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The basics and advances of immunomodulators and antigen presentation: a key to development of potent memory response against pathogens

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Bibliography

  • Nicholls EF, Madera L, Hancock RE. Immunomodulators as adjuvants for vaccines and antimicrobial therapy. Ann NY Acad Sci 2010;1213:46-61
  • Freeman BE, Hammarlund E, Raué HP, Slifka MK. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci USA 2012;109(25):9971-6
  • Kim JJ, Yang JS, Dentchev T, et al. Chemokine gene adjuvants can modulate immune responses induced by DNA vaccines. J Interferon Cytokine Res 2000;20(5):487-98
  • Bode C, Zhao G, Steinhagen F, et al. CpG DNA as a vaccine adjuvant. Expert Rev Vaccines 2011;10(4):499-511
  • Hong F, Hansen RD, Yan J, et al. Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Res 2003;63(24):9023-31
  • Terabe M, Berzofsky JA. Immunoregulatory T cells in tumor immunity. Curr Opin Immunol 2004;16(2):157-62
  • Smyth MJ, Hayakawa Y, Takeda K, Yagita H. New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2002;2(11):850-61
  • Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003;3(9):710-20
  • Hoover DM, Rajashankar KR, Blumenthal R, et al. The structure of human beta-defensin-2 shows evidence of higher order oligomerization. J Biol Chem 2000;275(42):32911-18
  • Vora P, Youdim A, Thomas LS, et al. Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J Immunol 2004;173(9):5398-405
  • Hertz CJ, Wu Q, Porter EM, et al. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol 2003;171(12):6820-6
  • Biragyn A, Ruffini PA, Leifer CA, et al. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 2002;298(5595):1025-9
  • Perregaux DG, Bhavsar K, Contillo L, et al. Antimicrobial peptides initiate IL-1 beta posttranslational processing: a novel role beyond innate immunity. J Immunol 2002;168(6):3024-32
  • Niyonsaba F, Ogawa H, Nagaoka I. Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils. Immunology 2004;111(3):273-81
  • Oppenheim JJ, Biragyn A, Kwak LW, Yang D. Roles of antimicrobial peptides such as defensins in innate and adaptive immunity. Ann Rheum Dis 2003;62(Suppl 2):ii17-21
  • Kane CD, Schuch R, Day WA Jr, Maurelli AT. MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion system. J Bacteriol 2002;184(16):4409-19
  • Peschel A, Otto M, Jack RW, et al. Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. J Biol Chem 1999;274(13):8405-10
  • Germain RN. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 1994;76(2):287-99
  • Burgdorf S, Kurts C. Endocytosis mechanisms and the cell biology of antigen presentation. Curr Opin Immunol 2008;20(1):89-95
  • Romagnani S. Th1/Th2 cells. Inflamm Bowel Dis 1999;5(4):285-94
  • Kuhn R, Rajewsky K, Muller W. Generation and analysis of interleukin-4 deficient mice. Science 1991;254(5032):707-10
  • Snapper CM, Peçanha LM, Levine AD, Mond JJ. IgE class switching is critically dependent upon the nature of the B cell activator, in addition to the presence of IL-4. J Immunol 1991;147(4):1163-70
  • Kidd P. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 2003;8(3):223-46
  • Moser M, Murphy KM. Dendritic cell regulation of TH1-TH2 development. Nat Immunol 2000;1(3):199-205
  • Modlin RL. Th1-Th2 paradigm: insights from leprosy. J Invest Dermatol 1994;102(6):828-32
  • Carvalho EM, Bacellar O, Brownell C, et al. Restoration of IFN-gamma production and lymphocyte proliferation in visceral leishmaniasis. J Immunol 1994;152(12):5949-56
  • Ghalib HW, Piuvezam MR, Skeiky YA, et al. Interleukin 10 production correlates with pathology in human Leishmania donovani infections. J Clin Invest 1993;92(1):324-9
  • Pirmez C, Yamamura M, Uyemura K, et al. Cytokine patterns in the pathogenesis of human leishmaniasis. J Clin Invest 1993;91(4):1390-5
  • Surcel HM, Troye-Blomberg M, Paulie S, et al. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens. Immunology 1994;81(2):171-6
  • Seah GT, Scott GM, Rook GA. Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis. J Infect Dis 2000;181(1):385-9
  • Viganó A, Principi N, Villa ML, et al. Immunologic characterization of children vertically infected with human immunodeficiency virus, with slow or rapid disease progression. J Pediatr 1995;126(3):368-74
  • Viganó A, Principi N, Crupi L, et al. Elevation of IgE in HIV-infected children and its correlation with the progression of disease. J Allergy Clin Immunol 1995;95(2):627-32
  • Crotty S, Ahmed R. Immunological memory in humans. Semin Immunol 2004;16(3):197-203
  • Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004;22:745-63
  • Hengel H, Koszinowski UH. Interference with antigen processing by viruses. Curr Opin Immunol 1997;9(4):470-6
  • Rock KL, Goldberg AL. Degradation of cell proteins and the generation of MHC class I-presented peptides. Annu Rev Immunol 1999;17:739-79
  • Levitskaya J, Sharipo A, Leonchiks A, et al. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc Natl Acad Sci USA 1997;94(23):12616-21
  • York IA. Immune evasion strategies of the herpesviruses. Chem Biol 1996;3(5):331-5
  • York IA, Rock KL. Antigen processing and presentation by the class I major histocompatibility complex. Annu Rev Immunol 1996;14:369-96
  • Ahn K, Angulo A, Ghazal P, et al. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process. Proc Natl Acad Sci USA 1996;93(20):10990-5
  • Aiken C, Konner J, Landau NR, et al. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 1994;76(5):853-64
  • Schwartz O, Maréchal V, Le Gall S, et al. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med 1996;2(3):338-42
  • Greenberg ME, Bronson S, Lock M, et al. Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J 1997;16(23):6964-76
  • Collins KL, Chen BK, Kalams SA, et al. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 1998;391(6665):397-401
  • Hoglund P, Sundbäck J, Olsson-Alheim MY, et al. Host MHC class I gene control of NK-cell specificity in the mouse. Immunol Rev 1997;155:11-28
  • Karre K. How to recognize a foreign submarine. Immunol Rev 1997;155:5-9
  • Miller DM, Rahill BM, Boss JM, et al. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. J Exp Med 1998;187(5):675-83
  • Sedmak DD, Guglielmo AM, Knight DA, et al. Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells. Am J Pathol 1994;144(4):683-92
  • Kalvakolanu DV. Virus interception of cytokine-regulated pathways. Trends Microbiol 1999;7(4):166-71
  • Goodbourn S, Didcock L, Randall RE. Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J Gen Virol 2000;81(Pt 10):2341-64
  • Tortorella D, Gewurz BE, Furman MH, et al. Viral subversion of the immune system. Annu Rev Immunol 2000;18:861-926
  • Smith GL, Symons JA, Khanna A, et al. Vaccinia virus immune evasion. Immunol Rev 1997;159:137-54
  • Zdanov A, Schalk-Hihi C, Menon S, et al. Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10. J Mol Biol 1997;268(2):460-7
  • Strockbine LD, Cohen JI, Farrah T, et al. The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor. J Virol 1998;72(5):4015-21
  • Karp CL, Scott IU, Chang TS, Pflugfelder SC. Conjunctival intraepithelial neoplasia. A possible marker for human immunodeficiency virus infection? Arch Ophthalmol 1996;114(3):257-61
  • Spriggs MK. One step ahead of the game: viral immunomodulatory molecules. Annu Rev Immunol 1996;14:101-30
  • Molinari M, Salio M, Galli C, et al. Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA. J Exp Med 1998;187(1):135-40
  • Mota LJ, Cornelis GR. The bacterial injection kit: type III secretion systems. Ann Med 2005;37(4):234-49
  • Viboud GI, Bliska JB. Yersinia outer proteins: role in modulation of host cell signaling responses and pathogenesis. Annu Rev Microbiol 2005;59:69-89
  • Gouin E, Gantelet H, Egile C, et al. A comparative study of the actin-based motilities of the pathogenic bacteria Listeria monocytogenes, Shigella flexneri and Rickettsia conorii. J Cell Sci 1999;112(Pt 11):1697-708
  • Hunt D, Wilson JE, Weih KA, et al. Francisella tularensis elicits IL-10 via a PGE(2)-inducible factor, to drive macrophage MARCH1 expression and class II down-regulation. PLoS One 2012;7(5):e37330
  • Dramsi S, Cossart P. Listeriolysin O: a genuine cytolysin optimized for an intracellular parasite. J Cell Biol 2002;156(6):943-6
  • Newton HJ, Ang DK, van Driel IR, Hartland EL. Molecular pathogenesis of infections caused by Legionella pneumophila. Clin Microbiol Rev 2010;23(2):274-98
  • Gercken J, Pryjma J, Ernst M, Flad HD. Defective antigen presentation by Mycobacterium tuberculosis-infected monocytes. Infect Immun 1994;62(8):3472-8
  • Clemens DL, Horwitz MA. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J Exp Med 1995;181(1):257-70
  • Sturgill-Koszycki S, Schlesinger PH, Chakraborty P, et al. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 1994;263(5147):678-81
  • Chan LL, Cheung BK, Li JC, Lau AS. A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gamma-induced MHC-II molecule on primary human blood macrophages. J Leukoc Biol 2010;88(2):303-11
  • Pai RK, Convery M, Hamilton TA, et al. Inhibition of IFN-gamma-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion. J Immunol 2003;171(1):175-84
  • Pecora ND, Fulton SA, Reba SM, et al. Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection. Cell Immunol 2009;254(2):94-104
  • Harding CV, Boom WH. Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors. Nat Rev Microbiol 2010;8(4):296-307
  • Agrewala JN, Kumar B, Vohra H. Potential role of B7-1 and CD28 molecules in immunosuppression in leprosy. Clin Exp Immunol 1998;111(1):56-63
  • Plotkin SA. Vaccines: past, present and future. Nat Med 2005;11(4 Suppl):S5-11
  • Iyer N, Marathe SA, Chaudhuri D, et al. Immunomodulation using agonists and antagonists: potential clinical applications. Expert Opin Investig Drugs 2012;21(1):67-81
  • Reed SG, Bertholet S, Coler RN, Friede M. New horizons in adjuvants for vaccine development. Trends Immunol 2009;30(1):23-32
  • Morefield GL, Sokolovska A, Jiang D, et al. Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro. Vaccine 2005;23(13):1588-95
  • Rajput ZI, Hu SH, Xiao CW, Arijo AG. Adjuvant effects of saponins on animal immune responses. J Zhejiang Univ Sci B 2007;8(3):153-61
  • Huckriede A, Bungener L, Daemen T, Wilschut J. Influenza virosomes in vaccine development. Methods Enzymol 2003;373:74-91
  • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010;11(5):373-84
  • Baldridge JR, Crane RT. Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines. Methods 1999;19(1):103-7
  • Fujihashi K, Sato S, Kiyono H. Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly. Exp Gerontol 2014;54C:21-6
  • Galli G, Hancock K, Hoschler K, et al. Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine. Proc Natl Acad Sci USA 2009;106(19):7962-7
  • Spickler AR, Roth JA. Adjuvants in veterinary vaccines: modes of action and adverse effects. J Vet Intern Med 2003;17(3):273-81
  • Aucouturier J, Dupuis L, Ganne V. Adjuvants designed for veterinary and human vaccines. Vaccine 2001;19(17-19):2666-72
  • Ott G, Barchfeld GL, Chernoff D, et al. MF59. Design and evaluation of a safe and potent adjuvant for human vaccines. Pharm Biotechnol 1995;6:277-96
  • Rouleau I, De Serres G, Drolet JP, et al. Increased risk of anaphylaxis following administration of 2009 AS03-adjuvanted monovalent pandemic A/H1N1 (H1N1pdm09) vaccine. Vaccine 2013;31(50):5989-96
  • Klucker MF, Dalençon F, Probeck P, Haensler J. AF03, an alternative squalene emulsion-based vaccine adjuvant prepared by a phase inversion temperature method. J Pharm Sci 2012;101(12):4490-500
  • Pichichero ME. Improving vaccine delivery using novel adjuvant systems. Hum Vaccin 2008;4(4):262-70
  • Manns MP, Pockros PJ, Norkrans G, et al. Long-term clearance of hepatitis C virus following interferon alpha-2b or peginterferon alpha-2b, alone or in combination with ribavirin. J Viral Hepat 2013;20(8):524-9
  • Marciano BE, Wesley R, De Carlo ES, et al. Long-term interferon-gamma therapy for patients with chronic granulomatous disease. Clin Infect Dis 2004;39(5):692-9
  • Kuritzkes DR. Neutropenia, neutrophil dysfunction, and bacterial infection in patients with human immunodeficiency virus disease: the role of granulocyte colony-stimulating factor. Clin Infect Dis 2000;30(2):256-60
  • Lofthouse SA, Andrews AE, Elhay MJ, et al. Cytokines as adjuvants for ruminant vaccines. Int J Parasitol 1996;26(8-9):835-42
  • Ahlers JD, Dunlop N, Alling DW, et al. Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs: granulocyte-macrophage colony-stimulating factor and TNF-alpha synergize with IL-12 to enhance induction of cytotoxic T lymphocytes. J Immunol 1997;158(8):3947-58
  • Dockrell DH, Kinghorn GR. Imiquimod and resiquimod as novel immunomodulators. J Antimicrob Chemother 2001;48(6):751-5
  • Batista-Duharte A, Lindblad EB, Oviedo-Orta E. Progress in understanding adjuvant immunotoxicity mechanisms. Toxicol Lett 2011;203(2):97-105
  • Herzog C, Hartmann K, Künzi V, et al. Eleven years of Inflexal V-a virosomal adjuvanted influenza vaccine. Vaccine 2009;27(33):4381-7
  • Bovier PA. Epaxal: a virosomal vaccine to prevent hepatitis A infection. Expert Rev Vaccines 2008;7(8):1141-50
  • Nussler AK, Thomson AW. Immunomodulatory agents in the laboratory and clinic. Parasitology 1992;105(Suppl):S5-23
  • St Georgiev V. Immunomodulatory activity of small peptides. Trends Pharmacol Sci 1990;11(9):373-8
  • Briskin DP. Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiol 2000;124(2):507-14
  • Khan N, Tamboli TE, Sharma VK, Kumar S. Phytochemical and pharmacological aspects of Nothapodytes nimmoniana. Herba Pol 2013;59(1):53-66
  • Xiang-guo L, Yi Zi Y, Xuan-ji J, et al. Ginsenoside content in the leaves and roots of panax ginseng at different ages. Life Sci J 2012;9(4):679-83
  • Bouic PJ. Plant sterols/sterolins for optimum immunity. Positive Health. 2007
  • Fraile L, Crisci E, Córdoba L, et al. Immunomodulatory properties of beta-sitosterol in pig immune responses. Int Immunopharmacol 2012;13(3):316-21
  • Kuduk-Jaworska J, Szpunar J, Gasiorowski K, Brokos B. Immunomodulating polysaccharide fractions of Menyanthes trifoliata L. Z Naturforsch C 2004;59(7-8):485-93
  • Tan BK, Vanitha J. Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review. Curr Med Chem 2004;11(11):1423-30
  • Zhao W, Ye Q, Tan X, et al. Three new sesquiterpene glycosides from Dendrobium nobile with immunomodulatory activity. J Nat Prod 2001;64(9):1196-200
  • Achan J, Talisuna AO, Erhart A, et al. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. Malar J 2011;10:144
  • Sunila ES, Kuttan G. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. J Ethnopharmacol 2004;90(2-3):339-46
  • Ho LJ, Juan TY, Chao P, et al. Plant alkaloid tetrandrine downregulates IκBalpha kinases IκBalpha-NFκB signaling pathway in human peripheral blood T cell. Br J Pharmacol 2004;143:919-27
  • Huang Y, Fang Y, Wu J, et al. Regulation of Vinca alkaloid-induced apoptosis by NF-kappaB/IkappaB pathway in human tumor cells. Mol Cancer Ther 2004;3(3):271-7
  • Cowan MM. Plant products as antimicrobial agents. Clin Microbiol Rev 1999;12(4):564-82
  • Mencherini T, Cau A, Bianco G, et al. An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties. J Pharm Pharmacol 2007;59(6):891-7
  • Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52(4):673-751
  • Kim JS, Jobin C. The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Immunology 2005;115(3):375-87
  • Mishra K, Dash AP, Dey N. Andrographolide: a novel antimalarial diterpene lactone compound from andrographis paniculata and its interaction with curcumin and artesunat. J Trop Med 2011;2011:579518
  • Patel K. A review on herbal immunoadjuvant. Int J Pharm Life Sci 2012;3(3):1568-76
  • Upadhyay AK, Kumar K, Kumar A, Mishra HS. Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Guduchi) - validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res 2010;1(2):112-21
  • More P, Pai K. Immunomodulatory effects of Tinospora cordifolia (Guduchi) on macrophage activation. Biol Med 2011;3(2):134-40
  • Jafarian A, Zolfaghari B, Parnianifard M. The effects of methanolic, chloroform, and ethylacetate extracts of the Cucurbita pepo L. on the delay type hypersensitivity and antibody production. Res Pharm Sci 2012;7(4):217-24
  • Chawla A, Chawla P, Mangalesh Roy RC. Asparagus racemosus (Willd): biological activities & its active principles. Indo-Global J Pharm Sci 2011;1(2):113-20
  • Razdan R, Roy SM. Study of the immunomodulatory activity of a polyherbal drug. Pharmacologyonline 2008;3:336-45
  • Kajaria D, Tripathi JS, Tiwari SK, Pandey BL. In-vitro evaluation of immunomodulatory effect of polyherbal compound – bharangyadi. J Drug Deliv Ther 2013;3(1):36-9
  • Hollman PC, de Vries JH, van Leeuwen SD, et al. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr 1995;62(6):1276-82
  • Patel J, Patel R, Khambholja K, Patel N. An overview of phytosomes as an advanced herbal drug delivery system. Asian J Pharm Sci 2009;4(6):363-71
  • Spelman K, Burns J, Nichols D, et al. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev 2006;11(2):128-50
  • Jang SI, Kim DK, Lillehoj HS, et al. Evaluation of Montanide ISA 71 VG adjuvant during profilin vaccination against experimental coccidiosis. PLoS One 2013;8(4):e59786
  • Mutwiri G, van Drunen Littel-van den Hurk S, Babiuk LA. Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotides. Adv Drug Deliv Rev 2009;61(3):226-32
  • Silva DG, Cooper PD, Petrovsky N. Inulin-derived adjuvants efficiently promote both Th1 and Th2 immune responses. Immunol Cell Biol 2004;82(6):611-16
  • Feinen B, Petrovsky N, Verma A, Merkel TJ. Advax-adjuvanted recombinant protective antigen provides protection against inhalational anthrax that is further enhanced by addition of murabutide adjuvant. Clin Vaccine Immunol 2014;21(4):580-6
  • Lebel MÈ, Daudelin JF, Chartrand K, et al. Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from listeria monocytogenes infection. J Immunol 2014;192(3):1071-8
  • Grover A, Troudt J, Foster C, et al. High mobility group box 1 (HMGB1) acts as an adjuvant for tuberculosis subunit vaccines. Immunology 2014;142(1):111-23
  • Chua BY, Olson MR, Bedoui S, et al. The use of a TLR2 agonist-based adjuvant for enhancing effector and memory CD8 T-cell responses. Immunol Cell Biol 2014;92(4):377-83
  • Kindrachuk J, Jenssen H, Elliott M, et al. A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity. Vaccine 2009;27(34):4662-71
  • Miller MM, Fogle JE, Tompkins MB. Infection with feline immunodeficiency virus directly activates CD4+ CD25+ T regulatory cells. J Virol 2013;87(16):9373-8
  • Brincks EL, Roberts AD, Cookenham T, et al. Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection. J Immunol 2013;190(7):3438-46
  • Luhn K, Simmons CP, Moran E, et al. Increased frequencies of CD4+ CD25(high) regulatory T cells in acute dengue infection. J Exp Med 2007;204(5):979-85
  • Bayry J. Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy. Virusdisease 2014;25(1):18-25
  • Han S, Quach T, Hu L, et al. Targeted delivery of a model immunomodulator to the lymphatic system: comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies. J Control Release 2014;177C:1-10
  • Reed SG, Orr MT, Fox CB. Key roles of adjuvants in modern vaccines. Nat Med 2013;19(12):1597-608
  • Devillea S, Carneaux E, Bertranda F, et al. Adjuvant formulation for companion animals vaccines. Procedia Vaccinol 2011;4:104-12

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