Bibliography
- Graf T, Enver T. Forcing cells to change lineages. Nature 2009;10:587-94
- Vierbuchen T, Ostermeier A, Pang ZP, Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010;463(7284):1035-41
- Thomson JA, Itskovitz-Eldor J, Shapiro SS, Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7
- Wilmut I, Schnieke AE, McWhir J, Viable offspring derived from fetal and adult mammalian cells. Nature 1997;385:810-3
- Taranger CK, Noer A, Sorensen AL, Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. Mol Biol Cell 2005;16:5719-35
- Tada M, Takahama Y, Abe K, Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol 2001;11:1553-8
- Do JT, Scholer HR. Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells 2004;22:941-9
- Cantz T, Bleidissel M, Stehling M, In vitro differentiation of reprogrammed murine somatic cells into hepatic precursor cells. Biol Chem 2008;389:889-96
- Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76
- Takahashi K, Tanabe K, Ohnuki M, Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72
- Yu J, Vodyanik MA, Smuga-Otto K, Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20
- Kim JB, Sebastiano V, Wu G, Oct4-induced pluripotency in adult neural stem cells. Cell 2009;136:411-9
- Zhou H, Wu S, Joo JY, Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 2009;4:381-4
- Jaenisch R, Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 2008;132:567-82
- Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 2007;1:39-49
- Chambers I, Colby D, Robertson M, Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:643-55
- Boyer LA, Lee TI, Cole MF, Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005;122:947-56
- Kim J, Chu J, Shen X, An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008;132:1049-61
- Lin CH, Lin C, Tanaka H, Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One 2009;4:e7839
- Knoepfler PS, Zhang XY, Cheng PF, Myc influences global chromatin structure. EMBO J 2006;25:2723-34
- Adhikary S, Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 2005;6:635-45
- Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007;448:313-7
- Rowland BD, Bernards R, Peeper DS. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol 2005;7:1074-82
- Stadtfeld M, Maherali N, Breault DT, Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2008;2:230-40
- Wernig M, Lengner CJ, Hanna J, A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol 2008;26:916-24
- Yamanaka S. Elite and stochastic models for induced pluripotent stem cell generation. Nature 2009;460:49-52
- Hanna J, Saha K, Pando B, Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 2009;462:595-601
- Li W, Ding S. Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends Pharmacol Sci 2010;31:36-45
- Utikal J, Polo JM, Stadtfeld M, Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 2009;460:1145-8
- Hong H, Takahashi K, Ichisaka T, Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009;460:1132-5
- Kawamura T, Suzuki J, Wang YV, Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009;460:1140-4
- Li H, Collado M, Villasante A, The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 2009;460:1136-9
- Marion RM, Strati K, Li H, A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 2009;460:1149-53
- Ying QL, Wray J, Nichols J, The ground state of embryonic stem cell self-renewal. Nature 2008;453:519-23
- Silva J, Barrandon O, Nichols J, Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol 2008;6:e253
- Shi Y, Desponts C, Do JT, Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008;3:568-74
- Huangfu D, Maehr R, Guo W, Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 2008;26:795-7
- Huangfu D, Osafune K, Maehr R, Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 2008;26:1269-75
- Bhutani N, Brady JJ, Damian M, Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 2010;463:1042-7
- Lyssiotis CA, Foreman RK, Staerk J, Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci USA 2009;106:8912-7
- Ichida JK, Blanchard J, Lam K, A small-molecule inhibitor of Tgf-beta signaling replaces Sox2 in reprogramming by inducing nanog. Cell Stem Cell 2009;5:491-503
- Esteban MA, Wang T, Qin B, Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 2010;6:71-9
- Xu Y, Shi Y, Ding S. A chemical approach to stem-cell biology and regenerative medicine. Nature 2008;453:338-44
- Woltjen K, Michael IP, Mohseni P, piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 2009;458:766-70
- O'Malley J, Woltjen K, Kaji K. New strategies to generate induced pluripotent stem cells. Curr Opin Biotechnol 2009;20:516-21
- Kaji K, Norrby K, Paca A, Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 2009;458:771-5
- Carey BW, Markoulaki S, Hanna J, Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci USA 2009;106:157-62
- Sommer CA, Stadtfeld M, Murphy GJ, iPS cell generation using a single lentiviral stem cell cassette. Stem Cells 2009;27:543-9
- Hotta A, Ellis J. Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states. J Cell Biochem 2008;105:940-8
- Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 1992;89:5547-51
- Gossen M, Freundlieb S, Bender G, Transcriptional activation by tetracyclines in mammalian cells. Science 1995;268:1766-9
- Brambrink T, Foreman R, Welstead GG, Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2008;2:151-9
- Voelkel C, Galla M, Maetzig T, Protein transduction from retroviral Gag precursors. Proc Natl Acad Sci USA 2010;107:7805-10
- Soldner F, Hockemeyer D, Beard C, Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 2009;136:964-77
- Chang CW, Lai YS, Pawlik KM, Polycistronic lentiviral vector for “hit and run” reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells 2009;27:1042-9
- Yusa K, Rad R, Takeda J, Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods 2009;6:363-9
- Stadtfeld M, Nagaya M, Utikal J, Induced pluripotent stem cells generated without viral integration. Science 2008;322:945-9
- Zhou W, Freed CR. Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells. Stem Cells 2009;27:2667-74
- Okita K, Nakagawa M, Hyenjong H, Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008;322:949-53
- Gonzalez F, Barragan Monasterio M, Tiscornia G, Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc Natl Acad Sci USA 2009;106:8918-22
- Yu J, Hu K, Smuga-Otto K, Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009;324:797-801
- Fusaki N, Ban H, Nishiyama A, Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci 2009;85(8):348-62
- Yakubov E, Rechavi G, Rozenblatt S, Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors. Biochem Biophys Res Commun 2010;394:189-93
- Kim D, Kim CH, Moon JI, Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009;4:472-6
- Paques F, Duchateau P. Meganucleases and DNA double-strand break-induced recombination: perspectives for gene therapy. Curr Gene Ther 2007;7:49-66
- Cathomen T, Joung JK. Zinc-finger nucleases: the next generation emerges. Mol Ther 2008;16:1200-7
- Carroll D. Progress and prospects: zinc-finger nucleases as gene therapy agents. Gene Ther 2008;15:1463-8
- Zou J, Maeder ML, Mali P, Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell 2009;5:97-110
- Hockemeyer D, Soldner F, Beard C, Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol 2009;27:851-7
- Cathomen T, Schambach A. Zinc positive: tailored genome engineering meets reprogramming. Gene Ther 2010;17:1-3
- Mandell JG, Barbas CF III. Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases. Nucleic Acids Res 2006;34(Web Server issue):W516-23
- Sander JD, Zaback P, Joung JK, Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool. Nucleic Acids Res 2007;35(Web Server issue):W599-605
- Maeder ML, Thibodeau-Beganny S, Osiak A, Rapid “open-source” engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell 2008;31:294-301
- Maeder ML, Thibodeau-Beganny S, Sander JD, Oligomerized pool engineering (OPEN): an ‘open-source’ protocol for making customized zinc-finger arrays. Nat Protoc 2009;4:1471-501
- Shrivastav M, De Haro LP, Nickoloff JA. Regulation of DNA double-strand break repair pathway choice. Cell Res 2008;18:134-47
- Lombardo A, Genovese P, Beausejour CM, Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol 2007;25:1298-306
- Capecchi MR. Altering the genome by homologous recombination. Science 1989;244:1288-92
- Kotin RM, Linden RM, Berns KI. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. EMBO J 1992;11:5071-8
- Bohne J, Cathomen T. Genotoxicity in gene therapy: an account of vector integration and designer nucleases. Curr Opin Mol Ther 2008;10:214-23
- Nishikawa S, Goldstein RA, Nierras CR. The promise of human induced pluripotent stem cells for research and therapy. Nat Rev Mol Cell Biol 2008;9:725-9
- Muller R, Lengerke C. Patient-specific pluripotent stem cells: promises and challenges. Nat Rev Endocrinol 2009;5:195-203
- Rideout WM, Hochedlinger K, Kyba M, Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 2002;109:17-27
- Kim JB, Zaehres H, Wu G, Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 2008;454:646-50
- Aasen T, Raya A, Barrero MJ, Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol 2008;26:1276-84
- Haase A, Olmer R, Schwanke K, Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell 2009;5:434-41
- Park IH, Arora N, Huo H, Disease-specific induced pluripotent stem cells. Cell 2008;134:877-86
- Hanna J, Wernig M, Markoulaki S, Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 2007;318:1920-3
- Xu D, Alipio Z, Fink LM, Phenotypic correction of murine hemophilia A using an iPS cell-based therapy. Proc Natl Acad Sci USA 2009;106:808-13
- Raya A, Rodriguez-Piza I, Guenechea G, Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 2009;460:53-9
- Kazuki Y, Hiratsuka M, Takiguchi M, Complete genetic correction of iPS cells from Duchenne muscular dystrophy. Mol Ther 2010;18(2):386-93
- Lee G, Papapetrou EP, Kim H, Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 2009;461:402-6
- Maehr R, Chen S, Snitow M, Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci USA 2009;106:15768-73
- Saha K, Jaenisch R. Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 2009;5:584-95
- Kiskinis E, Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J Clin Invest 2010;120:51-9
- Taylor CJ, Bolton EM, Pocock S, Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching. Lancet 2005;366:2019-25
- Nakatsuji N, Nakajima F, Tokunaga K. HLA-haplotype banking and iPS cells. Nat Biotechnol 2008;26:739-40
- hESC - Derived Therapies (GRNOPC1). Menolo Park, California: Geron Corporation 2010. Available from: http://www.geron.com/patients/clinicaltrials/hESC.aspx [Last accessed 26 May 2010]
- von Tigerstrom BJ. The challenges of regulating stem cell-based products. Trends Biotechnol 2008;26:653-8
- Guideline on human cell-based medicinal products. London, UK: European Medicines Agency, Committee For Medicinal Product For Human Use (CHMP), 2008. Available from: http://www.ema.europa.eu/pdfs/human/cpwp/41086906enfin.pdf [Last accessed 26 May 2010]
- Kaufman DS. Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells. Blood 2009;114:3513-23
- Colman A, Dreesen O. Pluripotent stem cells and disease modeling. Cell Stem Cell 2009;5:244-7
- Daley GQ, Scadden DT. Prospects for stem cell-based therapy. Cell 2008;132:544-8
- Hotta A, Cheung AY, Farra N, Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat Methods 2009;6:370-6
- Muller FJ, Laurent LC, Kostka D, Regulatory networks define phenotypic classes of human stem cell lines. Nature 2008;455:401-5
- Spits C, Mateizel I, Geens M, Recurrent chromosomal abnormalities in human embryonic stem cells. Nat Biotechnol 2008;26:1361-3
- Pick M, Stelzer Y, Bar-Nur O, Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells. Stem Cells 2009;27:2686-90
- Stadtfeld M, Apostolou E, Akutsu H, Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature 2010;465:175-81
- Liu H, Zhu F, Yong J, Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. Cell Stem Cell 2008;3:587-90
- Esteban MA, Xu J, Yang J, Generation of induced pluripotent stem cell lines from Tibetan miniature pig. J Biol Chem 2009;284:17634-40
- Li W, Wei W, Zhu S, Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009;4:16-9
- Liao J, Cui C, Chen S, Generation of induced pluripotent stem cell lines from adult rat cells. Cell Stem Cell 2009;4:11-5
- Esteban MA, Peng M, Deli Z, Porcine induced pluripotent stem cells may bridge the gap between mouse and human iPS. IUBMB Life 2010;62:277-82
- Tsai SY, Clavel C, Kim S, Oct4 and Klf4 reprogram dermal papilla cells into induced pluripotent stem cells. Stem Cells 2010;28:221-8
- Qin D, Gan Y, Shao K, Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors. J Biol Chem 2008;283:33730-5
- Ye Z, Zhan H, Mali P, Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 2009;114:5473-80
- Choi KD, Yu J, Smuga-Otto K, Hematopoietic and endothelial differentiation of human induced pluripotent stem cells. Stem Cells 2009;27:559-67
- Dimos JT, Rodolfa KT, Niakan KK, Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 2008;321:1218-21
- Ebert AD, Yu J, Rose FF Jr, Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009;457:277-80
- Osakada F, Ikeda H, Sasai Y, Stepwise differentiation of pluripotent stem cells into retinal cells. Nat Protoc 2009;4:811-24
- Sullivan GJ, Hay DC, Park IH, Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 2010;51:329-35
- Hacein-Bey-Abina S, Le Deist F, Carlier F, Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med 2002;346:1185-93
- Gaspar HB, Parsley KL, Howe S, Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet 2004;364:2181-7
- Aiuti A, Roncarolo MG. Ten years of gene therapy for primary immune deficiencies. Hematology Am Soc Hematol Educ Program 2009:682-9
- Hacein-Bey-Abina S, Garrigue A, Wang GP, Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest 2008;118:3132-42
- Wilson CA, Cichutek K. The US and EU regulatory perspectives on the clinical use of hematopoietic stem/progenitor cells genetically modified ex vivo by retroviral vectors. Methods Mol Biol 2009;506:477-88
- Wicke DC, Meyer J, Buesche G, Gene therapy of Mpl deficiency: challenging balance between leukemia and pancytopenia. Mol Ther 2010:18:343-52
- Bonini C, Ferrari G, Verzeletti S, HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 1997;276:1719-24
- Frank O, Rudolph C, Heberlein C, Tumor cells escape suicide gene therapy by genetic and epigenetic instability. Blood 2004;104:3543-9
- Shi Y, Do JT, Desponts C, A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2008;2:525-8