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Review

Targeting dendritic cells with antigen-containing liposomes: antitumour immunity

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Pages 1735-1747 | Published online: 23 Feb 2005

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  • VAN BROEKHOVEN CL, PARISH CR, DEMANGEL C, BRITTON WJ, ALTIN JG: Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumour immunity and for tumour immunotherapy. Cancer Res. (2004) 64:4357–4365.
  • ••This paper shows that tumour-derivedPMVs can be modified to target both tumour-associated antigens and a DC maturation signal directly to DCs in vivo for enhancement of antitumour immunity.
  • BONIFAZ LC, BONNYAY DP, CHARALAMBOUS A et al: In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. Exp. Med. (2004) 199(6):815–824.
  • ••This paper shows that a fusion proteinantigen targeted to DEC-205 on DCs in vivo elicits effective antitumour responses only when co-administered with a DC activation signal.

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