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Tendon healing and platelet-rich plasma therapies

, PhD, &
Pages 1415-1426 | Published online: 18 Aug 2010

Bibliography

  • Kannus P, Natri A. Etiology and pathophysiology of tendon ruptures in sports. Scand J Med Sci Sports 1997;7:107-12
  • Paalova M, Kannus P, Jarvinen M. Epidemiology of tendon problems in sports. In: Maffulli N, Renstrom P, Leadbetter W, editors, Tendon injuries: basic science and clinical medicine. Springer, London; 2005
  • Sanchez M, Anitua E, Orive G, Platelet-rich therapies in the treatment of orthopaedic sports injuries. Sports Med 2009;39:345-54
  • Bi Y, Eirchiou D, Kilts TM, Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med 2007;13:1219-27
  • Tempfer H, Wagner A, Gehwolf R, Perivascular cells of the supraspinatus tendon express both tendon and stem cell related markers. Histochem Cell Biol 2009;131:733-41
  • Ackermann PW, Salo PT, Hart DA. Neuronal pathways in tendon healing. Front Biosci 2009;14:5165-87
  • Tracey KJ. Reflex control of immunity. Nat Rev Immunol 2009;9:418-28
  • Stayaert AE, Burssens PJ, Vercruysse CW, The effects of substance P on the biomechanic properties of ruptured rat Achilles' tendon. Arch Phys Med Rehabil 2006;87:254-8
  • Burssens P, Steyaert A, Forsyth R, Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblasts proliferation, angiogenesis, and collagen organization during Achilles tendon healing. Foot Ankle Int 2005;26:832-9
  • Carlsson O, Schizas N, Li J, Ackermann PW. Substance P injections enhance tissue proliferation and regulate sensory nerve ingrowth in rat tendon repair. Scand J Med Sci Sports 2010: published online 10 March 2010, doi:10.1111/j.1600-0838.2009.01080.x
  • Mammoto T, Seerattan RA, Paulson KD, Nerve growth factor improves ligament healing. J Orthop Res 2008;26:957-64
  • Ivie TJ, Bray RC, Salo PT. Denervation impairs healing of the rabbit medial collateral ligament. J Orthop Res 2002;20:990-5
  • Yeung CK, Guo X, Ng GYF. Denervation impairs Achilles tendon healing in a rat model. 2005 ISB XXth Congress – ASB 29th Annual Meeting; 805. Available from: http://www.asbweb.org/conferences/2005/pdf/0805.pdf
  • Nelson L, Fairclough J, Archer CW. Use of stem cells in the biological repair of articular cartilage. Expert Opin Biol Ther 2010;10:43-55
  • Ackermann PW, Ahmed M, Kreicbergs A. Early nerve regeneration after Achilles tendon rupture – a prerequitie for healing? A study in the rat. J Ortho Res 2002;20:849-56
  • Poon IK, Hulett MD, Parish CR. Molecular mechanisms of late apoptotic/necrotic cell clearance. Cell Death Differ 2010;17:381-97
  • Borregaard N, Sorensen OE, Theilgaard-Monch K. Neutrophil granules: a library of innate immunity proteins. Trends Immunol 2007;28:340-5
  • Soehnlein O, Zernecke A, Weber C. Neutrophils launch monocyte extravasation by release granule proteins. Thromb Haemost 2009;102:198-205
  • Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 2006;6:173-82
  • Krysko DV, D'Herde K, Vandenabeele P. Clearance of apoptotic and necrotic cells and its immunological consequences. Apoptosis 2006;11:1709-26
  • Dovi JV, DiPietro LA. Accelerated wound closure in neutrophil depleted mice. J Leukoc Biol 2003;7:448-55
  • Godbout C, Bilodeau R, Van Rooijen N, Transient neutropenia increases macrophage accumulation and cell proliferation but does not improve repair following intratendinous rupture of Achilles tendon. J Orthop Res 2010;28:1084-91
  • Mirza R, DiPietro LA, Koh TJ. Selective and specific macrophage ablation is detrimental to wound healing in mice. Am J Pathol 2009;175:2454-62
  • Khanna A, Biswass S, Shang Y, Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice. PLoS One 2010;5:e9539
  • Brechot N, Gomez E, Bignon M, Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1 deficient mice. PLoS One 2008;3:e3950
  • Hays PL, Kawamura S, Deng XH, The role of macrophages in early healing of a tendon graft in a bone tunnel. J Bone Joint Surg Am 2008;90:565-79
  • Sercarz EE, Maveracki E. Recognition and function in a degenerate immune system. Mol Immunol 2004;16:737-45
  • Tsubone T, Moran SL, Amadio PC, Expression of growth factors in canine flexor tendon after laceration in vivo. Ann Plast Surg 2004;53:393-7
  • Chen CH, Cao Y, Wu YF, Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period. J Hand Surg 2008;33A:1834-42
  • Bring D, Reno C, Remstrom P, Prolonged immobilization compromises up-regulation of repair genes after tendon rupture in a rat model. Scand J Med Sci Sports 2010;20:411-17
  • Pryce BA, Watson SS, Murchison ND, Recruitment and maintenance of tendon progenitors by TGFbeta signalling are essential for tendon formation. Development 2009;136:1351-61
  • Chan K-M, Fu S-Ch, Wong Y-P, Expression of transforming growth factor beta isoforms and their roles in tendon healing. Wound Rep Reg 2008;16:399-407
  • Dahlgren LA, Mohammed HO, Nixon AJ. Expression of insulin-like growth factor binding proteins in healing tendon lesions. J Orthop Res 2006;24:183-92
  • Kjaer M, Landberg H, Heinemeir K, From mechanical loading to collagen synthesis, structural changes and function in human tendon. Scand J Med Sci Sports 2009;19:500-10
  • Riley G. Tendinopathy-from basic science to treatment. Nat Clin Pract Rheumatol 2008;4:82-8
  • Blair P, Flaumenhaft R. Platelet alpha-granules: basic biology and clinical correlates. Blood Rev 2009;23:177-89
  • Maynard DM, Heijnen HFG, Horme MK, Proteomic analysis of platelet alpha-granules using mass spectrometry. J Thromb Haemost 2007;5:1945-55
  • Semple JW, Freedman J. Platelets and innate immunity. Cell Mol Life Sci 2010;67:499-511
  • Min-Ho K, Fitz-Roy EC, Scott IS. Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding. Am J Physiol Cell Physiol 2009;296:848-56
  • Flad H-D, Brandt E. Platelet-derived chemokines: pathophysiology and therapeutic aspects. Cell Mol Life Sci 2010;67:2363-86
  • Anitua E, Sanchez M, Nurden AT, Platelet released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients. Rheumatology 2007;46:1769-72
  • John T, Lodka D, Kohl B, Effect of pro-inflammatory and immunoregulatory cytokines on human tenocytes. J Orthop Res 2010;28:1071-7
  • Menzies FM, Henriquez FL, Alexander J, Roberts CW. Sequential expression of macrophage anti-microbial/inflammatory and wound healing markers following innate, alternative and classical activation. Clin Exp Immunol 2010;160:369-79
  • Woodall J, Tucci M, Mishra A, Cellular effects of platelet-rich plasma interleukin 1 release from PRP treated macrophages. Biomed Sci Instrum 2008;44:489-94
  • von Hundelshausen P, Petersen F, Brandt E. Platelet derived chemokines in vascular biology. Thromb Haemost 2007;97:704-13
  • Senior RM, Griffin GL, Huang JS, Chemotactic activity of platelet alpha granule proteins for fibroblasts. J Cell Biol 1983;96:382-85
  • Nedeau AE, Bauer RJ, Gallagher K, A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells. Exp Cell Res 2008;314:2176-86
  • Kajikawa Y, Morihara T, Sakamoto H, Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 2008;215:837-45
  • Nurden AT, Nurden P, Sánchez M, Platelets and wound healing. Front Biosci 2008;13:3532-48
  • Isenberg JS, Frazier WA, Roberts DD. Thrombospondin-1: a physiological regulator of nitric oxide signalling. Cell Mol Life Sci 2008;65:728-42
  • Hsu C-W, Yuan K, Tseng C-C. The negative effect of platelet-rich plasma on the growth of human cells is associated with secreted thrombospondin-1. Oral Sur Oral Med Oral Pathol Oral Radiol Endod 2009;107:185-92
  • Villeneuve J, Block A, Le Bousse-Kerdiles MC, Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins. Exp Hematol 2009;37:849-56
  • Anitua E, Andia I, Sanchez M, Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res 2005;23:281-6
  • Anitua E, Sanchez M, Nurden AT, Reciprocal actions of platelet-secreted TGF-beta1 on the production of VEGF and HGF by human tendon cells. Plast Reconstr Surg 2007;119:950-9
  • Bates DO, Harper SJ. Regulation of vascular permeability by vascular endothelial growth factors. Vascular Pharmacol 2003;39:225-37
  • Anitua E, Sanchez M, Nurden AT, Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mat Res A 2006;77:285-93
  • Lyras D, Kazakos K, Verettas D, Immunohistochemical study of angiogenesis after local administration of platelet-rich plasma in a patellar tendon defect. Int Orthop 2010;34:143-8
  • Virchenko O, Genegard M, Aspenberg P. Independent and additive stimulation of tendon repair by thrombin and platelets. Acta Orthop 2006;77:960-6
  • Anitua E, Sanchez M, Zalduendo MM, Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif 2009;42:162-70
  • Cheng M, Wang H, Yoshida R, Murray MM. Platelets and plasma proteins are both required to stimulate collagen gene expression by anterior cruciate ligament cells in three dimensional culture. Tissue Eng Part A 2010;16:1479-89
  • Bosch G, van Schie HT, de Groot MW, Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: a placebo controlled experimental study. J Orthop Res 2010;28:211-17
  • Randelli PS, Arrigoni P, Cabitza P, Autologous platelet rich plasma for arthroscopic cuff repair. A pilot study. Disabil Rehabil 2008;30:1584-9
  • Filardo G, Kon E, Della Villa S, Use of platelet rich plasma for the treatment of refractory jumper's knee. Int Orthop 2010;34:909-15
  • Everts PA, Devilee RJ, Brown Mahoney C, Exogenous application of platelet-leukocyte gel during open subacromial decompression contributes to improved patient outcome. A prospective randomized double-blind study. Eur Surg Res 2008;40:203-10
  • Sánchez M, Anitua E, Azofra J, Comparison of surgically repaired Achilles tendon tears using PRGF. Am J Sports Med 2007;35:245-51
  • Kon E, Filardo G, Delcogliano M, Platelet-rich plasma: a pilot study for treatment of jumper's knee. Injury 2009;40:598-603
  • Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med 2006;34:1774-8
  • Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T. Positive effect of autologous platelet concentrate in lateral epicondylitis in a double blind randomized controlled trial. Am J Sports Med 2010;38:255-62
  • De Vos RJ, Weir A, van Schie HTM, Platelet-rich plasma injection for chronic Achilles tendinopathy. JAMA 2010;303:144-9
  • Smidt N, van der Windt DAWM, Assendelft WJJ, Corticosteroid injections, physiotherapy, or a wait-and-see policy for lateral epicondylitis: a randomised controlled trial. Lancet 2002;359:657-62
  • Fufa D, Shealy B, Jacobson M, Activation of platelet-rich plasma using soluble type-I collagen. J Oral Maxillofac Surg 2008;66:684-90
  • Ji Y, Lu Y, Yang F, Acute and gradual increases in BDNF concentration elicit distinct signalling and functions in neurons. Nat Neurosci 2010;13:302-9
  • Humphrey J, Chan O, Crisp T, The short-term effects of high volume image guided injections in resistant non-insertional Achilles tendinopathy. J Science Med Sport 2010;13:295-8
  • Maffulli N, Khan KM, Puddu GC. Overuse tendon conditions: time to change a confusing terminology. Arthroscopy 1998;14:840-3
  • Longo UG, Ronga N, Maffulli N. Achilles tendinopathy. Sports Med & Arthroscop Rev 2009;17:112-26
  • Egerbacher M, Arnoczky SP, Caballero O, Loss of homeostatic tension induces apoptosis in tendon cells. Clin Orthop Relat Res 2008;466:1562-8
  • Yuan J, Murrell GA, Wei AQ, Wang MX. Apoptosis in rotator cuff tendonopathy. J Orthop Res 2002;20:1372-9
  • Lian O, Scott A, Engebretsen L, Excessive apoptosis in patellar tendinopathy in Athletes. Am J Sports Med 2007;35:605-10
  • Pearce CJ, Ismail M, Calder JD. Is apoptosis a cause for non-insertional Achilles tendinopathy? Am J Sports Med 2009;37:2440-4
  • Millar NL, Wei AQ, Molloy TJ, Heat shock protein and apoptosis in supraspinatus tendinopathy. Clin Orthop Relat Res 2008;466:1569-76
  • Scott A, Khan KM, Duronio V. IGF-I activates PKB and prevents anoxic apoptosis in Achilles tendon cells. J Orthop Res 2005;23:1219-25
  • Gagarina V, Carlberg AL, Pereira-Mouries L, Hall DJ. Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins. J Biol Chem 2008;283:648-59
  • Longo UG, Franceschi F, Ruzzini L, Light microscopic histology of supraspinatus tendon ruptures. Knee Surg Sports Traumatol Arthroscop 2007;15:1390-4
  • Maffulli N, Longo UG, Franceschi F, Movin and Bonar scores assess the same characteristics of tendon histology. Clin Orthop Relat Res 2008;466:1605-11
  • Scott A, Lian O, Bahr R, VEGF expression in patellar tendinopathy: a preliminary study. Clin Orthop Relat Res 2008;466:1598-604
  • Danielson P, Andersson G, Alfredson H, Forsgren S. Marked sympathetic component in the perivascular innervation of the dorsal paratendinous tissue of the patellar tendon in arthroscopically treated tendinosis patients. Knee Surg Sports Traumatol Arthrosc 2008;16:621-6
  • Divani K, Chan O, Padhiar N, Site of maximum neovascularisation correlates with the site of pain in recalcitrant mid-tendon Achilles tendinopathy. Man Ther 2010: published online 28 April 2010, doi:10.1016/ j.math.2010.03.011
  • Brett M, Andres MD, George AC, Murrel MD. Treatment of tendinopathy. Clin Orthop Relat Res 2008;466:1539-54
  • Murrel GAC. Using nitric oxide to treat tendinopathy. Br J Sports Med 2007;41:227-31
  • Fredberg U, Stengaard-Pedersen K. Chronic tendinopathy tissue pathology, pain mechanisms, and aetiology with special focus on inflammation. Scand J Med Sci Sports 2008;18:3-15
  • Fedorczyk JM, Barr AE, Rani S, Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury. J Orthop Res 2010;28:298-307
  • Scott A, Lian O, Bahr R, Increased mast cell numbers in human patellar tendinosis: correlation with symptom duration and vascular hyperplasia. Br J Sports Med 2008;42:753-7
  • Zhang J, Wang JH. Production of PGE2 increases in tendons subjected to repetitive mechanical loading and induces differentiation of tendon stem cell into non-tenocytes. J Orthop Res 2010;28:198-203
  • Thampatty BP, Li H, Im HJ, Wang JH. EP4 receptors regulates collagen type-I, MMP-1, and MMP-3 gene expression in human tendon fibroblasts in response to IL-1 beta treatment. Gene 2007;386:154-61
  • Fredberg U, Ostgaard R. Effect of ultrasound-guided, peritendinous injections of adalimumab and anakinra in chronic Achilles tendinopathy: a pilot study. Scand J Med Sci Sports 2009;19:338-44
  • Danielson P. Reviving the “biochemical” hypothesis for tendinopathy: new findings suggest the involvement of locally produced signal substances. Br J Sports Med 2009;43:265-8
  • Bjur D, Danielson P, Alfredson H, Forsgren S. Presence of non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects and importance regarding Achilles tendon tendinosis. Cell Tissue Res 2008;331:385-400
  • Danielson P, Alfredson H, Forsgren S. Immunohistochemical and histochemical findings favouring the occurrence of autocrine/paracrine as well as nerve related cholinergic effects in chronic painful patellar tendon tendinosis. Microsc Res Tech 2006;69:808-19
  • Bagge J, Lorentzon R, Alfredson H, Forsgren S. Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon. Histol Histopathol 2009;24:839-48
  • Scott A, Bahr R. Neuropeptides in tendinopathy. Front Biosci 2009;14:2203-21
  • Gazerani P, Wang K, Cairns BE, Effect of subcutaneous administration of glutamate on pain, sensitization and vasomotor responses in healthy men and women. Pain 2006;124:338-48
  • Alfredson HS, Forsgren S, Thorsten K, Lorentzon R. In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMeDAR1 receptors, but not sings of inflammation in Jumper's knee. J Orthop Res 2001;19:881-6
  • Gibson W, Arendt-Nielsen L, Sessle BJ, Graven-Nielsen T. Glutamate and capsaicin-induced pain, hyperalgesis and modulatory interactions in human tendon tissue. Exp Brain Res 2009;194:173-82
  • Schizas N, Lian O, Frihagen F, Coexistence of up-regulated NMDA receptor 1 and glutamate on nerves, vessels and transformed tenocytes in tendinopathy. Scand J Med Sci Sports 2010;20:208-15

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