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Mesenchymal-stem-cell-based experimental and clinical trials: current status and open questions

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Pages 893-909 | Published online: 30 Mar 2011

Bibliography

  • Pittenger MF, Mackay AM, Beck SC, Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7
  • da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 2006;119:2204-13
  • Delorme B, Ringe J, Gallay N, Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells. Blood 2008;111:2631-5
  • Dominici M, Le Blanc K, Mueller I, Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-17
  • Eguchi G, Kodama R. Transdifferentiation. Curr Opin Cell Biol 1993;5:1023-8
  • Beresford WA. Direct transdifferentiation: can cells change their phenotype without dividing? Cell Differ Dev 1990;29:81-93
  • Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000;164:247-56
  • Li J, Tao R, Wu W, 3D PLGA scaffolds improve differentiation and function of bone marrow mesenchymal stem cell-derived hepatocytes. Stem Cells Dev 2010;19:1427-36
  • Chao KC, Chao KF, Fu YS, Islet-like clusters derived from mesenchymal stem cells in Wharton's jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS One 2008;3:e1451
  • Paunescu V, Deak E, Herman D, In vitro differentiation of human mesenchymal stem cells to epithelial lineage. J Cell Mol Med 2007;11:502-8
  • Sasaki M, Abe R, Fujita Y, Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol 2008;180:2581-7
  • Gong Z, Niklason LE. Small-diameter human vessel wall engineered from bone marrow-derived mesenchymal stem cells (hMSCs). FASEB J 2008;22:1635-48
  • Lange C, Togel F, Ittrich H, Administered mesenchymal stem cells enhance recovery from ischemia/ reperfusion-induced acute renal failure in rats. Kidney Int 2005;68:1613-17
  • Kinnaird T, Stabile E, Burnett MS, Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 2004;94:678-85
  • Rehman J, Traktuev D, Li J, Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004;109:1292-8
  • Chen L, Tredget EE, Wu PY, Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 2008;3:e1886
  • Takahashi M, Li TS, Suzuki R, Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. Am J Physiol Heart Circ Physiol 2006;291:H886-93
  • Zhao S, Wehner R, Bornhauser M, Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders. Stem Cells Dev 2010;19:607-14
  • Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008;8:726-36
  • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005;105:1815-22
  • Yang SH, Park MJ, Yoon IH, Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10. Exp Mol Med 2009;41:315-24
  • Chabannes D, Hill M, Merieau E, A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood 2007;110:3691-4
  • Selmani Z, Naji A, Zidi I, Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25high FOXP3+ regulatory T cells. Stem Cells 2008;26:212-22
  • Di Nicola M, Carlo-Stella C, Magni M, Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002;99:3838-43
  • Krampera M, Cosmi L, Angeli R, Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006;24:386-98
  • Tse WT, Pendleton JD, Beyer WM, Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003;75:389-97
  • Rasmusson I, Ringden O, Sundberg B, Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms. Exp Cell Res 2005;305:33-41
  • Rasmusson I, Ringden O, Sundberg B, Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 2003;76:1208-13
  • Krampera M, Glennie S, Dyson J, Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003;101:3722-9
  • Wang Y, Zhang A, Ye Z, Bone marrow-derived mesenchymal stem cells inhibit acute rejection of rat liver allografts in association with regulatory T-cell expansion. Transplant Proc 2009;41:4352-6
  • Prevosto C, Zancolli M, Canevali P, Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica 2007;92:881-8
  • Corcione A, Benvenuto F, Ferretti E, Human mesenchymal stem cells modulate B-cell functions. Blood 2006;107:367-72
  • Asari S, Itakura S, Ferreri K, Mesenchymal stem cells suppress B cell terminal differentiation. Exp Hematol 2009;37:604-15
  • Rasmusson I, Le Blanc K, Sundberg B, Mesenchymal stem cells stimulate antibody secretion in human B cells. Scand J Immunol 2007;65:336-43
  • Traggiai E, Volpi S, Schena F, Bone Marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients. Stem Cell 2008;26:562-9
  • Nauta AJ, Kruisselbrink AB, Lurvink E, Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J Immunol 2006;177:2080-7
  • Zhang W, Ge W, Li C, Effects of mesenchymal stem cells on differentiation, maturation and function of human monocyte-derived dendritic cells. Stem Cells Dev 2004;13:263-71
  • Beyth S, Borovsky Z, Mevorach D, Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 2005;105:2214-19
  • Meisel R, Zibert A, Laryea M, Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004;103:4619-21
  • Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007;127:514-25
  • Roberts CS, Maclean D, Maroko P, Relation of early mononuclear and polymorphonuclear cell infiltration to late scar thickness after experimentally induced myocardial infarction in the rat. Basic Res Cardiol 1985;80:202-9
  • Spaeth E, Klopp A, Dembinski J, Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther 2008;15:730-8
  • da Silva Meirelles L, Caplan AI, Nardi NB. In search of the in vivo identity of mesenchymal stem cells. Stem Cells 2008;26:2287-99
  • Son BR, Marquez-Curtis LA, Kucia M, Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. Stem Cells 2006;24:1254-64
  • Neuss S, Becher E, Woltje M, Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Stem cells 2004;22:405-14
  • Ponte AL, Marais E, Gallay N, The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells 2007;25:1737-45
  • Schmidt A, Ladage D, Steingen C, Mesenchymal stem cells transmigrate over the endothelial barrier. Eur J Cell Biol 2006;85:1179-88
  • Segers VF, Van Riet I, Andries LJ, Mesenchymal stem cell adhesion to cardiac microvascular endothelium: activators and mechanisms. Am J Physiol Heart Circ Physiol 2006;290:H1370-7
  • Ruster B, Gottig S, Ludwig RJ, Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells. Blood 2006;108:3938-44
  • Assis AC, Carvalho JL, Jacoby BA, Time-dependent migration of systemically delivered bone marrow mesenchymal stem cells to the infarcted heart. Cell Transplant 2010;19:219-30
  • Ortiz LA, Gambelli F, McBride C, Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and amelioratesits fibrotic effects. Proc Natl Acad Sci USA 2003;100:8407-11
  • Chen J, Li Y, Wang L, Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 2001;32:1005-11
  • Hofstetter CP, Schwarz EJ, Hess D, Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci USA 2002;99:2199-204
  • Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986;315:1650-9
  • Kidd S, Spaeth E, Dembinski JL, Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging. Stem Cells 2009;27:2614-23
  • Studeny M, Marini FC, Champlin RE, Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 2002;62:3603-8
  • Nakamura K, Ito Y, Kawano Y, Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther 2004;11:1155-64
  • Ren C, Kumar S, Chanda D, Cancer gene therapy using mesenchymal stem cells expressing interferon-beta in a mouse prostate cancer lung metastasis model. Gene Ther 2008;15:1446-53
  • Ren C, Kumar S, Chanda D, Therapeutic potential of mesenchymal stem cells producing interferon-alpha in a mouse melanoma lung metastasis model. Stem Cells 2008;26:2332-8
  • Zhu W, Xu W, Jiang R, Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp Mol Pathol 2006;80:267-74
  • Galie M, Konstantinidou G, Peroni D, Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice. Oncogene 2008;27:2542-51
  • Delcarpio JB, Claycomb WC. Cardiomyocyte transfer into the mammalian heart. Cell-to-cell interactions in vivo and in vitro. Ann NY Acad Sci 1995;752:267-85
  • Murry CE, Wiseman RW, Schwartz SM, Skeletal myoblast transplantation for repair of myocardial necrosis. J Clin Invest 1996;98:2512-23
  • Chen SL, Fang WW, Ye F, Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 2004;94:92-5
  • Katritsis DG, Sotiropoulou PA, Karvouni E, Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardium. Catheter Cardiovasc Interv 2005;65:321-9
  • Chen S, Liu Z, Tian N, Intracoronary transplantation of autologous bone marrow mesenchymal stem cells for ischemic ardiomyopathy due to isolated chronic occluded left anterior descending artery. J Invasive Cardiol 2006;18:552-6
  • Ripa RS, Haack-Sorensen M, Wang Y, Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial. Circulation 2007;116:I24-30
  • Mohyeddin-Bonab M, Mohamad-Hassani MR, Alimoghaddam K, Autologous in vitro expanded mesenchymal stem cell therapy for human old myocardial infarction. Arch Iran Med 2007;10:467-73
  • Katritsis DG, Sotiropoulou P, Giazitzoglou E, Electrophysiological effects of intracoronary transplantation of Autologous mesenchymal and endothelial progenitor cells. Europace 2007;9:167-71
  • Hare JM, Traverse JH, Henry TD, A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 2009;54:2277-86
  • Vulliet PR, Greeley M, Halloran SM, Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet 2004;363:783-4
  • Breitbach M, Bostani T, Roell W, Potential risks of bone marrow cell transplantation into infarcted hearts. Blood 2007;110:1362-9
  • Hu X, Yu SP, Fraser JL, Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J Thorac Cardiovasc Surg 2008;135:799-808
  • Hung SC, Pochampally RR, Hsu SC, Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo. PLoS One 2007;2:e416
  • Hahn JY, Cho HJ, Kang HJ, Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J Am Coll Cardiol 2008;51:933-43
  • Pasha Z, Wang Y, Sheikh R, Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. Cardiovasc Res 2008;77:134-42
  • Haider HKH, Ashraf M. Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation. J Mol Cell Cardiol 2008;45:554-66
  • Yang YJ, Qian HY, Huang J, Combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells increases benefits in infarcted swine hearts. Arterioscler Thromb Vasc Biol 2009;29:2076-82
  • Bang OY, Lee JS, Lee PH, Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005;57:874-82
  • Lee JS, Hong JM, Moon GJ, A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells 2010;28:1099-106
  • Mohyeddin Bonab M, Yazdanbakhsh S, Lotfi J, Does mesenchymal stem cell therapy help multiple sclerosis patients? Report of a pilot study. Iran J Immunol 2007;4:50-7
  • Lee PH, Kim JW, Bang OY, Autologous mesenchymal stem cell therapy delays the progression of neurological deficits in patients with multiple system atrophy. Clin Pharmacol Ther 2008;83:723-30
  • Pal R, Venkataramana NK, Bansal A, Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study. Cytotherapy 2009;11:897-911
  • Moviglia GA, Fernandez Vina R, Brizuela JA, Combined protocol of cell therapy for chronic spinal cord injury. Report on the electrical and functional recovery of two patients. Cytotherapy 2006;8:202-9
  • Mazzini L, Mareschi K, Ferrero I, Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis. Neurol Res 2006;28:523-6
  • Koc ON, Day J, Nieder M, Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant 2002;30:215-22
  • Venkataramana NK, Kumar SK, Balaraju S, Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease. Transl Res 2010;155:62-70
  • Abdel Aziz MT, Atta HM, Mahfouz S, Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis. Clin Biochem 2007;40:893-9
  • Tsai PC, Fu TW, Chen YM, The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis. Liver Transpl 2009;15:484-95
  • Li JT, Liao ZX, Ping J, Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. J Gastroenterol 2008;43:419-28
  • Kharaziha P, Hellstrom PM, Noorinayer B, Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial. Eur J Gastroenterol Hepatol 2009;21:1199-205
  • Mohamadnejad M, Alimoghaddam K, Mohyeddin-Bonab M, Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis. Arch Iran Med 2007;10:459-66
  • Mohamadnejad M, Namiri M, Bagheri M, Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis. World J Gastroenterol 2007;13:3359-63
  • Morigi M, Imberti B, Zoja C, Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 2004;15:1794-804
  • Togel F, Hu Z, Weiss K, Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 2005;289:F31-42
  • Zhuo W, Liao L, Xu T, Mesenchymal stem cells ameliorate ischemia-reperfusion-induced renal dysfunction by improving the antioxidant/oxidant balance in the ischemic kidney. Urol Int 2011;86:191-6
  • Radhakrishnan J, Kiryluk K. Acute renal failure outcomes in children and adults. Kidney Int 2006;69:17-9
  • Parekkadan B, Tilles AW, Yarmush ML. Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells. Stem Cells 2008;26:1913-19
  • Zappia E, Casazza S, Pedemonte E, Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 2005;106:1755-61
  • Fiorina P, Jurewicz M, Augello A, Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes. J Immunol 2009;183:993-1004
  • Sun L, Akiyama K, Zhang H, Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells 2009;27:1421-32
  • Liang J, Zhang H, Hua B, Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis 2010;69:1423-9
  • Bocelli-Tyndall C, Bracci L, Spagnoli G, Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous and allogeneic-stimulated lymphocytes in vitro. Rheumatology 2007;46:403-8
  • Sun LY, Zhang HY, Feng XB, Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 2007;16:121-8
  • Duijvestein M, Vos AC, Roelofs H, Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study. Gut 2010;59:1662-9
  • Ciccocioppo R, Bernardo ME, Sgarella A, Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease. Gut 2011: published online 21 January 2011, doi:10.1136/gut.2010.214841
  • Hoogduijn MJ, Crop MJ, Korevaar SS, Susceptibility of human mesenchymal stem cells to tacrolimus, mycophenolic acid, and rapamycin. Transplantation 2008;86:1283-91
  • Buron F, Perrin H, Malcus C, Human mesenchymal stem cells and immunosuppressive drug interactions in allogeneic responses: an in vitro study using human cells. Transplant Proc 2009;41:3347-52
  • Buron F, Morelon E, Perrin H, Mesenchymal stem cell and immunosuppressive drug interactions. Transplantation 2009;87:1899-900
  • Shi D, Liao L, Zhang B, Human adipose tissue-derived mesenchymal stem cells facilitate the immunosuppressive effect of Cyclosporin A on T lymphocytes through Jagged-1 mediated inhibition of NF-kappaB signaling. Exp Hematol 2011;39:214-24
  • Brittberg M, Lindahl A, Nilsson A, Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994;331:889-95
  • Quintavalla J, Uziel-Fusi S, Yin J, Fluorescently labeled mesenchymal stem cells (MSCs) maintain multilineage potential and can be detected following implantation into articular cartilage defects. Biomaterials 2002;23:109-19
  • Haleem AM, Singergy AA, Sabry D, The clinical use of human culture-expanded autologous bone marrow mesenchymal stem cells transplanted on platelet-rich fibrin glue in the treatment of articular cartilage defects: a pilot study and preliminary results. Cartilage 2010;1:253-61
  • Horwitz EM, Prockop DJ, Fitzpatrick LA, Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999;5:309-13
  • Wakitani S, Imoto K, Yamamoto T, Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage 2002;10:199-206
  • Wakitani S, Mitsuoka T, Nakamura N, Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports. Cell Transplant 2004;13:595-600
  • Reddi AH. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol 1998;16:247-52
  • Aung T, Miyoshi H, Tun T, Chondroinduction of mouse mesenchymal stem cells in three-dimensional highly porous matrix scaffolds. J Biomed Mater Res 2002;61:75-82
  • Tuan RS, Boland G, Tuli R. Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther 2003;5:32-45
  • Quarto R, Mastrogiacomo M, Cancedda R, Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 2001;344:385-6
  • Matthay MA, Thompson BT, Read EJ, Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest 2010;138:965-72
  • Patel KM, Crisostomo P, Lahm T, Mesenchymal stem cells attenuate hypoxic pulmonary vasoconstriction by a paracrine mechanism. J Surg Res 2007;143:281-5
  • Kursova LV, Konoplyannikov AG, Pasov VV, Possibilities for the use of autologous mesenchymal stem cells in the therapy of radiation-induced lung injuries. Bull Exp Biol Med 2009;147:542-6
  • Antoniou KM, Papadaki HA, Soufla G, Investigation of bone marrow mesenchymal stem cells (BM MSCs) involvement in Idiopathic Pulmonary Fibrosis (IPF). Respir Med 2010;104:1535-42
  • Dash NR, Dash SN, Routray P, Targeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells. Rejuvenation Res 2009;12:359-66
  • Vojtassak J, Danisovic L, Kubes M, Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot. Neuro Endocrinol Lett 2006;27(Suppl 2):134-7
  • Falanga V, Iwamoto S, Chartier M, Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Eng 2007;13:1299-312
  • Lasala GP, Silva JA, Gardner PA, Combination stem cell therapy for the treatment of severe limb ischemia: safety and efficacy analysis. Angiology 2010;61:551-6
  • Fu X, Qu Z, Sheng Z. Potentiality of mesenchymal stem cells in regeneration of sweat glands. J Surg Res 2006;136:204-8
  • Bey E, Prat M, Duhamel P, Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrations. Wound Repair Regen 2010;18:50-8
  • Lataillade JJ, Doucet C, Bey E, New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. Regen Med 2007;2:785-94
  • Garcia-Olmo D, Garcia-Arranz M, Herreros D, A Phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 2005;48:1416-23
  • Garcia-Olmo D, Herreros D, Pascual I, Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a Phase II clinical trial. Dis Colon Rectum 2009;52:79-86
  • in 't Anker PS, Noort WA, Kruisselbrink AB, Nonexpanded primary lung and bone marrow-derived mesenchymal cells promote the engraftment of umbilical cord blood-derived CD34+ cells in NOD/SCID mice. Exp Hematol 2003;31:881-9
  • Koc ON, Gerson SL, Cooper BW, Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 2000;18:307-16
  • Le Blanc K, Frassoni F, Ball L, Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008;371:1579-86
  • Meuleman N, Tondreau T, Ahmad I, Infusion of mesenchymal stromal cells can aid hematopoietic recovery following allogeneic hematopoietic stem cell myeloablative transplant: a pilot study. Stem Cells Dev 2009;18:1247-52
  • Lazarus HM, Koc ON, Devine SM, Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 2005;11:389-98
  • Deeg HJ. How I treat refractory acute GVHD. Blood 2007;109:4119-26
  • Ringden O, Uzunel M, Rasmusson I, Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006;81:1390-7
  • Fang B, Song Y, Liao L, Favorable response to human adipose tissue-derived mesenchymal stem cells in steroid-refractory acute graft-versus-host disease. Transplant Proc 2007;39:3358-62
  • Fang B, Song YP, Liao LM, Treatment of severe therapy-resistant acute graft-versus-host disease with human adipose tissue-derived mesenchymal stem cells. Bone Marrow Transplant 2006;38:389-90
  • Weng JY, Du X, Geng SX, Mesenchymal stem cell as salvage treatment for refractory chronic GVHD. Bone Marrow Transplant 2010;45:1732-40
  • Bartholomew A, Sturgeon C, Siatskas M, Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002;30:42-8
  • Casiraghi F, Azzollini N, Cassis P, Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells. J Immunol 2008;181:3933-46
  • Ding Y, Xu D, Feng G, Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9. Diabetes 2009;58:1797-806
  • Zuk PA, Zhu M, Ashjian P, Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-95
  • Stenderup K, Justesen J, Clausen C, Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone 2003;33:919-26
  • Mueller SM, Glowacki J. Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges. J Cell Biochem 2001;82:583-90
  • Pappa KI, Anagnou NP. Novel sources of fetal stem cells: where do they fit on the developmental continuum? Regen Med 2009;4:423-33
  • Wang M, Yang Y, Yang D, The immunomodulatory activity of human umbilical cord blood-derived mesenchymal stem cells in vitro. Immunology 2009;126:220-32
  • Jo CH, Kim OS, Park EY, Fetal mesenchymal stem cells derived from human umbilical cord sustain primitive characteristics during extensive expansion. Cell Tissue Res 2008;334:423-33
  • Roubelakis MG, Pappa KI, Bitsika V, Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells. Stem Cells Dev 2007;16:931-52
  • Kern S, Eichler H, Stoeve J, Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006;24:1294-301
  • Tsai MS, Hwang SM, Chen KD, Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow. Stem Cells 2007;25:2511-23
  • Schallmoser K, Bartmann C, Rohde E, Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions. Haematologica 2010;95:867-74
  • Banfi A, Muraglia A, Dozin B, Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: implications for their use in cell therapy. Exp Hematol 2000;28:707-15
  • Rombouts WJ, Ploemacher RE. Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture. Leukemia 2003;17:160-70
  • Wagner W, Horn P, Castoldi M, Replicative senescence of mesenchymal stem cells: a continuous and organized process. PLoS One 2008;3:e2213
  • Sarugaser R, Hanoun L, Keating A, Human mesenchymal stem cells self-renew and differentiate according to a deterministic hierarchy. PLoS One 2009;4:e6498
  • Egermann M, Heil P, Tami A, Assessment of in vitro aging of mesenchymal stem cell. J Orthop Res 2010;28:798-804
  • Karp JM, Leng Teo GS. Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell 2009;4:206-16
  • Devine SM, Cobbs C, Jennings M, Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood 2003;101:2999-3001
  • Walczak P, Zhang J, Gilad AA, Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke 2008;39:1569-74
  • Henning RJ, Burgos JD, Vasko M, Human cord blood cells and myocardial infarction: effect of dose and route of administration on infarct size. Cell Transplant 2007;16:907-17
  • Behr L, Hekmati M, Fromont G, Intra renal arterial injection of autologous mesenchymal stem cells in an ovine model in the postischemic kidney. Nephron Physiol 2007;107:65-76
  • de Vasconcelos Dos Santos A, da Costa Reis J, Diaz Paredes B, Therapeutic window for treatment of cortical ischemia with bone marrow-derived cells in rats. Brain Res 2010;1306:149-58
  • Komatsu K, Honmou O, Suzuki J, Therapeutic time window of mesenchymal stem cells derived from bone marrow after cerebral ischemia. Brain Res 2010;1334:84-92
  • Isakova IA, Baker K, DuTreil M, Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells 2007;25:3261-70
  • Gastens MH, Goltry K, Prohaska W, Good manufacturing practice-compliant expansion of marrow-derived stem and progenitor cells for cell therapy. Cell Transplant 2007;16:685-96
  • Takagi M, Umetsu Y, Fujiwara M, High inoculation cell density could accelerate the differentiation of human bone marrow mesenchymal stem cells to chondrocyte cells. J Biosci Bioeng 2007;103:98-100
  • Seeger FH, Tonn T, Krzossok N, Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction. Eur Heart J 2007;28:766-72
  • Furlani D, Li W, Pittermann E, A transformed cell population derived from cultured mesenchymal stem cells has no functional effect after transplantation into the injured heart. Cell Transplant 2009;18:319-31
  • Cyranoski D. FDA challenges stem-cell clinic. Nature 2010;466:909

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