Using stem cells to produce insulin

Bibliography

• Soria B, Roche E, Berna G, et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000;49:157-62
   PubMed Web of Science ®Google Scholar
• ViaCyte I. ViaCyte’s VC-01™ investigational stem cell-derived islet replacement therapy successfully implanted into first patient. 2014
   Google Scholar
• Pagliuca FW, Millman JR, Gurtler M, et al. Generation of functional human pancreatic beta cells in vitro. Cell 2014;159:428-39
   PubMed Web of Science ®Google Scholar
• Pezzolla D, López-Beas J, Lachaud CC, et al. Resveratrol ameliorates the maturation process of β-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells. PLoS One 2015;10:e0119904
   Google Scholar
• Rezania A, Bruin JE, Arora P, et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat Biotechnol 2014;32:1121-33
   PubMed Web of Science ®Google Scholar
• Russ HA, Parent AV, Ringler JJ, et al. Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. EMBO J 2015. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Leon-Quinto T, Jones J, Skoudy A, et al. In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells. Diabetologia 2004;47:1442-51
   PubMed Web of Science ®Google Scholar
• Vaca P, Martin F, Vegara-Meseguer JM, et al. Induction of differentiation of embryonic stem cells into insulin-secreting cells by fetal soluble factors. Stem Cells 2006;24:258-65
   PubMed Web of Science ®Google Scholar
• Lumelsky N, Blondel O, Laeng P, et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001;292:1389-94
   PubMed Web of Science ®Google Scholar
• Roche E, Jones J, Arribas MI, et al. Role of small bioorganic molecules in stem cell differentiation to insulin-producing cells. Bioorg Med Chem 2006;14:6466-74
   PubMed Web of Science ®Google Scholar
• Hori Y, Rulifson IC, Tsai BC, et al. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci USA 2002;99:16105-10
   PubMed Web of Science ®Google Scholar
• Blyszczuk P, Czyz J, Kania G, et al. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci USA 2003;100:998-1003
   PubMed Web of Science ®Google Scholar
• Soria B. In-vitro differentiation of pancreatic beta-cells. Differentiation 2001;68:205-19
   PubMed Web of Science ®Google Scholar
• Soria B, Quesada I, Ropero AB, et al. Novel players in pancreatic islet signaling: from membrane receptors to nuclear channels. Diabetes 2004;53(Suppl 1):S86-91
   Google Scholar
• Soria B, Roche E, Reig JA, Martin F. Generation of insulin-producing cells from stem cells. Novartis Found Symp 2005;265:158-67; discussion 167-73, 204-11
   PubMedGoogle Scholar
• Murry CE, Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 2008;132:661-80
   PubMed Web of Science ®Google Scholar
• Rojas A, Khoo A, Tejedo JR, et al. Islet cell development. Adv Exp Med Biol 2010;654:59-75
   PubMed Web of Science ®Google Scholar
• Nair G, Hebrok M. Islet formation in mice and men: lessons for the generation of functional insulin-producing beta-cells from human pluripotent stem cells. Curr Opin Genet Dev 2015;32:171-80
   PubMed Web of Science ®Google Scholar
• D’Amour KA, Agulnick AD, Eliazer S, et al. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 2005;23:1534-41
   PubMed Web of Science ®Google Scholar
• Banting FG, Best CH, Collip JB, et al. Pancreatic Extracts in the Treatment of Diabetes Mellitus. Can Med Assoc J 1922;12:141-6
   PubMedGoogle Scholar
• Pertusa JA, Sanchez-Andres JV, Martin F, Soria B. Effects of calcium buffering on glucose-induced insulin release in mouse pancreatic islets: an approximation to the calcium sensor. J Physiol 1999;520(Pt 2):473-83
   PubMed Web of Science ®Google Scholar
• Andreu E, Soria B, Sanchez-Andres JV. Oscillation of gap junction electrical coupling in the mouse pancreatic islets of Langerhans. J Physiol 1997;498(Pt 3):753-61
   PubMed Web of Science ®Google Scholar
• Quesada I, Rovira JM, Martin F, et al. Nuclear KATP channels trigger nuclear Ca(2+) transients that modulate nuclear function. Proc Natl Acad Sci USA 2002;99:9544-9
   PubMed Web of Science ®Google Scholar
• Soria B, Navas S, Hmadcha A, Hamill OP. Single mechanosensitive and Ca(2)(+)-sensitive channel currents recorded from mouse and human embryonic stem cells. J Membr Biol 2013;246:215-30
   PubMed Web of Science ®Google Scholar
• Vegara-Meseguer JM, Perez-Sanchez H, Araujo R, et al. L-type Ca channels and SK channels in mouse embryonic stem cells and their contribution to cell proliferation. J Membr Biol 2015; Epub ahead of print
   PubMed Web of Science ®Google Scholar
• Todorova MG, Soria B, Quesada I. Gap junctional intercellular communication is required to maintain embryonic stem cells in a non-differentiated and proliferative state. J Cell Physiol 2008;214:354-62
   PubMed Web of Science ®Google Scholar
• Mora-Castilla S, Tejedo JR, Tapia-Limonchi R, et al. Transient downregulation of nanog and Oct4 induced by DETA/NO exposure in mouse embryonic stem cells leads to mesodermal/endodermal lineage differentiation. Stem Cells Int 2014;2014:379678
   PubMedGoogle Scholar
• D’Amour KA, Bang AG, Eliazer S, et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006;24:1392-401
   PubMed Web of Science ®Google Scholar
• Ruhnke M, Ungefroren H, Nussler A, et al. Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology 2005;128:1774-86
   PubMed Web of Science ®Google Scholar
• Karaoz E, Okcu A, Unal ZS, et al. Adipose tissue-derived mesenchymal stromal cells efficiently differentiate into insulin-producing cells in pancreatic islet microenvironment both in vitro and in vivo. Cytotherapy 2013;15:557-70
   PubMed Web of Science ®Google Scholar
• Cano DA, Soria B, Martin F, Rojas A. Transcriptional control of mammalian pancreas organogenesis. Cell Mol Life Sci 2014;71:2383-402
   PubMed Web of Science ®Google Scholar
• Shih HP, Wang A, Sander M. Pancreas organogenesis: from lineage determination to morphogenesis. Annu Rev Cell Dev Biol 2013;29:81-105
   PubMed Web of Science ®Google Scholar
• Ang SL, Wierda A, Wong D, et al. The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 1993;119:1301-15
   PubMed Web of Science ®Google Scholar
• Kanai-Azuma M, Kanai Y, Gad JM, et al. Depletion of definitive gut endoderm in Sox17-null mutant mice. Development 2002;129:2367-79
   PubMed Web of Science ®Google Scholar
• Patient RK, McGhee JD. The GATA family (vertebrates and invertebrates). Curr Opin Genet Dev 2002;12:416-22
   PubMed Web of Science ®Google Scholar
• Grapin-Botton A, Melton DA. Endoderm development: from patterning to organogenesis. Trends Genet 2000;16:124-30
   PubMed Web of Science ®Google Scholar
• Kumar M, Melton D. Pancreas specification: a budding question. Curr Opin Genet Dev 2003;13:401-7
   PubMed Web of Science ®Google Scholar
• Stainier DY. A glimpse into the molecular entrails of endoderm formation. Genes Dev 2002;16:893-907
   PubMed Web of Science ®Google Scholar
• Wells JM, Melton DA. Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 2000;127:1563-72
   PubMed Web of Science ®Google Scholar
• Lawson KA, Meneses JJ, Pedersen RA. Cell fate and cell lineage in the endoderm of the presomite mouse embryo, studied with an intracellular tracer. Dev Biol 1986;115:325-39
   PubMed Web of Science ®Google Scholar
• Deutsch G, Jung J, Zheng M, et al. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 2001;128:871-81
   PubMed Web of Science ®Google Scholar
• Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 1998;12:1705-13
   PubMed Web of Science ®Google Scholar
• Martin M, Gallego-Llamas J, Ribes V, et al. Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol 2005;284:399-411
   PubMed Web of Science ®Google Scholar
• Rossi JM, Dunn NR, Hogan BL, Zaret KS. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev 2001;15:1998-2009
   PubMed Web of Science ®Google Scholar
• Guz Y, Montminy MR, Stein R, et al. Expression of murine STF-1, a putative insulin gene transcription factor, in b cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 1995;121:149-61
   PubMed Web of Science ®Google Scholar
• Offield MF, Jetton TL, Labosky PA, et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 1996;122:983-95
   PubMed Web of Science ®Google Scholar
• Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994;371:606-9
   PubMed Web of Science ®Google Scholar
• Stoffers DA, Zinkin NT, Stanojevic V, et al. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 1997;15:106-10
   PubMed Web of Science ®Google Scholar
• Krapp A, Knofler M, Ledermann B, et al. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev 1998;12:3752-63
   PubMed Web of Science ®Google Scholar
• Sellick GS, Barker KT, Stolte-Dijkstra I, et al. Mutations in PTF1A cause pancreatic and cerebellar agenesis. Nat Genet 2004;36:1301-5
   PubMed Web of Science ®Google Scholar
• Allen HL, Flanagan SE, Shaw-Smith C, et al. GATA6 haploinsufficiency causes pancreatic agenesis in humans. Nat Genet 2011;44:20-2
   PubMed Web of Science ®Google Scholar
• Carrasco M, Delgado I, Soria B, et al. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest 2012;122:3504-15
   PubMed Web of Science ®Google Scholar
• Xuan S, Borok MJ, Decker KJ, et al. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest 2012;122:3516-28
   PubMed Web of Science ®Google Scholar
• Jorgensen MC, Ahnfelt-Ronne J, Hald J, et al. An illustrated review of early pancreas development in the mouse. Endocr Rev 2007;28:685-705
   PubMed Web of Science ®Google Scholar
• Apelqvist A, Li H, Sommer L, et al. Notch signalling controls pancreatic cell differentiation. Nature 1999;400:877-81
   PubMed Web of Science ®Google Scholar
• Jensen J, Pedersen EE, Galante P, et al. Control of endodermal endocrine development by Hes-1. Nat Genet 2000;24:36-44
   PubMed Web of Science ®Google Scholar
• Schwitzgebel VM, Scheel DW, Conners JR, et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 2000;127:3533-42
   PubMed Web of Science ®Google Scholar
• Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002;129:2447-57
   PubMed Web of Science ®Google Scholar
• Gradwohl G, Dierich A, LeMeur M, Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 2000;97:1607-11
   PubMed Web of Science ®Google Scholar
• Mastracci TL, Sussel L. The endocrine pancreas: insights into development, differentiation, and diabetes. Wiley Interdiscip Rev Dev Biol 2012;1:609-28
   Google Scholar
• Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. Dev Dyn 2011;240:530-65
   PubMed Web of Science ®Google Scholar
• Smith SB, Qu HQ, Taleb N, et al. Rfx6 directs islet formation and insulin production in mice and humans. Nature 2010;463:775-80
   PubMed Web of Science ®Google Scholar
• Soyer J, Flasse L, Raffelsberger W, et al. Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development 2010;137:203-12
   PubMed Web of Science ®Google Scholar
• Chandra V, Albagli-Curiel O, Hastoy B, et al. RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human beta cells. Cell Rep 2014;9:2206-18
   PubMed Web of Science ®Google Scholar
• Piccand J, Strasser P, Hodson DJ, et al. Rfx6 maintains the functional identity of adult pancreatic beta cells. Cell Rep 2014;9:2219-32
   PubMed Web of Science ®Google Scholar
• Collombat P, Hecksher-Sorensen J, Broccoli V, et al. The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development 2005;132:2969-80
   PubMed Web of Science ®Google Scholar
• Collombat P, Mansouri A, Hecksher-Sorensen J, et al. Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev 2003;17:2591-603
   PubMed Web of Science ®Google Scholar
• Gannon M, Ables ET, Crawford L, et al. pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 2008;314:406-17
   PubMed Web of Science ®Google Scholar
• Henseleit KD, Nelson SB, Kuhlbrodt K, et al. NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development 2005;132:3139-49
   PubMed Web of Science ®Google Scholar
• Sosa-Pineda B, Chowdhury K, Torres M, et al. The Pax4 gene is essential for differentiation of insulin-producing b cells in the mammalian pancreas. Nature 1997;386:399-402
   PubMed Web of Science ®Google Scholar
• Ahlgren U, Jonsson J, Jonsson L, et al. beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 1998;12:1763-8
   PubMed Web of Science ®Google Scholar
• Matsuoka TA, Zhao L, Artner I, et al. Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells. Mol Cell Biol 2003;23:6049-62
   PubMed Web of Science ®Google Scholar
• Serup P, Jensen J, Andersen FG, et al. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Proc Natl Acad Sci USA 1996;93:9015-20
   PubMed Web of Science ®Google Scholar
• Aramata S, Han SI, Yasuda K, Kataoka K. Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1. Biochim Biophys Acta 2005;1730:41-6
   PubMed Web of Science ®Google Scholar
• Kataoka K, Han SI, Shioda S, et al. MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem 2002;277:49903-10
   PubMed Web of Science ®Google Scholar
• Olbrot M, Rud J, Moss LG, Sharma A. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci USA 2002;99:6737-42
   PubMed Web of Science ®Google Scholar
• Soria B, Pezzolla D, López J, et al. Generation of pancreatic islets from stem cells. In: Robert L, Vacanti JP, editors. Principles of tissue engineering. 4th edition. Elsevier BV, Oxford (United Kingdom); 2014. p. 837-47
   Google Scholar
• Kroon E, Martinson LA, Kadoya K, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 2008;26:443-52
   PubMed Web of Science ®Google Scholar
• Rezania A, Bruin JE, Riedel MJ, et al. Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice. Diabetes 2012;61:2016-29
   PubMed Web of Science ®Google Scholar
• Rezania A, Bruin JE, Xu J, et al. Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells 2013;31:2432-42
   PubMed Web of Science ®Google Scholar
• Sumi T, Tsuneyoshi N, Nakatsuji N, Suemori H. Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling. Development 2008;135:2969-79
   PubMed Web of Science ®Google Scholar
• Teo AK, Ali Y, Wong KY, et al. Activin and BMP4 synergistically promote formation of definitive endoderm in human embryonic stem cells. Stem Cells 2012;30:631-42
   PubMed Web of Science ®Google Scholar
• Borowiak M, Maehr R, Chen S, et al. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 2009;4:348-58
   PubMed Web of Science ®Google Scholar
• Johannesson M, Stahlberg A, Ameri J, et al. FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner. PLoS ONE 2009;4:e4794
   Web of Science ®Google Scholar
• Ameri J, Stahlberg A, Pedersen J, et al. FGF2 specifies hESC-derived definitive endoderm into foregut/midgut cell lineages in a concentration-dependent manner. Stem Cells 2010;28:45-56
   PubMed Web of Science ®Google Scholar
• Jiang J, Au M, Lu K, et al. Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 2007;25:1940-53
   PubMed Web of Science ®Google Scholar
• Jiang W, Shi Y, Zhao D, et al. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res 2007;17:333-44
   PubMed Web of Science ®Google Scholar
• Zhang D, Jiang W, Liu M, et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 2009;19:429-38
   PubMed Web of Science ®Google Scholar
• Kim SK, Melton DA. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Natl Acad Sci USA 1998;95:13036-41
   PubMed Web of Science ®Google Scholar
• Cho YM, Lim JM, Yoo DH, et al. Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem Biophys Res Commun 2008;366:129-34
   PubMed Web of Science ®Google Scholar
• Phillips BW, Hentze H, Rust WL, et al. Directed differentiation of human embryonic stem cells into the pancreatic endocrine lineage. Stem Cells Dev 2007;16:561-78
   PubMed Web of Science ®Google Scholar
• Champeris Tsaniras S. Generating mature beta-cells from embryonic stem cells: strategies for late-stage differentiation. Vitam Horm 2011;87:79-92
   PubMed Web of Science ®Google Scholar
• Nostro MC, Keller G. Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine. Semin Cell Dev Biol 2012;23:701-10
   PubMed Web of Science ®Google Scholar
• Baetge EE. Production of beta-cells from human embryonic stem cells. Diabetes Obes Metab 2008;10(Suppl 4):186-94
   PubMed Web of Science ®Google Scholar
• Schiesser JV, Wells JM. Generation of beta cells from human pluripotent stem cells: are we there yet? Ann N Y Acad Sci 2014;1311:124-37
   PubMed Web of Science ®Google Scholar
• Basford CL, Prentice KJ, Hardy AB, et al. The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells. Diabetologia 2012;55:358-71
   PubMed Web of Science ®Google Scholar
• Bruin JE, Erener S, Vela J, et al. Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells. Stem Cell Res 2014;12:194-208
   PubMed Web of Science ®Google Scholar
• Hrvatin S, O’Donnell CW, Deng F, et al. Differentiated human stem cells resemble fetal, not adult, beta cells. Proc Natl Acad Sci USA 2014;111:3038-43
   PubMed Web of Science ®Google Scholar
• Shiroi A, Yoshikawa M, Yokota H, et al. Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone. Stem Cells 2002;20:284-92
   PubMed Web of Science ®Google Scholar
• Bluth MH, Patel SA, Dieckgraefe BK, et al. Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis. World J Gastroenterol 2006;12:4511-16
   PubMed Web of Science ®Google Scholar
• Takasawa S, Ikeda T, Akiyama T, et al. Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration. FEBS Lett 2006;580:585-91
   PubMed Web of Science ®Google Scholar
• Gouge RC, Marshburn P, Gordon BE, et al. Nitric oxide as a regulator of embryonic development. Biol Reprod 1998;58:875-9
   PubMed Web of Science ®Google Scholar
• Sengoku K, Takuma N, Horikawa M, et al. Requirement of nitric oxide for murine oocyte maturation, embryo development, and trophoblast outgrowth in vitro. Mol Reprod Dev 2001;58:262-8
   PubMed Web of Science ®Google Scholar
• Kanno S, Kim PK, Sallam K, et al. Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells. Proc Natl Acad Sci USA 2004;101:12277-81
   PubMed Web of Science ®Google Scholar
• Mujoo K, Sharin VG, Bryan NS, et al. Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells. Proc Natl Acad Sci USA 2008;105:18924-9
   PubMed Web of Science ®Google Scholar
• Mora-Castilla S, Tejedo JR, Hmadcha A, et al. Nitric oxide repression of Nanog promotes mouse embryonic stem cell differentiation. Cell Death Differ 2010;17:1025-33
   PubMed Web of Science ®Google Scholar
• Horrillo A, Pezzolla D, Fraga MF, et al. Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment. Cell Death Dis 2013;4:e570
   Google Scholar
• Hmadcha A, Bedoya FJ, Sobrino F, Pintado E. Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production. J Exp Med 1999;190:1595-604
   PubMed Web of Science ®Google Scholar
• Hinton A, Hunter S, Reyes G, et al. From pluripotency to islets: miRNAs as critical regulators of human cellular differentiation. Adv Genet 2012;79:1-34
   PubMed Web of Science ®Google Scholar
• Sun LL, Jiang BG, Li WT, et al. MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression. Diabetes Res Clin Pract 2011;91:94-100
   PubMed Web of Science ®Google Scholar
• Tang X, Muniappan L, Tang G, Ozcan S. Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription. RNA 2009;15:287-93
   PubMed Web of Science ®Google Scholar
• Baroukh N, Ravier MA, Loder MK, et al. MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines. J Biol Chem 2007;282:19575-88
   PubMed Web of Science ®Google Scholar
• Ramachandran D, Roy U, Garg S, et al. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic beta-islets. FEBS J 2011;278:1167-74
   PubMed Web of Science ®Google Scholar
• Rosa A, Papaioannou MD, Krzyspiak JE, Brivanlou AH. miR-373 is regulated by TGFbeta signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells. Dev Biol 2014;391:81-8
   PubMed Web of Science ®Google Scholar
• Melkman-Zehavi T, Oren R, Kredo-Russo S, et al. miRNAs control insulin content in pancreatic beta-cells via downregulation of transcriptional repressors. EMBO J 2011;30:835-45
   PubMed Web of Science ®Google Scholar
• Kloosterman WP, Lagendijk AK, Ketting RF, et al. Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biol 2007;5:e203
   PubMed Web of Science ®Google Scholar
• Poy MN, Hausser J, Trajkovski M, et al. miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci USA 2009;106:5813-18
   PubMed Web of Science ®Google Scholar
• Joglekar MV, Joglekar VM, Hardikar AA. Expression of islet-specific microRNAs during human pancreatic development. Gene Expr Patterns 2009;9:109-13
   PubMed Web of Science ®Google Scholar
• Nieto M, Hevia P, Garcia E, et al. Antisense miR-7 impairs insulin expression in developing pancreas and in cultured pancreatic buds. Cell Transplant 2012;21:1761-74
   PubMed Web of Science ®Google Scholar
• Lahmy R, Soleimani M, Sanati MH, et al. Pancreatic islet differentiation of human embryonic stem cells by microRNA overexpression. J Tissue Eng Regen Med 2013; Epub ahead of print
   PubMed Web of Science ®Google Scholar
• Haumaitre C. Epigenetic regulation of pancreatic islets. Curr Diab Rep 2013;13:624-32
   PubMed Web of Science ®Google Scholar
• Russ HA, Hebrok M. Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors. EMBO J 2014;33:2135-6
   PubMed Web of Science ®Google Scholar
• Lenoir O, Flosseau K, Ma FX, et al. Specific control of pancreatic endocrine beta- and delta-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Diabetes 2011;60:2861-71
   PubMed Web of Science ®Google Scholar
• Xu CR, Li LC, Donahue G, et al. Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification. EMBO J 2014;33:2157-70
   PubMed Web of Science ®Google Scholar
• Schulz TC, Young HY, Agulnick AD, et al. A scalable system for production of functional pancreatic progenitors from human embryonic stem cells. PLoS One 2012;7:e37004
   PubMed Web of Science ®Google Scholar
• Shim JH, Kim SE, Woo DH, et al. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 2007;50:1228-38
   PubMed Web of Science ®Google Scholar
• Vetterli L, Brun T, Giovannoni L, et al. Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. J Biol Chem 2011;286:6049-60
   PubMed Web of Science ®Google Scholar
• Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-42
   PubMed Web of Science ®Google Scholar
• Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003;425:191-6
   PubMed Web of Science ®Google Scholar
• Calvanese V, Lara E, Suarez-Alvarez B, et al. Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Proc Natl Acad Sci USA 2010;107:13736-41
   PubMed Web of Science ®Google Scholar
• Vaca P, Berna G, Araujo R, et al. Nicotinamide induces differentiation of embryonic stem cells into insulin-secreting cells. Exp Cell Res 2008;314:969-74
   PubMed Web of Science ®Google Scholar
• Zhang Y, Jayaprakasam B, Seeram NP, et al. Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds. J Agric Food Chem 2004;52:228-33
   PubMed Web of Science ®Google Scholar
• Bordone L, Motta MC, Picard F, et al. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol 2006;4:e31
   PubMed Web of Science ®Google Scholar
• Affourtit C, Brand MD. Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion. Biochem J 2008;409:199-204
   PubMed Web of Science ®Google Scholar
• Moynihan KA, Grimm AA, Plueger MM, et al. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab 2005;2:105-17
   PubMed Web of Science ®Google Scholar
• Fiori JL, Shin YK, Kim W, et al. Resveratrol prevents beta-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet. Diabetes 2013;62:3500-13
   PubMed Web of Science ®Google Scholar
• Xie S, Sinha RA, Singh BK, et al. Resveratrol induces insulin gene expression in mouse pancreatic alpha-cells. Cell Biosci 2013;3:47
   Google Scholar
• Eshpeter A, Jiang J, Au M, et al. In vivo characterization of transplanted human embryonic stem cell-derived pancreatic endocrine islet cells. Cell Prolif 2008;41:843-58
   PubMed Web of Science ®Google Scholar
• Steiner DF, James DE. Cellular and molecular biology of the beta cell. Diabetologia 1992;35(Suppl 2):S41-8
   PubMed Web of Science ®Google Scholar
• Thorens B. Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes. Am J Physiol 1996;270(4 Pt 1):G541-53
   Google Scholar
• Kelly OG, Chan MY, Martinson LA, et al. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat Biotechnol 2011;29:750-6
   PubMed Web of Science ®Google Scholar
• Shiraki N, Yoshida T, Araki K, et al. Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm. Stem Cells 2008;26:874-85
   PubMed Web of Science ®Google Scholar
• Ensenat-Waser R, Santana A, Vicente-Salar N, et al. Isolation and characterization of residual undifferentiated mouse embryonic stem cells from embryoid body cultures by fluorescence tracking. In Vitro Cell Dev Biol Anim 2006;42:115-23
   PubMed Web of Science ®Google Scholar
• Lavon N, Yanuka O, Benvenisty N. The effect of overexpression of Pdx1 and Foxa2 on the differentiation of human embryonic stem cells into pancreatic cells. Stem Cells 2006;24:1923-30
   PubMed Web of Science ®Google Scholar
• Ruby KM, Zheng B. Gene targeting in a HUES line of human embryonic stem cells via electroporation. Stem Cells 2009;27:1496-506
   PubMed Web of Science ®Google Scholar
• Elliott DA, Braam SR, Koutsis K, et al. NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat Methods 2011;8:1037-40
   PubMed Web of Science ®Google Scholar
• Cai Q, Bonfanti P, Sambathkumar R, et al. Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells. Stem Cells Transl Med 2014;3:489-99
   Google Scholar
• Liu H, Yang H, Zhu D, et al. Systematically labeling developmental stage-specific genes for the study of pancreatic beta-cell differentiation from human embryonic stem cells. Cell Res 2014;24:1181-200
   PubMed Web of Science ®Google Scholar
• King FW, Liszewski W, Ritner C, Bernstein HS. High-throughput tracking of pluripotent human embryonic stem cells with dual fluorescence resonance energy transfer molecular beacons. Stem Cells Dev 2011;20:475-84
   PubMed Web of Science ®Google Scholar
• Migliorini A, Bader E, Lickert H. Islet cell plasticity and regeneration. Mol Metab 2014;3:268-74
   Google Scholar
• Rodriguez-Diaz R, Dando R, Jacques-Silva MC, et al. Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans. Nat Med 2011;17:888-92
   PubMed Web of Science ®Google Scholar
• Skoudy A, Rovira M, Savatier P, et al. Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells. Biochem J 2004;379(Pt 3):749-56
   PubMed Web of Science ®Google Scholar
• Alvarez-Mercado AI, Cobo-Vuilleumier N, Suarez Martin E, Gauthier BR. Emerging therapeutic targets in regenerative medicine for the treatment of diabetes mellitus: a patent literature review. Recent Pat Regen Med 2013;3:56-62
   Google Scholar
• Keenan HA, Sun JK, Levine J, et al. Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes 2010;59:2846-53
   PubMed Web of Science ®Google Scholar
• Meier JJ, Bhushan A, Butler AE, et al. Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 2005;48:2221-8
   PubMed Web of Science ®Google Scholar
• Pipeleers D, In’t Veld P, Pipeleers-Marichal M, Gorus F. The beta cell population in type 1 diabetes. Novartis Found Symp 2008;292:19-24; discussion 24-31, 122-9, 202-3
   PubMedGoogle Scholar
• Sherry NA, Kushner JA, Glandt M, et al. Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes 2006;55:3238-45
   PubMed Web of Science ®Google Scholar
• Tonne JM, Sakuma T, Munoz-Gomez M, et al. Beta cell regeneration after single-round immunological destruction in a mouse model. Diabetologia 2015;58:313-23
   PubMed Web of Science ®Google Scholar
• Granger A, Kushner JA. Cellular origins of beta-cell regeneration: a legacy view of historical controversies. J Intern Med 2009;266:325-38
   PubMed Web of Science ®Google Scholar
• Bonner-Weir S, Li WC, Ouziel-Yahalom L, et al. Beta-cell growth and regeneration: replication is only part of the story. Diabetes 2010;59:2340-8
   PubMed Web of Science ®Google Scholar
• Inada A, Nienaber C, Katsuta H, et al. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci USA 2008;105:19915-19
   PubMed Web of Science ®Google Scholar
• Peshavaria M, Larmie BL, Lausier J, et al. Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse. Diabetes 2006;55:3289-98
   PubMed Web of Science ®Google Scholar
• Chera S, Baronnier D, Ghila L, et al. Diabetes recovery by age-dependent conversion of pancreatic delta-cells into insulin producers. Nature 2014;514:503-7
   PubMed Web of Science ®Google Scholar
• Thorel F, Nepote V, Avril I, et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 2010;464:1149-54
   PubMed Web of Science ®Google Scholar
• Xu X, D’Hoker J, Stange G, et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 2008;132:197-207
   PubMed Web of Science ®Google Scholar
• Chung CH, Hao E, Piran R, et al. Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells. Stem Cells 2010;28:1630-8
   PubMed Web of Science ®Google Scholar
• Seaberg RM, Smukler SR, Kieffer TJ, et al. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol 2004;22:1115-24
   PubMed Web of Science ®Google Scholar
• Smukler SR, Arntfield ME, Razavi R, et al. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell 2011;8:281-93
   PubMed Web of Science ®Google Scholar
• Cobo-Vuilleumier N, Gauthier BR. To b-e or not to b-e replicating after 30: Retrospective dating of human pancreatic islets. J Clin Endocrinol Metab 2010;95:4552-4
   PubMed Web of Science ®Google Scholar
• Perl S, Kushner JA, Buchholz BA, et al. Significant human {beta}-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab 2010;95:E234-E39
   PubMed Web of Science ®Google Scholar
• Zhou Q, Brown J, Kanarek A, et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008;455:627-32
   PubMed Web of Science ®Google Scholar
• Ianus A, Holz G, Theise N, Hussain M. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003;111:843-50
   PubMed Web of Science ®Google Scholar
• Hasegawa Y, Ogihara T, Yamada T, et al. Bone marrow (BM) transplantation promotes beta-cell regeneration after acute injury through BM cell mobilization. Endocrinology 2007;148:2006-15
   PubMed Web of Science ®Google Scholar
• Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41-6
   PubMed Web of Science ®Google Scholar
• Teta M, Rankin MM, Long SY, et al. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 2007;12:817-26
   PubMed Web of Science ®Google Scholar
• Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by beta cell regeneration. J Clin Invest 2007;117:2553-61
   PubMed Web of Science ®Google Scholar
• Brennand K, Huangfu D, Melton D. All beta Cells Contribute Equally to Islet Growth and Maintenance. PLoS Biol 2007;5:e163
   PubMed Web of Science ®Google Scholar
• Spijker HS, Ravelli RB, Mommaas-Kienhuis AM, et al. Conversion of mature human beta-cells into glucagon-producing alpha-cells. Diabetes 2013;62:2471-80
   PubMed Web of Science ®Google Scholar
• Willcox A, Richardson SJ, Bone AJ, et al. Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia 2010;53:2020-8
   PubMed Web of Science ®Google Scholar
• In’t Veld P, Lievens D, De Grijse J, et al. Screening for insulitis in adult autoantibody-positive organ donors. Diabetes 2007;56:2400-4
   PubMed Web of Science ®Google Scholar
• Meier JJ, Lin JC, Butler AE, et al. Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 2006;49:1838-44
   PubMed Web of Science ®Google Scholar
• Carrasco M, Rojas A, Delgado I, et al. Islets of Langerhans. In: Islam S, editor. Regulation of pancreatic islet formation. Springer, Dordrecht (Netherlands); 2015. p. 109-29
   Google Scholar
• Collombat P, Xu X, Ravassard P, et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 2009;138:449-62
   PubMed Web of Science ®Google Scholar
• Courtney M, Gjernes E, Druelle N, et al. The inactivation of Arx in pancreatic alpha-cells triggers their neogenesis and conversion into functional beta-like cells. PLoS Genet 2013;9:e1003934
   PubMed Web of Science ®Google Scholar
• Hu He KH, Lorenzo PI, Brun T, et al. In vivo conditional Pax4 overexpression in mature islet {beta}-cells prevents stress-induced hyperglycemia in mice. Diabetes 2011;60:1705-15
   PubMed Web of Science ®Google Scholar
• Brun T, Herrera P, Brighouse D, et al. Identification and characterization of a mouse islet cell subpopulation expressing high levels of the transcription factor Pax4. Diabetes 2007(Suppl 1):56:A424
   Google Scholar
• Dirice E, Kahraman S, Jiang W, et al. Soluble factors secreted by T cells promote beta-cell proliferation. Diabetes 2014;63:188-202
   PubMed Web of Science ®Google Scholar
• Habener JF. Stanojevic V. alpha-cell role in beta-cell generation and regeneration. Islets 2012;4:188-98
   PubMed Web of Science ®Google Scholar
• Yuan Y, Hartland K, Boskovic Z, et al. A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem Biol 2013;20:1513-22
   PubMed Web of Science ®Google Scholar