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Original Research

Extracellular GC-rich DNA activates TLR9- and NF-kB-dependent signaling pathways in human adipose-derived mesenchymal stem cells (haMSCs)

, PhD, , , , PhD, , , PhD, , , , , & show all
Pages S99-S111 | Published online: 18 May 2012

Bibliography

  • Hahn S, Rusterholz C, Hosli I, Cell-free nucleic acids as potential markers for preeclampsia. Placenta 2011(Suppl):17-20
  • Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 2011;11(6):426-37
  • Veiko NN, Bulycheva NA, Roginko OA, Ribosomal repeat in cell free DNA as a marker for cell death. Biochem (Moscow) Suppl B Biomed Chem 2008;2(2):198-207
  • Suzuki N, Kamataki A, Yamaki J, Characterization of circulating DNA in healthy human plasma. Clin Chim Acta 2008;387:55-8
  • Peters DL, Pretorius PJ. Origin, translocation and destination of extracellular occurring DNA – a new paradigm in genetic behaviour. Clin Chim Acta 2011;412(12):806-11
  • Veiko NN, Shubaeva NO, Ivanova SM, Blood serum DNA in patients with rheumatoid arthritis is considerably enriched with fragments of ribosomal repeats containing immunostimulatory CpG-motifs. Bull Exp Biol Med 2006;142(3):313-16
  • Veiko NN, Spitkovskii DM. The accumulation of single-stranded breaks does not lead to paired DNA damage–the characteristic of the transcribing fragment of the human ribosomal operon that allows its being detected in biological fluids at the death of different body cells. Radiats Biol Radioecol 2000;40(4):396-404
  • Kostiuk SV, Zamulaeva IA, Agapova RK, The changing of cell-free DNA properties of peripheral blood and TCR-mutant cell frequency in individuals exposed to ionizing radiation. Bull Exp Biol Med 2007;144(3):304-8
  • Takagi M. Toll-like receptor. J Clin Exp Hematop 2011;51(2):77-92
  • Konkova MS, Ermakov AV, Efremova LV, Influence of X-ray and/or CpG-DNA induced oxidative stress and adaptive response in human lymphocytes. Int J Low Radiat 2010;7(6):446-52
  • Veiko NN, Kalashnikova EA, Kokarovtseva SN, Stimulatory effect of fragments from transcribed region of ribosomal repeat on human peripheral blood lymphocytes. Bull Exp Biol Med 2006;142(4):428-2
  • Malinovskaya EM, Kostyuk SV, Ermakov AV, Fragments of cell-free DNA (cfDNA) enhance transcription activity in human mesenchymal stem cells (hMSCs) and inhibit their in vitro differentiation. In: Gahan P, editor. Book “Circulating nucleic acids in plasma and serum”. Springer Science+Business Media B.V; 2010. chapter № 30
  • Ermakov AV, Konkova MS, Kostyuk SV, Oxidative stress as a significant factor for development of an adaptive response in irradiated and nonirradiated human lymphocytes after inducing the bystander effect by low-dose X-radiation. Mutat Res 2009;669(1-2):155-61
  • Singer NG, Caplan AI. Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol 2011;6:457-78
  • English K, Mahon BP. Allogeneic mesenchymal stem cells: agents of immune modulation. J Cell Biochem 2011;112(8):1963-8
  • Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 2008;132(4):598-611
  • Lehrer MS, Sun TT, Lavker RM. Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation. J Cell Sci 1998;111(Pt 19):2867-75
  • Tomchuck SL, Zwezdaryk KJ, Coffelt SB, Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. Stem Cells 2008;26(1):99-107
  • Hwa Cho H, Bae YC, Jung JS. Role of toll-like receptors on human adipose-derived stromal cells. Stem Cells 2006;24(12):2744-52
  • Ermakov AV, Kon'kova, Kostyuk SV, Bystander effect development in human mesenchymal stem cells after exposure to adaptive dose of X-radiation. Radiats Biol Radioecol 2010;50(1):42-51
  • Kostyuk SV, Malinovskaya EM, Ermakov AV, Fragments of cell free DNA increase transcription in human mesenchymal stem cells, activate TLR-dependent signal pathway, and suppress apoptosis. Biochem (Moscow) Suppl B Biomed Chem 2012;6(1):68-74
  • Mosmann T, Kostyuk SV. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65(1-2):55-63
  • Sarkar FH, Li Y, Wang Z, Kong D. NF-kappaB signaling pathway and its therapeutic implications in human diseases. Int Rev Immunol 2008;27(5):293-319
  • Van den Berk LC, Jansen BJ, Siebers-Vermeulen KG, Mesenchymal stem cells respond to TNF but do not produce TNF. J Leukoc Biol 2010;87(2):283-9
  • Hess K, Ushmorov A, Fiedler J, TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway. Bone 2009;45(2):367-76
  • Bocker W, Docheva D, Prall WC, IKK-2 is required for TNF-alpha-induced invasion and proliferation of human mesenchymal stem cells. Mol Med (Berl) 2008;86(10):1183-92
  • Widera D, Mikenberg I, Elvers M, Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling. BMC Neurosci 2006;7:64
  • Widera D, Mikenberg I, Kaus A, Nuclear Factor-kappaB controls the reaggregation of 3D neurosphere cultures in vitro. Eur Cell Mater 2006;11:76-84
  • Schmal H, Niemeyer P, Roesslein M, Comparison of cellular functionality of human mesenchymal stromal cells and PBMC. Cytotherapy 2007;9(1):69-79
  • Chang J, Zhang C, Tani-Ishii N, NF-kappaB activation in human dental pulp stem cells by TNF and LPS. J Dent Res 2005;84(11):994-8
  • Huang H, Zhao N, Xu X, Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells. Cell Prolif 2011;44(5):420-7
  • Kim YS, Park HJ, Hong MH, TNF-alpha enhances engraftment of mesenchymal stem cells into infarcted myocardium. Front Biosci 2009;14:2845-56
  • Zhao W, Li JJ, Cao DY, Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis. World J Gastroenterol 2012;18(10):1048-58
  • Holladay CA, Duffy AM, Chen X, Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold. Biomaterials 2012;33(5):1303-14
  • Li J, Zhu H, Liu Y, Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and up-regulates interleukin-10 expression in Macaca fascicularis. Brain Res 2010;1334:65-72
  • Manning E, Pham S, Li S, Interleukin-10 delivery via mesenchymal stem cells: a novel gene therapy approach to prevent lung ischemia-reperfusion injury. Hum Gene Ther 2010;21(6):713-27
  • Choi JJ, Yoo SA, Park SJ, Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice. Clin Exp Immunol 2008;153(2):269-76
  • Du YY, Zhou SH, Zhou T, Immuno-inflammatory regulation effect of mesenchymal stem cell transplantation in a rat model of myocardial infarction. Cytotherapy 2008;10(5):469-78
  • Li Z, Wei H, Deng L, Expression and secretion of interleukin-1beta, tumor necrosis factor-alpha and interleukin-10 by hypoxia- and serum-deprivation-stimulated mesenchymal stem cells. FEBS J 2010;277(18):3688-98
  • Leach JK, Van Tuyle G, Lin PS, Ionizing radiation-induced mitochondria-dependent generation of reactive oxygen/nitrogen. Cancer Res 2001;61:3894-901
  • Lobrich M, Shibata A, Beucher A, gammaH2AX foci analysis for monitoring DNA double-strand break repair. Strengths, limitations and optimization. Cell Cycle 2010;9:662-9
  • Ermakov AV, Konkova MS, Kostyuk SV, An extracellular DNA mediated bystander effect produced from low dose irradiated endothelial cells. Mutat Res 2011;712(1-2):1-10
  • Bulicheva N, Fidelina O, Mkrtumova N, Effect of cell-free DNA of patients with cardiomyopathy and rDNA on the frequency of contraction of electrically paced neonatal rat ventricular myocytes in culture. Ann NY Acad Sci 2008;1137:273-7
  • Efremova LV, Kostyuk SV, Konorova IL, Accumulating fragments of extracellular DNA (ecDNA) influence rat primary cerebellum granule cell culture chapter 29. In: Gahan P, editor. Book “Circulating nucleic acids in plasma and serum”. Springer Science+Business Media B.V; 2010
  • Efremova LV, Alekseeva AY, Konkova MS, Extracellular DNA affects NO content in human endothelial cells. Bull Exp Biol Med 2010;149(2):196-200
  • Pouzet B, Vilquin JT, Hagege AA, Factors affecting functional outcome after autologous skeletal myoblast transplantation. Ann Thorac Surg 2001;71:844-50
  • Niagara MI, Haider HKH, Jiang S, Pharmacologically preconditioned skeletal myoblasts are resistant to oxidative stress and promote angiomyogenesis via release of paracrine factors in the infarcted heart. Circ Res 2007;100(4):545-55
  • Toma C, Pittenger MF, Cahill KS, Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002;1:93-8
  • Haider HKh, Ashraf M. Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation. J Mol Cell Cardiol 2008;45(4):554-66
  • Yao Y, Zhang F, Wang L, Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction. J Biomed Sci 2009;16:74
  • Wang ZJ, Zhang FM, Wang LS, Lipopolysaccharides can protect mesenchymal stem cells (MSCs) from oxidative stress-induced apoptosis and enhance proliferation of MSCs via Toll-like receptor(TLR)-4 and PI3K/Akt. Cell Biol Int 2009;33(6):665-74
  • Afzal MR, Haider HKh, Idris NM, Preconditioning promotes survival and angiomyogenic potential of mesenchymal stem cells in the infarcted heart via NF-kappaB signaling. Antioxid Redox Signal 2010;12(6):693-702
  • Haider HKh, Lee YJ, Jiang S, Phosphodiesterase inhibition with tadalafil provides longer and sustained protection of stem cells. Am J Physiol Heart Circ Physiol 2010;299(5):1395-404
  • Kim HW, Haider HK, Jiang S, Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J Biol Chem 2009;284(48):33161-8

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