2009;200:715-23
  • Stranger-Jones YK, Bae T, Schneewind O. Vaccine assembly from surface proteins of Staphylococcus aureus. Proc Natl Acad Sci USA 2006;103:16942-7
  • Mazmanian SK, Liu G, Ton-That H, Schneewind O. Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Science 1999;285:760-3
  • Rohde H, Burandt EC, Siemssen N, Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections. Biomaterials 2007;28:1711-20
  • Vuong C, Voyich JM, Fischer ER, Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system. Cell Microbiol 2004;6:269-75
  • McKenney D, Pouliot K, Wang Y, Vaccine potential of poly-1-6 beta-D-N-succinylglucosamine, an immunoprotective surface polysaccharide of Staphylococcus aureus and Staphylococcus epidermidis. J Biotechnol 2000;83:37-44
  • Maira-Litran T, Kropec A, Goldmann DA, Pier GB. Comparative opsonic and protective activities of Staphylococcus aureus conjugate vaccines containing native or deacetylated Staphylococcal Poly-N-acetyl-beta-(1-6)-glucosamine. Infect Immun 2005;73:6752-62
  • Vuong C, Kocianova S, Voyich JM, A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence. J Biol Chem 2004;279:54881-6
  • Spellberg B, Ibrahim AS, Yeaman MR, The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus. Infect Immun 2008;76:4574-80
  • Posey JE, Gherardini FC. Lack of a role for iron in the Lyme disease pathogen. Science 2000;288:1651-3
  • Skaar EP, Schneewind O. Iron-regulated surface determinants (Isd) of Staphylococcus aureus: stealing iron from heme. Microbes Infect 2004;6:390-7
  • Stauff DL, Skaar EP. The heme sensor system of Staphylococcus aureus. Contrib Microbiol 2009;16:120-35
  • Benjamin DK, Schelonka R, White R, A blinded, randomized, multicenter study of an intravenous Staphylococcus aureus immune globulin. J Perinatol 2006;26:290-5
  • Rupp ME, Holley HP Jr, Lutz J, Phase II, randomized, multicenter, double-blind, placebo-controlled trial of a polyclonal anti-Staphylococcus aureus capsular polysaccharide immune globulin in treatment of Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 2007;51:4249-54
  • McDevitt D, Francois P, Vaudaux P, Foster TJ. Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus. Mol Microbiol 1994;11:237-48
  • Foster TJ, Hook M. Surface protein adhesins of Staphylococcus aureus. Trends Microbiol 1998;6:484-8
  • Vernachio JH, Bayer AS, Ames B, Human immunoglobulin G recognizing fibrinogen-binding surface proteins is protective against both Staphylococcus aureus and Staphylococcus epidermidis infections in vivo. Antimicrob Agents Chemother 2006;50:511-8
  • Josefsson E, Hartford O, O'Brien L, Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant. J Infect Dis 2001;184:1572-80
  • Bloom B, Schelonka R, Kueser T, Multicenter study to assess safety and efficacy of INH-A21, a donor-selected human staphylococcal immunoglobulin, for prevention of nosocomial infections in very low birth weight infants. Pediatr Infect Dis J 2005;24:858-66
  • DeJonge M, Burchfield D, Bloom B, Clinical trial of safety and efficacy of INH-A21 for the prevention of nosocomial staphylococcal bloodstream infection in premature infants. J Pediatr 2007;151:260-5, 5 e1
  • Patti JM. A humanized monoclonal antibody targeting Staphylococcus aureus. Vaccine 2004;22(Suppl 1):S39-43
  • Weems JJ Jr, Steinberg JP, Filler S, Phase II, randomized, double-blind, multicenter study comparing the safety and pharmacokinetics of tefibazumab to placebo for treatment of Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 2006;50:2751-5
  • Burnie JP, Matthews RC, Carter T, Identification of an immunodominant ABC transporter in methicillin-resistant Staphylococcus aureus infections. Infect Immun 2000;68:3200-9
  • Fournier B, Philpott DJ. Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev 2005;18:521-40
  • Standiford TJ, Arenberg DA, Danforth JM, Lipoteichoic acid induces secretion of interleukin-8 from human blood monocytes: a cellular and molecular analysis. Infect Immun 1994;62:119-25
  • Hashimoto M, Tawaratsumida K, Kariya H, Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus. J Immunol 2006;177:3162-9
  • Gross M, Cramton SE, Gotz F, Peschel A. Key role of teichoic acid net charge in Staphylococcus aureus colonization of artificial surfaces. Infect Immun 2001;69:3423-6
  • Weisman LE, Thackray HM, Garcia-Prats JA, Phase 1/2 double-blind, placebo-controlled, dose escalation, safety, and pharmacokinetic study of pagibaximab (BSYX-A110), an antistaphylococcal monoclonal antibody for the prevention of staphylococcal bloodstream infections, in very-low-birth-weight neonates. Antimicrob Agents Chemother 2009;53:2879-86
  • Ragle BE, Bubeck Wardenburg J. Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia. Infect Immun 2009;77:2712-8
  • McCormick JK, Yarwood JM, Schlievert PM. Toxic shock syndrome and bacterial superantigens: an update. Annu Rev Microbiol 2001;55:77-104
  • LeClaire RD, Hunt RE, Bavari S. Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination. Infect Immun 2002;70:2278-81
  • Lowell GH, Colleton C, Frost D, Immunogenicity and efficacy against lethal aerosol staphylococcal enterotoxin B challenge in monkeys by intramuscular and respiratory delivery of proteosome-toxoid vaccines. Infect Immun 1996;64:4686-93
  • Alksne LE, Projan SJ. Bacterial virulence as a target for antimicrobial chemotherapy. Curr Opin Biotechnol 2000;11:625-36
  • Novick RP. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol 2003;48:1429-49
  • Otto M. Quorum-sensing control in Staphylococci – a target for antimicrobial drug therapy? FEMS Microbiol Lett 2004;241:135-41
  • Vuong C, Kocianova S, Yao Y, Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo. J Infect Dis 2004;190:1498-505
  • Vuong C, Saenz HL, Gotz F, Otto M. Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus. J Infect Dis 2000;182:1688-93
  • Ji G, Beavis R, Novick RP. Bacterial interference caused by autoinducing peptide variants. Science 1997;276:2027-30
  • Lyon GJ, Mayville P, Muir TW, Novick RP. Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proc Natl Acad Sci USA 2000;97:13330-5
  • Park J, Jagasia R, Kaufmann GF, Infection control by antibody disruption of bacterial quorum sensing signaling. Chem Biol 2007;14:1119-27
  • Otto M. Antibodies to block staph virulence. Chem Biol 2007;14:1093-4
  • Gyimesi E, Bankovich AJ, Schuman TA, Staphylococcus aureus bound to complement receptor 1 on human erythrocytes by bispecific monoclonal antibodies is phagocytosed by acceptor macrophages. Immunol Lett 2004;95:185-92
  • Mohamed N, Jones SM, Casey LS, Heteropolymers: a novel technology against blood-borne infections. Curr Opin Mol Ther 2005;7:144-50
  • Lindorfer MA, Hahn CS, Foley PL, Taylor RP. Heteropolymer-mediated clearance of immune complexes via erythrocyte CR1: mechanisms and applications. Immunol Rev 2001;183:10-24
  • Kluytmans J, van Belkum A, Verbrugh H. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 1997;10:505-20
  • von Eiff C, Becker K, Machka K, Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group. N Engl J Med 2001;344:11-6
  • Coates T, Bax R, Coates A. Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects. J Antimicrob Chemother 2009;64:9-15
  • Clarke SR, Brummell KJ, Horsburgh MJ, Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. J Infect Dis 2006;193:1098-108
  • Schaffer AC, Solinga RM, Cocchiaro J, Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model. Infect Immun 2006;74:2145-53
  • Goodyear CS, Silverman GJ. Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes. Proc Natl Acad Sci USA 2004;101:11392-7
  • Forsgren A, Nordstrom K. Protein A from Staphylococcus aureus: the biological significance of its reaction with IgG. Ann NY Acad Sci 1974;236:252-66
  • DeLeo FR, Otto M. An antidote for Staphylococcus aureus pneumonia? J Exp Med 2008;205:271-4
  • Foster TJ. Immune evasion by staphylococci. Nat Rev Microbiol 2005;3:948-58
  • Wang R, Braughton KR, Kretschmer D, Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 2007;13:1510-4

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.