264
Views
9
CrossRef citations to date
0
Altmetric
Original Research

Oncogenic transformation induced by cell-free nucleic acids circulating in plasma (genometastasis) remains after the surgical resection of the primary tumor: a pilot study

, , , , &
Pages S61-S68 | Published online: 08 May 2012

Bibliography

  • Garcia-Olmo DC, Dominguez C, Garcia-Arranz M, Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells. Cancer Res 2010;70:560-7
  • Garcia-Olmo D, Garcia-Olmo DC, Ontanon J, Tumor DNA circulating in the plasma might play a role in metastasis. The hypothesis of genometastasis. Histol Histopathol 1999;14:1159-64
  • Garcia-Olmo D, Garcia-Olmo DC, Ontanon J, Horizontal transfer of DNA and the “genometastasis hypothesis”. Blood 2000;95:724-5
  • Bergsmedh A, Szeles A, Henriksson M, Horizontal transfer of oncogenes by uptake of apoptotic bodies. Proc Natl Acad Sci USA 2001;98:6407-11
  • Ehnfors J, Kost-Alimova M, Persson NL, Horizontal transfer of tumor DNA to endothelial cells in vivo. Cell Death Differ 2009;16:749-57
  • Lindforss U, Zetterquist H, Papadogiannakis N, Persistence of K-ras mutations in plasma after colorectal tumor resection. Anticancer Res 2005;25:657-61
  • Ryan BM, Lefort F, McManus R, A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up. Gut 2003;52:101-8
  • Garcia-Olmo DC, Gutierrez-Gonzalez L, Samos J, Surgery and hematogenous dissemination: comparison between the detection of circulating tumor cells and of tumor DNA in plasma before and after tumor resection in rats. Ann Surg Oncol 2006;13:1136-44
  • Garcia-Olmo D, Garcia-Arranz M, Garcia LG, Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: a new cell-based therapy. Int J Colorectal Dis 2003;18:451-4
  • Serrano-Heras G, Dominguez-Berzosa C, Collantes E, NIH-3T3 fibroblasts cultured with plasma from colorectal cancer patients generate poorly differentiated carcinomas in mice. Cancer Lett 2012;316:85-90
  • International Agency for Research on Cancer (IARC). 2010. Available from: http://www-dep.iarc.fr/
  • Fleischhacker M, Schmidt B. Circulating nucleic acids (CNAs) and cancer–a survey. Biochim Biophys Acta 2007;1775:181-232
  • Lecomte T, Ceze N, Dorval E, Circulating free tumor DNA and colorectal cancer. Gastroenterol Clin Biol 2010;34:662-81
  • Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 2011;11:426-37
  • Ziegler A, Zangemeister-Wittke U, Stahel RA. Circulating DNA: a new diagnostic gold mine? Cancer Treat Rev 2002;28:255-71
  • Trevisiol C, Di Fabio F, Nascimbeni R, Prognostic value of circulating KRAS2 gene mutations in colorectal cancer with distant metastases. Int J Biol Markers 2006;21:223-8
  • Guadalajara H, Dominguez-Berzosa C, Garcia-Arranz M, The concentration of deoxyribonucleic acid in plasma from 73 patients with colorectal cancer and apparent clinical correlations. Cancer Detect Prev 2008;32:39-44
  • Anker P, Lyautey J, Lefort F, Transformation of NIH/3T3 cells and SW 480 cells displaying K-ras mutation. C R Acad Sci III 1994;317:869-74
  • Belting M, Wittrup A. Nanotubes, exosomes, and nucleic acid-binding peptides provide novel mechanisms of intercellular communication in eukaryotic cells: implications in health and disease. J Cell Biol 2008;183:1187-91
  • Skog J, Wurdinger T, van Rijn S, Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008;10:1470-6
  • Anker P, Jachertz D, Maurice PA, Nude mice injected with DNA released by antigen-stimulated human T-lymphocytes produce specific antibodies expressing human characteristics. Cell Biochem Funct 1984;2:33-7
  • Valadi H, Ekstrom K, Bossios A, Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007;9:654-9
  • Weigelt B, Peterse JL, van 't Veer LJ. Breast cancer metastasis: markers and models. Nat Rev Cancer 2005;5:591-602
  • Hunter KW, Crawford NPS, Alsarraj J. Mechanisms of metastasis. Breast Cancer Res 2008;10(Suppl 1):S2
  • Garcia-Olmo DC, Gutierrez-Gonzalez L, Ruiz-Piqueras R, Detection of circulating tumor cells and of tumor DNA in plasma during tumor progression in rats. Cancer Lett 2005;217:115-23
  • Garcia-Olmo DC, Samos J, Picazo MG, Loss of a reporter gene for green fluorescent protein during tumor progression suggests the recruitment of host cells in rats with experimentally induced colon cancer. Histol Histopathol 2008;23:1205-11

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.