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New approaches to expand hematopoietic stem and progenitor cells

, & , MD PhD
Pages 743-756 | Published online: 23 Apr 2012

Bibliography

  • Becker AJ, Mc CE, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 1963;197:452-4
  • Wu AM, Till JE, Siminovitch L, McCulloch EA. Cytological evidence for a relationship between normal hemotopoietic colony-forming cells and cells of the lymphoid system. J Exp Med 1968;127:455-64
  • Morrison SJ, Uchida N, Weissman IL. The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol 1995;11:35-71
  • Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell 2000;100:157-68
  • Thomas ED, Lochte HL Jr, Lu WC, Ferrebee JW. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med 1957;257:491-6
  • Gluckman E, Broxmeyer HA, Auerbach AD, Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 1989;321:1174-8
  • Appelbaum FR. Hematopoietic-cell transplantation at 50. N Engl J Med 2007;357:1472-5
  • Yazaki M, Atsuta Y, Kato K, Incidence and risk factors of early bacterial infections after unrelated cord blood transplantation. Biol Blood Marrow Transplant 2009;15:439-46
  • Delaney C, Gutman JA, Appelbaum FR. Cord blood transplantation for haematological malignancies: conditioning regimens, double cord transplant and infectious complications. Br J Haematol 2009;147:207-16
  • Escalon MP, Komanduri KV. Cord blood transplantation: evolving strategies to improve engraftment and immune reconstitution. Curr Opin Oncol 2010;22:122-9
  • Sauvageau G, Iscove NN, Humphries RK. In vitro and in vivo expansion of hematopoietic stem cells. Oncogene 2004;23:7223-32
  • Hofmeister CC, Zhang J, Knight KL, Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche. Bone Marrow Transplant 2007;39:11-23
  • Tung SS, Parmar S, Robinson SN, Ex vivo expansion of umbilical cord blood for transplantation. Best Pract Res Clin Haematol 2010;23:245-57
  • Osawa M, Hanada K, Hamada H, Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996;273:242-5
  • Kiel MJ, Yilmaz OH, Iwashita T, SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005;121:1109-21
  • Kim I, He S, Yilmaz OH, Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood 2006;108:737-44
  • Baum CM, Weissman IL, Tsukamoto AS, Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci USA 1992;89:2804-8
  • McCune JM, Namikawa R, Kaneshima H, The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 1988;241:1632-9
  • Ito M, Hiramatsu H, Kobayashi K, NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 2002;100:3175-82
  • Shultz LD, Lyons BL, Burzenski LM, Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 2005;174:6477-89
  • Wang JC, Doedens M, Dick JE. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood 1997;89:3919-24
  • Rocha V, Labopin M, Sanz G, Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004;351:2276-85
  • Krause DS, Fackler MJ, Civin CI, May WS. CD34: structure, biology, and clinical utility. Blood 1996;87:1-13
  • Vogel W, Scheding S, Kanz L, Brugger W. Clinical applications of CD34(+) peripheral blood progenitor cells (PBPC). Stem Cells 2000;18:87-92
  • Nakamura Y, Ando K, Chargui J, Ex vivo generation of CD34(+) cells from CD34(-) hematopoietic cells. Blood 1999;94:4053-9
  • Wang J, Kimura T, Asada R, SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injection. Blood 2003;101:2924-31
  • Yahata T, Ando K, Sato T, A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow. Blood 2003;101:2905-13
  • Bhatia M, Wang JC, Kapp U, Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci USA 1997;94:5320-5
  • Craig W, Kay R, Cutler RL, Lansdorp PM. Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med 1993;177:1331-42
  • Yin AH, Miraglia S, Zanjani ED, AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 1997;90:5002-12
  • Majeti R, Park CY, Weissman IL. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 2007;1:635-45
  • Bertoncello I, Williams B. Hematopoietic stem cell characterization by Hoechst 33342 and rhodamine 123 staining. Methods Mol Biol 2004;263:181-200
  • McKenzie JL, Takenaka K, Gan OI, Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population. Blood 2007;109:543-5
  • Notta F, Doulatov S, Laurenti E, Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 2011;333:218-21
  • Zon LI. Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature 2008;453:306-13
  • Kataoka K, Sato T, Yoshimi A, Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity. J Exp Med 2011;208:2403-16
  • Aguila JR, Liao W, Yang J, SALL4 is a robust stimulator for the expansion of hematopoietic stem cells. Blood 2011;118:576-85
  • Kato Y, Iwama A, Tadokoro Y, Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis. J Exp Med 2005;202:169-79
  • Wierenga AT, Vellenga E, Schuringa JJ. Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels. Mol Cell Biol 2008;28:6668-80
  • Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 2002;109:39-45
  • Schiedlmeier B, Klump H, Will E, High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. Blood 2003;101:1759-68
  • Amsellem S, Pflumio F, Bardinet D, Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein. Nat Med 2003;9:1423-7
  • Park IK, Qian D, Kiel M, Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003;423:302-5
  • Iwama A, Oguro H, Negishi M, Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity 2004;21:843-51
  • Oguro H, Iwama A, Morita H, Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med 2006;203:2247-53
  • Oguro H, Yuan J, Ichikawa H, Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell 2010;6:279-86
  • Rizo A, Olthof S, Han L, Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis. Blood 2009;114:1498-505
  • Faubert A, Chagraoui J, Mayotte N, Complementary and independent function for Hoxb4 and Bmi1 in HSC activity. Cold Spring Harb Symp Quant Biol 2008;73:555-64
  • Konuma T, Nakamura S, Miyagi S, Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells. Exp Hematol 2011;39:697-709
  • Adams GB, Scadden DT. The hematopoietic stem cell in its place. Nat Immunol 2006;7:333-7
  • Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 2008;132:598-611
  • Zhang J, Niu C, Ye L, Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425:836-41
  • Ellis SL, Grassinger J, Jones A, The relationship between bone, hemopoietic stem cells, and vasculature. Blood 2011;118:1516-24
  • Lo Celso C, Scadden DT. The haematopoietic stem cell niche at a glance. J Cell Sci 2011;124:3529-35
  • Nagasawa T, Omatsu Y, Sugiyama T. Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells. Trends Immunol 2011;32:315-20
  • Yamazaki S, Ema H, Karlsson G, Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell 2011;147:1146-58
  • Broudy VC. Stem cell factor and hematopoiesis. Blood 1997;15:1345-64
  • Ding L, Saunders TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 2012;481:457-62
  • Yoshihara H, Arai F, Hosokawa K, Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 2007;13:685-97
  • Qian H, Buza-Vidas N, Hyland CD, Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell 2007;13:671-84
  • Arai F, Hirao A, Ohmura M, Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004;118:149-61
  • Stier S, Ko Y, Forkert R, Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med 2005;201:1781-91
  • Nilsson SK, Johnston HM, Whitty GA, Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood 2005;106:1232-9
  • Calvi LM, Adams GB, Weibrecht KW, Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003;425:841-6
  • Varnum-Finney B, Xu L, Brashem-Stein C, Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med 2000;6:1278-81
  • Mancini SJ, Mantei N, Dumortier A, Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood 2005;105:2340-2
  • Maillard I, Koch U, Dumortier A, Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell 2008;2:356-66
  • Lapidot T, Dar A, Kollet O. How do stem cells find their way home? Blood 2005;106:1901-10
  • Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006;25:977-88
  • Kiel MJ, Acar M, Radice GL, Morrison SJ. Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. Cell Stem Cell 2009;4:170-9
  • Hosokawa K, Arai F, Yoshihara H, Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow. Cell Stem Cell 2010;6:194-8
  • Yokota T, Oritani K, Mitsui H, Growth-supporting activities of fibronectin on hematopoietic stem/progenitor cells in vitro and in vivo: structural requirement for fibronectin activities of CS1 and cell-binding domains. Blood 1998;91:3263-72
  • Avigdor A, Goichberg P, Shivtiel S, CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 2004;103:2981-9
  • Hai-Jiang W, Xin-Na D, Hui-Jun D. Expansion of hematopoietic stem/progenitor cells. Am J Hematol 2008;83:922-6
  • Abboud MR, Xu F, Payne A, Laver J. Effects of recombinant human Steel factor (c-kit ligand) on early cord blood hematopoietic precursors. Exp Hematol 1994;22:388-92
  • Ohmizono Y, Sakabe H, Kimura T, Thrombopoietin augments ex vivo expansion of human cord blood-derived hematopoietic progenitors in combination with stem cell factor and flt3 ligand. Leukemia 1997;11:524-30
  • Piacibello W, Sanavio F, Garetto L, The role of c-Mpl ligands in the expansion of cord blood hematopoietic progenitors. Stem Cells 1998;16:243-8
  • McKenna HJ, de Vries P, Brasel K, Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells. Blood 1995;86:3413-20
  • Solanilla A, Grosset C, Duchez P, Flt3-ligand induces adhesion of haematopoietic progenitor cells via a very late antigen (VLA)-4- and VLA-5-dependent mechanism. Br J Haematol 2003;120:782-6
  • Zheng Y, Sun A, Han ZC. Stem cell factor improves SCID-repopulating activity of human umbilical cord blood-derived hematopoietic stem/progenitor cells in xenotransplanted NOD/SCID mouse model. Bone Marrow Transplant 2005;35:137-42
  • Shpall EJ, Quinones R, Giller R, Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant 2002;8:368-76
  • Yao CL, Chu IM, Hsieh TB, Hwang SM. A systematic strategy to optimize ex vivo expansion medium for human hematopoietic stem cells derived from umbilical cord blood mononuclear cells. Exp Hematol 2004;32:720-7
  • Yao CL, Feng YH, Lin XZ, Characterization of serum-free ex vivo-expanded hematopoietic stem cells derived from human umbilical cord blood CD133(+) cells. Stem Cells Dev 2006;15:70-8
  • Peled T, Landau E, Mandel J, Linear polyamine copper chelator tetraethylenepentamine augments long-term ex vivo expansion of cord blood-derived CD34+ cells and increases their engraftment potential in NOD/SCID mice. Exp Hematol 2004;32:547-55
  • Peled T, Glukhman E, Hasson N, Chelatable cellular copper modulates differentiation and self-renewal of cord blood-derived hematopoietic progenitor cells. Exp Hematol 2005;33:1092-100
  • de Lima M, McMannis J, Gee A, Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial. Bone Marrow Transplant 2008;41:771-8
  • in 't Anker PS, Noort WA, Kruisselbrink AB, Nonexpanded primary lung and bone marrow-derived mesenchymal cells promote the engraftment of umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp Hematol 2003;31:881-9
  • Le Blanc K, Frassoni F, Ball L, Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008;371:1579-86
  • Bernardo ME, Ball LM, Cometa AM, The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group. Bone Marrow Transplant 2011;46:200-7
  • Kelly SS, Sola CB, de Lima M, Shpall E. Ex vivo expansion of cord blood. Bone Marrow Transplant 2009;44:673-81
  • de Lima M, Robinson S, McMannis J, Mesenchymal stem cell based cord blood expansion leads to rapid engraftment of platelets and neutrophils. Blood 2010;116:abstract 362
  • Palsson BO, Paek SH, Schwartz RM, Expansion of human bone marrow progenitor cells in a high cell density continuous perfusion system. Biotechnology 1993;11:368-72
  • Liu Y, Liu T, Fan X, Ex vivo expansion of hematopoietic stem cells derived from umbilical cord blood in rotating wall vessel. J Biotechnol 2006;124:592-601
  • Jaroscak J, Goltry K, Smith A, Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase I trial using the AastromReplicell System. Blood 2003;101:5061-7
  • Zhang CC, Kaba M, Iizuka S, Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood 2008;111:3415-23
  • Himburg HA, Muramoto GG, Daher P, Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med 2010;16:475-82
  • Stier S, Cheng T, Dombkowski D, Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood 2002;99:2369-78
  • Suzuki T, Yokoyama Y, Kumano K, Highly efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc chimeric protein. Stem Cells 2006;24:2456-65
  • Delaney C, Heimfeld S, Brashem-Stein C, Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 2010;16:232-6
  • Ding S, Schultz PG. A role for chemistry in stem cell biology. Nat Biotechnol 2004;22:833-40
  • Chute JP, Muramoto GG, Whitesides J, Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc Natl Acad Sci USA 2006;103:11707-12
  • Ko KH, Holmes T, Palladinetti P, GSK-3beta inhibition promotes engraftment of ex vivo-expanded hematopoietic stem cells and modulates gene expression. Stem Cells 2011;29:108-18
  • Reya T, Duncan AW. Ailles L, et al. role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003;423:409-14
  • Malhotra S, Kincade PW. Wnt-related molecules and signaling pathway equilibrium in hematopoiesis. Cell Stem Cell 2009;4:27-36
  • Nishino T, Miyaji K, Ishiwata N, Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL. Exp Hematol 2009;37:1364-77
  • Tarasova A, Haylock D, Winkler D. Principal signalling complexes in haematopoiesis: structural aspects and mimetic discovery. Cytokine Growth Factor Rev 2011;22:231-53
  • Sangeetha VM, Kale VP, Limaye LS. Expansion of cord blood CD34 cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse. PLoS One 2010;5:e12221
  • Yang M, Li K, Ng PC, Promoting effects of serotonin on hematopoiesis: ex vivo expansion of cord blood CD34+ stem/progenitor cells, proliferation of bone marrow stromal cells, and antiapoptosis. Stem Cells 2007;25:1800-6
  • Araki H, Baluchamy S, Yoshinaga K, Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues. Exp Hematol 2009;37:1084-95
  • Araki H, Yoshinaga K, Boccuni P, Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. Blood 2007;109:3570-8
  • De Felice L, Tatarelli C, Mascolo MG, Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cells. Cancer Res 2005;65:1505-13
  • Peled T, Shoham H, Aschengrau D, Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment. Exp Hematol 2012; published online 20 Dec 2012; doi: 10.1016/j.exphm.2011.12.005
  • Nishino T, Wang C, Mochizuki-Kashio M, Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One 2011;6:e24298
  • Boitano AE, Wang J, Romeo R, Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010;329:1345-8
  • Csaszar E, Kirouac DC, Yu M, Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling. Cell Stem Cell 2012;10:218-29
  • Kaufman DS. Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells. Blood 2009;114:3513-23
  • Kyba M, Perlingeiro RC, Daley GQ. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell 2002;109:29-37
  • Kitajima K, Minehata K, Sakimura K, In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx2. Blood 2011;117:3748-58
  • Ledran MH, Krassowska A, Armstrong L, Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell 2008;3:85-98
  • Danet GH, Pan Y, Luongo JL, Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest 2003;112:126-35
  • Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 2011;9:298-310
  • Lu J, Aggarwal R, Pompili VJ, Das H. A novel technology for hematopoietic stem cell expansion using combination of nanofiber and growth factors. Recent Pat Nanotechnol 2010;4:125-35

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