Fecal microbiota transplantation for Clostridium difficile infection: back to the future

Bibliography

• Burke KE, Lamont JT. Clostridium difficile infection: a worldwide disease. Gut Liver 2014;8:1-6
   PubMed Web of Science ®Google Scholar
• Hall I, O’Toole E. Intestinal flora in newborn infants with a description of a new pathogenic anaerobe, bacillus difficilis. Am J Dis Child 1935;49:309-402
   Google Scholar
• Bassetti M, Villa G, Pecori D, et al. Epidemiology, diagnosis and treatment of Clostridium difficile infection. Expert Rev Anti Infect Ther 2012;10:1405-23
   PubMed Web of Science ®Google Scholar
• Bartlett JG, Chang TW, Gurwith M, et al. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med 1978;298:531-4
   PubMed Web of Science ®Google Scholar
• Rupnik M, Wilcox MH, Gerding DN. Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol 2009;7:526-36
   PubMed Web of Science ®Google Scholar
• Yakob L, Riley TV, Paterson DL, et al. Clostridium difficile exposure as an insidious source of infection in healthcare settings: an epidemiological model. BMC Infect Dis 2013;13:1471-2334
   Google Scholar
• Bobulsky GS, Al-Nassir WN, Riggs MM, et al. Clostridium difficile skin contamination in patients with C. difficile-associated disease. Clin Infect Dis 2008;46:447-50
   PubMed Web of Science ®Google Scholar
• Eyre DW, Cule ML, Wilson DJ, et al. Diverse sources of C. difficile infection identified on whole-genome sequencing. N Engl J Med 2013;369:1195-205
   PubMed Web of Science ®Google Scholar
• Poutanen SM, Simor AE. Clostridium difficile-associated diarrhea in adults. Cmaj 2004;171:51-8
   PubMed Web of Science ®Google Scholar
• Sunenshine RH, McDonald LC. Clostridium difficile-associated disease: new challenges from an established pathogen. Cleve Clin J Med 2006;73:187-97
   PubMed Web of Science ®Google Scholar
• Davies KA, Longshaw CM, Davis GL, et al. Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID). Lancet Infect Dis 2014;14:1208-19
   PubMed Web of Science ®Google Scholar
• Kelly CP, LaMont JT. Clostridium difficile - more difficult than ever. N Engl J Med 2008;359:1932-40
   PubMed Web of Science ®Google Scholar
• Magill SS, Edwards JR, Bamberg W, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med 2014;370:1198-208
   PubMed Web of Science ®Google Scholar
• Miller BA, Chen LF, Sexton DJ, et al. Comparison of the burdens of hospital-onset, healthcare facility-associated Clostridium difficile Infection and of healthcare-associated infection due to methicillin-resistant Staphylococcus aureus in community hospitals. Infect Control Hosp Epidemiol 2011;32:387-90
   PubMed Web of Science ®Google Scholar
• Lucado J, Gould C, Elixhauser A. Clostridium difficile Infections (CDI) in Hospital Stays, 2009: Statistical Brief #124. In: Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville (MD): Agency for Health Care Policy and Research (US): 2006-2012
   Google Scholar
• Gupta A, Khanna S. Community-acquired Clostridium difficile infection: an increasing public health threat. Infect Drug Resist 2014;7:63-72
   PubMed Web of Science ®Google Scholar
• He M, Miyajima F, Roberts P, et al. Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nat Genet 2013;45:109-13
   PubMed Web of Science ®Google Scholar
• Hall AJ, Curns AT, McDonald LC, et al. The roles of Clostridium difficile and norovirus among gastroenteritis-associated deaths in the United States, 1999-2007. Clin Infect Dis 2012;55:216-23
   PubMed Web of Science ®Google Scholar
• Collins DA, Hawkey PM, Riley TV. Epidemiology of Clostridium difficile infection in Asia. Antimicrob Resist Infect Control 2013;2:2047-994
   Google Scholar
• Surawicz CM, Brandt LJ, Binion DG, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol 2013;108:478-98
   PubMed Web of Science ®Google Scholar
• Bouza E. Consequences of Clostridium difficile infection: understanding the healthcare burden. Clin Microbiol Infect 2012;6:5-12
   Google Scholar
• Fitzpatrick F, Barbut F. Breaking the cycle of recurrent Clostridium difficile infections. Clin Microbiol Infect 2012;18(Suppl 6):2-4
   PubMedGoogle Scholar
• Debast SB, Bauer MP, Kuijper EJ. European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Clin Microbiol Infect 2014;2:1-26
   Google Scholar
• Kelly CP. Can we identify patients at high risk of recurrent Clostridium difficile infection? Clin Microbiol Infect 2012;6:21-7
   Google Scholar
• McFarland LV, Surawicz CM, Rubin M, et al. Recurrent Clostridium difficile disease: epidemiology and clinical characteristics. Infect Control Hosp Epidemiol 1999;20:43-50
   PubMed Web of Science ®Google Scholar
• Borody TJ, Campbell J. Fecal microbiota transplantation: techniques, applications, and issues. Gastroenterol Clin North Am 2012;41:781-803
   PubMed Web of Science ®Google Scholar
• Chang JY, Antonopoulos DA, Kalra A, et al. Decreased diversity of the fecal Microbiome in recurrent Clostridium difficile-associated diarrhea. J Infect Dis 2008;197:435-8
   PubMed Web of Science ®Google Scholar
• Singh R, Nieuwdorp M, ten Berge IJ, et al. The potential beneficial role of faecal microbiota transplantation in diseases other than Clostridium difficile infection. Clin Microbiol Infect 2014;20:1119-25
   PubMed Web of Science ®Google Scholar
• Zhang F, Luo W, Shi Y, et al. Should we standardize the 1,700-year-old fecal microbiota transplantation? Am J Gastroenterol 2012;107:1755
   PubMed Web of Science ®Google Scholar
• Ley RE, Lozupone CA, Hamady M, et al. Worlds within worlds: evolution of the vertebrate gut microbiota. Nat Rev Microbiol 2008;6:776-88
   PubMed Web of Science ®Google Scholar
• Borody TJ, Warren EF, Leis SM, et al. Bacteriotherapy using fecal flora: toying with human motions. J Clin Gastroenterol 2004;38:475-83
   PubMed Web of Science ®Google Scholar
• Lewin RA. Merde: excursions in scientific, cultural and socio-historical coprology. Random House; New York: 1999
   Google Scholar
• Eiseman B, Silen W, Bascom GS, et al. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery 1958;44:854-9
   PubMed Web of Science ®Google Scholar
• Schwan A, Sjolin S, Trottestam U, et al. Relapsing Clostridium difficileenterocolitis cured by rectal infusion of homologous faeces. Lancet 1983;2(8354):845
   PubMed Web of Science ®Google Scholar
• Aroniadis OC, Brandt LJ. Fecal microbiota transplantation: past, present and future. Curr Opin Gastroenterol 2013;29:79-84
   PubMed Web of Science ®Google Scholar
• Aas J, Gessert CE, Bakken JS. Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube. Clin Infect Dis 2003;36:580-5
   PubMed Web of Science ®Google Scholar
• Persky SE, Brandt LJ. Treatment of recurrent Clostridium difficile-associated diarrhea by administration of donated stool directly through a colonoscope. Am J Gastroenterol 2000;95:3283-5
   PubMed Web of Science ®Google Scholar
• Silverman MS, Davis I, Pillai DR. Success of self-administered home fecal transplantation for chronic Clostridium difficile infection. Clin Gastroenterol Hepatol 2010;8:471-3
   PubMed Web of Science ®Google Scholar
• Fujimura KE, Slusher NA, Cabana MD, et al. Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther 2010;8:435-54
   PubMed Web of Science ®Google Scholar
• Aziz Q, Dore J, Emmanuel A, et al. Gut microbiota and gastrointestinal health: current concepts and future directions. Neurogastroenterol Motil 2013;25:4-15
   PubMed Web of Science ®Google Scholar
• Sekirov I, Russell SL, Antunes LC, et al. Gut microbiota in health and disease. Physiol Rev 2010;90:859-904
   PubMed Web of Science ®Google Scholar
• Dominguez-Bello MG, Blaser MJ, Ley RE, et al. Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology 2011;140:1713-19
   PubMed Web of Science ®Google Scholar
• Eckburg PB, Bik EM, Bernstein CN, et al. Diversity of the human intestinal microbial flora. Science 2005;308:1635-8
   PubMed Web of Science ®Google Scholar
• Rajilic-Stojanovic M, Heilig HG, Tims S, et al. Long-term monitoring of the human intestinal microbiota composition. Environ Microbiol 2012;15:1462-2920
   Google Scholar
• Faith JJ, Guruge JL, Charbonneau M, et al. The long-term stability of the human gut microbiota. Science 2013;341:1237439
   PubMed Web of Science ®Google Scholar
• Bruggemann H, Gottschalk G. Comparative genomics of clostridia: link between the ecological niche and cell surface properties. Ann NY AcadSci 2008;1125:73-81
   PubMed Web of Science ®Google Scholar
• Britton RA, Young VB. Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance. Trends Microbiol 2012;20:313-19
   PubMed Web of Science ®Google Scholar
• Bien J, Palagani V, Bozko P. The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease? Therap Adv Gastroenterol 2013;6:53-68
   PubMed Web of Science ®Google Scholar
• Hawrelak JA, Myers SP. The causes of intestinal dysbiosis: a review. Altern Med Rev 2004;9:180-97
   PubMedGoogle Scholar
• Sullivan A, Edlund C, Nord CE. Effect of antimicrobial agents on the ecological balance of human microflora. Lancet Infect Dis 2001;1:101-14
   PubMedGoogle Scholar
• Dial S, Delaney JA, Barkun AN, et al. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. Jama 2005;294:2989-95
   PubMed Web of Science ®Google Scholar
• Bibbo S, Lopetuso LR, Ianiro G, et al. Role of microbiota and innate immunity in recurrent Clostridium difficile infection. J Immunol Res 2014;2014:462740
   PubMed Web of Science ®Google Scholar
• Freter R. The fatal enteric cholera infection in the guinea pig, achieved by inhibition of normal enteric flora. J Infect Dis 1955;97:57-65
   PubMed Web of Science ®Google Scholar
• Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. N Engl J Med 2002;346:334-9
   PubMed Web of Science ®Google Scholar
• Bartlett JG. Clostridium difficile: progress and challenges. Ann NY Acad Sci 2010;1213:62-9
   PubMed Web of Science ®Google Scholar
• Stevens V, Dumyati G, Fine LS, et al. Cumulative antibiotic exposures over time and the risk of Clostridium difficile infection. Clin Infect Dis 2011;53:42-8
   PubMed Web of Science ®Google Scholar
• Borody TJ, Brandt LJ, Paramsothy S, et al. Fecal microbiota transplantation: a new standard treatment option for Clostridium difficile infection: Expert Rev Anti Infect Ther. 2013;11(5):447-9
   Google Scholar
• Johnson S, Louie TJ, Gerding DN, et al. Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials. Clin Infect Dis 2014;59:345-54
   PubMed Web of Science ®Google Scholar
• Wilcox MH. Editorial Commentary: the trials and tribulations of treating Clostridium difficile infection-one step backward, one step forward, but still progress. Clin Infect Dis 2014;59:355-7
   PubMed Web of Science ®Google Scholar
• Agito MD, Atreja A, Rizk MK. Fecal microbiota transplantation for recurrent C. difficile infection: ready for prime time? Cleve Clin J Med 2013;80:101-8
   PubMed Web of Science ®Google Scholar
• Khoruts A, Dicksved J, Jansson JK, et al. Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. J Clin Gastroenterol 2010;44:354-60
   PubMed Web of Science ®Google Scholar
• Fuentes S, van Nood E, Tims S, et al. Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent Clostridium difficile infection. Isme J 2014;8:1621-33
   PubMed Web of Science ®Google Scholar
• van Nood E, Dijkgraaf MG, Keller JJ. Duodenal infusion of feces for recurrent Clostridium difficile. N Engl J Med 2013;368:2145
   PubMed Web of Science ®Google Scholar
• Petrof EO, Khoruts A. From stool transplants to next-generation microbiota therapeutics. Gastroenterology 2014;146:1573-82
   PubMed Web of Science ®Google Scholar
• Britton RA, Young VB. Role of the intestinal microbiota in resistance to colonization by Clostridium difficile. Gastroenterology 2014;146:1547-53
   PubMed Web of Science ®Google Scholar
• Freter R, Brickner H, Botney M, et al. Mechanisms that control bacterial populations in continuous-flow culture models of mouse large intestinal flora. Infect Immun 1983;39:676-85
   PubMed Web of Science ®Google Scholar
• Sambol SP, Merrigan MM, Tang JK, et al. Colonization for the prevention of Clostridium difficile disease in hamsters. J Infect Dis 2002;186:1781-9
   PubMed Web of Science ®Google Scholar
• Vincent C, Stephens DA, Loo VG, et al. Reductions in intestinal Clostridiales precede the development of nosocomial Clostridium difficile infection. Microbiome 2013;1:2049-618
   Google Scholar
• Rea MC, Dobson A, O’Sullivan O, et al. Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a model of the distal colon. Proc Natl Acad Sci USA 2011;108(Suppl 1):4639-44
   PubMed Web of Science ®Google Scholar
• Weingarden AR, Chen C, Bobr A, et al. Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection. Am J Physiol Gastrointest Liver Physiol 2014;306:310-19
   PubMed Web of Science ®Google Scholar
• Sorg JA, Sonenshein AL. Bile salts and glycine as cogerminants for Clostridium difficile spores. J Bacteriol 2008;190:2505-12
   PubMed Web of Science ®Google Scholar
• Hofmann AF, Hagey LR. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci 2008;65:2461-83
   PubMed Web of Science ®Google Scholar
• Sorg JA, Sonenshein AL. Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination. J Bacteriol 2009;191:1115-17
   PubMed Web of Science ®Google Scholar
• Giel JL, Sorg JA, Sonenshein AL, et al. Metabolism of bile salts in mice influences spore germination in Clostridium difficile. PLoS One 2010;5:e8740
   PubMed Web of Science ®Google Scholar
• Peniche AG, Savidge TC, Dann SM. Recent insights into Clostridium difficile pathogenesis. Curr Opin Infect Dis 2013;26:447-53
   PubMed Web of Science ®Google Scholar
• Macpherson AJ, McCoy KD. Stratification and compartmentalisation of immunoglobulin responses to commensal intestinal microbes. Semin Immunol 2013;25:358-63
   Google Scholar
• Kelly CP, Kyne L. The host immune response to Clostridium difficile. J Med Microbiol 2011;60:1070-9
   PubMed Web of Science ®Google Scholar
• Ryan A, Lynch M, Smith SM, et al. A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins. PLoS Pathog 2011;7:e1002076
   PubMed Web of Science ®Google Scholar
• Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004;118:229-41
   PubMed Web of Science ®Google Scholar
• Lawley TD, Clare S, Walker AW, et al. Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog 2012;8:e1002995
   PubMed Web of Science ®Google Scholar
• Brandt LJ, Aroniadis OC. An overview of fecal microbiota transplantation: techniques, indications, and outcomes. Gastrointest Endosc 2013;78:240-9
   PubMed Web of Science ®Google Scholar
• Bakken JS, Borody T, Brandt LJ, et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol 2011;9:1044-9
   PubMed Web of Science ®Google Scholar
• Lagier JC. Faecal microbiota transplantation: from practice to legislation before considering industrialization. Clin Microbiol Infect 2014;20:1112-18
   PubMed Web of Science ®Google Scholar
• Kapel N, Thomas M, Corcos O, et al. Practical implementation of faecal transplantation. Clin Microbiol Infect 2014;20:1098-105
   PubMed Web of Science ®Google Scholar
• Owens C, Broussard E, Surawicz C. Fecal microbiota transplantation and donor standardization. Trends Microbiol 2013;21:443-5
   PubMed Web of Science ®Google Scholar
• Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin Infect Dis 2011;53:994-1002
   PubMed Web of Science ®Google Scholar
• Kassam Z, Lee CH, Hunt RH. Review of the emerging treatment of Clostridium difficile infection with fecal microbiota transplantation and insights into future challenges. Clin Lab Med 2014;34:787-98
   PubMed Web of Science ®Google Scholar
• Youngster I, Sauk J, Pindar C, et al. Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: a randomized, open-label, controlled pilot study. Clin Infect Dis 2014;58:1515-22
   PubMed Web of Science ®Google Scholar
• Youngster I, Russell GH, Pindar C, et al. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. Jama 2014;312:1772-8
   PubMed Web of Science ®Google Scholar
• Dinleyici EC, Eren M, Ozen M, et al. Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea. Expert Opin Biol Ther 2012;12:395-410
   PubMed Web of Science ®Google Scholar
• Zipursky JS, Sidorsky TI, Freedman CA, et al. Patient attitudes toward the use of fecal microbiota transplantation in the treatment of recurrent Clostridium difficile infection. Clin Infect Dis 2012;55:1652-8
   PubMed Web of Science ®Google Scholar
• Zipursky JS, Sidorsky TI, Freedman CA, et al. Physician attitudes toward the use of fecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection. Can J Gastroenterol Hepatol 2014;28:319-24
   PubMed Web of Science ®Google Scholar
• Duke PS, Fardy J. Recurrent Clostridium difficile infection treated with home fecal transplantation: a case report. J Med Case Rep 2014;8:1752-947
   Google Scholar
• Wilson DE, Chosewood LC. Biosafety in Microbiological and Biomedical Laboratories, (BMBL), Centers for Disease Control and Prevention/National Institute of Health. 5th edition. U.S. Government Printing Office; Washington, DC: 2009
   Google Scholar
• Zanella Terrier MC, Simonet ML, et al. Recurrent Clostridium difficile infections: the importance of the intestinal microbiota. World J Gastroenterol 2014;20:7416-23
   PubMed Web of Science ®Google Scholar
• Vyas D, L’Esperance H E, Vyas A. Stool therapy may become a preferred treatment of recurrent Clostridium difficile? World J Gastroenterol 2013;19:4635-7
   PubMed Web of Science ®Google Scholar
• Cammarota G, Ianiro G, Gasbarrini A. Fecal microbiota transplantation for the treatment of Clostridium difficile infection: a systematic review. J Clin Gastroenterol 2014;48:693-702
   PubMed Web of Science ®Google Scholar
• Konijeti GG, Sauk J, Shrime MG, et al. Cost-effectiveness of competing strategies for management of recurrent Clostridium difficile infection: a decision analysis. Clin Infect Dis 2014;58:1507-14
   PubMed Web of Science ®Google Scholar
• Varier RU, Biltaji E, Smith KJ, et al. Cost-effectiveness analysis of treatment strategies for initial Clostridium difficile infection. Clin Microbiol Infect 2014;20:1343-51
   PubMedGoogle Scholar
• Kelly CR, Ihunnah C, Fischer M, et al. Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients. Am J Gastroenterol 2014;109:1065-71
   PubMed Web of Science ®Google Scholar
• Brandt LJ. American Journal of Gastroenterology Lecture: intestinal microbiota and the role of fecal microbiota transplant (FMT) in treatment of C. difficile infection. Am J Gastroenterol 2013;108:177-85
   PubMed Web of Science ®Google Scholar
• De Leon LM, Watson JB, Kelly CR. Transient flare of ulcerative colitis after fecal microbiota transplantation for recurrent Clostridium difficile infection. Clin Gastroenterol Hepatol 2013;11:1036-8
   PubMed Web of Science ®Google Scholar
• Koenigsknecht MJ, Young VB. Faecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection: current promise and future needs. Curr Opin Gastroenterol 2013;29:628-32
   PubMed Web of Science ®Google Scholar
• Austin M, Mellow M, Tierney WM. Fecal microbiota transplantation in the treatment of Clostridium difficile infections. Am J Med 2014;127:479-83
   PubMed Web of Science ®Google Scholar
• Petrof EO, Claud EC, Gloor GB, et al. Microbial ecosystems therapeutics: a new paradigm in medicine? Benef Microbes 2013;4:53-65
   PubMed Web of Science ®Google Scholar
• Tvede M, Rask-Madsen J. Bacteriotherapy for chronic relapsing Clostridium difficilediarrhoea in six patients. Lancet 1989;1:1156-60
   PubMed Web of Science ®Google Scholar
• Petrof EO, Gloor GB, Vanner SJ, et al. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ’RePOOPulating’ the gut. Microbiome 2013;1:2049-618
   Google Scholar
• Adamu BO, Lawley TD. Bacteriotherapy for the treatment of intestinal dysbiosis caused by Clostridium difficile infection. Curr Opin Microbiol 2013;16:596-601
   PubMed Web of Science ®Google Scholar
• Bagdasarian N, Rao K, Malani PN. Diagnosis and treatment of Clostridium difficile in adults: a systematic review. Jama 2015;313:398-408
   PubMed Web of Science ®Google Scholar
• Borody TJ, Peattie D, Kapur A. Could fecal microbiota transplantation cure all Clostridium difficile infections? Future Microbiol 2014;9:1-3
   PubMed Web of Science ®Google Scholar
• Khoruts A. Faecal microbiota transplantation in 2013: developing human gut microbiota as a class of therapeutics. Nat Rev Gastroenterol Hepatol 2014;11:79-80
   Google Scholar
• Cornely OA. Current and emerging management options for Clostridium difficile infection: what is the role of fidaxomicin? Clin Microbiol Infect 2012;6:28-35
   Google Scholar
• Cornely OA, Nathwani D, Ivanescu C, et al. Clinical efficacy of fidaxomicin compared with vancomycin and metronidazole in Clostridium difficile infections: a meta-analysis and indirect treatment comparison. J Antimicrob Chemother 2014;69:2892-900
   PubMed Web of Science ®Google Scholar
• Bartsch SM, Umscheid CA, Fishman N, et al. Is fidaxomicin worth the cost? An economic analysis. Clin Infect Dis 2013;57:555-61
   PubMed Web of Science ®Google Scholar
• Vassallo A, Tran MC, Goldstein EJ. Clostridium difficile: improving the prevention paradigm in healthcare settings. Expert Rev Anti Infect Ther 2014;12:1087-102
   PubMed Web of Science ®Google Scholar
• De Palma M, Grillo M, Borgia G, et al. Antibiotic prophylaxis and risk of infections in thyroid surgery: results from a national study (UEC-Italian Endocrine Surgery Units Association). Updates Surg 2013;65:213-16
   PubMedGoogle Scholar
• Gentile I, Rosato L, Avenia N, et al. Do Italian surgeons use antibiotic prophylaxis in thyroid surgery? Results from a national study (UEC--Italian Endocrine Surgery Units Association). Ann Ital Chir 2014;85:33-7
   PubMed Web of Science ®Google Scholar
• Abou Chakra CN, Pepin J, Sirard S, et al. Risk factors for recurrence, complications and mortality in Clostridium difficile infection: a systematic review. PLoS One 2014;9:e98400
   PubMed Web of Science ®Google Scholar
• Garborg K, Waagsbo B, Stallemo A, et al. Results of faecal donor instillation therapy for recurrent Clostridium difficile-associated diarrhoea. Scand J Infect Dis 2010;42:857-61
   PubMed Web of Science ®Google Scholar
• Mattila E, Uusitalo-Seppala R, Wuorela M, et al. Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection. Gastroenterology 2012;142:490-6
   PubMed Web of Science ®Google Scholar
• Brandt LJ, Aroniadis OC, Mellow M, et al. Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection. Am J Gastroenterol 2012;107:1079-87
   PubMed Web of Science ®Google Scholar
• Jorup-Ronstrom C, Hakanson A, Sandell S, et al. Fecal transplant against relapsing Clostridium difficile-associated diarrhea in 32 patients. Scand J Gastroenterol 2012;47:548-52
   PubMed Web of Science ®Google Scholar
• Rubin TA, Gessert CE, Aas J, et al. Fecal microbiome transplantation for recurrent Clostridium difficile infection: report on a case series. Anaerobe 2013;19:22-6
   PubMed Web of Science ®Google Scholar
• Terwee CB, Mokkink LB, Knol DL, et al. Rating the methodological quality in systematic reviews of studies on measurement properties: a scoring system for the COSMIN checklist. Qual Life Res 2012;21:651-7
   PubMed Web of Science ®Google Scholar